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The map label for this gene is proA

Identifier: 119946573

GI number: 119946573

Start: 3639030

End: 3640277

Strand: Reverse

Name: proA

Synonym: Ping_2952

Alternate gene names: 119946573

Gene position: 3640277-3639030 (Counterclockwise)

Preceding gene: 119946574

Following gene: 119946571

Centisome position: 79.84

GC content: 42.55

Gene sequence:

>1248_bases
ATGGATTTACAATCATTAGGTAAATTAGCAAAAGAAGCAAGTTATGAACTTGCAATTACTGGCAGCGAAAAAAAGAATGC
CGCATTAGAAGCGATTGCTTTAGCGTTAGAGGCTAATCAGGATAAGATTGTTTCAGCCAATAAGGAAGATATTCAAGCGG
GTAAAGAAGCCGGATTAACGGAAGCGTTATTAGACCGTCTGTTGCTTGATGAAACGCGTTTAGCTGGCGTTGTTAGTGAT
GTGCGCAGTGTGATTAAATTAGACGATCCTGTCGGTGAAGAGTTTGATGGTAAGCTCCTTGAAAATGGCTTGAAACTCAG
TAAACGTCGCGTGCCAATTGGTGTGATTGGCGTGATTTATGAAGCTCGCCCAAATGTGACTATTGATATCGCGGTATTGA
GTTTGAAAACCGGTAATGCGTGTATTTTACGTGGTGGTAAAGAGACTATTCGCTCTAATATCGTCTTAGTAGAAGTGATT
CAAGCGGCTTTAAAATCCGTTGGTTTACCAGAAACCTCAGTGCAGTATATTAAAAGTACGGACCGCGCTTTAGTGGGCGA
GCTTTTAAAAATGGATGACTACGTGGATATGATTATTCCACGCGGTAATGCCGGACTGCAAAAATTCTGTAAAGAAAACA
GTAATATCCCAGTGATCGTTGGCGGCATTGGTGTCTGTCATCTGTTTGCTGACAAAAGTGTCGATCAGGAAAAAGCCTTG
GCTATTGTTGCCAATGCCAAAGTACAAAGACCGACAGTGTGTAATGCATTAGAGACGCTATTAGTGCATCAGGATATTGC
TGAGGAATTTTTGCCTAAACTGCATGCTCACCTTGCCCCTATGGGCGTGACACTGATTGCAGAAGAAAAAGCAAAAGCTA
TTTTAGGTGACAAAGCAACCCTTGCGGAGGCAGGTGATTTCGATCGCGAATGGTTATGTTTAAATTTAGGGGTTAAAGTA
GTTGCTGATTTCCATGAGGCTATTATGCATATTCGCACCCATAGCTCTGGTCATTCTGACGGTATTTTAACCAATGATTT
TACCATTGCGAATAAGTTTATTAATGTCGTCAATTCTGCTGCTGTTTACATCAATGCGAGCACGCGCTTTACCGATGGCA
GCCAATTCGGATTAGGGGCCGAAGTCGCTGTATCAACGCAAAAACTGCATGCACGCGGCCCGATGGGATTACAAGAACTG
ACCACTTACAAGTGGATTGGTATTGGCGAAAACTTAATCCGTCCTTAA

Upstream 100 bases:

>100_bases
TTGAAGCAGTATTAGGTTTTGAACATGGTAGAGTCGTTATACATCGAGATGATTTAGTACTCTTATAAACGATAATTAAT
ACTTAATTAAGGAAAAGTTC

Downstream 100 bases:

>100_bases
ATAACAGCCGTCAGTTTTCGGCTGTCGGCTGTCGGCTTTCAGCTCGAAGGCTCGAAGCTGGAAAGCTTTCAGCCTTATAG
CTTTATAGCCTTTCAGCCTC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDLQSLGKLAKEASYELAITGSEKKNAALEAIALALEANQDKIVSANKEDIQAGKEAGLTEALLDRLLLDETRLAGVVSD
VRSVIKLDDPVGEEFDGKLLENGLKLSKRRVPIGVIGVIYEARPNVTIDIAVLSLKTGNACILRGGKETIRSNIVLVEVI
QAALKSVGLPETSVQYIKSTDRALVGELLKMDDYVDMIIPRGNAGLQKFCKENSNIPVIVGGIGVCHLFADKSVDQEKAL
AIVANAKVQRPTVCNALETLLVHQDIAEEFLPKLHAHLAPMGVTLIAEEKAKAILGDKATLAEAGDFDREWLCLNLGVKV
VADFHEAIMHIRTHSSGHSDGILTNDFTIANKFINVVNSAAVYINASTRFTDGSQFGLGAEVAVSTQKLHARGPMGLQEL
TTYKWIGIGENLIRP

Sequences:

>Translated_415_residues
MDLQSLGKLAKEASYELAITGSEKKNAALEAIALALEANQDKIVSANKEDIQAGKEAGLTEALLDRLLLDETRLAGVVSD
VRSVIKLDDPVGEEFDGKLLENGLKLSKRRVPIGVIGVIYEARPNVTIDIAVLSLKTGNACILRGGKETIRSNIVLVEVI
QAALKSVGLPETSVQYIKSTDRALVGELLKMDDYVDMIIPRGNAGLQKFCKENSNIPVIVGGIGVCHLFADKSVDQEKAL
AIVANAKVQRPTVCNALETLLVHQDIAEEFLPKLHAHLAPMGVTLIAEEKAKAILGDKATLAEAGDFDREWLCLNLGVKV
VADFHEAIMHIRTHSSGHSDGILTNDFTIANKFINVVNSAAVYINASTRFTDGSQFGLGAEVAVSTQKLHARGPMGLQEL
TTYKWIGIGENLIRP
>Mature_415_residues
MDLQSLGKLAKEASYELAITGSEKKNAALEAIALALEANQDKIVSANKEDIQAGKEAGLTEALLDRLLLDETRLAGVVSD
VRSVIKLDDPVGEEFDGKLLENGLKLSKRRVPIGVIGVIYEARPNVTIDIAVLSLKTGNACILRGGKETIRSNIVLVEVI
QAALKSVGLPETSVQYIKSTDRALVGELLKMDDYVDMIIPRGNAGLQKFCKENSNIPVIVGGIGVCHLFADKSVDQEKAL
AIVANAKVQRPTVCNALETLLVHQDIAEEFLPKLHAHLAPMGVTLIAEEKAKAILGDKATLAEAGDFDREWLCLNLGVKV
VADFHEAIMHIRTHSSGHSDGILTNDFTIANKFINVVNSAAVYINASTRFTDGSQFGLGAEVAVSTQKLHARGPMGLQEL
TTYKWIGIGENLIRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=413, Percent_Identity=35.3510895883777, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI21361368, Length=413, Percent_Identity=35.3510895883777, Blast_Score=232, Evalue=6e-61,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=58.7951807228916, Blast_Score=486, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=35.9223300970874, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=35.9223300970874, Blast_Score=244, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=422, Percent_Identity=38.3886255924171, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=35.3808353808354, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PSYIN (A1SYT9)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944253.1
- ProteinModelPortal:   A1SYT9
- SMR:   A1SYT9
- STRING:   A1SYT9
- GeneID:   4623468
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2952
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A1SYT9
- ProtClustDB:   PRK00197
- BioCyc:   PING357804:PING_2952-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44685; Mature: 44685

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQSLGKLAKEASYELAITGSEKKNAALEAIALALEANQDKIVSANKEDIQAGKEAGLT
CCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHCCHHCCHH
EALLDRLLLDETRLAGVVSDVRSVIKLDDPVGEEFDGKLLENGLKLSKRRVPIGVIGVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHCCCCEEEEEEEE
EARPNVTIDIAVLSLKTGNACILRGGKETIRSNIVLVEVIQAALKSVGLPETSVQYIKST
ECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
DRALVGELLKMDDYVDMIIPRGNAGLQKFCKENSNIPVIVGGIGVCHLFADKSVDQEKAL
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEECCCEEEEEHHCCCCCHHHHE
AIVANAKVQRPTVCNALETLLVHQDIAEEFLPKLHAHLAPMGVTLIAEEKAKAILGDKAT
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHH
LAEAGDFDREWLCLNLGVKVVADFHEAIMHIRTHSSGHSDGILTNDFTIANKFINVVNSA
HHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCE
AVYINASTRFTDGSQFGLGAEVAVSTQKLHARGPMGLQELTTYKWIGIGENLIRP
EEEEECCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHEEEEECCHHHCCC
>Mature Secondary Structure
MDLQSLGKLAKEASYELAITGSEKKNAALEAIALALEANQDKIVSANKEDIQAGKEAGLT
CCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHCCHHCCHH
EALLDRLLLDETRLAGVVSDVRSVIKLDDPVGEEFDGKLLENGLKLSKRRVPIGVIGVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHCCCCEEEEEEEE
EARPNVTIDIAVLSLKTGNACILRGGKETIRSNIVLVEVIQAALKSVGLPETSVQYIKST
ECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
DRALVGELLKMDDYVDMIIPRGNAGLQKFCKENSNIPVIVGGIGVCHLFADKSVDQEKAL
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEECCCEEEEEHHCCCCCHHHHE
AIVANAKVQRPTVCNALETLLVHQDIAEEFLPKLHAHLAPMGVTLIAEEKAKAILGDKAT
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHH
LAEAGDFDREWLCLNLGVKVVADFHEAIMHIRTHSSGHSDGILTNDFTIANKFINVVNSA
HHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCE
AVYINASTRFTDGSQFGLGAEVAVSTQKLHARGPMGLQELTTYKWIGIGENLIRP
EEEEECCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA