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The map label for this gene is uppS [H]

Identifier: 119946593

GI number: 119946593

Start: 3665468

End: 3666247

Strand: Reverse

Name: uppS [H]

Synonym: Ping_2972

Alternate gene names: 119946593

Gene position: 3666247-3665468 (Counterclockwise)

Preceding gene: 119946594

Following gene: 119946592

Centisome position: 80.41

GC content: 40.9

Gene sequence:

>780_bases
ATGCTAACTAATGTTCCGCTATTTTTCAATTCATCAAGGTTGATTGTGACCACATCAAATGAAAATTTAAAACATGCCAG
GCATGTCGCTATTATTATGGACGGAAATGGTCGCTGGGCACAAAGCAAAGGTAAGCATCGTGTATTAGGGCATAAGCACG
GCGTTCAATCTTTACGTCGGGCAATTGCTTTTGCAAGCGAGCAAAAGCTTGAAGCATTAACCTTGTTCGCCTTCAGCAGT
GAAAATTGGCAACGCCCGGTGCAGGAAGTTGATATGCTGATGGCGCTTTTTTTTACTGTATTAAGCAGTGAAGTCAAAAA
ATTACAGAAAAACAATATTAAACTTAAAGTGATTGGTGAGTTGTCCGGATTTAGCGAAGGGCTACAAAAAAAAATCATTG
AAGCTGAAAATAGAACCCAAGCTAATACTGGTTTAGTGGTCAATGTTGCCGCAAATTATGGTGGCCGCTGGGATATAACG
CAGGCAACCAAAAAGTTAGCTACTTTAGTGGCGGCAGGTAAGCTTAAGGTAGAAGATATCAATGAGCAGCTGCTTAATAA
CGTTACCTGTTTGGCAGAATTACCGCCAGTGGATCTTCTAATCCGCACGGGGGGGGACCAACGTATTAGTAACTTTATAT
TATGGCAACTGGCTTATGCGGAATTTTATTTTACCGATGTTTTGTGGCCGGATTTTGATGGTCAAGAATTTCAATATGCG
CTAGATGTATTTTCAAGTAAAGAACGCCGCTTTGGAAAAACCGGTGCACAACTAAGTTAA

Upstream 100 bases:

>100_bases
CTAATGATCATATTAAACAGATTGAAGATCTGCTTGTCGTCAAAGAAGCTGAGCTACTTGAAGTTTAACTATCTAGTGTT
AGCGTATCCCTATTTTGGAT

Downstream 100 bases:

>100_bases
TAATTAATTTGCTGGTTTTCTCAGTACAAACGTATTTAATCAAGGTGTTTCTGTGCAACAACGAATTATAACTGCTTTAA
TTTTAGCTCCTCTTACCATT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MLTNVPLFFNSSRLIVTTSNENLKHARHVAIIMDGNGRWAQSKGKHRVLGHKHGVQSLRRAIAFASEQKLEALTLFAFSS
ENWQRPVQEVDMLMALFFTVLSSEVKKLQKNNIKLKVIGELSGFSEGLQKKIIEAENRTQANTGLVVNVAANYGGRWDIT
QATKKLATLVAAGKLKVEDINEQLLNNVTCLAELPPVDLLIRTGGDQRISNFILWQLAYAEFYFTDVLWPDFDGQEFQYA
LDVFSSKERRFGKTGAQLS

Sequences:

>Translated_259_residues
MLTNVPLFFNSSRLIVTTSNENLKHARHVAIIMDGNGRWAQSKGKHRVLGHKHGVQSLRRAIAFASEQKLEALTLFAFSS
ENWQRPVQEVDMLMALFFTVLSSEVKKLQKNNIKLKVIGELSGFSEGLQKKIIEAENRTQANTGLVVNVAANYGGRWDIT
QATKKLATLVAAGKLKVEDINEQLLNNVTCLAELPPVDLLIRTGGDQRISNFILWQLAYAEFYFTDVLWPDFDGQEFQYA
LDVFSSKERRFGKTGAQLS
>Mature_259_residues
MLTNVPLFFNSSRLIVTTSNENLKHARHVAIIMDGNGRWAQSKGKHRVLGHKHGVQSLRRAIAFASEQKLEALTLFAFSS
ENWQRPVQEVDMLMALFFTVLSSEVKKLQKNNIKLKVIGELSGFSEGLQKKIIEAENRTQANTGLVVNVAANYGGRWDIT
QATKKLATLVAAGKLKVEDINEQLLNNVTCLAELPPVDLLIRTGGDQRISNFILWQLAYAEFYFTDVLWPDFDGQEFQYA
LDVFSSKERRFGKTGAQLS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=209, Percent_Identity=35.8851674641148, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI45580742, Length=209, Percent_Identity=35.8851674641148, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=59.3886462882096, Blast_Score=300, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=35.6807511737089, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=225, Percent_Identity=33.7777777777778, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=31.924882629108, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18857969, Length=237, Percent_Identity=35.4430379746835, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29116; Mature: 29116

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNVPLFFNSSRLIVTTSNENLKHARHVAIIMDGNGRWAQSKGKHRVLGHKHGVQSLRR
CCCCCCEEECCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
AIAFASEQKLEALTLFAFSSENWQRPVQEVDMLMALFFTVLSSEVKKLQKNNIKLKVIGE
HHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
LSGFSEGLQKKIIEAENRTQANTGLVVNVAANYGGRWDITQATKKLATLVAAGKLKVEDI
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHCCEEEHHH
NEQLLNNVTCLAELPPVDLLIRTGGDQRISNFILWQLAYAEFYFTDVLWPDFDGQEFQYA
HHHHHCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LDVFSSKERRFGKTGAQLS
HHHHHCHHHHHCCCCCCCC
>Mature Secondary Structure
MLTNVPLFFNSSRLIVTTSNENLKHARHVAIIMDGNGRWAQSKGKHRVLGHKHGVQSLRR
CCCCCCEEECCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
AIAFASEQKLEALTLFAFSSENWQRPVQEVDMLMALFFTVLSSEVKKLQKNNIKLKVIGE
HHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
LSGFSEGLQKKIIEAENRTQANTGLVVNVAANYGGRWDITQATKKLATLVAAGKLKVEDI
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHCCEEEHHH
NEQLLNNVTCLAELPPVDLLIRTGGDQRISNFILWQLAYAEFYFTDVLWPDFDGQEFQYA
HHHHHCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LDVFSSKERRFGKTGAQLS
HHHHHCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA