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The map label for this gene is kefC [H]

Identifier: 119946577

GI number: 119946577

Start: 3643447

End: 3645411

Strand: Reverse

Name: kefC [H]

Synonym: Ping_2956

Alternate gene names: 119946577

Gene position: 3645411-3643447 (Counterclockwise)

Preceding gene: 119946578

Following gene: 119946576

Centisome position: 79.95

GC content: 41.07

Gene sequence:

>1965_bases
GTGCTTAATGATCTGTTATTATTACTCTTTTTTGCAATTGTCAGCGTACTTATCTTTAAACGCCTGAGATTGTCGAATAT
TGTCGCCTACCTCTTTACCGGATTTGTGCTGGGTCCCTCGCTGTTTAATCTTCTTAACTCTTATCATGAAATAGAGCTGG
TTGCCGAGTTTGGTATCGTTTTTTTAATGTTTTCACTCGGATTGGAGTTTTCATTAAACAAATTGATTAAAATGAGTCGG
GCTGTTTTTGGCATTGGGGCACTGCAGGTATGTGCTTCATTTTTTCTGTTCTATTGGTTATGCCAATTATTTGATCTGAA
CTGGCAGCAGGCATTTACCGTTGCTGCGGTCTTAACCATGTCGTCAACGGCCATTATTGTTAAAGTATTAAGCGATCAGC
AGAGGTTACAATCAAGAATTGGTCGACTGGCAATCTCCATTCTTCTTTTTCAAGATCTTGCCGTGGTCCCCTTCTTAATT
ATTATTCCTATTATTGCAATGCCGGGGCTTGAAGGCGATATCGTGACCGCTTTGTTGCTTGCCTTTGTAAAAGGGGCGTT
AGCTGTCGCTGTTATCTTATCCGTTGGGCGCTGGTTACTGCCAATGTTTTTTGATGAAATGGCGAGTATGCGTTTTGATG
AGATTTTTATTCTATCAACGCTGTTTGTCACTATCTTAGCCGCCTGGTTTACGCAATTATTGGGTCTATCTATGGCATTA
GGGGCTTTTTTGGCGGGTATGATGCTTAGCGAAAGTCATTACCGCCATCAACTTTTGGCCGATATTAGGCCATTTAAAGA
TATTTTGATGGCCATTTTTTTTATCTCAATTGGTACGCTTTTACAGTATCAGGTGTTACTCGATGATTTTGGCATATTAA
TTTTAATCGTAATAGGTGTGATGCTGGCAAAAATCTTAACCATCACCTTAGCGGCCGTTATTATGCAAGAGAAATTATCA
ACAGCGCTGGGAACCGGTATTGCTTTAGCACAAATGGGTGAGTTTGGTTTTATATTGGTCGCATTGGCAAGTAAATATAA
ATTATTAGACGCGCAGTTATCCTCTCTGATTATTGCAACAGGAGTAATTAGCATGACGCTGACGCCCTTATTGGTAAAAT
ACAGCAGTTATATCTCACGCGAATTATTACACCATTCGGCCAACGCTTTTCGTTTTCAAAAAACTTTGCCCGGGCAATTT
ACAAAACATACCATTATTTGTGGTTATGGACGTGTCGGGCAAATTGTTTCACGGTTTTTAAAAAATGAATCGCTGCCCTT
TATTGTTTTGGACAGAGATCCTATGCGGGTTAAAGAAGCTAGGGAAGGAGGGGAACTCATTGAGTTTGGCGATGCGAGCC
GCAGGGAAATATTGTTACTTGCCGGTATTGAAAAAGCCAATTTATTAATTATCACTTTTGATGACCTGCGGCGTTCAATG
GCTTTATTAGGGCTGATTAGGGTGCTAAATCCAAGCCTGAAAGTGCTAGTGCGCACCAAGGATGATAAGGGTCTGGATCT
GTTAAAAGAGGCGGGTGCTACCGAGGTTATCCCCGAGGTATTAGAGGGCAGTTTGATGTTGGTTGCCCATGTTTTGTTTT
TATCGGGCGTACCAAGTAGGCGAATTTTGCAGCGTTTAGAGAGTGAACGCAACATTAAGTACCAACATCTGCATGGTTTT
TATTATGGACAAAATAGCCGAAGTGAAAAAAATGCATGGCATATAGAACAGTTACATGCGGTAACTTTAACTGAAGAGGC
TGAGGTAGTGGGCAGTTGTGTGCAGGAATTTCACCTTGCCGGCGTTATAATAAAATCTCTGCATCGGGAAAATGGAGCAG
AGGTGCTCATTTCAGAAAAAGTACTTTTTGAACCGGGTGATCTGGTTTTGCTGCAGGGCGATAAAGACAGGTTACAACTT
GCTGAGAAAATTTTGCTTGGAAAGTGTTACTATGTTCCTGTTTAA

Upstream 100 bases:

>100_bases
ATATTATTAAGCTGTTTTATGACTTGATTAGCTATACTTGGTGAATAAATTTTAATTTGCTTTATATGCCGGTTGAATTC
AGAGGGAGCTAGCGGAAAAA

Downstream 100 bases:

>100_bases
ATCCTAATAATTTCGATGTATCTTTAAGTGGTTGGGGAAGAACTGCTTAAGCAGGTAAAAATTGTGCCAGCTAAAAAAAG
TGAGGCGCAGGAAGAGTATT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MLNDLLLLLFFAIVSVLIFKRLRLSNIVAYLFTGFVLGPSLFNLLNSYHEIELVAEFGIVFLMFSLGLEFSLNKLIKMSR
AVFGIGALQVCASFFLFYWLCQLFDLNWQQAFTVAAVLTMSSTAIIVKVLSDQQRLQSRIGRLAISILLFQDLAVVPFLI
IIPIIAMPGLEGDIVTALLLAFVKGALAVAVILSVGRWLLPMFFDEMASMRFDEIFILSTLFVTILAAWFTQLLGLSMAL
GAFLAGMMLSESHYRHQLLADIRPFKDILMAIFFISIGTLLQYQVLLDDFGILILIVIGVMLAKILTITLAAVIMQEKLS
TALGTGIALAQMGEFGFILVALASKYKLLDAQLSSLIIATGVISMTLTPLLVKYSSYISRELLHHSANAFRFQKTLPGQF
TKHTIICGYGRVGQIVSRFLKNESLPFIVLDRDPMRVKEAREGGELIEFGDASRREILLLAGIEKANLLIITFDDLRRSM
ALLGLIRVLNPSLKVLVRTKDDKGLDLLKEAGATEVIPEVLEGSLMLVAHVLFLSGVPSRRILQRLESERNIKYQHLHGF
YYGQNSRSEKNAWHIEQLHAVTLTEEAEVVGSCVQEFHLAGVIIKSLHRENGAEVLISEKVLFEPGDLVLLQGDKDRLQL
AEKILLGKCYYVPV

Sequences:

>Translated_654_residues
MLNDLLLLLFFAIVSVLIFKRLRLSNIVAYLFTGFVLGPSLFNLLNSYHEIELVAEFGIVFLMFSLGLEFSLNKLIKMSR
AVFGIGALQVCASFFLFYWLCQLFDLNWQQAFTVAAVLTMSSTAIIVKVLSDQQRLQSRIGRLAISILLFQDLAVVPFLI
IIPIIAMPGLEGDIVTALLLAFVKGALAVAVILSVGRWLLPMFFDEMASMRFDEIFILSTLFVTILAAWFTQLLGLSMAL
GAFLAGMMLSESHYRHQLLADIRPFKDILMAIFFISIGTLLQYQVLLDDFGILILIVIGVMLAKILTITLAAVIMQEKLS
TALGTGIALAQMGEFGFILVALASKYKLLDAQLSSLIIATGVISMTLTPLLVKYSSYISRELLHHSANAFRFQKTLPGQF
TKHTIICGYGRVGQIVSRFLKNESLPFIVLDRDPMRVKEAREGGELIEFGDASRREILLLAGIEKANLLIITFDDLRRSM
ALLGLIRVLNPSLKVLVRTKDDKGLDLLKEAGATEVIPEVLEGSLMLVAHVLFLSGVPSRRILQRLESERNIKYQHLHGF
YYGQNSRSEKNAWHIEQLHAVTLTEEAEVVGSCVQEFHLAGVIIKSLHRENGAEVLISEKVLFEPGDLVLLQGDKDRLQL
AEKILLGKCYYVPV
>Mature_654_residues
MLNDLLLLLFFAIVSVLIFKRLRLSNIVAYLFTGFVLGPSLFNLLNSYHEIELVAEFGIVFLMFSLGLEFSLNKLIKMSR
AVFGIGALQVCASFFLFYWLCQLFDLNWQQAFTVAAVLTMSSTAIIVKVLSDQQRLQSRIGRLAISILLFQDLAVVPFLI
IIPIIAMPGLEGDIVTALLLAFVKGALAVAVILSVGRWLLPMFFDEMASMRFDEIFILSTLFVTILAAWFTQLLGLSMAL
GAFLAGMMLSESHYRHQLLADIRPFKDILMAIFFISIGTLLQYQVLLDDFGILILIVIGVMLAKILTITLAAVIMQEKLS
TALGTGIALAQMGEFGFILVALASKYKLLDAQLSSLIIATGVISMTLTPLLVKYSSYISRELLHHSANAFRFQKTLPGQF
TKHTIICGYGRVGQIVSRFLKNESLPFIVLDRDPMRVKEAREGGELIEFGDASRREILLLAGIEKANLLIITFDDLRRSM
ALLGLIRVLNPSLKVLVRTKDDKGLDLLKEAGATEVIPEVLEGSLMLVAHVLFLSGVPSRRILQRLESERNIKYQHLHGF
YYGQNSRSEKNAWHIEQLHAVTLTEEAEVVGSCVQEFHLAGVIIKSLHRENGAEVLISEKVLFEPGDLVLLQGDKDRLQL
AEKILLGKCYYVPV

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=378, Percent_Identity=26.1904761904762, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786232, Length=520, Percent_Identity=31.1538461538462, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1789749, Length=526, Percent_Identity=34.4106463878327, Blast_Score=248, Evalue=9e-67,
Organism=Escherichia coli, GI1786685, Length=524, Percent_Identity=29.5801526717557, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322367, Length=380, Percent_Identity=21.5789473684211, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 72905; Mature: 72905

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDLLLLLFFAIVSVLIFKRLRLSNIVAYLFTGFVLGPSLFNLLNSYHEIELVAEFGIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLMFSLGLEFSLNKLIKMSRAVFGIGALQVCASFFLFYWLCQLFDLNWQQAFTVAAVLTM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SSTAIIVKVLSDQQRLQSRIGRLAISILLFQDLAVVPFLIIIPIIAMPGLEGDIVTALLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AFVKGALAVAVILSVGRWLLPMFFDEMASMRFDEIFILSTLFVTILAAWFTQLLGLSMAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAFLAGMMLSESHYRHQLLADIRPFKDILMAIFFISIGTLLQYQVLLDDFGILILIVIGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAKILTITLAAVIMQEKLSTALGTGIALAQMGEFGFILVALASKYKLLDAQLSSLIIAT
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVISMTLTPLLVKYSSYISRELLHHSANAFRFQKTLPGQFTKHTIICGYGRVGQIVSRFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHCCCCCCCCCEEEECCCHHHHHHHHHH
KNESLPFIVLDRDPMRVKEAREGGELIEFGDASRREILLLAGIEKANLLIITFDDLRRSM
CCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCEEEEEHHHHHHHH
ALLGLIRVLNPSLKVLVRTKDDKGLDLLKEAGATEVIPEVLEGSLMLVAHVLFLSGVPSR
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCHH
RILQRLESERNIKYQHLHGFYYGQNSRSEKNAWHIEQLHAVTLTEEAEVVGSCVQEFHLA
HHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GVIIKSLHRENGAEVLISEKVLFEPGDLVLLQGDKDRLQLAEKILLGKCYYVPV
HHHHHHHHCCCCCEEEEECCEEECCCCEEEEECCHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MLNDLLLLLFFAIVSVLIFKRLRLSNIVAYLFTGFVLGPSLFNLLNSYHEIELVAEFGIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLMFSLGLEFSLNKLIKMSRAVFGIGALQVCASFFLFYWLCQLFDLNWQQAFTVAAVLTM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SSTAIIVKVLSDQQRLQSRIGRLAISILLFQDLAVVPFLIIIPIIAMPGLEGDIVTALLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AFVKGALAVAVILSVGRWLLPMFFDEMASMRFDEIFILSTLFVTILAAWFTQLLGLSMAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAFLAGMMLSESHYRHQLLADIRPFKDILMAIFFISIGTLLQYQVLLDDFGILILIVIGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAKILTITLAAVIMQEKLSTALGTGIALAQMGEFGFILVALASKYKLLDAQLSSLIIAT
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVISMTLTPLLVKYSSYISRELLHHSANAFRFQKTLPGQFTKHTIICGYGRVGQIVSRFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHCCCCCCCCCEEEECCCHHHHHHHHHH
KNESLPFIVLDRDPMRVKEAREGGELIEFGDASRREILLLAGIEKANLLIITFDDLRRSM
CCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCEEEEEHHHHHHHH
ALLGLIRVLNPSLKVLVRTKDDKGLDLLKEAGATEVIPEVLEGSLMLVAHVLFLSGVPSR
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCHH
RILQRLESERNIKYQHLHGFYYGQNSRSEKNAWHIEQLHAVTLTEEAEVVGSCVQEFHLA
HHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GVIIKSLHRENGAEVLISEKVLFEPGDLVLLQGDKDRLQLAEKILLGKCYYVPV
HHHHHHHHCCCCCEEEEECCEEECCCCEEEEECCHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA