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The map label for this gene is kefC [H]

Identifier: 119946668

GI number: 119946668

Start: 3744929

End: 3746800

Strand: Direct

Name: kefC [H]

Synonym: Ping_3047

Alternate gene names: 119946668

Gene position: 3744929-3746800 (Clockwise)

Preceding gene: 119946667

Following gene: 119946669

Centisome position: 82.13

GC content: 43.8

Gene sequence:

>1872_bases
ATGACAACCACAATAAGAAACCTTATGACCGAATATTTTGTTTATGCTTTTATTTATCTGGCTGCTGCTGTAATAGCTGT
CCCTATTGCGACACGCTGCGGACTCGGTTCAGTGCTCGGGTATTTAATCGCAGGGGTGGTGATCGGCCCGATTATTGGTT
TAGTGGGTGATGAGACCAGCAGTATTAAACACTTTGCTGAATTTGGGGTTGTCCTGATGCTGTTTTTGGTCGGTCTGGAA
CTCGAACCAAAACTGCTTTGGAAAATGCGTAATCGCCTGCTGGGATTAGGTGGACTTCAAGTTATTTTAAGCACCCTATT
AGTGATGGGGATTGCATTCTATTTTGTCGATCATTGGGCAACCGCCTTAACGATTGGTTTGATTTTGTCACCTTCTTCAA
CAGCGATTGTGCTGCAAACCTTTAATGAAAAAGGGTTAAGCAAAACAACAGGTGGCAAAAATGCCTTTTCAATTTTGCTC
TTTCAGGATATAGCGGTTATTCCGATGCTGGCATTAATACCCTTAATGGCTTTGCCCGAACTTATCGAAAAATCACAGCA
GCTGGCATCAACCGCAGCGCAGCAAAACGAGCACTTAAGTTTAGTGGCAGGCTTACCGAGCTGGGCTTACGCACTGACCG
TTGTCACCTCCATTATAGCGGTCGTCTCTGGTGGACACTATTTAAGCCGCCCTTTATTCAGATTTGTCGCCAGCTCAGGT
TTACGAGAAATGTTCACCGCCTCGGCATTGATGCTGGTGATCGGCATCGCTGCATTAATGAGTTTAGTGGATTTATCCCC
CGCCCTGGGCACTTTTTTAGCGGGTGTTGTATTGGCAAACTCAGAGTTTCGCCATGAATTAAAATCTAATATTGAGCCCT
TTAAAGGGCTTTTACTGGGACTGTTTTTTATTACCGTTGGCGCAGGGATAGATTTTAATCTTTTATATTCTGACTTTATG
GTGATCCTCACGCTAACCCTCGGCATCATCTTATTAAAAGCGACTGTTTTATTTTTTCTGGCGATAATATTTAAAATTAA
GAACAGTGACCGTTGGTTGTTTGCCTTGAGCCTCGCCCAAGCGGGTGAGTTTGGTTTGGTTTTATTAAGCTTTACGGTAC
AGCAGCATGTTTTACCCTCGGCAATGGCCGCGCCTTTATCACTGGTTATTACGCTATCCATGTTTCTGACACCCGCCCTG
TTTATTTTCTTCGAAAAGGTTATTTTACCGCATCATCAGCAAACCAGTAACCGCCGCGCACAAGATAAAATAGATCAAAC
AGGCTCTGTAATTATTGCCGGAGCGGGTCGATTTGGACAGGTAGTTAATCGCTTACTGGTCGCCAATAATGTCCCCACGG
TAGTGATCGATCATGAGTCAAGCATGATCGATCGCTTAAGGCAGGTTAATGTAAAAAGTTTTTACGGGGATGTAACACGC
CCGGATATTATGCGTACCGCAGGCATTGAGCAGGCAAAATTATTAATTGTTTCGATCGACGATAAAATACGTGCCACTGA
GTTAGTTAACTATATAAAACACACTCACCCGCAGGTAAAAATTCTCGCACGCGCTTATGATCGCGGTCATTATTATTCAC
TTGCCCACGCCGGGGCCGACTATATTATCAGTGAAACCTACCTGTCCGCTGTAGAGTTGGGAACACAAGCCTTGAAAGAT
TTAGGCTTTGCTCAAGATAATGTCACTAACCTGCGCCATAAATTCATGAATGCAGAGGTAAAAGGCAGCCGTTCTTTATA
CAAAATATGGCAGGAAAGCAGCTCCGAACACACTTTTGATAGTGACTACCAGCAACTCTTTATCGAGCTTGAAGAGGAGT
TAAGTGAGATCATGGATGAAAATGAAAGCTAA

Upstream 100 bases:

>100_bases
TTAACCTTATTTACGGATTAATCAGCTAATACCAAAAGAACGAAAAAGATGATCACCCTTGCTGGTTAAAATCCTTGATC
ACTTCATTAATTCTTTTGGT

Downstream 100 bases:

>100_bases
CAAGGCGGATAATGAAGAAATGATCAAATTTAATGGCGGTCTTATTTGAGTGCCAACTAGCACAGTCCATAATAACAATC
GCATACCCCGTAGGGTGCGC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MTTTIRNLMTEYFVYAFIYLAAAVIAVPIATRCGLGSVLGYLIAGVVIGPIIGLVGDETSSIKHFAEFGVVLMLFLVGLE
LEPKLLWKMRNRLLGLGGLQVILSTLLVMGIAFYFVDHWATALTIGLILSPSSTAIVLQTFNEKGLSKTTGGKNAFSILL
FQDIAVIPMLALIPLMALPELIEKSQQLASTAAQQNEHLSLVAGLPSWAYALTVVTSIIAVVSGGHYLSRPLFRFVASSG
LREMFTASALMLVIGIAALMSLVDLSPALGTFLAGVVLANSEFRHELKSNIEPFKGLLLGLFFITVGAGIDFNLLYSDFM
VILTLTLGIILLKATVLFFLAIIFKIKNSDRWLFALSLAQAGEFGLVLLSFTVQQHVLPSAMAAPLSLVITLSMFLTPAL
FIFFEKVILPHHQQTSNRRAQDKIDQTGSVIIAGAGRFGQVVNRLLVANNVPTVVIDHESSMIDRLRQVNVKSFYGDVTR
PDIMRTAGIEQAKLLIVSIDDKIRATELVNYIKHTHPQVKILARAYDRGHYYSLAHAGADYIISETYLSAVELGTQALKD
LGFAQDNVTNLRHKFMNAEVKGSRSLYKIWQESSSEHTFDSDYQQLFIELEEELSEIMDENES

Sequences:

>Translated_623_residues
MTTTIRNLMTEYFVYAFIYLAAAVIAVPIATRCGLGSVLGYLIAGVVIGPIIGLVGDETSSIKHFAEFGVVLMLFLVGLE
LEPKLLWKMRNRLLGLGGLQVILSTLLVMGIAFYFVDHWATALTIGLILSPSSTAIVLQTFNEKGLSKTTGGKNAFSILL
FQDIAVIPMLALIPLMALPELIEKSQQLASTAAQQNEHLSLVAGLPSWAYALTVVTSIIAVVSGGHYLSRPLFRFVASSG
LREMFTASALMLVIGIAALMSLVDLSPALGTFLAGVVLANSEFRHELKSNIEPFKGLLLGLFFITVGAGIDFNLLYSDFM
VILTLTLGIILLKATVLFFLAIIFKIKNSDRWLFALSLAQAGEFGLVLLSFTVQQHVLPSAMAAPLSLVITLSMFLTPAL
FIFFEKVILPHHQQTSNRRAQDKIDQTGSVIIAGAGRFGQVVNRLLVANNVPTVVIDHESSMIDRLRQVNVKSFYGDVTR
PDIMRTAGIEQAKLLIVSIDDKIRATELVNYIKHTHPQVKILARAYDRGHYYSLAHAGADYIISETYLSAVELGTQALKD
LGFAQDNVTNLRHKFMNAEVKGSRSLYKIWQESSSEHTFDSDYQQLFIELEEELSEIMDENES
>Mature_622_residues
TTTIRNLMTEYFVYAFIYLAAAVIAVPIATRCGLGSVLGYLIAGVVIGPIIGLVGDETSSIKHFAEFGVVLMLFLVGLEL
EPKLLWKMRNRLLGLGGLQVILSTLLVMGIAFYFVDHWATALTIGLILSPSSTAIVLQTFNEKGLSKTTGGKNAFSILLF
QDIAVIPMLALIPLMALPELIEKSQQLASTAAQQNEHLSLVAGLPSWAYALTVVTSIIAVVSGGHYLSRPLFRFVASSGL
REMFTASALMLVIGIAALMSLVDLSPALGTFLAGVVLANSEFRHELKSNIEPFKGLLLGLFFITVGAGIDFNLLYSDFMV
ILTLTLGIILLKATVLFFLAIIFKIKNSDRWLFALSLAQAGEFGLVLLSFTVQQHVLPSAMAAPLSLVITLSMFLTPALF
IFFEKVILPHHQQTSNRRAQDKIDQTGSVIIAGAGRFGQVVNRLLVANNVPTVVIDHESSMIDRLRQVNVKSFYGDVTRP
DIMRTAGIEQAKLLIVSIDDKIRATELVNYIKHTHPQVKILARAYDRGHYYSLAHAGADYIISETYLSAVELGTQALKDL
GFAQDNVTNLRHKFMNAEVKGSRSLYKIWQESSSEHTFDSDYQQLFIELEEELSEIMDENES

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=386, Percent_Identity=27.4611398963731, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786232, Length=554, Percent_Identity=44.043321299639, Blast_Score=421, Evalue=1e-118,
Organism=Escherichia coli, GI1789749, Length=582, Percent_Identity=38.4879725085911, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786685, Length=532, Percent_Identity=29.5112781954887, Blast_Score=182, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 68398; Mature: 68267

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTIRNLMTEYFVYAFIYLAAAVIAVPIATRCGLGSVLGYLIAGVVIGPIIGLVGDETS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHH
SIKHFAEFGVVLMLFLVGLELEPKLLWKMRNRLLGLGGLQVILSTLLVMGIAFYFVDHWA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TALTIGLILSPSSTAIVLQTFNEKGLSKTTGGKNAFSILLFQDIAVIPMLALIPLMALPE
HHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEKSQQLASTAAQQNEHLSLVAGLPSWAYALTVVTSIIAVVSGGHYLSRPLFRFVASSG
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LREMFTASALMLVIGIAALMSLVDLSPALGTFLAGVVLANSEFRHELKSNIEPFKGLLLG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHH
LFFITVGAGIDFNLLYSDFMVILTLTLGIILLKATVLFFLAIIFKIKNSDRWLFALSLAQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHC
AGEFGLVLLSFTVQQHVLPSAMAAPLSLVITLSMFLTPALFIFFEKVILPHHQQTSNRRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
QDKIDQTGSVIIAGAGRFGQVVNRLLVANNVPTVVIDHESSMIDRLRQVNVKSFYGDVTR
HHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHCCCCC
PDIMRTAGIEQAKLLIVSIDDKIRATELVNYIKHTHPQVKILARAYDRGHYYSLAHAGAD
CHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHHCCCC
YIISETYLSAVELGTQALKDLGFAQDNVTNLRHKFMNAEVKGSRSLYKIWQESSSEHTFD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
SDYQQLFIELEEELSEIMDENES
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTTIRNLMTEYFVYAFIYLAAAVIAVPIATRCGLGSVLGYLIAGVVIGPIIGLVGDETS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHH
SIKHFAEFGVVLMLFLVGLELEPKLLWKMRNRLLGLGGLQVILSTLLVMGIAFYFVDHWA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TALTIGLILSPSSTAIVLQTFNEKGLSKTTGGKNAFSILLFQDIAVIPMLALIPLMALPE
HHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEKSQQLASTAAQQNEHLSLVAGLPSWAYALTVVTSIIAVVSGGHYLSRPLFRFVASSG
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LREMFTASALMLVIGIAALMSLVDLSPALGTFLAGVVLANSEFRHELKSNIEPFKGLLLG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHH
LFFITVGAGIDFNLLYSDFMVILTLTLGIILLKATVLFFLAIIFKIKNSDRWLFALSLAQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHC
AGEFGLVLLSFTVQQHVLPSAMAAPLSLVITLSMFLTPALFIFFEKVILPHHQQTSNRRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
QDKIDQTGSVIIAGAGRFGQVVNRLLVANNVPTVVIDHESSMIDRLRQVNVKSFYGDVTR
HHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHCCCCC
PDIMRTAGIEQAKLLIVSIDDKIRATELVNYIKHTHPQVKILARAYDRGHYYSLAHAGAD
CHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHHCCCC
YIISETYLSAVELGTQALKDLGFAQDNVTNLRHKFMNAEVKGSRSLYKIWQESSSEHTFD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
SDYQQLFIELEEELSEIMDENES
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA