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The map label for this gene is pyrH

Identifier: 119946595

GI number: 119946595

Start: 3666870

End: 3667619

Strand: Reverse

Name: pyrH

Synonym: Ping_2974

Alternate gene names: 119946595

Gene position: 3667619-3666870 (Counterclockwise)

Preceding gene: 119946596

Following gene: 119946594

Centisome position: 80.44

GC content: 41.33

Gene sequence:

>750_bases
ATGAAAACAAAACCAAAATCTGCATATCGCCGCATTTTATTAAAATTAAGTGGTGAGGCTTTGGTCGGCGAGGAGGGCTT
TGGTATTGATCCTAAAGTGCTGGATCGCATGGCGCTTGAAATTAAATCATTAATAGAAGTAGGTGTGCAGGTTGGGTTAG
TTATCGGTGGCGGCAATATTTTCCGTGGCGCAGGTCTCGCTGAAGCTGGGATGAACCGCGTTGTTGGTGACCATATGGGT
ATGCTGGCGACGGTAATGAACGGTCTTGCAATGCGCGATGCCCTGCAGCGTTCGCATGTTAATTCGCGTTTAATGTCAGC
GATTCCTTTAAATGGTGTTTGTGATGATTACAACTGGGCAAAGGCAATAAGATACCTTAAACAAGGCACTGTGGTGATTT
TTGCCGCTGGCACAGGTAACCCATTTTTTACTACGGATTCGGCAGCTTGTTTACGTGGTATTGAAATTGAAGCCGATGCT
GTTTTAAAAGGTACAAAAGTAGATGGAGTTTTTGATGCCGATCCGGCTAAAAATCCTGATGCAAAATTATATAAAGAGAT
TGATTATCAATTAGTATTGGAAAAAGAGTTAAAAGTAATGGATCTCGCTGCGTTTACATTAGCACGGGATCATAGTTTAC
CTATACGCGTATTTAATATGAACAAACCCGGTGCGTTAAACCGTGTTGTGTTAGGCGAAGATGAAGGTACAACTATTAAA
CATTGTGAGACAATAATAGAAAAAGAATAA

Upstream 100 bases:

>100_bases
ATATTGTCTTTAAAATTTAATTAGTTATACCTGTTAGGTTAACAAATTACGACACAATTTATTAACCTAACCGGTATTAA
GTCTACATTAAGGAACTAGC

Downstream 100 bases:

>100_bases
TCAATTTATAACCGAAAATTAGGGAAATTTTTATGATCAATGAAGTTAAAAGTGATGCTCAATCCCGTATGGATAAAAGT
GTTGAAGCATTTAGAAGCCA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKTKPKSAYRRILLKLSGEALVGEEGFGIDPKVLDRMALEIKSLIEVGVQVGLVIGGGNIFRGAGLAEAGMNRVVGDHMG
MLATVMNGLAMRDALQRSHVNSRLMSAIPLNGVCDDYNWAKAIRYLKQGTVVIFAAGTGNPFFTTDSAACLRGIEIEADA
VLKGTKVDGVFDADPAKNPDAKLYKEIDYQLVLEKELKVMDLAAFTLARDHSLPIRVFNMNKPGALNRVVLGEDEGTTIK
HCETIIEKE

Sequences:

>Translated_249_residues
MKTKPKSAYRRILLKLSGEALVGEEGFGIDPKVLDRMALEIKSLIEVGVQVGLVIGGGNIFRGAGLAEAGMNRVVGDHMG
MLATVMNGLAMRDALQRSHVNSRLMSAIPLNGVCDDYNWAKAIRYLKQGTVVIFAAGTGNPFFTTDSAACLRGIEIEADA
VLKGTKVDGVFDADPAKNPDAKLYKEIDYQLVLEKELKVMDLAAFTLARDHSLPIRVFNMNKPGALNRVVLGEDEGTTIK
HCETIIEKE
>Mature_249_residues
MKTKPKSAYRRILLKLSGEALVGEEGFGIDPKVLDRMALEIKSLIEVGVQVGLVIGGGNIFRGAGLAEAGMNRVVGDHMG
MLATVMNGLAMRDALQRSHVNSRLMSAIPLNGVCDDYNWAKAIRYLKQGTVVIFAAGTGNPFFTTDSAACLRGIEIEADA
VLKGTKVDGVFDADPAKNPDAKLYKEIDYQLVLEKELKVMDLAAFTLARDHSLPIRVFNMNKPGALNRVVLGEDEGTTIK
HCETIIEKE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=78.2426778242678, Blast_Score=389, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PSYIN (A1SYW1)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944275.1
- ProteinModelPortal:   A1SYW1
- SMR:   A1SYW1
- STRING:   A1SYW1
- GeneID:   4624778
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2974
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A1SYW1
- BioCyc:   PING357804:PING_2974-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27004; Mature: 27004

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 58-58 BINDING 62-62 BINDING 77-77 BINDING 165-165 BINDING 171-171 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKPKSAYRRILLKLSGEALVGEEGFGIDPKVLDRMALEIKSLIEVGVQVGLVIGGGNI
CCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCE
FRGAGLAEAGMNRVVGDHMGMLATVMNGLAMRDALQRSHVNSRLMSAIPLNGVCDDYNWA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
KAIRYLKQGTVVIFAAGTGNPFFTTDSAACLRGIEIEADAVLKGTKVDGVFDADPAKNPD
HHHHHHHCCCEEEEEECCCCCCEECCHHHHHCCCEECCCCEEECCCCCCEECCCCCCCCC
AKLYKEIDYQLVLEKELKVMDLAAFTLARDHSLPIRVFNMNKPGALNRVVLGEDEGTTIK
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCHHH
HCETIIEKE
HHHHHHCCC
>Mature Secondary Structure
MKTKPKSAYRRILLKLSGEALVGEEGFGIDPKVLDRMALEIKSLIEVGVQVGLVIGGGNI
CCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCE
FRGAGLAEAGMNRVVGDHMGMLATVMNGLAMRDALQRSHVNSRLMSAIPLNGVCDDYNWA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
KAIRYLKQGTVVIFAAGTGNPFFTTDSAACLRGIEIEADAVLKGTKVDGVFDADPAKNPD
HHHHHHHCCCEEEEEECCCCCCEECCHHHHHCCCEECCCCEEECCCCCCEECCCCCCCCC
AKLYKEIDYQLVLEKELKVMDLAAFTLARDHSLPIRVFNMNKPGALNRVVLGEDEGTTIK
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCHHH
HCETIIEKE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA