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The map label for this gene is zitB [H]

Identifier: 120597951

GI number: 120597951

Start: 1272501

End: 1273529

Strand: Direct

Name: zitB [H]

Synonym: Sputw3181_1124

Alternate gene names: 120597951

Gene position: 1272501-1273529 (Clockwise)

Preceding gene: 120597950

Following gene: 120597952

Centisome position: 27.03

GC content: 60.25

Gene sequence:

>1029_bases
ATGTCCCAATCGCACGATGAACATGGTCACGACCATGACCACACTCCAAAAGTGACCGGCGCTAACGAACGCAAGGTCTT
GCTGTCCTTCTTCCTGATCTTCGGCTTCATGATCGTGGAGGCTGTCGGCGGCGTGCTGTCGGGCTCGCTGGCCCTTCTGG
CCGATGCGGGCCACATGCTGACCGATGCAGCAGCGCTGGCTCTGGCATACGCGGCATTCCGGTTCGGGCGCCGACCAGCT
GACAGCAAGCGCACCTTTGGCTACCTTCGGTTCGAGGTCATCGCCGGCTTCCTGAACGCTGTGACGCTCTTTGTGATCGT
GGCATGGATCGCCTATGAAGCATGGGAGCGACTGCAAGCTCCGCCCGCCATCCTTGCCGGCCCGATGATGATCGTCGCCG
TGCTTGGATTGTTGGTAAACGTTCTGGTGTTGTGGATCATGACCCGCGGAGAGACCGATCACGTCAACGTGAAGGGGGCC
ATCCTGCACGTGATGGGCGACCTGCTGGGCTCGGTCGGTGCCATCGTCGCTGCAGTGGTCATCTATCTCATTGGTTGGAC
GCCAATTGACCCCATCCTGTCGGTGCTGGTGGCAGCCCTGATCCTGCGCAGCGCCTGGAAGCTCCTGGCGAAATCGATCC
ACATTTTGCTCGAAGGTGCGCCCGAGGACGCTTCTCCGGAGCAGGTGGAACAAGGCCTGATGGGCGCGGTGCCTGGCTTG
GCGGCCGTCAGTCATGTGCATGTATGGCAGCTTACCTCTGGTCGCACGATGGCCACGCTGCACGTTCGCCCTAGTGTGGC
TGAGGAAGCGCGCACCGTGGTCAAGTGCGTAGAGGTGGTGCTTCGAGAGCAATTTGGCATCGAGCACGTGACGGTCGGGA
TCGAATGGAACTCTCCTGGTGAAAAGAACCTTTGCAGCTTGCAGCCGACAGGTGGGCCGCAAGGGCACACCCCACATGAG
CATGACACTAGCCACAGCCATGAAAAGGGTCATAAGCACGACCATTCCGTCCCGGGTCATCAACACTGA

Upstream 100 bases:

>100_bases
CAGTCCTTAGTATGGTTTGCTAAAAATACATTGCATAAACATATGTTCATGTATTATATTTTACGTACAGTCAACCACCT
AATTTCTGCGCGAGGCCCTG

Downstream 100 bases:

>100_bases
TGCTGCAGCCAGCGTAGTGCTGGCAGCTCAGGGACAAGAAATCCATGACTTCTCGAAAACACGCCAATGGCGACAATGCT
CAGAATTGCGCCACCAATGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSQSHDEHGHDHDHTPKVTGANERKVLLSFFLIFGFMIVEAVGGVLSGSLALLADAGHMLTDAAALALAYAAFRFGRRPA
DSKRTFGYLRFEVIAGFLNAVTLFVIVAWIAYEAWERLQAPPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHVNVKGA
ILHVMGDLLGSVGAIVAAVVIYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEQVEQGLMGAVPGL
AAVSHVHVWQLTSGRTMATLHVRPSVAEEARTVVKCVEVVLREQFGIEHVTVGIEWNSPGEKNLCSLQPTGGPQGHTPHE
HDTSHSHEKGHKHDHSVPGHQH

Sequences:

