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The map label for this gene is hemD [H]

Identifier: 119947243

GI number: 119947243

Start: 4455661

End: 4456395

Strand: Reverse

Name: hemD [H]

Synonym: Ping_3641

Alternate gene names: 119947243

Gene position: 4456395-4455661 (Counterclockwise)

Preceding gene: 119947244

Following gene: 119947242

Centisome position: 97.74

GC content: 42.45

Gene sequence:

>735_bases
ATGAAAGAAGCGCGCTTATTAGTGACACGTTTTGCACCTCATGCACAACGCTTAGTGAATTTACTCAATGCGCAGGGGAC
GGTTGCCTTTGCGCAACCCTTATTGGCACTTCAGAAAACAACAGAATTTAACCATGCAAGTAAAGTGTTGGCAAAAAATT
ATGATTATATTATCGCGGTAAGTCCCAATGCGGTTGACTATACCCAGAAGGCTCTGGCGGGTATCAACTGGCCGCAGACT
GAATATTTAGCTGTTGGATTAGCGACTCAGGCTAAGCTAAAAGCAGCAACCACGCAGAATGTCGTTGTGCCTGAAAAATG
CTTTGATAGTGAAGGGTTACTTGATTTACCCTTATTACTGAATTTACAGGGTAAGCATATCCTTATTTTACGCGGAGTCG
GCGGCCGTGAGTTACTCTGTGACACCTTAAGACAACGCGGGGCAATCGTTGATTATTATCAGCCTTATCAACGTGTTGCT
ATTGTACTGTGTGGGAAAGCTTTAATAAAAGAATGGCAACAACAAAATATTAATGGTGCTATTATCAGTAGTATTGAATT
GCTGGAAAGATTAATGTCTGTTGTGCCGCTTGCCGCGCATGAATGGTTGAAGGAGCTTACTATTTATGCCCCAAGTGAGC
GTATACTCGATCAGGCAAAGCGTTGGGGCTGGTCAAATACAAAAGTACTTCCCGGAATGTCTGATCAGCAAGTGATTGAT
TATTTTAAACATTAG

Upstream 100 bases:

>100_bases
CTGGCCATCAGAATGATGCGCAGCAATTAGGCATTACCCTTGCTGAGCAATTATTAGCCTGCGGCGCAGAAGAAATTCTT
GCTGAAGTTTATAAAAACCA

Downstream 100 bases:

>100_bases
TAAAAAAAGATAGTCATGTATATTAGTAATTAAACCTTTTTGACTAAAAAATGTGAGGGTGGTTATGACCAAGAGTAATA
ATGATAATGATAATGAAGAA

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MKEARLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAKNYDYIIAVSPNAVDYTQKALAGINWPQT
EYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLLNLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVA
IVLCGKALIKEWQQQNINGAIISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVID
YFKH

Sequences:

>Translated_244_residues
MKEARLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAKNYDYIIAVSPNAVDYTQKALAGINWPQT
EYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLLNLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVA
IVLCGKALIKEWQQQNINGAIISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVID
YFKH
>Mature_244_residues
MKEARLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAKNYDYIIAVSPNAVDYTQKALAGINWPQT
EYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLLNLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVA
IVLCGKALIKEWQQQNINGAIISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVID
YFKH

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=230, Percent_Identity=36.0869565217391, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27330; Mature: 27330

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEARLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAKNYDYIIAV
CCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
SPNAVDYTQKALAGINWPQTEYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLL
CCCCHHHHHHHHHCCCCCCHHHEEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCEE
NLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNINGA
ECCCCEEEEEECCCCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEECCCCCHHHHHH
YFKH
HHCC
>Mature Secondary Structure
MKEARLLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAKNYDYIIAV
CCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
SPNAVDYTQKALAGINWPQTEYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLL
CCCCHHHHHHHHHCCCCCCHHHEEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCEE
NLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNINGA
ECCCCEEEEEECCCCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEECCCCCHHHHHH
YFKH
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]