Click here to switch to the map view.

The map label for this gene is mscM [H]

Identifier: 119946389

GI number: 119946389

Start: 3391392

End: 3392657

Strand: Reverse

Name: mscM [H]

Synonym: Ping_2763

Alternate gene names: 119946389

Gene position: 3392657-3391392 (Counterclockwise)

Preceding gene: 119946390

Following gene: 119946388

Centisome position: 74.41

GC content: 36.81

Gene sequence:

>1266_bases
ATGATTAATACCGTTATTAATAAGTATCAAACAATTTTTTCAGATCAAGCATTAGCAATAGATATTTCAGTTATCTCAAT
GCTGTTAATGCTTATCTTAATCTCGATGATCGCAAATTATATTACCAAAAAAATAATAACTGTTTTTGTTAAAAAATTTA
TTGATAAGACGAGAAGTCAATGGGATAACATCTTTTACGACTGTCATGTATTCACCCGTTTATCCCACTTGATACCAATA
TTGTTCTTTAGTGTCGGTTCAACAATCATTTTTCCAGCAGATGCTTACCCGCTTTTATTGGATAATCTTTCTAAATTTAC
TTCGCTGTATTTGATTCTTGCCTTTGCCCTTGTCATTCATAGCCTACTGGCGGCATTTGATGCTATTTACCGTACCTACA
AAATGTCAAAGCAACGGCCAATCAACAATTATGTTCAAGTTCTAAAGATTATTCTGTGGATTTTTACCACGGTTGCCTCC
ATCTCACTTCTGCTCAGCAAGGATCTTTGGGCATTATTTTTAGGTATGAGCGGCATGATGGCGATCATTATGCTGGTCTT
TAAAGACACTCTCCTTGGACTTGTGGCCGGTATGCAGATTACTGCTAATGATATGTTACGTCTTGATGATTGGTTGGAAA
TGCCAAGTCGTAATGCGGATGGTGATGTGATTGATATAACCCTTAATACGGTTAAGGTCAGAAACTGGGATAAAACGATC
ACGACTATTCCTACCCATGCTTTGATGTCGGAGTCGTTCAAAAATTGGCGGGGAATGACCGAGTCGGGAGGGCGGAGAAT
CAAGCGTTCTATCTCAATTGATATGACATCGGTAAAATTTTGCGATCAAGAAATGCTTCAGTCTTTTATGAAAATTGAGA
TTCTTAAGGATTATTTACTTAAGAAACAAAAAGAAATAGAGACTTACAATAAAGAAACAGGAAACGATTTAAGTAACCCT
GCTAATGGCAGGCGGCTCACTAATATAGGTACCTTTAGGGCATATCTATCCGCTTATTTGAAAAAAAATCCTAAAATACA
TCAAGAGTTGACTTTTATGGTGAGGCAGTTGTCACCAAGTTCTACGGGCGTACCTATTGAAGTTTATGTTTTTAGTAACG
ATCAGGATTGGGTTAATTATGAGGGAATTCAAGCGGACATTTTTGACCATATTTTAGCCGTTATTCCTGAGTTTGGCCTG
AGAGTTTTTCAGGATCCTACTGGTTCTAATTTTGAAAAAGCCTTCAGTCGATCCGCTAATAATTAA

Upstream 100 bases:

>100_bases
TTTGGTATAATTTGCAATTGTTGTTTATTCTATTGTAAAAAAAAGAACAGACCCTGATAGATTATATTATTAAATAAACA
TCAAAGGATAAGGTTAATTA

Downstream 100 bases:

>100_bases
ATAATGTCATACTATTTTTGCGCCTTTGCAGGCGCATTATTAACTAATATCCTTAAAGTTGCTAAGTCTTGCCGACATTT
TACCTCAGTATAAATTCTAC

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MINTVINKYQTIFSDQALAIDISVISMLLMLILISMIANYITKKIITVFVKKFIDKTRSQWDNIFYDCHVFTRLSHLIPI
LFFSVGSTIIFPADAYPLLLDNLSKFTSLYLILAFALVIHSLLAAFDAIYRTYKMSKQRPINNYVQVLKIILWIFTTVAS
ISLLLSKDLWALFLGMSGMMAIIMLVFKDTLLGLVAGMQITANDMLRLDDWLEMPSRNADGDVIDITLNTVKVRNWDKTI
TTIPTHALMSESFKNWRGMTESGGRRIKRSISIDMTSVKFCDQEMLQSFMKIEILKDYLLKKQKEIETYNKETGNDLSNP
ANGRRLTNIGTFRAYLSAYLKKNPKIHQELTFMVRQLSPSSTGVPIEVYVFSNDQDWVNYEGIQADIFDHILAVIPEFGL
RVFQDPTGSNFEKAFSRSANN

