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The map label for this gene is lpdA [H]

Identifier: 119946393

GI number: 119946393

Start: 3403616

End: 3405757

Strand: Direct

Name: lpdA [H]

Synonym: Ping_2767

Alternate gene names: 119946393

Gene position: 3403616-3405757 (Clockwise)

Preceding gene: 119946392

Following gene: 119946394

Centisome position: 74.65

GC content: 42.25

Gene sequence:

>2142_bases
ATGGACAGAAAAAAAATAATTATTGCCATCTTAGCGTGCATCGCACTGTGGTTCGTTTTTGAGTTTAATCATCTGCTAAC
GCTGGAAAATGCCAAAATTTATCAAGCGCAACTGAACGGTTATATCAATGACAACTTCCTGCTCGCCAGTGTGCTTTATT
TTATCTTATACACTGTTAGTACTGCTCTTTCAGTTCCCGGTGCCATTATTTTCACTCTGCTCGGTGCTGCATTATTTGGC
TTTTGGTGGAGTCTTTTATTCGTTTCATTTGCGAGCAGCATAGGGGCTACCTTAGCTTTTCTCTTTAGCCGTTATATGCT
GCAGGATTGGGTACAAAGACGATTTGGCGGAAAGCTCAAAGCGATAAATCGAGGAATAGAAAAAGATGGTAGCCTTTACC
TGCTAACACTGAGACTGATTCCCATTTTCCCTTTTTTTATGATCAACTTACTGATGGGTTTAACCACCCTATCGGCAAAA
AAATATTATTTATTTAGTCAACTCGGTATGTTACCCGCCACTGCAGTTTTCCTCAATGCAGGTACACAGCTTGCCGATAT
CAACTCATTAGCCGGCTTACTCTCACCTTCTGTTTTATTGTCTCTTGCGGCATTAGGATTAATGCCCCTTATAAGCAAAT
TTATTATCAATAGTATTAAGCAAAATAAAGTTTATCGAGGCTGGCAGAAACCCAAATCTTTCGATCAAAATATGGTCGTG
ATTGGGGCGGGTTCAGGTGGACTGGTAACGGCTTACATTGCAGCCGCAGTAAAAGCCAAAGTGACATTAATTGAAAAACA
TAAGATGGGAGGTGATTGTTTAAATACGGGCTGTGTTCCATCCAAGGCATTAATTAGAACGGCTCATAATATTAAAGAGA
TATTAAATGCTCAGCAGTTTGGCGTGGACGCACAAATAAACAGTATTGATTTTAAAAAAGTGATGACCCGCGTACAAAAT
GTGATCAAAAAAATCGAGCCACATGACTCAAGCGAACGTTATTCAGACTTGGGTGTGACTTGCCTGCAGGGTGAAGCAAA
AATCATTTCCCCTTGGCAGGTTGAATTAAACGGTAACGTTATCACTACTCAGAATATTGTTATCGCAACGGGGGCGAAAC
CTTTTATACCGCCGATTCCCGGTTTAGATAAGGTAAGTTACGTGACTTCCGATACAATTTGGTCATTACCCGAGTTACCT
AAAAAGCTATTAGTGCTTGGCGGAGGCCCTATCGGCTGTGAATTAGCCCAGTGCTTTAACCTCCTTGGCAGTGAGGTGAC
TATTGTTGAGCGCTTACCACAATTACTAATACGAGAAGATCAAGATGCAGCAGATCTGGTCAGCAAGCAATTAATGAAAG
AAGGTGTTGAAATATTAGTTAATCATAACGTGACCGGTTTTTCCCGTGATGAAAATACCCAGTCAGTGGCATTAGAGTTT
CAACAGCAGACTGTTTTGAAAGAATTTGATGTAGTGCTTGTCGCGATTGGCCGAAAAGCAAATGTAGGCGGCTTTGGCTT
AGAAGAGTTGGGTATTGAATTGACCGAGACAAAAACCATTGCAGTTAATGACTACTTACAAACAAAATACGCAAATATAT
ATGCCGTTGGCGATGTTGCAGGGCCTTTTCAATTAACCCATGCAGCGGCGCACCAGGCTTGGTATGCCGCTGTAAACGGA
TTATTCGGTCGCTTTAAAAAATTCAAAACCGATTATTCGGTGATGCCCGCGGCAGTCTACACCTATCCTGAAGTTGCGCG
GGTTGGACTTAATGAAAAAGAAGCTAAGCAGGCTGATATAAACTATGAAATCACACAATATGAATTAAATGATTTAGACA
GGGCCATTACCGATGACCATGACCAGGGGTTTGTAAAGGTATTAACCGCAACCGGCAGTGATAAAATTTTAGGGGCAACC
ATAGTCGGCTCGCATGCTGGCGACCTGCTTACAGAATTCACCCTGGCAATGCGTTACAAACTGGGTTTAAATAAGATTCT
CGGCACCATCCACCCCTACCCCACCATGAGCGAAGCAAATAAAGCGACAGCCGGAATGTGGAAGAAAGACCATGCGCCGC
AAACGCTGCTGCTGTGGGTCGAGAAATATTTTAATTGGACGCGTAAAAAGGATCTATCATGA

