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The map label for this gene is ada [H]

Identifier: 120598329

GI number: 120598329

Start: 1717487

End: 1719178

Strand: Direct

Name: ada [H]

Synonym: Sputw3181_1511

Alternate gene names: 120598329

Gene position: 1717487-1719178 (Clockwise)

Preceding gene: 120598327

Following gene: 120598330

Centisome position: 36.48

GC content: 49.65

Gene sequence:

>1692_bases
ATGAGTGCAGATAGAGCCTCTGAGAGTGCAAATAAGCGTGATGAAATAGACTCAATGCATTCGCTGGAGTTCAGTGCAGG
GCAACTTTCTGCGTCCATTTGCCGTGAAGCGAGGATGAGCCGCGATCCGCGTTTTGATGGTAAGTTTTTTGTGGGCGTAT
TAACGACGGGCATTTATTGCCGAACTGTGTGTCCTGCTGTGGCACCAAAAGAGCAAAATGTGCGTTATTTTGATTCGGCC
ATTAAAGCCGCGCAGGCGGGATTACGCCCATGTTTACGTTGTCGGCCCGACAGTGCGCCGGGATCGAATCCTTGGAAGGG
GACTGGCACAACGTTAGCGAGGGCCATTAGTTTAATCGAAGCGGGCGCCTTAGCGGGAAAGTCATCGGGAGAGCCAGCCT
CGACAGTAACACAATTGGCTGACCGATTAGGGATCAGCAGTCGTTATCTCAATAAGCTCTTTACCGAAGGCTTTGGCACT
TCGCCAAAACAATATGCCTTATATCGGCAGTTACTGTTTGCTAAACAATTATTGCACCAAACCCAATTACCTATCACTCA
AGTCGCGATGGCGGCGGGTTTCAACAGTATTCGCCGTTTCAATGAGGCGTTTAAGCAAACCTTGCAATTGACGCCGACCC
AGTTAAGAAAGAGTGCATTAACCAAAGCGGCAAAGGAGTCCATGAGTGAGCCACTAACAGGATTAGGTGAGATTGATACA
ATGGGTGAATTTGTGCCGCACTATGGATTAACCTTGTATCAGTATTATCGGCCTCCATTGGATTGGACATCACAGCTGGC
GTTTTATCGATTACGTGCAGTAACAGGGATGGAATGGTTCACACCGCAGATGAGTCATCCACAAGCGAGCGATGTCGTTG
GCGATGAGGCGTCCGTGGTAGATGAGGCCAAAGCTGGCGATAATGGGCTCGAATATGGTCGCTGTTTTGCCCTAGGTAAG
ATGCGCGGCACAGTGCACATTATCCATGAGCCTAAGCTAAATCGCTTCAAACTCGCGATAATGTTGACCGAAGATTCCCT
TGTCGATGAGCTGCAATTGCTGGTCACTGAAGTGCGACGCATTTTAGATCTCGATGCGGATATGCTGCAGATTGAACAAG
GCTTAAGTGCGCTACCAAGTTTAGGATTAACACCGTTTTCGGGATTACGCATTCCCGGTGCAGGCTCCTTATTTGAGGCG
GCCTGCCGTGCGATTTTAGGCCAACAAGTGACGGTAGTGCAGGCGACTAAGCTACTTAATCAATTGGTTGAAGCCTATGG
CGAGCGCTTTAGTCTCAATGGTTGCGAGTATCGTTTATTTCCTACACCCGAGGCCATTCGTGAGGCGAGTCTAACAGAGC
TAAAAATGCCCGGCGCTCGTAAATTAGCCCTCAATGCGCTCGCGGCGTTTATCTGCGATCATCCTGAGGCGAGTGTCGAT
GATTGGCTCAGCGTTAAGGGCATAGGTCCTTGGACAATCGCGTATGCTAAGCTCCGCGGTTTGGGCGATCCCAATGTGTT
TTTGCATACCGATTTGATTGTTAAAAAGCATTTGCTGGCCTTGTATGGCAAGACCCATAGGCTGGATGAAGCCGCTGCGG
GTGCAGTCAACTACCCGCAGCTGTGCCAGCAATTGAGTCAAGAAATCGCGCCTTGGGGCAGTTATTTAACCTTTCAGCTT
TGGCATCAATAG

Upstream 100 bases:

>100_bases
ATGATTGAGTTCCGTTTTCCGCTAGTGCTACATGCTAGTTTTACGTAAAGTAATGAACAAGAAATTAATTGTGAGCGAAT
ATTGTCGGGCGTGATGAAAA

Downstream 100 bases:

>100_bases
CGACTAAAACGATTTAAGTTGAAGACATAAATAGAGAGATAAATTATGAAGCATGCGATTCGTCAATTGAGCCAAGCGCC
GAGTATTGCAGCGTATCAGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSADRASESANKRDEIDSMHSLEFSAGQLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
IKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVAMAAGFNSIRRFNEAFKQTLQLTPTQLRKSALTKAAKESMSEPLTGLGEIDT
MGEFVPHYGLTLYQYYRPPLDWTSQLAFYRLRAVTGMEWFTPQMSHPQASDVVGDEASVVDEAKAGDNGLEYGRCFALGK
MRGTVHIIHEPKLNRFKLAIMLTEDSLVDELQLLVTEVRRILDLDADMLQIEQGLSALPSLGLTPFSGLRIPGAGSLFEA
ACRAILGQQVTVVQATKLLNQLVEAYGERFSLNGCEYRLFPTPEAIREASLTELKMPGARKLALNALAAFICDHPEASVD
DWLSVKGIGPWTIAYAKLRGLGDPNVFLHTDLIVKKHLLALYGKTHRLDEAAAGAVNYPQLCQQLSQEIAPWGSYLTFQL
WHQ

Sequences:

>Translated_563_residues
MSADRASESANKRDEIDSMHSLEFSAGQLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
IKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVAMAAGFNSIRRFNEAFKQTLQLTPTQLRKSALTKAAKESMSEPLTGLGEIDT
MGEFVPHYGLTLYQYYRPPLDWTSQLAFYRLRAVTGMEWFTPQMSHPQASDVVGDEASVVDEAKAGDNGLEYGRCFALGK
MRGTVHIIHEPKLNRFKLAIMLTEDSLVDELQLLVTEVRRILDLDADMLQIEQGLSALPSLGLTPFSGLRIPGAGSLFEA
ACRAILGQQVTVVQATKLLNQLVEAYGERFSLNGCEYRLFPTPEAIREASLTELKMPGARKLALNALAAFICDHPEASVD
DWLSVKGIGPWTIAYAKLRGLGDPNVFLHTDLIVKKHLLALYGKTHRLDEAAAGAVNYPQLCQQLSQEIAPWGSYLTFQL
WHQ
>Mature_562_residues
SADRASESANKRDEIDSMHSLEFSAGQLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSAI
KAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGTS
PKQYALYRQLLFAKQLLHQTQLPITQVAMAAGFNSIRRFNEAFKQTLQLTPTQLRKSALTKAAKESMSEPLTGLGEIDTM
GEFVPHYGLTLYQYYRPPLDWTSQLAFYRLRAVTGMEWFTPQMSHPQASDVVGDEASVVDEAKAGDNGLEYGRCFALGKM
RGTVHIIHEPKLNRFKLAIMLTEDSLVDELQLLVTEVRRILDLDADMLQIEQGLSALPSLGLTPFSGLRIPGAGSLFEAA
CRAILGQQVTVVQATKLLNQLVEAYGERFSLNGCEYRLFPTPEAIREASLTELKMPGARKLALNALAAFICDHPEASVDD
WLSVKGIGPWTIAYAKLRGLGDPNVFLHTDLIVKKHLLALYGKTHRLDEAAAGAVNYPQLCQQLSQEIAPWGSYLTFQLW
HQ

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=319, Percent_Identity=30.0940438871473, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788542, Length=192, Percent_Identity=28.6458333333333, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 61956; Mature: 61825

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
SADRASESANKRDEIDSMHSLEFSAGQLSASICREARMSRDPRFDGKFFVGVLTTGIYC
CCCCCHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHH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HHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]