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The map label for this gene is lrp [H]

Identifier: 119947208

GI number: 119947208

Start: 4420745

End: 4421212

Strand: Reverse

Name: lrp [H]

Synonym: Ping_3606

Alternate gene names: 119947208

Gene position: 4421212-4420745 (Counterclockwise)

Preceding gene: 119947209

Following gene: 119947191

Centisome position: 96.96

GC content: 41.88

Gene sequence:

>468_bases
ATGAAAGAGCTGGATCGTATTGATCGTAAAATATTAAATGAGTTGCAAAAAGATGGGCGGATATCCAATGTTGAACTTTC
CAAACGTGTTGATCTTAGTCCTACACCTTGCCTTGAGCGAGTAAGACGCCTTGAGCGTCAGGGGTTTATAACGGGTTACA
TTGCCACACTCAATCCGCAATATTTAGGAGCTGCACTACTGGTTTTTATTGAGGTAACCTTGAGCCGCGGCGCACCAGAT
GTGTTTGAGCAGTTTAATAAAGCCGTTTTGAAGTCAGATGCATTTCAAGAATGTCATTTAGTGTCAGGCGATTTTGACTA
CCTGCTGAAGGCGCGCGTTGCTGACATGTCTGCGTATCGTAAATTACTTGCAGAAACGTTATTGACTTTACCCAGTATTA
AAGAGACTCGGACTTATGTGGTAATGGAAGAGGTTAAGGTAAATAGCCAGTTGATCATAAAATGCTAA

Upstream 100 bases:

>100_bases
TTTTTGAGGCAATTTACTAATGAGTATTGGTATCGCTTGATAGGATCTGAGTTTTATGAAATAAAGAGCTTAATTAAATG
AATTCAAACAAGGCTGGGCA

Downstream 100 bases:

>100_bases
TGCAGAAAAAGCGCCACCTCATGGAGGCGCTCAATAAAGGTTATGCTAATGCGACTTTAGGATCAACAAACTCAAATCCT
AAGTTTTCTGCCACGCTGGC

Product: transcriptional regulator of AsnC/Lrp family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MKELDRIDRKILNELQKDGRISNVELSKRVDLSPTPCLERVRRLERQGFITGYIATLNPQYLGAALLVFIEVTLSRGAPD
VFEQFNKAVLKSDAFQECHLVSGDFDYLLKARVADMSAYRKLLAETLLTLPSIKETRTYVVMEEVKVNSQLIIKC

Sequences:

>Translated_155_residues
MKELDRIDRKILNELQKDGRISNVELSKRVDLSPTPCLERVRRLERQGFITGYIATLNPQYLGAALLVFIEVTLSRGAPD
VFEQFNKAVLKSDAFQECHLVSGDFDYLLKARVADMSAYRKLLAETLLTLPSIKETRTYVVMEEVKVNSQLIIKC
>Mature_155_residues
MKELDRIDRKILNELQKDGRISNVELSKRVDLSPTPCLERVRRLERQGFITGYIATLNPQYLGAALLVFIEVTLSRGAPD
VFEQFNKAVLKSDAFQECHLVSGDFDYLLKARVADMSAYRKLLAETLLTLPSIKETRTYVVMEEVKVNSQLIIKC

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=79.7385620915033, Blast_Score=253, Evalue=4e-69,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=30.4635761589404, Blast_Score=92, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17694; Mature: 17694

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELDRIDRKILNELQKDGRISNVELSKRVDLSPTPCLERVRRLERQGFITGYIATLNPQ
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHH
YLGAALLVFIEVTLSRGAPDVFEQFNKAVLKSDAFQECHLVSGDFDYLLKARVADMSAYR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHH
KLLAETLLTLPSIKETRTYVVMEEVKVNSQLIIKC
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKELDRIDRKILNELQKDGRISNVELSKRVDLSPTPCLERVRRLERQGFITGYIATLNPQ
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHH
YLGAALLVFIEVTLSRGAPDVFEQFNKAVLKSDAFQECHLVSGDFDYLLKARVADMSAYR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHH
KLLAETLLTLPSIKETRTYVVMEEVKVNSQLIIKC
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]