>Translated_342_residues
MSQSHDEHGHDHDHTPKVTGANERKVLLSFFLIFGFMIVEAVGGVLSGSLALLADAGHMLTDAAALALAYAAFRFGRRPA
DSKRTFGYLRFEVIAGFLNAVTLFVIVAWIAYEAWERLQAPPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHVNVKGA
ILHVMGDLLGSVGAIVAAVVIYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEQVEQGLMGAVPGL
AAVSHVHVWQLTSGRTMATLHVRPSVAEEARTVVKCVEVVLREQFGIEHVTVGIEWNSPGEKNLCSLQPTGGPQGHTPHE
HDTSHSHEKGHKHDHSVPGHQH
>Mature_341_residues
SQSHDEHGHDHDHTPKVTGANERKVLLSFFLIFGFMIVEAVGGVLSGSLALLADAGHMLTDAAALALAYAAFRFGRRPAD
SKRTFGYLRFEVIAGFLNAVTLFVIVAWIAYEAWERLQAPPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHVNVKGAI
LHVMGDLLGSVGAIVAAVVIYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEQVEQGLMGAVPGLA
AVSHVHVWQLTSGRTMATLHVRPSVAEEARTVVKCVEVVLREQFGIEHVTVGIEWNSPGEKNLCSLQPTGGPQGHTPHEH
DTSHSHEKGHKHDHSVPGHQH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=318, Percent_Identity=28.3018867924528, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI21359890, Length=310, Percent_Identity=26.7741935483871, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI64762489, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=28.3828382838284, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=28.3828382838284, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=28.3828382838284, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=28.3828382838284, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI21361112, Length=303, Percent_Identity=27.3927392739274, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI20070323, Length=339, Percent_Identity=25.3687315634218, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI52351208, Length=209, Percent_Identity=32.0574162679426, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=25.6521739130435, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=41.2213740458015, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI222080086, Length=130, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40255009, Length=130, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786966, Length=296, Percent_Identity=46.2837837837838, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=28.2051282051282, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=301, Percent_Identity=30.8970099667774, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17555796, Length=326, Percent_Identity=27.6073619631902, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320411, Length=177, Percent_Identity=37.8531073446328, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=164, Percent_Identity=29.8780487804878, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=146, Percent_Identity=34.2465753424658, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583858, Length=369, Percent_Identity=23.8482384823848, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656728, Length=340, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656724, Length=340, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656720, Length=340, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656715, Length=340, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357035, Length=340, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585900, Length=124, Percent_Identity=31.4516129032258, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585898, Length=124, Percent_Identity=31.4516129032258, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585896, Length=124, Percent_Identity=31.4516129032258, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921672, Length=124, Percent_Identity=31.4516129032258, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24584409, Length=141, Percent_Identity=35.4609929078014, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645863, Length=142, Percent_Identity=32.3943661971831, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36874; Mature: 36743

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSHDEHGHDHDHTPKVTGANERKVLLSFFLIFGFMIVEAVGGVLSGSLALLADAGHML
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
TDAAALALAYAAFRFGRRPADSKRTFGYLRFEVIAGFLNAVTLFVIVAWIAYEAWERLQA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHVNVKGAILHVMGDLLGSVGAIVAAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEQVEQGLMGAVPGL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHH
AAVSHVHVWQLTSGRTMATLHVRPSVAEEARTVVKCVEVVLREQFGIEHVTVGIEWNSPG
HHHHHHEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
EKNLCSLQPTGGPQGHTPHEHDTSHSHEKGHKHDHSVPGHQH
CCCCEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQSHDEHGHDHDHTPKVTGANERKVLLSFFLIFGFMIVEAVGGVLSGSLALLADAGHML
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
TDAAALALAYAAFRFGRRPADSKRTFGYLRFEVIAGFLNAVTLFVIVAWIAYEAWERLQA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHVNVKGAILHVMGDLLGSVGAIVAAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEQVEQGLMGAVPGL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHH
AAVSHVHVWQLTSGRTMATLHVRPSVAEEARTVVKCVEVVLREQFGIEHVTVGIEWNSPG
HHHHHHEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
EKNLCSLQPTGGPQGHTPHEHDTSHSHEKGHKHDHSVPGHQH
CCCCEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]