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The map label for this gene is atoC [H]

Identifier: 120598248

GI number: 120598248

Start: 1612136

End: 1613476

Strand: Direct

Name: atoC [H]

Synonym: Sputw3181_1425

Alternate gene names: 120598248

Gene position: 1612136-1613476 (Clockwise)

Preceding gene: 120598247

Following gene: 120598249

Centisome position: 34.24

GC content: 43.92

Gene sequence:

>1341_bases
ATGTCTGAAGCCAAGTTACTCTTAGTTGAAGACGACGCCTCATTAAGGGAAGCCTTACTCGATACTTTATTACTTGCACA
GTATGAATGTATTGATGTGGCTTGTGGTGAAGATGCCATTCTTGCATTAAAACAGCATCAATTTGATCTCGTGATAAGTG
ATGTGCAGATGGAGGGTATTGGCGGTTTAGGTTTGCTAAATTACCTGCAGCAACATCATCCTAAATTGCCCGTATTGCTG
ATGACGGCCTATGCCACGATTGGCAGTGCCGTTAGCGCGATTAAACTAGGTGCAGTTGACTATTTAGCCAAACCCTTTGC
GCCAGAAGTATTGTTAAATCAAGTTTCTCGCTATTTACCTTTAAAAACCAACGTTGATAAGCCCATTGTTGCTGATGAGA
AGAGTCTTGCATTGTTATCACTAGCACAACGCGTTGCAGCATCCGATGCTTCTGTGATGATCATGGGACCCAGTGGTTCG
GGTAAAGAAGTACTCGCTCGTTATATTCATCAGCATAGCAGCCGTGCCGAACAAGCCTTTGTTGCCATCAACTGTGCCGC
TATTCCTGAAAATATGCTTGAAGCAACTCTCTTCGGATATGAAAAGGGCGCATTTACTGGTGCTTACCAAGCATGCCCTG
GTAAGTTTGAACAAGCGCAAGGTGGGACTTTGCTGCTCGATGAAATATCAGAAATGGATTTAGGTTTACAGGCAAAATTA
TTACGGGTGTTACAAGAGCGTGAAGTTGAACGATTAGGTGGTCGTAAGACGATTAAGCTCGATGTTCGTGTATTGGCGAC
CTCAAATCGTGATTTAAAAGCGGTAGTAGCCGCAGGTGGATTTAGGGAAGATCTTTATTACCGTATCAATGTATTTCCAT
TAACATGGCCGGCGCTCAATCAAAGGCCTGCGGATATCTTACCGCTTGCTCGCCATTTATTGGCTAAGCATGCAAAAGCT
CTCAATATCGGTGCTATACCTGAATTAGATGAACAAGCATGCCGGCGTTTACTTAGCCATCGCTGGCCAGGAAACGTTCG
AGAGCTAGATAATATTGTCCAAAGAGCCTTGATCTTACGGACAGGTCCAGTGATTACCGCCAATGATATTATTATTGATG
TGCAGGGTGCGTTGATAAGTGATGAATTTGAAGTGTCAGCGTCTGAGCCAGAAGGGTTAGGTGAAGAACTTAAAGCACAG
GAACATGTGATTATTTTAGAAACCTTAGCCCAGTGTCAGGGTAGCCGAAAACTTGTGGCTGAAAAACTGGGGATCAGTGC
TCGAACTTTACGATATAAAATGGCTCGTATGCGGGATATGGGGATTCAATTACCCAGTTAA

Upstream 100 bases:

>100_bases
GGAGAAATACAACTTCGCTGCCTACCGAATAAGGGCTGTACTGTTTCGTTAGTTTTCCCTCGTGCAAAATCGGCGGTTGT
ATTGCCTTTGGAGAAAACCC

Downstream 100 bases:

>100_bases
CTTCAGTAAAAGCATGCATGTTAGCAAATGCACTTTAATGCCTTTTAGGATTAAGGTGCATTTGTATCTTGCTGATTTAC
CTAGTGAGTTAATCTTCCAA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSEAKLLLVEDDASLREALLDTLLLAQYECIDVACGEDAILALKQHQFDLVISDVQMEGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKTNVDKPIVADEKSLALLSLAQRVAASDASVMIMGPSGS
GKEVLARYIHQHSSRAEQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKA
LNIGAIPELDEQACRRLLSHRWPGNVRELDNIVQRALILRTGPVITANDIIIDVQGALISDEFEVSASEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPS

Sequences:

>Translated_446_residues
MSEAKLLLVEDDASLREALLDTLLLAQYECIDVACGEDAILALKQHQFDLVISDVQMEGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKTNVDKPIVADEKSLALLSLAQRVAASDASVMIMGPSGS
GKEVLARYIHQHSSRAEQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKA
LNIGAIPELDEQACRRLLSHRWPGNVRELDNIVQRALILRTGPVITANDIIIDVQGALISDEFEVSASEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPS
>Mature_445_residues
SEAKLLLVEDDASLREALLDTLLLAQYECIDVACGEDAILALKQHQFDLVISDVQMEGIGGLGLLNYLQQHHPKLPVLLM
TAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKTNVDKPIVADEKSLALLSLAQRVAASDASVMIMGPSGSG
KEVLARYIHQHSSRAEQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKLL
RVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKAL
NIGAIPELDEQACRRLLSHRWPGNVRELDNIVQRALILRTGPVITANDIIIDVQGALISDEFEVSASEPEGLGEELKAQE
HVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=448, Percent_Identity=41.9642857142857, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=40.2684563758389, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=36.2869198312236, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1788905, Length=369, Percent_Identity=41.1924119241192, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=314, Percent_Identity=46.8152866242038, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=43.5331230283912, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1789233, Length=307, Percent_Identity=41.6938110749186, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87081872, Length=302, Percent_Identity=37.0860927152318, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=46.551724137931, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786524, Length=302, Percent_Identity=40.3973509933775, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787583, Length=302, Percent_Identity=36.4238410596026, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789828, Length=293, Percent_Identity=35.1535836177474, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081858, Length=309, Percent_Identity=29.4498381877023, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=35.5140186915888, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48793; Mature: 48662

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKLLLVEDDASLREALLDTLLLAQYECIDVACGEDAILALKQHQFDLVISDVQMEGI
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCEEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKTNVDKPIVADEKSLALLSLAQRVAASDASVMIMGPSGSGKEVLARYIHQHSSRAEQAF
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCC
QRPADILPLARHLLAKHAKALNIGAIPELDEQACRRLLSHRWPGNVRELDNIVQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TGPVITANDIIIDVQGALISDEFEVSASEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEEECCCEECCCCEECCCCCCCCCHHHHCCCCEEHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPS
HHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEAKLLLVEDDASLREALLDTLLLAQYECIDVACGEDAILALKQHQFDLVISDVQMEGI
CCCEEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCEEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKTNVDKPIVADEKSLALLSLAQRVAASDASVMIMGPSGSGKEVLARYIHQHSSRAEQAF
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCC
QRPADILPLARHLLAKHAKALNIGAIPELDEQACRRLLSHRWPGNVRELDNIVQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TGPVITANDIIIDVQGALISDEFEVSASEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEEECCCEECCCCEECCCCCCCCCHHHHCCCCEEHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPS
HHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]