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The map label for this gene is hemH

Identifier: 120598529

GI number: 120598529

Start: 1969906

End: 1970949

Strand: Direct

Name: hemH

Synonym: Sputw3181_1712

Alternate gene names: 120598529

Gene position: 1969906-1970949 (Clockwise)

Preceding gene: 120598528

Following gene: 120598530

Centisome position: 41.84

GC content: 44.73

Gene sequence:

>1044_bases
ATGTTAGCCTGCCGAGGTAATTGGCTGATAAAAGGTAACACATTGACTTCTCCCTCTCCTGCGTTTGGCGTGTTATTAGT
AAATCTTGGTACGCCCGATGAACCTACTCCAAAAGCGGTTAAGCGGTTTCTCAAGCAGTTTTTAAGTGATCCTCGGGTCG
TCGATCTCTCGCCTTGGCTGTGGCAACCGCTGTTAAATGGCATTATTCTCAATACGCGTCCTGCGAAAGTGGCCAAGTTA
TATCAGAGTATTTGGACAGATGAAGGCTCGCCCTTAATGGTGTTAAGCTCACGCCAAGCCCAAAAATTGGCGGTGGATTT
AAGCGCGACCTTTAATCAAGATATTCCCGTTGAATTGGGGATGAGCTACGGTAATCCGTCGATTGATAGCGGTTTTGCGA
GGCTTAAGGCACAAGGTGCTGAGCGGATTGTAGTCTTACCTCTTTATCCGCAATATTCTTGCTCGACGGTAGCAAGCGTG
TTTGATGCTGTTGCCAGTTATCTTAAAACCGTGCGCGATATGCCGGAACTTCGTTTTAATAAACACTATTTTGACCATGA
AGCTTATATCGCAGCACTTGCCCACAGTGTCAAACGCCATTGGAAAACCTATGGTCAAGCGGACAAATTACTGCTTTCGT
TCCACGGCATTCCACTACGTTATGTGAAAGAGGGCGATCCATACCGCGAACAATGTCTTGTGACAGCGAAACTTTTGGCA
CAAAAGCTTGAGTTGAATGAAGCACAATGGCAGGTTTGTTTTCAATCGCGCTTTGGTCGTGAAGAATGGCTTACCCCCTA
TGCTGATGAATTGCTTGCTAAGTTACCTTCACAGGGCATTAAAAGTGTTGATGTCATTTGTCCCGCTTTTGCAACCGATT
GCCTAGAAACCCTAGAAGAGATTTCTATTGGTGGCAAAGAAACCTTCTTACATGCGGGTGGTGAAACATATCGTTTTATT
CCCTGCCTTAATGATGATGAGATGCATATAGAATTATTAAGGCAATTAGTCCAAGAACAGGCACATTCTTGGAATTATCC
CTAA

Upstream 100 bases:

>100_bases
TTGCCAGTGTACTTAAATAAGCCACATTAGCTAAATTCGAGAACAAGTTCTCATATTAAGAAAAAGCCTGCCTAAGCAGG
CTTTTTTTATGTGTGACTGA

Downstream 100 bases:

>100_bases
GCGCTGAAAATGCAGGACTAAGGCTGTTTAAGGAGTTAAAGGAGGCGAACTACATTTTTAAGTAAACATTGCGAAGCATT
GTTGATCCCCCTAGTTTCAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLACRGNWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPLLNGIILNTRPAKVAKL
YQSIWTDEGSPLMVLSSRQAQKLAVDLSATFNQDIPVELGMSYGNPSIDSGFARLKAQGAERIVVLPLYPQYSCSTVASV
FDAVASYLKTVRDMPELRFNKHYFDHEAYIAALAHSVKRHWKTYGQADKLLLSFHGIPLRYVKEGDPYREQCLVTAKLLA
QKLELNEAQWQVCFQSRFGREEWLTPYADELLAKLPSQGIKSVDVICPAFATDCLETLEEISIGGKETFLHAGGETYRFI
PCLNDDEMHIELLRQLVQEQAHSWNYP

Sequences:

>Translated_347_residues
MLACRGNWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPLLNGIILNTRPAKVAKL
YQSIWTDEGSPLMVLSSRQAQKLAVDLSATFNQDIPVELGMSYGNPSIDSGFARLKAQGAERIVVLPLYPQYSCSTVASV
FDAVASYLKTVRDMPELRFNKHYFDHEAYIAALAHSVKRHWKTYGQADKLLLSFHGIPLRYVKEGDPYREQCLVTAKLLA
QKLELNEAQWQVCFQSRFGREEWLTPYADELLAKLPSQGIKSVDVICPAFATDCLETLEEISIGGKETFLHAGGETYRFI
PCLNDDEMHIELLRQLVQEQAHSWNYP
>Mature_347_residues
MLACRGNWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWLWQPLLNGIILNTRPAKVAKL
YQSIWTDEGSPLMVLSSRQAQKLAVDLSATFNQDIPVELGMSYGNPSIDSGFARLKAQGAERIVVLPLYPQYSCSTVASV
FDAVASYLKTVRDMPELRFNKHYFDHEAYIAALAHSVKRHWKTYGQADKLLLSFHGIPLRYVKEGDPYREQCLVTAKLLA
QKLELNEAQWQVCFQSRFGREEWLTPYADELLAKLPSQGIKSVDVICPAFATDCLETLEEISIGGKETFLHAGGETYRFI
PCLNDDEMHIELLRQLVQEQAHSWNYP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=24.9258160237389, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=24.9258160237389, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=52.3809523809524, Blast_Score=321, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6324750, Length=331, Percent_Identity=24.4712990936556, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=24.188790560472, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24651774, Length=267, Percent_Identity=23.2209737827715, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39130; Mature: 39130

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLACRGNWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWL
CEEECCCEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHH
WQPLLNGIILNTRPAKVAKLYQSIWTDEGSPLMVLSSRQAQKLAVDLSATFNQDIPVELG
HHHHHCCEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHEEEEHHCCCCCCCCEEC
MSYGNPSIDSGFARLKAQGAERIVVLPLYPQYSCSTVASVFDAVASYLKTVRDMPELRFN
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
KHYFDHEAYIAALAHSVKRHWKTYGQADKLLLSFHGIPLRYVKEGDPYREQCLVTAKLLA
CHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHH
QKLELNEAQWQVCFQSRFGREEWLTPYADELLAKLPSQGIKSVDVICPAFATDCLETLEE
HHHHCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ISIGGKETFLHAGGETYRFIPCLNDDEMHIELLRQLVQEQAHSWNYP
HCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLACRGNWLIKGNTLTSPSPAFGVLLVNLGTPDEPTPKAVKRFLKQFLSDPRVVDLSPWL
CEEECCCEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHH
WQPLLNGIILNTRPAKVAKLYQSIWTDEGSPLMVLSSRQAQKLAVDLSATFNQDIPVELG
HHHHHCCEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHEEEEHHCCCCCCCCEEC
MSYGNPSIDSGFARLKAQGAERIVVLPLYPQYSCSTVASVFDAVASYLKTVRDMPELRFN
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
KHYFDHEAYIAALAHSVKRHWKTYGQADKLLLSFHGIPLRYVKEGDPYREQCLVTAKLLA
CHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHH
QKLELNEAQWQVCFQSRFGREEWLTPYADELLAKLPSQGIKSVDVICPAFATDCLETLEE
HHHHCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ISIGGKETFLHAGGETYRFIPCLNDDEMHIELLRQLVQEQAHSWNYP
HCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]