Click here to switch to the map view.

The map label for this gene is cusC [C]

Identifier: 120597605

GI number: 120597605

Start: 864273

End: 865688

Strand: Direct

Name: cusC [C]

Synonym: Sputw3181_0774

Alternate gene names: 120597605

Gene position: 864273-865688 (Clockwise)

Preceding gene: 120597604

Following gene: 120597606

Centisome position: 18.36

GC content: 46.75

Gene sequence:

>1416_bases
ATGAATAATCTAATATTAAATCGTAAAATTATGTTACGTACTTGCGCCATCGCTGTAGGTGTTGCATTACTCGGCGGCTG
CGGTAGTTTTATGCGCTCAGACTTTGAGCCCCTCGCGTTGACGATACCAAGTCATTGGCAGCATACACAGGTCAACGAAC
AGGTGAGAGTTGATCCTTGGTGGCAGCAGTTTCAGCAGCCAGATCTTAATAAGTTAGTAAGCCAAGTGCTAAGCAGTAAC
AATGACTTAGCCCTTGCAACCTTGACACTACGTAAGGCGCGTTTACAGGCAGGGCTTGCCCAAGATGCACTTTACCCGCA
GTTATCCTCAAACCTTTCTGCATCGCGCAGTAACCCCCTGGATGGTGGCGAATCAACCAAGAGCTATCAGGCCAAGCTTT
CAGTCAGTTATGAAGTCGATTTATGGGGAAAAGTCTCGGCAGAGATGGATCAAGCTCAGTGGTCGGCATTAGCGAGTGCG
GAGGATAGAGAAAGTACCACTCAAAGTTTAGTGGCAACTACAGCATCGCTTTATTGGAAGATGGGCTATTTAAATCAAAG
GATTGCTTTAAGCAGCCGCAGTATTGACCACAGTCGACAAACACTGGCATTAACCCAGCGTCAGTATGATTCTGGAGCGG
TGACTCAAGTCAATGTGTTAGAGGCTAAGCGTAGCCTAGCGGGACAAGAGGCATCCCATAGTCAACTTATCCAACAGTTA
ACGGAGGCGGGAAATGCGCTTGCCATTTTACTGAATCAAGCACCTGGAGAGGCTTTCGTTGAGATTAACGCCTTACCTGA
TGTTGCAGTGCCGGAGATTGCCGTGGGGATGCCAGCGGATCTATTGGTGAGACGCCCTGATGTTAAGGCATCTTTATATC
AATTACGTTCAGCACTCGCCAGTAAAGATGCGACTTATACCCGTTACTTTCCGAGTTTGAGTTTAACTGGCAGTGTGGGG
GAGTCGACCTCAGAGTTAAAAGAATTATTGCGCAATCCCGTGGGTAGTTTAGGTGCAGGCTTAGTGTTGCCATTTTTACA
GTGGAATCAAATGCAAATTAATAACGACATTGCTGAAATTGATTATCAAACTGCAGTCGTAAATTACCGTAAGACACTGT
ATTCCGCCTTTGAGGATGTTGATAATGCCATCTCGGCTAAGCAGCAATTTGCTTATCAAGGAGACAAATTACAGCAACAG
TATAATGCTGCGGTAGCGGTCGAGGCCATTTATGAAAGCCAGTATCGCCATGGTGCGATAGGTATTCAAGATTGGATTAA
TGCCCAAGAAAATCGACGTGCAGCGGAGGCGTCTTTGCTCGAAAACCGCTATAACCAACTGACGGCCCAAGCAACGCTCT
ACCAAGCCCTTGGTGGGAGCGATATCGCCCCAGAGATTGCTCAGATTTCTAACTAA

Upstream 100 bases:

>100_bases
GCCTGTTCGACGTTAATCGGTGTGCTATTTGGCTTTTTACCCGCCCGCAACGCGGCGCGATTAGATCCCGTTGACGCCTT
AGCAAGAGAGTAATAACACC

Downstream 100 bases:

>100_bases
TTTTGTTTTTATATATAAAGCCGCAGCAACTCTTGTTGCTGCGGCTTTATATTATTGATTGGTCAGTGAGGTTATTAACG
AATATGGTTTCATCTGATTT

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MNNLILNRKIMLRTCAIAVGVALLGGCGSFMRSDFEPLALTIPSHWQHTQVNEQVRVDPWWQQFQQPDLNKLVSQVLSSN
NDLALATLTLRKARLQAGLAQDALYPQLSSNLSASRSNPLDGGESTKSYQAKLSVSYEVDLWGKVSAEMDQAQWSALASA
EDRESTTQSLVATTASLYWKMGYLNQRIALSSRSIDHSRQTLALTQRQYDSGAVTQVNVLEAKRSLAGQEASHSQLIQQL
TEAGNALAILLNQAPGEAFVEINALPDVAVPEIAVGMPADLLVRRPDVKASLYQLRSALASKDATYTRYFPSLSLTGSVG
ESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIAEIDYQTAVVNYRKTLYSAFEDVDNAISAKQQFAYQGDKLQQQ
YNAAVAVEAIYESQYRHGAIGIQDWINAQENRRAAEASLLENRYNQLTAQATLYQALGGSDIAPEIAQISN

Sequences:

>Translated_471_residues
MNNLILNRKIMLRTCAIAVGVALLGGCGSFMRSDFEPLALTIPSHWQHTQVNEQVRVDPWWQQFQQPDLNKLVSQVLSSN
NDLALATLTLRKARLQAGLAQDALYPQLSSNLSASRSNPLDGGESTKSYQAKLSVSYEVDLWGKVSAEMDQAQWSALASA
EDRESTTQSLVATTASLYWKMGYLNQRIALSSRSIDHSRQTLALTQRQYDSGAVTQVNVLEAKRSLAGQEASHSQLIQQL
TEAGNALAILLNQAPGEAFVEINALPDVAVPEIAVGMPADLLVRRPDVKASLYQLRSALASKDATYTRYFPSLSLTGSVG
ESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIAEIDYQTAVVNYRKTLYSAFEDVDNAISAKQQFAYQGDKLQQQ
YNAAVAVEAIYESQYRHGAIGIQDWINAQENRRAAEASLLENRYNQLTAQATLYQALGGSDIAPEIAQISN
>Mature_471_residues
MNNLILNRKIMLRTCAIAVGVALLGGCGSFMRSDFEPLALTIPSHWQHTQVNEQVRVDPWWQQFQQPDLNKLVSQVLSSN
NDLALATLTLRKARLQAGLAQDALYPQLSSNLSASRSNPLDGGESTKSYQAKLSVSYEVDLWGKVSAEMDQAQWSALASA
EDRESTTQSLVATTASLYWKMGYLNQRIALSSRSIDHSRQTLALTQRQYDSGAVTQVNVLEAKRSLAGQEASHSQLIQQL
TEAGNALAILLNQAPGEAFVEINALPDVAVPEIAVGMPADLLVRRPDVKASLYQLRSALASKDATYTRYFPSLSLTGSVG
ESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIAEIDYQTAVVNYRKTLYSAFEDVDNAISAKQQFAYQGDKLQQQ
YNAAVAVEAIYESQYRHGAIGIQDWINAQENRRAAEASLLENRYNQLTAQATLYQALGGSDIAPEIAQISN

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=457, Percent_Identity=27.5711159737418, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI2367348, Length=502, Percent_Identity=22.9083665338645, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51718; Mature: 51718

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLILNRKIMLRTCAIAVGVALLGGCGSFMRSDFEPLALTIPSHWQHTQVNEQVRVDPW
CCCCEECHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCCCCCCCCCCCEECCHH
WQQFQQPDLNKLVSQVLSSNNDLALATLTLRKARLQAGLAQDALYPQLSSNLSASRSNPL
HHHHCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DGGESTKSYQAKLSVSYEVDLWGKVSAEMDQAQWSALASAEDRESTTQSLVATTASLYWK
CCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MGYLNQRIALSSRSIDHSRQTLALTQRQYDSGAVTQVNVLEAKRSLAGQEASHSQLIQQL
HHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHH
TEAGNALAILLNQAPGEAFVEINALPDVAVPEIAVGMPADLLVRRPDVKASLYQLRSALA
HHCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHCCCCHHHEEECCCHHHHHHHHHHHHH
SKDATYTRYFPSLSLTGSVGESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIAEI
CCCCCEEEECCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCHHHH
DYQTAVVNYRKTLYSAFEDVDNAISAKQQFAYQGDKLQQQYNAAVAVEAIYESQYRHGAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GIQDWINAQENRRAAEASLLENRYNQLTAQATLYQALGGSDIAPEIAQISN
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MNNLILNRKIMLRTCAIAVGVALLGGCGSFMRSDFEPLALTIPSHWQHTQVNEQVRVDPW
CCCCEECHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCCCCCCCCCCCEECCHH
WQQFQQPDLNKLVSQVLSSNNDLALATLTLRKARLQAGLAQDALYPQLSSNLSASRSNPL
HHHHCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DGGESTKSYQAKLSVSYEVDLWGKVSAEMDQAQWSALASAEDRESTTQSLVATTASLYWK
CCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MGYLNQRIALSSRSIDHSRQTLALTQRQYDSGAVTQVNVLEAKRSLAGQEASHSQLIQQL
HHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHH
TEAGNALAILLNQAPGEAFVEINALPDVAVPEIAVGMPADLLVRRPDVKASLYQLRSALA
HHCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHCCCCHHHEEECCCHHHHHHHHHHHHH
SKDATYTRYFPSLSLTGSVGESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIAEI
CCCCCEEEECCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCHHHH
DYQTAVVNYRKTLYSAFEDVDNAISAKQQFAYQGDKLQQQYNAAVAVEAIYESQYRHGAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GIQDWINAQENRRAAEASLLENRYNQLTAQATLYQALGGSDIAPEIAQISN
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]