Sequences:

>Translated_421_residues
MINTVINKYQTIFSDQALAIDISVISMLLMLILISMIANYITKKIITVFVKKFIDKTRSQWDNIFYDCHVFTRLSHLIPI
LFFSVGSTIIFPADAYPLLLDNLSKFTSLYLILAFALVIHSLLAAFDAIYRTYKMSKQRPINNYVQVLKIILWIFTTVAS
ISLLLSKDLWALFLGMSGMMAIIMLVFKDTLLGLVAGMQITANDMLRLDDWLEMPSRNADGDVIDITLNTVKVRNWDKTI
TTIPTHALMSESFKNWRGMTESGGRRIKRSISIDMTSVKFCDQEMLQSFMKIEILKDYLLKKQKEIETYNKETGNDLSNP
ANGRRLTNIGTFRAYLSAYLKKNPKIHQELTFMVRQLSPSSTGVPIEVYVFSNDQDWVNYEGIQADIFDHILAVIPEFGL
RVFQDPTGSNFEKAFSRSANN
>Mature_421_residues
MINTVINKYQTIFSDQALAIDISVISMLLMLILISMIANYITKKIITVFVKKFIDKTRSQWDNIFYDCHVFTRLSHLIPI
LFFSVGSTIIFPADAYPLLLDNLSKFTSLYLILAFALVIHSLLAAFDAIYRTYKMSKQRPINNYVQVLKIILWIFTTVAS
ISLLLSKDLWALFLGMSGMMAIIMLVFKDTLLGLVAGMQITANDMLRLDDWLEMPSRNADGDVIDITLNTVKVRNWDKTI
TTIPTHALMSESFKNWRGMTESGGRRIKRSISIDMTSVKFCDQEMLQSFMKIEILKDYLLKKQKEIETYNKETGNDLSNP
ANGRRLTNIGTFRAYLSAYLKKNPKIHQELTFMVRQLSPSSTGVPIEVYVFSNDQDWVNYEGIQADIFDHILAVIPEFGL
RVFQDPTGSNFEKAFSRSANN

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=384, Percent_Identity=44.2708333333333, Blast_Score=330, Evalue=9e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 48174; Mature: 48174

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTVINKYQTIFSDQALAIDISVISMLLMLILISMIANYITKKIITVFVKKFIDKTRSQ
CCCHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDNIFYDCHVFTRLSHLIPILFFSVGSTIIFPADAYPLLLDNLSKFTSLYLILAFALVIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLLAAFDAIYRTYKMSKQRPINNYVQVLKIILWIFTTVASISLLLSKDLWALFLGMSGMM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIMLVFKDTLLGLVAGMQITANDMLRLDDWLEMPSRNADGDVIDITLNTVKVRNWDKTI
HHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCHH
TTIPTHALMSESFKNWRGMTESGGRRIKRSISIDMTSVKFCDQEMLQSFMKIEILKDYLL
HHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KKQKEIETYNKETGNDLSNPANGRRLTNIGTFRAYLSAYLKKNPKIHQELTFMVRQLSPS
HHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
STGVPIEVYVFSNDQDWVNYEGIQADIFDHILAVIPEFGLRVFQDPTGSNFEKAFSRSAN
CCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
N
C
>Mature Secondary Structure
MINTVINKYQTIFSDQALAIDISVISMLLMLILISMIANYITKKIITVFVKKFIDKTRSQ
CCCHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDNIFYDCHVFTRLSHLIPILFFSVGSTIIFPADAYPLLLDNLSKFTSLYLILAFALVIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLLAAFDAIYRTYKMSKQRPINNYVQVLKIILWIFTTVASISLLLSKDLWALFLGMSGMM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIMLVFKDTLLGLVAGMQITANDMLRLDDWLEMPSRNADGDVIDITLNTVKVRNWDKTI
HHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCHH
TTIPTHALMSESFKNWRGMTESGGRRIKRSISIDMTSVKFCDQEMLQSFMKIEILKDYLL
HHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KKQKEIETYNKETGNDLSNPANGRRLTNIGTFRAYLSAYLKKNPKIHQELTFMVRQLSPS
HHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
STGVPIEVYVFSNDQDWVNYEGIQADIFDHILAVIPEFGLRVFQDPTGSNFEKAFSRSAN
CCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]