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The map label for this gene is hisQ [H]

Identifier: 119946457

GI number: 119946457

Start: 3480385

End: 3481125

Strand: Reverse

Name: hisQ [H]

Synonym: Ping_2832

Alternate gene names: 119946457

Gene position: 3481125-3480385 (Counterclockwise)

Preceding gene: 119946458

Following gene: 119946456

Centisome position: 76.35

GC content: 41.3

Gene sequence:

>741_bases
ATGCTTGAACTACAAAATTACTCGGGAATATTGCTTGAAGGTGCATGGCTAACTATTCAAGTGGCATTGCTGTCACTCTT
GTTAGCTGTTTTTCTTGGGCTACTGGGGGCCTCGGCTAAACTGTCTCATTCTGTTTTTTTAAAAGGCATCGGGACACTGT
ATACGACGCTCATTCGTGGTATCCCGGACCTGATTTTAATGCTCCTGATTTTCTTTGGTGGGCAGGTATTAGTCAATAAT
CTCAGTTACAGCTTAAATGAATGGATCAACCGGACGTTAACCGGCTTTAATCCAAACCATGAGTGGGCTGCATATTTACC
CGATTATATTAATATTAGCCCTTATATCGCGGGCATTATTACCATAGGTTTTATTTTTGGTGCCTATATGGCAGAAACAT
TCCGTGGTGCTTTTTTGGCTGTTGAAAAGGGGCAGTTAGAGGCGGCTACGGCTTATGGTATGAACAAATACAAACTGTTT
TTGCGGGTGATGTTTCCTCAGATGATGCGCCACGCGCTACCGGGAATAGGAAATAATTGGTTAGTTTTATTAAAAACAAC
AGCGTTGGTTTCAGTTATCGGTTTACAAGATATGGTTAAAATTGCAGGGGATGCGGGTGGTTCGACTCAACAACCTTTTA
CCTTTTATATCGCCATTGCGCTGGTTTTTCTTTTTTTTACGTCTGTTTCCAGTCTCCTTTTTAGTTGGGCTGAACGTAAA
TATACAATTAAAACGAGGTAG

Upstream 100 bases:

>100_bases
TAAATGCTTATCTTCCCCCTTGTTTTGAATCTATAGGTTCAAAACGAGGCAGGACTGAAAGGATGGGAAACCATCCTTTT
TTATTAAAAAAGAAATAATT

Downstream 100 bases:

>100_bases
AGATGGATTTTTCAATATTTATTAACGAATACCAGTTTTACCTTGCGGGTTTATGGACAACGGTGTGGTTAGTGGCACTT
TCATTGTTATTGGGGCTGTT

Product: ABC polar amino acid transporter inner membrane protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLELQNYSGILLEGAWLTIQVALLSLLLAVFLGLLGASAKLSHSVFLKGIGTLYTTLIRGIPDLILMLLIFFGGQVLVNN
LSYSLNEWINRTLTGFNPNHEWAAYLPDYINISPYIAGIITIGFIFGAYMAETFRGAFLAVEKGQLEAATAYGMNKYKLF
LRVMFPQMMRHALPGIGNNWLVLLKTTALVSVIGLQDMVKIAGDAGGSTQQPFTFYIAIALVFLFFTSVSSLLFSWAERK
YTIKTR

Sequences:

>Translated_246_residues
MLELQNYSGILLEGAWLTIQVALLSLLLAVFLGLLGASAKLSHSVFLKGIGTLYTTLIRGIPDLILMLLIFFGGQVLVNN
LSYSLNEWINRTLTGFNPNHEWAAYLPDYINISPYIAGIITIGFIFGAYMAETFRGAFLAVEKGQLEAATAYGMNKYKLF
LRVMFPQMMRHALPGIGNNWLVLLKTTALVSVIGLQDMVKIAGDAGGSTQQPFTFYIAIALVFLFFTSVSSLLFSWAERK
YTIKTR
>Mature_246_residues
MLELQNYSGILLEGAWLTIQVALLSLLLAVFLGLLGASAKLSHSVFLKGIGTLYTTLIRGIPDLILMLLIFFGGQVLVNN
LSYSLNEWINRTLTGFNPNHEWAAYLPDYINISPYIAGIITIGFIFGAYMAETFRGAFLAVEKGQLEAATAYGMNKYKLF
LRVMFPQMMRHALPGIGNNWLVLLKTTALVSVIGLQDMVKIAGDAGGSTQQPFTFYIAIALVFLFFTSVSSLLFSWAERK
YTIKTR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=243, Percent_Identity=47.7366255144033, Blast_Score=224, Evalue=3e-60,
Organism=Escherichia coli, GI1787087, Length=226, Percent_Identity=34.5132743362832, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787030, Length=234, Percent_Identity=26.4957264957265, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788226, Length=237, Percent_Identity=26.1603375527426, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788645, Length=234, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786874, Length=235, Percent_Identity=25.1063829787234, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27255; Mature: 27255

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELQNYSGILLEGAWLTIQVALLSLLLAVFLGLLGASAKLSHSVFLKGIGTLYTTLIRG
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
IPDLILMLLIFFGGQVLVNNLSYSLNEWINRTLTGFNPNHEWAAYLPDYINISPYIAGII
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHH
TIGFIFGAYMAETFRGAFLAVEKGQLEAATAYGMNKYKLFLRVMFPQMMRHALPGIGNNW
HHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LVLLKTTALVSVIGLQDMVKIAGDAGGSTQQPFTFYIAIALVFLFFTSVSSLLFSWAERK
EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTIKTR
EEECCC
>Mature Secondary Structure
MLELQNYSGILLEGAWLTIQVALLSLLLAVFLGLLGASAKLSHSVFLKGIGTLYTTLIRG
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
IPDLILMLLIFFGGQVLVNNLSYSLNEWINRTLTGFNPNHEWAAYLPDYINISPYIAGII
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHH
TIGFIFGAYMAETFRGAFLAVEKGQLEAATAYGMNKYKLFLRVMFPQMMRHALPGIGNNW
HHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCE
LVLLKTTALVSVIGLQDMVKIAGDAGGSTQQPFTFYIAIALVFLFFTSVSSLLFSWAERK
EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YTIKTR
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]