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The map label for this gene is gmk [H]

Identifier: 119947225

GI number: 119947225

Start: 4439756

End: 4440379

Strand: Direct

Name: gmk [H]

Synonym: Ping_3623

Alternate gene names: 119947225

Gene position: 4439756-4440379 (Clockwise)

Preceding gene: 119947224

Following gene: 119947226

Centisome position: 97.37

GC content: 40.87

Gene sequence:

>624_bases
ATGTCCCAAGTTGGTACACTGTATATTGTATCCGCCCCAAGCGGAGCAGGAAAGTCTAGTCTTATTAATGCACTTTTGGC
TGAAAAAAAAGATTGGCAGGCGCAAGTTTCTATTTCTCACACAACACGACAAGCACGTGTGGGTGAAGTAGACGGTGAAC
ATTATTATTTTGTCAGTACAGAAAATTTTAAAAAGCTGATTGCTGAAAATGCTTTTTTTGAATGGGCGGAAGTATTTGGT
AACTATTACGGCACGTCACGTATCGCAATAGAAGAGGCTCTAGCTAAAGGAGTCGACGTGCTTCTAGACATTGACTGGCA
AGGTGCGCGACAGGTTAGAAACATGATGCCTGATGCTAAAGGTATCTTTATTCTTCCGCCCAGCCGGACAGAGTTAGAAG
CGCGCTTAAATAAACGCGGTCAAGACAGTAAAGAAATCATAACCAAGCGCATGAACCAAGCACAAGCTGAAATGTCACAT
TATGATGAATACGATTATTTAATCATTAATGATGATTTTGACAGCGCCAGTAAAGAATTATCCGCTATTATGAAAGCACG
GCGGAATGAACAAGCCAAGCAGGCGATAAAATACCAAACAACCATTAAAGAGTTATTAGCTTAA

Upstream 100 bases:

>100_bases
TAAAAATAAGGGATAATTTGCGACTCACAAAAGTCGCCACCCATTTTGAACTAAAAAAGGGGTGATTAATTCCAATTCAT
ATTTTCAGGAATGATTGTTT

Downstream 100 bases:

>100_bases
TAATTCCAACACGAAGTTTGTGGATCAATTGTAATTTTGAACGTATAATTAGCGCCCGTTTTTGGGTAATTAAATTTTTG
GAGTTCAGCAATGGCACGTG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSQVGTLYIVSAPSGAGKSSLINALLAEKKDWQAQVSISHTTRQARVGEVDGEHYYFVSTENFKKLIAENAFFEWAEVFG
NYYGTSRIAIEEALAKGVDVLLDIDWQGARQVRNMMPDAKGIFILPPSRTELEARLNKRGQDSKEIITKRMNQAQAEMSH
YDEYDYLIINDDFDSASKELSAIMKARRNEQAKQAIKYQTTIKELLA

Sequences:

>Translated_207_residues
MSQVGTLYIVSAPSGAGKSSLINALLAEKKDWQAQVSISHTTRQARVGEVDGEHYYFVSTENFKKLIAENAFFEWAEVFG
NYYGTSRIAIEEALAKGVDVLLDIDWQGARQVRNMMPDAKGIFILPPSRTELEARLNKRGQDSKEIITKRMNQAQAEMSH
YDEYDYLIINDDFDSASKELSAIMKARRNEQAKQAIKYQTTIKELLA
>Mature_206_residues
SQVGTLYIVSAPSGAGKSSLINALLAEKKDWQAQVSISHTTRQARVGEVDGEHYYFVSTENFKKLIAENAFFEWAEVFGN
YYGTSRIAIEEALAKGVDVLLDIDWQGARQVRNMMPDAKGIFILPPSRTELEARLNKRGQDSKEIITKRMNQAQAEMSHY
DEYDYLIINDDFDSASKELSAIMKARRNEQAKQAIKYQTTIKELLA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=177, Percent_Identity=42.3728813559322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4504221, Length=177, Percent_Identity=42.3728813559322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI226874831, Length=177, Percent_Identity=42.3728813559322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=36.3128491620112, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI14780902, Length=201, Percent_Identity=29.3532338308458, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI111154074, Length=158, Percent_Identity=34.8101265822785, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI186700629, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI186972120, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI186700627, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=64.0394088669951, Blast_Score=275, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=38.121546961326, Blast_Score=133, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=38.121546961326, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=28.021978021978, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=28.021978021978, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=42.3913043478261, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356141, Length=191, Percent_Identity=40.3141361256544, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23422; Mature: 23291

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVGTLYIVSAPSGAGKSSLINALLAEKKDWQAQVSISHTTRQARVGEVDGEHYYFVST
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCCEEEEEEC
ENFKKLIAENAFFEWAEVFGNYYGTSRIAIEEALAKGVDVLLDIDWQGARQVRNMMPDAK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCC
GIFILPPSRTELEARLNKRGQDSKEIITKRMNQAQAEMSHYDEYDYLIINDDFDSASKEL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
SAIMKARRNEQAKQAIKYQTTIKELLA
HHHHHHHCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SQVGTLYIVSAPSGAGKSSLINALLAEKKDWQAQVSISHTTRQARVGEVDGEHYYFVST
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCCEEEEEEC
ENFKKLIAENAFFEWAEVFGNYYGTSRIAIEEALAKGVDVLLDIDWQGARQVRNMMPDAK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCC
GIFILPPSRTELEARLNKRGQDSKEIITKRMNQAQAEMSHYDEYDYLIINDDFDSASKEL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
SAIMKARRNEQAKQAIKYQTTIKELLA
HHHHHHHCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA