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The map label for this gene is guaB [H]

Identifier: 119946571

GI number: 119946571

Start: 3635920

End: 3637386

Strand: Reverse

Name: guaB [H]

Synonym: Ping_2950

Alternate gene names: 119946571

Gene position: 3637386-3635920 (Counterclockwise)

Preceding gene: 119946573

Following gene: 119946570

Centisome position: 79.77

GC content: 44.72

Gene sequence:

>1467_bases
ATGCTACGAATTGTCAAAGATGCATTAACATTTGATGATGTACTATTAGTACCCAGTCATTCGACTGTACTGCCAAATAC
TGCTGACCTAAGAACTAAACTAACGCCAAATATCTCATTAAATATTCCGGTGGTTTCAGCTGCCATGGATACTGTTACTG
AATCTCGTTTTGCTATTGCTTTAGCACAAGAGGGCGGTATTGGTTTTATCCACAAAAACATGTCAATTGCATTACAAGCT
GAAGAAGTCCGTTTGGTGAAAATTCATGAGAGTGGTGTGGTTGCAAGCCCAATTACGGTTTCTCCGAAGACAACACTTGA
AGAAATTAAAGAGTTAACCGACAAACATGGCTTTGCAGGTTATCCTGTTGTTGAAGATTCAGGTGAATTGATTGGGATTA
TTACTGGCCGTGATGTTTTATTTGAAACCGATTTAAACAAACTGGTTTCTTCTGTTATGACGGGGAAAAAAGATCTGGTC
ACTGCTAAATCAAATACCCCGCGTGATGAAATTGAAAAATTAATGCATGCCCACCGCATCGAAAAAGTATTGTTAACCGA
TGATAACTTTAAATTGTGCGGCATGATAACAGTAAAAGATTTCCGTAAGGCGGAACAGAAACCTAATGCATGTAAAGATG
AATTAGGCCGTTTACGCGTAGGCGCTGCAGTTGGTGCGGGTGCGGGTAATGAAGAACGCGTTGCGGCATTAGTTGCAGCG
GGGGTCGATGTACTGTTAATTGACTCTTCACACGGTCACTCTCAAGGTGTTTTAGATCGTATTAAAGCCACCCGCCTGGC
TTTTCCTGATTTAGATATTATTGGTGGTAATGTGGCCACGGGTGACGGCGCTTTAGCTTTGGTTGAAGCGGGTTGTAGCT
CGGTTAAGGTTGGCATCGGCCCTGGTTCAATCTGCACAACACGTATTGTGACAGGTGTTGGTGTGCCGCAAATCACGGCT
ATTTCAGACGCAGTCGCAGCCCTTGAAGGTACGGGTGTGCCGGTTATCGCCGATGGTGGTATTCGTTTCTCCGGTGATAT
TGCCAAAGCATTAGCTGCTGGCGCGTCATGTGTGATGATGGGCAGTATGTTTGCCGGTACTGAAGAGTCTCCCGGTGAGA
TAATTTTATTCCAGGGACGTTCATACAAATCATATCGTGGTATGGGATCGGTAGCTGCCATGTCGCAGGGTTCATCGGAT
CGTTACTTCCAGTCAGATAATGCGGCGGACAAATTAGTACCTGAAGGTATTGAAGGGCGCGTTGCTTATAAAGGCAAAGT
AAAAGAGATTATTCATCAGCAGATGGGCGGTGTACGTTCCTCTATGGGTCTAACCGGCTGTGCAACTATTCATGATATGA
ATACTAAAGCGATGTTTGTGAAGATCACCAGTGCAGGTATGGGTGAAAGCCACGTGCACGATGTGGCTATTACCAAAGAA
GCGCCAAACTACCGCGCCGATGGTTAA

Upstream 100 bases:

>100_bases
TTGTACTTAGCTCACAGAACGATTAAAATCCCAGCGCAATATGATACTCAGAAATTTGAGTATATTGAATAATCCTCCCA
ACTATAAGTGAGATATTGCA

Downstream 100 bases:

>100_bases
TCGCTGAGCAAGTTATTTACCGGTGCACTGCCTGCACGGGTAAATTATTATCAGTCACTGTCAATGGCAGAGAACTGAAA
AATTATTACTAAGACGGTTT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRIVKDALTFDDVLLVPSHSTVLPNTADLRTKLTPNISLNIPVVSAAMDTVTESRFAIALAQEGGIGFIHKNMSIALQA
EEVRLVKIHESGVVASPITVSPKTTLEEIKELTDKHGFAGYPVVEDSGELIGIITGRDVLFETDLNKLVSSVMTGKKDLV
TAKSNTPRDEIEKLMHAHRIEKVLLTDDNFKLCGMITVKDFRKAEQKPNACKDELGRLRVGAAVGAGAGNEERVAALVAA
GVDVLLIDSSHGHSQGVLDRIKATRLAFPDLDIIGGNVATGDGALALVEAGCSSVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVAALEGTGVPVIADGGIRFSGDIAKALAAGASCVMMGSMFAGTEESPGEIILFQGRSYKSYRGMGSVAAMSQGSSD
RYFQSDNAADKLVPEGIEGRVAYKGKVKEIIHQQMGGVRSSMGLTGCATIHDMNTKAMFVKITSAGMGESHVHDVAITKE
APNYRADG

Sequences:

>Translated_488_residues
MLRIVKDALTFDDVLLVPSHSTVLPNTADLRTKLTPNISLNIPVVSAAMDTVTESRFAIALAQEGGIGFIHKNMSIALQA
EEVRLVKIHESGVVASPITVSPKTTLEEIKELTDKHGFAGYPVVEDSGELIGIITGRDVLFETDLNKLVSSVMTGKKDLV
TAKSNTPRDEIEKLMHAHRIEKVLLTDDNFKLCGMITVKDFRKAEQKPNACKDELGRLRVGAAVGAGAGNEERVAALVAA
GVDVLLIDSSHGHSQGVLDRIKATRLAFPDLDIIGGNVATGDGALALVEAGCSSVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVAALEGTGVPVIADGGIRFSGDIAKALAAGASCVMMGSMFAGTEESPGEIILFQGRSYKSYRGMGSVAAMSQGSSD
RYFQSDNAADKLVPEGIEGRVAYKGKVKEIIHQQMGGVRSSMGLTGCATIHDMNTKAMFVKITSAGMGESHVHDVAITKE
APNYRADG
>Mature_488_residues
MLRIVKDALTFDDVLLVPSHSTVLPNTADLRTKLTPNISLNIPVVSAAMDTVTESRFAIALAQEGGIGFIHKNMSIALQA
EEVRLVKIHESGVVASPITVSPKTTLEEIKELTDKHGFAGYPVVEDSGELIGIITGRDVLFETDLNKLVSSVMTGKKDLV
TAKSNTPRDEIEKLMHAHRIEKVLLTDDNFKLCGMITVKDFRKAEQKPNACKDELGRLRVGAAVGAGAGNEERVAALVAA
GVDVLLIDSSHGHSQGVLDRIKATRLAFPDLDIIGGNVATGDGALALVEAGCSSVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVAALEGTGVPVIADGGIRFSGDIAKALAAGASCVMMGSMFAGTEESPGEIILFQGRSYKSYRGMGSVAAMSQGSSD
RYFQSDNAADKLVPEGIEGRVAYKGKVKEIIHQQMGGVRSSMGLTGCATIHDMNTKAMFVKITSAGMGESHVHDVAITKE
APNYRADG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=485, Percent_Identity=38.9690721649485, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=39.1592920353982, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=39.1592920353982, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=39.1592920353982, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=39.1592920353982, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=39.0134529147982, Blast_Score=295, Evalue=8e-80,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=38.2743362831858, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=35.8407079646018, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI50541954, Length=271, Percent_Identity=35.0553505535055, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI50541952, Length=271, Percent_Identity=35.0553505535055, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI50541948, Length=271, Percent_Identity=35.0553505535055, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI50541956, Length=271, Percent_Identity=35.0553505535055, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=35.3658536585366, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=77.7319587628866, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=34.3891402714932, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=35.1578947368421, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=36.9668246445498, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=34.453781512605, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=40.4123711340206, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.0946502057613, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=446, Percent_Identity=42.3766816143498, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.0584795321637, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=110, Percent_Identity=42.7272727272727, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=39.2116182572614, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=39.2116182572614, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=40, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51252; Mature: 51252

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIVKDALTFDDVLLVPSHSTVLPNTADLRTKLTPNISLNIPVVSAAMDTVTESRFAIA
CCEEEEHHCCCCCEEEECCCCEECCCCHHCEEEECCCEEEECCCHHHHHHHHHCCEEEEE
LAQEGGIGFIHKNMSIALQAEEVRLVKIHESGVVASPITVSPKTTLEEIKELTDKHGFAG
EECCCCEEEEECCEEEEEEECCEEEEEEECCCEEECCEEECCCHHHHHHHHHHHHCCCCC
YPVVEDSGELIGIITGRDVLFETDLNKLVSSVMTGKKDLVTAKSNTPRDEIEKLMHAHRI
CCEEECCCCEEEEEECCCEEEECCHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHH
EKVLLTDDNFKLCGMITVKDFRKAEQKPNACKDELGRLRVGAAVGAGAGNEERVAALVAA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSQGVLDRIKATRLAFPDLDIIGGNVATGDGALALVEAGCSSVKVGIG
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCEEECCCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAISDAVAALEGTGVPVIADGGIRFSGDIAKALAAGASCVMM
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCCEEEE
GSMFAGTEESPGEIILFQGRSYKSYRGMGSVAAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCHHHHCCCCCCCEECCCCCHHHCCCCCCCCE
VAYKGKVKEIIHQQMGGVRSSMGLTGCATIHDMNTKAMFVKITSAGMGESHVHDVAITKE
EEECCHHHHHHHHHHCCHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCCCCEEEEEECC
APNYRADG
CCCCCCCC
>Mature Secondary Structure
MLRIVKDALTFDDVLLVPSHSTVLPNTADLRTKLTPNISLNIPVVSAAMDTVTESRFAIA
CCEEEEHHCCCCCEEEECCCCEECCCCHHCEEEECCCEEEECCCHHHHHHHHHCCEEEEE
LAQEGGIGFIHKNMSIALQAEEVRLVKIHESGVVASPITVSPKTTLEEIKELTDKHGFAG
EECCCCEEEEECCEEEEEEECCEEEEEEECCCEEECCEEECCCHHHHHHHHHHHHCCCCC
YPVVEDSGELIGIITGRDVLFETDLNKLVSSVMTGKKDLVTAKSNTPRDEIEKLMHAHRI
CCEEECCCCEEEEEECCCEEEECCHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHH
EKVLLTDDNFKLCGMITVKDFRKAEQKPNACKDELGRLRVGAAVGAGAGNEERVAALVAA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSQGVLDRIKATRLAFPDLDIIGGNVATGDGALALVEAGCSSVKVGIG
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCEEECCCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAISDAVAALEGTGVPVIADGGIRFSGDIAKALAAGASCVMM
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCCEEEE
GSMFAGTEESPGEIILFQGRSYKSYRGMGSVAAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCHHHHCCCCCCCEECCCCCHHHCCCCCCCCE
VAYKGKVKEIIHQQMGGVRSSMGLTGCATIHDMNTKAMFVKITSAGMGESHVHDVAITKE
EEECCHHHHHHHHHHCCHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCCCCEEEEEECC
APNYRADG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]