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The map label for this gene is guaA

Identifier: 119946570

GI number: 119946570

Start: 3634203

End: 3635783

Strand: Reverse

Name: guaA

Synonym: Ping_2949

Alternate gene names: 119946570

Gene position: 3635783-3634203 (Counterclockwise)

Preceding gene: 119946571

Following gene: 119946569

Centisome position: 79.74

GC content: 44.53

Gene sequence:

>1581_bases
ATGGACAAAAACATTCATGAACAGCGAATTCTGATTTTAGATTTCGGTTCTCAGTACACCCAATTAATCGCGCGTCGCAT
TCGTGAAATAGGTGTTTACTGTGAACTTTGGAGCTGGGATGTTGATGAGCAGGATATTAAAGATTTTGCTCCTAACGGCA
TTATTTTAGCGGGTGGCCCTGAAAGTGTCACCGCTGAAGGTTCTCCTCGTGCACCTGAATATGTCTTTACTGCGGGGGTT
CCTGTATTAGGTATCTGCTACGGTATGCAGACTATGTCCGAGCAACTCGGTGGATCGGTCATTAAAGGTGAAGGCGAAGG
CGAATTTGGTTACGCACAGATTGAAGTCAAAGGGGCCTCTGAACTATTCAAACTGATTGAAGATGCGGTTGCACAAAATG
GTAATGCTTTATTAGATGTTTGGATGAGTCATGGCGATAAAGTGTCCGCTATTCCGGCCGGTTTTACGACTATTGCTAAT
ACTGCTACCTGTCAGTTTGCTGCTATTGCCAATGAAGAAAAACGTTTTTATGGTGTACAGTTTCATCCGGAAGTCACTCA
TACTCGCCAGGGTGAGCGTATGTTACGCCACTTTGTGATGGATATTTGTGGCTGTGAGACGCTTTGGACATCAAGTTCAA
TCATCGAAGATGCGGTTGCGCGCATGAAAGCGCAGATTGGTGATGATGAAGTTATTCTTGGTCTTTCCGGCGGTGTTGAT
TCCTCCGTTGTGGCAATGTTATTACAACGCGCTATTGGTGATAAACTTACCTGTGTCTTTGTTGATAACGGTTTACTGCG
TTTAAATGAAGGCCAGCAGGTGATGGATATGTTTGGTGATCACTTCGGATTAAAAATCATTCATGTTAATGCAGAACACC
GTTTCTTGGAGCAGATGGCTGGCGAAAGCGATCCTGAAGCGAAACGTAAAATCATTGGCCGTGTTTTTGTCGAAATTTTC
GATGAAGAATCTAAAAAACTTAAAAATGCCAAATGGTTAGCGCAGGGTACTATCTACCCCGATGTAATCGAATCAGCAGG
CTCTAAAACGGGTAAAGCACAGGTGATTAAATCTCACCATAATGTGGGCGGATTACCCGATGATATGGAAATGGGTCTGG
TTGAACCACTGCGTGAATTGTTTAAAGATGAAGTACGTAAAATCGGCTTAGAGTTAGGTCTACCTTATGAGATGCTTTAC
CGTCATCCTTTCCCGGGGCCGGGTCTAGGCGTACGTGTGCTGGGTGAAGTGAAGAAAGAGTACTGCGATTTACTGCGCCG
CGCCGATGCGATATTTATTGAAGAGTTACATAAAGCGGATCTTTACCATAAAGTCAGTCAAGCCTTTGTGGTCTTCCTGC
CGGTACGCTCCGTGGGTGTAATGGGCGATTGTCGTAAATACGATTGGGTTGTGTCCCTGCGTTGTGTGGAAACAATCGAC
TTTATGACCGCGCGTTGGTCACATCTTCCTTATGATTTAATCGGTCATGTATCAAATCGTATCATCAATGAAATTGATGG
TATTTCCCGTGTAGTGTACGATGTTTCAGGTAAACCGCCTGCAACCATCGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
CGGGTAAATTATTATCAGTCACTGTCAATGGCAGAGAACTGAAAAATTATTACTAAGACGGTTTTTACCGTCTTTATTTT
TTATAAAAAGGGATCATCCA

Downstream 100 bases:

>100_bases
TTATTTAAGTATAACTCATTGATTTAATTATATTAATTACTTACACATTTGTTTCACACTTAAAATCAATCGTTGATTTA
ATTGAAGTTTTCTCATACAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGPESVTAEGSPRAPEYVFTAGV
PVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGASELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIAN
TATCQFAAIANEEKRFYGVQFHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVD
SSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMAGESDPEAKRKIIGRVFVEIF
DEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLY
RHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETID
FMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE

Sequences:

>Translated_526_residues
MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGPESVTAEGSPRAPEYVFTAGV
PVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGASELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIAN
TATCQFAAIANEEKRFYGVQFHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVD
SSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMAGESDPEAKRKIIGRVFVEIF
DEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLY
RHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETID
FMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE
>Mature_526_residues
MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGPESVTAEGSPRAPEYVFTAGV
PVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGASELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIAN
TATCQFAAIANEEKRFYGVQFHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVD
SSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMAGESDPEAKRKIIGRVFVEIF
DEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLY
RHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETID
FMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=570, Percent_Identity=35.6140350877193, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1788854, Length=526, Percent_Identity=78.5171102661597, Blast_Score=870, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=47.5285171102662, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281365319, Length=568, Percent_Identity=33.9788732394366, Blast_Score=282, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_PSYIN (A1SYT6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944250.1
- ProteinModelPortal:   A1SYT6
- SMR:   A1SYT6
- STRING:   A1SYT6
- GeneID:   4623465
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2949
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   A1SYT6
- ProtClustDB:   PRK00074
- BioCyc:   PING357804:PING_2949-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58570; Mature: 58570

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 182-182 ACT_SITE 184-184

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCEEEECCC
ESVTAEGSPRAPEYVFTAGVPVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGAS
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCHH
ELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIANTATCQFAAIANEEKRFYGVQ
HHHHHHHHHHHCCCCEEEEHHHCCCCEEEECCCCHHHHCCCCCEEEEEECCCCCEEEEEE
FHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVD
ECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMA
HHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHCCCCCCEEEEEECHHHHHHHHHC
GESDPEAKRKIIGRVFVEIFDEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHCCCCCCHHHHHHHCC
NVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLYRHPFPGPGLGVRVLGEVKKE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
YCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCCEEEHHHHHHHH
FMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
>Mature Secondary Structure
MDKNIHEQRILILDFGSQYTQLIARRIREIGVYCELWSWDVDEQDIKDFAPNGIILAGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCEEEECCC
ESVTAEGSPRAPEYVFTAGVPVLGICYGMQTMSEQLGGSVIKGEGEGEFGYAQIEVKGAS
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCHH
ELFKLIEDAVAQNGNALLDVWMSHGDKVSAIPAGFTTIANTATCQFAAIANEEKRFYGVQ
HHHHHHHHHHHCCCCEEEEHHHCCCCEEEECCCCHHHHCCCCCEEEEEECCCCCEEEEEE
FHPEVTHTRQGERMLRHFVMDICGCETLWTSSSIIEDAVARMKAQIGDDEVILGLSGGVD
ECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SSVVAMLLQRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDHFGLKIIHVNAEHRFLEQMA
HHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHCCCCCCEEEEEECHHHHHHHHHC
GESDPEAKRKIIGRVFVEIFDEESKKLKNAKWLAQGTIYPDVIESAGSKTGKAQVIKSHH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHCCCCCCHHHHHHHCC
NVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLYRHPFPGPGLGVRVLGEVKKE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
YCDLLRRADAIFIEELHKADLYHKVSQAFVVFLPVRSVGVMGDCRKYDWVVSLRCVETID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCCEEEHHHHHHHH
FMTARWSHLPYDLIGHVSNRIINEIDGISRVVYDVSGKPPATIEWE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA