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The map label for this gene is ftsI [H]

Identifier: 120597215

GI number: 120597215

Start: 413748

End: 415499

Strand: Direct

Name: ftsI [H]

Synonym: Sputw3181_0384

Alternate gene names: 120597215

Gene position: 413748-415499 (Clockwise)

Preceding gene: 120597214

Following gene: 120597216

Centisome position: 8.79

GC content: 47.43

Gene sequence:

>1752_bases
ATGATTAGGCAAGCAAAAACCAAACAGGCGAGTAAAAAGCAAAAACCGCAACTTATCCATTGGCGTTTATACGTGGTGGT
TGGGTTTGTGTTTGCGCTATTTTCGAGCTTGGTGGGGCGGGCTGCTTATATTCAAATTATCGAGCCAGATAAGTTACGCC
ATGAAAGTGATATGCGTACTCTGCGTACCACGAGCCGTGAGGTTCAGCGAGGGTTAATCACAGATCGAAATGGTGATATG
CTTGCCGTGAGCGTGCCAGTGCGTGCGGTTTGGGCCGATCCAAAGCAAGTTAATGACAGCAATAGTTTTGCCGATATGCG
CCGCTGGCAAGCGTTGGCCGATGTGTTACATGAACCGTTAGCAGATGTGCTAGATAGAGTTCGTAGTAACCCCACTAAAC
GCTTTACCTATCTTAAACGTCAAGTCACCCCCGCAGTGGCGGATTACATTACTCAGCTGAAGTTACCTGGGGTGTTTTTA
AAATCAGAATCCCGCCGTTATTATCCAGGTGGTGAAATTACCGCTCAGCTTATTGGTATCACTAACATTGATGATGTTGG
GATTGAAGGCGTTGAAAATGCCTACAATAGTTGGTTGACAGGCACGCCATCCAAACAAAAGGTGCGCAAGTCGCGTGATG
GTCATGTCGTTGAGCACCTCGATATAGTACAAGAAGGCGAGAGTCCAAATGATCTTGTACTGAGTATTGATCATCGTATT
CAGCAGTTAGCCTACCGTGAGCTTAAACGTACTACAGAGATGAACCAAGCCACCTCTGGCTCGATTGTCGTACTGGACAT
CCATACGGGTGAAGTGCTTGCCATGGTAAACACCCCCTCTTATAACCCCAATTCTCGCGATAATCTGCAAACCTTCAGAA
TGCGTAATCGCGCTATGACAGACACTTTTGAACCGGGGTCGACGATTAAACCTTTTGTCGTGGCGGCGGCGCTTGAGGCT
GGCACTGTTAAGGCAACGGATATTATCCCGACTTCTCCAGGTTGGATGCGTTTAGGTGGGCGTCAAGTACGTGACCCTAA
TAATTATGGTGATATGAGCCTTGCGCGTATTCTGGCGAAATCCAGTAACGTAGGGATCAGTAAGTTAGCCCTGTCCATTC
CGGTACAACAACTGCTAGGTACTTATCAGTCCATGGGGTTAGGTAGTTTTTCGGGGATTAATCTTACGGGTGAAAGTGCG
GGTCTTATTCAGGATCGTCATCGTTGGTCTGACTTTGAGCGTGCAACGCTTTCTTTTGGTTATGGTTTAACGGCAACAAC
GCTACAACTTGCGCGTATGTATGCCACTTTAGGCAATGGCGGTACTTTGTATCCAGTGTCGATTTTAAAATTGAAAAAAC
CACCTGAAGGTGAGCGAGTTATCTCAGCTAAGGTTGCCCGCGATGTATTACAGATGCTGGTGACTGTGACTGAAAAAGGT
GGCACAGGCACCTTAGCGCATATTGATGGTTATCCTGTCGCGGGTAAATCTGGGACGAGTCGTAAAGCCGTTGCAGGTGG
CTATGGTGATGATTATGTTGCGTTATTTGCGGGCGTTGCGCCAGCGAATAATCCCAAGTTAGCCATAGTTGTTGTGGTCA
ACGAGCCTAAGGGTGATTTGTATTATGGTGGTTCAGTGGCAGGGCCGGCATTTGCCAAGGTAATGTCTGGCGCACTGCAA
ATGTTAAATGTCGAACCTATTTCCGATAAAGAACAGGTGCAATTGGCCGGAATTGCAGGGAGAGCAGAATGA

Upstream 100 bases:

>100_bases
CATAGCCGTATTACGCGTATTGCATCGAAAGAACTCAACATGAGTCGCCCGTTACCCAGCGAAGAAATTGTGGTAAAGGT
GCCGTGAGTATAGGGAAGAT

Downstream 100 bases:

>100_bases
TGTTGCTACGGGACCTGTTAGCGCCTTGGTTTATATATTCGGGTGATCAGTCTTTCAATGAGTTGACCTTAGATAGCCGC
GCAATACGCCGCGGCGATGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MIRQAKTKQASKKQKPQLIHWRLYVVVGFVFALFSSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDM
LAVSVPVRAVWADPKQVNDSNSFADMRRWQALADVLHEPLADVLDRVRSNPTKRFTYLKRQVTPAVADYITQLKLPGVFL
KSESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVEHLDIVQEGESPNDLVLSIDHRI
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNSRDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEA
GTVKATDIIPTSPGWMRLGGRQVRDPNNYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESA
GLIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLYPVSILKLKKPPEGERVISAKVARDVLQMLVTVTEKG
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQ
MLNVEPISDKEQVQLAGIAGRAE

Sequences:

>Translated_583_residues
MIRQAKTKQASKKQKPQLIHWRLYVVVGFVFALFSSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDM
LAVSVPVRAVWADPKQVNDSNSFADMRRWQALADVLHEPLADVLDRVRSNPTKRFTYLKRQVTPAVADYITQLKLPGVFL
KSESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVEHLDIVQEGESPNDLVLSIDHRI
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNSRDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEA
GTVKATDIIPTSPGWMRLGGRQVRDPNNYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESA
GLIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLYPVSILKLKKPPEGERVISAKVARDVLQMLVTVTEKG
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQ
MLNVEPISDKEQVQLAGIAGRAE
>Mature_583_residues
MIRQAKTKQASKKQKPQLIHWRLYVVVGFVFALFSSLVGRAAYIQIIEPDKLRHESDMRTLRTTSREVQRGLITDRNGDM
LAVSVPVRAVWADPKQVNDSNSFADMRRWQALADVLHEPLADVLDRVRSNPTKRFTYLKRQVTPAVADYITQLKLPGVFL
KSESRRYYPGGEITAQLIGITNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVEHLDIVQEGESPNDLVLSIDHRI
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNSRDNLQTFRMRNRAMTDTFEPGSTIKPFVVAAALEA
GTVKATDIIPTSPGWMRLGGRQVRDPNNYGDMSLARILAKSSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESA
GLIQDRHRWSDFERATLSFGYGLTATTLQLARMYATLGNGGTLYPVSILKLKKPPEGERVISAKVARDVLQMLVTVTEKG
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDLYYGGSVAGPAFAKVMSGALQ
MLNVEPISDKEQVQLAGIAGRAE

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=567, Percent_Identity=48.5008818342152, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1786854, Length=610, Percent_Identity=25.9016393442623, Blast_Score=138, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63668; Mature: 63668

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQAKTKQASKKQKPQLIHWRLYVVVGFVFALFSSLVGRAAYIQIIEPDKLRHESDMRT
CCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCHHHHHH
LRTTSREVQRGLITDRNGDMLAVSVPVRAVWADPKQVNDSNSFADMRRWQALADVLHEPL
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHH
ADVLDRVRSNPTKRFTYLKRQVTPAVADYITQLKLPGVFLKSESRRYYPGGEITAQLIGI
HHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEE
TNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVEHLDIVQEGESPNDLVLSIDHRI
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEHHHHH
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNSRDNLQTFRMRNRAMT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
DTFEPGSTIKPFVVAAALEAGTVKATDIIPTSPGWMRLGGRQVRDPNNYGDMSLARILAK
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEECCCEECCCCCCCCCHHHHHHHHH
SSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESAGLIQDRHRWSDFERATLSFG
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCHHHHHHHHCC
YGLTATTLQLARMYATLGNGGTLYPVSILKLKKPPEGERVISAKVARDVLQMLVTVTEKG
CCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDL
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCE
YYGGSVAGPAFAKVMSGALQMLNVEPISDKEQVQLAGIAGRAE
EECCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MIRQAKTKQASKKQKPQLIHWRLYVVVGFVFALFSSLVGRAAYIQIIEPDKLRHESDMRT
CCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHCCHHHHHH
LRTTSREVQRGLITDRNGDMLAVSVPVRAVWADPKQVNDSNSFADMRRWQALADVLHEPL
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHH
ADVLDRVRSNPTKRFTYLKRQVTPAVADYITQLKLPGVFLKSESRRYYPGGEITAQLIGI
HHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEE
TNIDDVGIEGVENAYNSWLTGTPSKQKVRKSRDGHVVEHLDIVQEGESPNDLVLSIDHRI
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEHHHHH
QQLAYRELKRTTEMNQATSGSIVVLDIHTGEVLAMVNTPSYNPNSRDNLQTFRMRNRAMT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
DTFEPGSTIKPFVVAAALEAGTVKATDIIPTSPGWMRLGGRQVRDPNNYGDMSLARILAK
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEECCCEECCCCCCCCCHHHHHHHHH
SSNVGISKLALSIPVQQLLGTYQSMGLGSFSGINLTGESAGLIQDRHRWSDFERATLSFG
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCHHHHHHHHCC
YGLTATTLQLARMYATLGNGGTLYPVSILKLKKPPEGERVISAKVARDVLQMLVTVTEKG
CCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GTGTLAHIDGYPVAGKSGTSRKAVAGGYGDDYVALFAGVAPANNPKLAIVVVVNEPKGDL
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCE
YYGGSVAGPAFAKVMSGALQMLNVEPISDKEQVQLAGIAGRAE
EECCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]