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The map label for this gene is mmuM [H]

Identifier: 120596921

GI number: 120596921

Start: 107492

End: 108394

Strand: Direct

Name: mmuM [H]

Synonym: Sputw3181_0088

Alternate gene names: 120596921

Gene position: 107492-108394 (Clockwise)

Preceding gene: 120596920

Following gene: 120596922

Centisome position: 2.28

GC content: 66.11

Gene sequence:

>903_bases
ATGAAGAAGCAGGCATTGTGGGTACTGGATGGTGGCATGGGACGCGAGCTGGCACGGCGAGGGGCGCCCTTTCGCCAACC
TGAATGGTCGGCGCTGGCGCTGATGGAGGCACCACAGACGGTGCGCGAAGTACATCAGGCCTATGTGGCGAGCGGTGCCC
GTATCATCACCACCAACAGTTATGCCTTGGTGCCGTTTCATATCGGTGCCGAGCGATTTGCCGCCGAAGGGGAAGCGCTG
GCGGCGCTGGCTGGCCAGCTGGCCCGTGAGGTTGCCAATGAGCAACCGGGCTCGGTGCAGGTCGCAGGATCCCTGCCGCC
GCTGTTTGGCTCCTACCGCGCCGACCTGTTCGAGGCGGACAGAGTGGGCGAGCTGGCCACACCGCTCATTCGGGCGCTGA
CGCCCCATGTGGACATCTGGCTGGCCGAAACCATGAGCCTGATTGCCGAGCCGCTGGCCCTCAAGGCGCTGTTGCCACAG
GATGGCAAGCCGTTCTGGGTCTCCTTCACGCTGGAAGATGAAGCGCCGGGCTGCGAGCCTGCGCTTCGTTCCGGTGAGCG
GGTGGCGGATGCCGTCACCGCACTGGCATCGGCCGGTGTGGATGCCATCTTGTTCAACTGCTGTCAGCCCGAGGTGATCG
AGGCCGCGCTGACGGTGGCCGGTGACAGCTTGCAGGTGCTGGGTCGAGGGGATATTCGCCTCGGCGCCTATGCCAACGCC
TTTCCGCCCCAACCCAAAGAGGCGACCGCCAACGACGGGCTGGACGAGATCCGCGCCGATCTTGGGCCGCTGGATTACCT
CGGCTGGGCCGAGCGCTGGCGCGCCGTGGGGGCCTCTCTCATCGGCGGCTGCTGCGGCATCGGCCCCGAGCATATTCAGG
CACTGGCCAGCCGGTTGCGCTAA

Upstream 100 bases:

>100_bases
CATCTAAACATCTGGATGTTTTTGCGGCTATTAAGGTTTTTATTTTAATAATCAGTACCTTGATAGATGACGTTGTACAA
AAAAGGTAGATATTACGCTG

Downstream 100 bases:

>100_bases
GGAGAGCACATGAAAGAGAGCAAAATAGGCCTCTGGTCCCTCACTGCGCTGGTGTTCAGCTCCATGGTGGGGGCGGGCAT
CTTCAGCTTGCCCCAGAACA

Product: homocysteine S-methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKKQALWVLDGGMGRELARRGAPFRQPEWSALALMEAPQTVREVHQAYVASGARIITTNSYALVPFHIGAERFAAEGEAL
AALAGQLAREVANEQPGSVQVAGSLPPLFGSYRADLFEADRVGELATPLIRALTPHVDIWLAETMSLIAEPLALKALLPQ
DGKPFWVSFTLEDEAPGCEPALRSGERVADAVTALASAGVDAILFNCCQPEVIEAALTVAGDSLQVLGRGDIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALASRLR

Sequences:

>Translated_300_residues
MKKQALWVLDGGMGRELARRGAPFRQPEWSALALMEAPQTVREVHQAYVASGARIITTNSYALVPFHIGAERFAAEGEAL
AALAGQLAREVANEQPGSVQVAGSLPPLFGSYRADLFEADRVGELATPLIRALTPHVDIWLAETMSLIAEPLALKALLPQ
DGKPFWVSFTLEDEAPGCEPALRSGERVADAVTALASAGVDAILFNCCQPEVIEAALTVAGDSLQVLGRGDIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALASRLR
>Mature_300_residues
MKKQALWVLDGGMGRELARRGAPFRQPEWSALALMEAPQTVREVHQAYVASGARIITTNSYALVPFHIGAERFAAEGEAL
AALAGQLAREVANEQPGSVQVAGSLPPLFGSYRADLFEADRVGELATPLIRALTPHVDIWLAETMSLIAEPLALKALLPQ
DGKPFWVSFTLEDEAPGCEPALRSGERVADAVTALASAGVDAILFNCCQPEVIEAALTVAGDSLQVLGRGDIRLGAYANA
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALASRLR

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=316, Percent_Identity=32.5949367088608, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 31885; Mature: 31885

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQALWVLDGGMGRELARRGAPFRQPEWSALALMEAPQTVREVHQAYVASGARIITTNS
CCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEEECC
YALVPFHIGAERFAAEGEALAALAGQLAREVANEQPGSVQVAGSLPPLFGSYRADLFEAD
EEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
RVGELATPLIRALTPHVDIWLAETMSLIAEPLALKALLPQDGKPFWVSFTLEDEAPGCEP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCH
ALRSGERVADAVTALASAGVDAILFNCCQPEVIEAALTVAGDSLQVLGRGDIRLGAYANA
HHHCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCEEECCCCCC
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALASRLR
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKQALWVLDGGMGRELARRGAPFRQPEWSALALMEAPQTVREVHQAYVASGARIITTNS
CCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEEECC
YALVPFHIGAERFAAEGEALAALAGQLAREVANEQPGSVQVAGSLPPLFGSYRADLFEAD
EEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
RVGELATPLIRALTPHVDIWLAETMSLIAEPLALKALLPQDGKPFWVSFTLEDEAPGCEP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCH
ALRSGERVADAVTALASAGVDAILFNCCQPEVIEAALTVAGDSLQVLGRGDIRLGAYANA
HHHCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCEEECCCCCC
FPPQPKEATANDGLDEIRADLGPLDYLGWAERWRAVGASLIGGCCGIGPEHIQALASRLR
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]