Upstream 100 bases:

>100_bases
TATTAAGCGAAAAGTATAAATAATTAACACGGAAATTTTTTATAGATCTTCCCGGTCTATTGAAAACTACAATTTATTTT
TAACCTCAGGAAAATGATCA

Downstream 100 bases:

>100_bases
AAAAATTAATCACTCTGTTCAGCCTGTTACTACTGACAACCTTTGCTCAGGCAGAAGATGTAAATTGGCAGAAGATTGAA
GAAAAAGCTCAGAGTCAAAC

Product: mercuric reductase, membrane-associated

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MDRKKIIIAILACIALWFVFEFNHLLTLENAKIYQAQLNGYINDNFLLASVLYFILYTVSTALSVPGAIIFTLLGAALFG
FWWSLLFVSFASSIGATLAFLFSRYMLQDWVQRRFGGKLKAINRGIEKDGSLYLLTLRLIPIFPFFMINLLMGLTTLSAK
KYYLFSQLGMLPATAVFLNAGTQLADINSLAGLLSPSVLLSLAALGLMPLISKFIINSIKQNKVYRGWQKPKSFDQNMVV
IGAGSGGLVTAYIAAAVKAKVTLIEKHKMGGDCLNTGCVPSKALIRTAHNIKEILNAQQFGVDAQINSIDFKKVMTRVQN
VIKKIEPHDSSERYSDLGVTCLQGEAKIISPWQVELNGNVITTQNIVIATGAKPFIPPIPGLDKVSYVTSDTIWSLPELP
KKLLVLGGGPIGCELAQCFNLLGSEVTIVERLPQLLIREDQDAADLVSKQLMKEGVEILVNHNVTGFSRDENTQSVALEF
QQQTVLKEFDVVLVAIGRKANVGGFGLEELGIELTETKTIAVNDYLQTKYANIYAVGDVAGPFQLTHAAAHQAWYAAVNG
LFGRFKKFKTDYSVMPAAVYTYPEVARVGLNEKEAKQADINYEITQYELNDLDRAITDDHDQGFVKVLTATGSDKILGAT
IVGSHAGDLLTEFTLAMRYKLGLNKILGTIHPYPTMSEANKATAGMWKKDHAPQTLLLWVEKYFNWTRKKDLS

Sequences:

>Translated_713_residues
MDRKKIIIAILACIALWFVFEFNHLLTLENAKIYQAQLNGYINDNFLLASVLYFILYTVSTALSVPGAIIFTLLGAALFG
FWWSLLFVSFASSIGATLAFLFSRYMLQDWVQRRFGGKLKAINRGIEKDGSLYLLTLRLIPIFPFFMINLLMGLTTLSAK
KYYLFSQLGMLPATAVFLNAGTQLADINSLAGLLSPSVLLSLAALGLMPLISKFIINSIKQNKVYRGWQKPKSFDQNMVV
IGAGSGGLVTAYIAAAVKAKVTLIEKHKMGGDCLNTGCVPSKALIRTAHNIKEILNAQQFGVDAQINSIDFKKVMTRVQN
VIKKIEPHDSSERYSDLGVTCLQGEAKIISPWQVELNGNVITTQNIVIATGAKPFIPPIPGLDKVSYVTSDTIWSLPELP
KKLLVLGGGPIGCELAQCFNLLGSEVTIVERLPQLLIREDQDAADLVSKQLMKEGVEILVNHNVTGFSRDENTQSVALEF
QQQTVLKEFDVVLVAIGRKANVGGFGLEELGIELTETKTIAVNDYLQTKYANIYAVGDVAGPFQLTHAAAHQAWYAAVNG
LFGRFKKFKTDYSVMPAAVYTYPEVARVGLNEKEAKQADINYEITQYELNDLDRAITDDHDQGFVKVLTATGSDKILGAT
IVGSHAGDLLTEFTLAMRYKLGLNKILGTIHPYPTMSEANKATAGMWKKDHAPQTLLLWVEKYFNWTRKKDLS
>Mature_713_residues
MDRKKIIIAILACIALWFVFEFNHLLTLENAKIYQAQLNGYINDNFLLASVLYFILYTVSTALSVPGAIIFTLLGAALFG
FWWSLLFVSFASSIGATLAFLFSRYMLQDWVQRRFGGKLKAINRGIEKDGSLYLLTLRLIPIFPFFMINLLMGLTTLSAK
KYYLFSQLGMLPATAVFLNAGTQLADINSLAGLLSPSVLLSLAALGLMPLISKFIINSIKQNKVYRGWQKPKSFDQNMVV
IGAGSGGLVTAYIAAAVKAKVTLIEKHKMGGDCLNTGCVPSKALIRTAHNIKEILNAQQFGVDAQINSIDFKKVMTRVQN
VIKKIEPHDSSERYSDLGVTCLQGEAKIISPWQVELNGNVITTQNIVIATGAKPFIPPIPGLDKVSYVTSDTIWSLPELP
KKLLVLGGGPIGCELAQCFNLLGSEVTIVERLPQLLIREDQDAADLVSKQLMKEGVEILVNHNVTGFSRDENTQSVALEF
QQQTVLKEFDVVLVAIGRKANVGGFGLEELGIELTETKTIAVNDYLQTKYANIYAVGDVAGPFQLTHAAAHQAWYAAVNG
LFGRFKKFKTDYSVMPAAVYTYPEVARVGLNEKEAKQADINYEITQYELNDLDRAITDDHDQGFVKVLTATGSDKILGAT
IVGSHAGDLLTEFTLAMRYKLGLNKILGTIHPYPTMSEANKATAGMWKKDHAPQTLLLWVEKYFNWTRKKDLS

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=34.4827586206897, Blast_Score=230, Evalue=4e-60,
Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=28.2275711159737, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=27.348643006263, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=27.348643006263, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=27.348643006263, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=27.348643006263, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=27.348643006263, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI22035672, Length=432, Percent_Identity=28.7037037037037, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI291045266, Length=435, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=25.9860788863109, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=32.3008849557522, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=29.6875, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=28.7257019438445, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=28.7703016241299, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789065, Length=211, Percent_Identity=27.0142180094787, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87081964, Length=179, Percent_Identity=27.9329608938547, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=35.4978354978355, Blast_Score=242, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=27.1762208067941, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=422, Percent_Identity=27.4881516587678, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=422, Percent_Identity=27.4881516587678, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=437, Percent_Identity=25.629290617849, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI115533280, Length=186, Percent_Identity=21.505376344086, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532687, Length=192, Percent_Identity=26.0416666666667, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=487, Percent_Identity=32.4435318275154, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=28.1995661605206, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=25.7928118393235, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=34.4902386117137, Blast_Score=236, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24640553, Length=486, Percent_Identity=29.4238683127572, Blast_Score=142, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=29.4238683127572, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640551, Length=489, Percent_Identity=29.4478527607362, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=27.0103092783505, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 78666; Mature: 78666

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKKIIIAILACIALWFVFEFNHLLTLENAKIYQAQLNGYINDNFLLASVLYFILYTVS
CCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHH
TALSVPGAIIFTLLGAALFGFWWSLLFVSFASSIGATLAFLFSRYMLQDWVQRRFGGKLK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AINRGIEKDGSLYLLTLRLIPIFPFFMINLLMGLTTLSAKKYYLFSQLGMLPATAVFLNA
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCC
GTQLADINSLAGLLSPSVLLSLAALGLMPLISKFIINSIKQNKVYRGWQKPKSFDQNMVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IGAGSGGLVTAYIAAAVKAKVTLIEKHKMGGDCLNTGCVPSKALIRTAHNIKEILNAQQF
EECCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GVDAQINSIDFKKVMTRVQNVIKKIEPHDSSERYSDLGVTCLQGEAKIISPWQVELNGNV
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEECCCCEEECCEEEEECCCE
ITTQNIVIATGAKPFIPPIPGLDKVSYVTSDTIWSLPELPKKLLVLGGGPIGCELAQCFN
EEECCEEEEECCCCCCCCCCCCCCHHHCCCCCHHCCHHCCHHEEEECCCCCHHHHHHHHH
LLGSEVTIVERLPQLLIREDQDAADLVSKQLMKEGVEILVNHNVTGFSRDENTQSVALEF
HHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCHHHHHHH
QQQTVLKEFDVVLVAIGRKANVGGFGLEELGIELTETKTIAVNDYLQTKYANIYAVGDVA
HHHHHHHHHCEEEEEECCCCCCCCCCHHHHCCEEECCEEEEECHHHHHHCCCEEEECCCC
GPFQLTHAAAHQAWYAAVNGLFGRFKKFKTDYSVMPAAVYTYPEVARVGLNEKEAKQADI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHCCCCHHHHHHCCC
NYEITQYELNDLDRAITDDHDQGFVKVLTATGSDKILGATIVGSHAGDLLTEFTLAMRYK
CEEEEEEEHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
LGLNKILGTIHPYPTMSEANKATAGMWKKDHAPQTLLLWVEKYFNWTRKKDLS
HHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MDRKKIIIAILACIALWFVFEFNHLLTLENAKIYQAQLNGYINDNFLLASVLYFILYTVS
CCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHH
TALSVPGAIIFTLLGAALFGFWWSLLFVSFASSIGATLAFLFSRYMLQDWVQRRFGGKLK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AINRGIEKDGSLYLLTLRLIPIFPFFMINLLMGLTTLSAKKYYLFSQLGMLPATAVFLNA
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCC
GTQLADINSLAGLLSPSVLLSLAALGLMPLISKFIINSIKQNKVYRGWQKPKSFDQNMVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IGAGSGGLVTAYIAAAVKAKVTLIEKHKMGGDCLNTGCVPSKALIRTAHNIKEILNAQQF
EECCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GVDAQINSIDFKKVMTRVQNVIKKIEPHDSSERYSDLGVTCLQGEAKIISPWQVELNGNV
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEECCCCEEECCEEEEECCCE
ITTQNIVIATGAKPFIPPIPGLDKVSYVTSDTIWSLPELPKKLLVLGGGPIGCELAQCFN
EEECCEEEEECCCCCCCCCCCCCCHHHCCCCCHHCCHHCCHHEEEECCCCCHHHHHHHHH
LLGSEVTIVERLPQLLIREDQDAADLVSKQLMKEGVEILVNHNVTGFSRDENTQSVALEF
HHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCHHHHHHH
QQQTVLKEFDVVLVAIGRKANVGGFGLEELGIELTETKTIAVNDYLQTKYANIYAVGDVA
HHHHHHHHHCEEEEEECCCCCCCCCCHHHHCCEEECCEEEEECHHHHHHCCCEEEECCCC
GPFQLTHAAAHQAWYAAVNGLFGRFKKFKTDYSVMPAAVYTYPEVARVGLNEKEAKQADI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHCCCCHHHHHHCCC
NYEITQYELNDLDRAITDDHDQGFVKVLTATGSDKILGATIVGSHAGDLLTEFTLAMRYK
CEEEEEEEHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
LGLNKILGTIHPYPTMSEANKATAGMWKKDHAPQTLLLWVEKYFNWTRKKDLS
HHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]