Click here to switch to the map view.

The map label for this gene is rcsC [H]

Identifier: 119946177

GI number: 119946177

Start: 3099250

End: 3101778

Strand: Reverse

Name: rcsC [H]

Synonym: Ping_2537

Alternate gene names: 119946177

Gene position: 3101778-3099250 (Counterclockwise)

Preceding gene: 119946178

Following gene: 119946170

Centisome position: 68.03

GC content: 44.09

Gene sequence:

>2529_bases
ATGAATGAGATGCAGCTTAGCGATGAAAATAAACGCCTGAAATATGATAATGCCAAACTCCTGAAAATTAATGAGGCATT
GATGCAGCGCGTGGAAGAGGGTGGTAATCAGTCGGCACCCTATGCCGCTTTTGAGCATTCAGTACATTTAGCCGAACAGG
TCAGGGAAAAAACTCAAACACTGGGTGAAACCCTGTCACAGCTGGAACGCCGCAACCGGCAATTAAAAACCTTTCAACAG
CGCTTTACCGATGCCATCGAAAGCCTTTCTGAAGCCTTCGTTTTATTAGACTGTGACGGACAAATTATTCTTCAGAACAG
CAATTTTGAAGCCTTTCTGCAGACATCAAATCTGCCCTCAGAAACTGTGCTTAATCTTAAAGCGCTAACCGAAAAAAAAG
ATCATCAAAAAAACACTAATAATGATGGCCAGCTGCTAAAACCGGTTTTTCAGTTATCCGACGGACGCTGGTTTCAGCTT
AACGAACGTCCTACTGTCGAAGGTGGAAGGGTATTGCTTTATACGGATATCAGCGCATTAAAAAAAGCTGAAACAGTACG
TTACGAACAGGCAATGGCGCAGAAATCCGTACAGCTTCATAGTCTGGTGGATAATTTATCTCAGGGTGTGGTGCTGCTGA
GCAGTGAAAAGCAGATTGAAGTCTGGAACAGCCGTTTTGTACAACTGAGTCAGTTAGCGACGCAGCAGCTGCACGCTAAT
ATCGGTTTGCGGGATTTGCAGGCCCTGACCGAGTTGGAACTGCCCACCCATCCGCGTTTGGGCAGTGATTTTTATGTGCA
GACCTTACAAGGTGGAACCGTACTGGAAATAAGAGTTCACCAGCTTCATGATGGAAAAACCATCATAACCTACACCGATA
TTACCGAGCGCCACCGCAATCAACAATCTCTGCAGGAAAATGAGCGCCGGCTGCGCCTGATAACAGATAACGTACCGGCG
ATGATTGCTTATATCGGTGCTGATCTTAAGTTTGAATTTACCAATCAGGTTTATATTGACTGGTACGGCAGCACTTCGCG
GGGTTTGGATATTACTGAGCTGGATAAAAGCCTTAATTATAAGCAGATTAAGCCTTTTGTTCAGCGCGCCCTAAAGGGTG
AAAGTGTCATTTTTGAAAGTAGAGAACTAAACCGCACCGGTGAACCTAATTATCTGCTTAAATCCTATGTCCCAAACCTT
GACGGCAACGGCGTTGTACTGGGATTTTTTGTTTTAATTCGCAATATTACCGAGCGCAGGATAAATGCATTAGCCCTGCA
GAAAGCCCATGATCAGCTGGAAAGGAGGGTTGTTGAGCGTACTTCGCAGCTTTCGAGCCTTAACCAAAAATTGCTTAATG
AAGTTGAAGAACGCCGCCGGGTACAAACTGACCTACAGGCTGCCACACGCGAAGCTGAACAAGCTAATTTTTCTAAAACA
AAATTTCTTGCGGCCGTCAGTCACGATTTACTGCAACCGCTTAATGCTGCCCAGCTGTTTACCAGCTCAATTGTTGAAAA
GACTGTTGATGCTCAATTAGCCCCTTTAATTAACTCAGTCAGTAGCTCACTTGATGATTTAGAAAACCTGATCTGCACAC
TGGTTGATATTTCCAAATTAGATGCGGGTGTGGTGAAAGCGGATAAATGTAATTTTAAGCTTTCCGATTTATTGGATAAC
TTAGCGCGAGAGTACCAGCAGCAAAGTGGCCTTTACGGTGTGCAGTTGCGCTATGTTAGCTGTGACAGCCTAGTGCACAG
CGACAGTTTTTTATTGGCCCGCATCCTGCGTAATTTTTTATCCAATGCCTTCAGATATACTGACAAAGGAAAAGTGCTAC
TCGGTTGCCGGCGTGTGGATAATAAACTCTGCATCGAAGTATGGGACAACGGCGCAGGTATCGCGCAGGATCAGCAGACT
GAAATATTTAAAGAATTTAAACGTCTGAAATCATCACGCAGCGCATTCACCAACGGTTTAGGTCTGGGTCTGGCCATTGT
TGATAAAATATCCAAGGTACTTGAACATCCGGTTAAGGTCTCCTCGACACTGGGAAAAGGTTCACTGTTTTCAGTAACAG
TACCGCTGGCTGATAAGACTGATTTACCCCAGCCTGCGGCGCAGCTTAATCAGGCATTAACCAAGACAGAGTTAGCCGGG
CGCACCGTTTGGTTGGTTGATAACGATTTTAATATTTGCGCGGCAATGAAACAGTTGCTCGAAACCTGGGACTGTACCAT
TATCACCGCAGCAAGCCTTGCAGATTTACAAGCGCAGGTGGATATTGGCAATGACCATGCGAATATTTTAATCGTTGATT
ACCATCTTGATGACGGCATTAACGGCCTGGACGTTGCAGAGCAGATTAATCACTTACGCAGCACGCCATTACCGGTATTA
ATGATCACCGCTAATTACAACAAATCATTACAAAAAGAAATTAAAGAACACGGTTTATTGTTATTACATAAACCCGTCAG
GGCAATAAAATTAAAAACAACTATGTTGTATTTGTTAAATAAGAAATAG

Upstream 100 bases:

>100_bases
AGTCAATACAAAATAGCCGGTTTTAATACTTATGGTGAACATATTAACGGCATTCATCTTAATCAAACCTTTACCGGTGT
TTATATCGCGGGAGGCTCGA

Downstream 100 bases:

>100_bases
GAATCGGTTGTTGGCGGTCGGCTGTTAGCTGTCGGTGGTCGGTTGTTGGCTGTCAGCCGTTAGCTGTCGGCCTTATAGCC
ATCCTGCCTTCAAGCTTTAC

Product: fused sensor protein/response regulator

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 842; Mature: 842

Protein sequence:

>842_residues
MNEMQLSDENKRLKYDNAKLLKINEALMQRVEEGGNQSAPYAAFEHSVHLAEQVREKTQTLGETLSQLERRNRQLKTFQQ
RFTDAIESLSEAFVLLDCDGQIILQNSNFEAFLQTSNLPSETVLNLKALTEKKDHQKNTNNDGQLLKPVFQLSDGRWFQL
NERPTVEGGRVLLYTDISALKKAETVRYEQAMAQKSVQLHSLVDNLSQGVVLLSSEKQIEVWNSRFVQLSQLATQQLHAN
IGLRDLQALTELELPTHPRLGSDFYVQTLQGGTVLEIRVHQLHDGKTIITYTDITERHRNQQSLQENERRLRLITDNVPA
MIAYIGADLKFEFTNQVYIDWYGSTSRGLDITELDKSLNYKQIKPFVQRALKGESVIFESRELNRTGEPNYLLKSYVPNL
DGNGVVLGFFVLIRNITERRINALALQKAHDQLERRVVERTSQLSSLNQKLLNEVEERRRVQTDLQAATREAEQANFSKT
KFLAAVSHDLLQPLNAAQLFTSSIVEKTVDAQLAPLINSVSSSLDDLENLICTLVDISKLDAGVVKADKCNFKLSDLLDN
LAREYQQQSGLYGVQLRYVSCDSLVHSDSFLLARILRNFLSNAFRYTDKGKVLLGCRRVDNKLCIEVWDNGAGIAQDQQT
EIFKEFKRLKSSRSAFTNGLGLGLAIVDKISKVLEHPVKVSSTLGKGSLFSVTVPLADKTDLPQPAAQLNQALTKTELAG
RTVWLVDNDFNICAAMKQLLETWDCTIITAASLADLQAQVDIGNDHANILIVDYHLDDGINGLDVAEQINHLRSTPLPVL
MITANYNKSLQKEIKEHGLLLLHKPVRAIKLKTTMLYLLNKK

Sequences:

>Translated_842_residues
MNEMQLSDENKRLKYDNAKLLKINEALMQRVEEGGNQSAPYAAFEHSVHLAEQVREKTQTLGETLSQLERRNRQLKTFQQ
RFTDAIESLSEAFVLLDCDGQIILQNSNFEAFLQTSNLPSETVLNLKALTEKKDHQKNTNNDGQLLKPVFQLSDGRWFQL
NERPTVEGGRVLLYTDISALKKAETVRYEQAMAQKSVQLHSLVDNLSQGVVLLSSEKQIEVWNSRFVQLSQLATQQLHAN
IGLRDLQALTELELPTHPRLGSDFYVQTLQGGTVLEIRVHQLHDGKTIITYTDITERHRNQQSLQENERRLRLITDNVPA
MIAYIGADLKFEFTNQVYIDWYGSTSRGLDITELDKSLNYKQIKPFVQRALKGESVIFESRELNRTGEPNYLLKSYVPNL
DGNGVVLGFFVLIRNITERRINALALQKAHDQLERRVVERTSQLSSLNQKLLNEVEERRRVQTDLQAATREAEQANFSKT
KFLAAVSHDLLQPLNAAQLFTSSIVEKTVDAQLAPLINSVSSSLDDLENLICTLVDISKLDAGVVKADKCNFKLSDLLDN
LAREYQQQSGLYGVQLRYVSCDSLVHSDSFLLARILRNFLSNAFRYTDKGKVLLGCRRVDNKLCIEVWDNGAGIAQDQQT
EIFKEFKRLKSSRSAFTNGLGLGLAIVDKISKVLEHPVKVSSTLGKGSLFSVTVPLADKTDLPQPAAQLNQALTKTELAG
RTVWLVDNDFNICAAMKQLLETWDCTIITAASLADLQAQVDIGNDHANILIVDYHLDDGINGLDVAEQINHLRSTPLPVL
MITANYNKSLQKEIKEHGLLLLHKPVRAIKLKTTMLYLLNKK
>Mature_842_residues
MNEMQLSDENKRLKYDNAKLLKINEALMQRVEEGGNQSAPYAAFEHSVHLAEQVREKTQTLGETLSQLERRNRQLKTFQQ
RFTDAIESLSEAFVLLDCDGQIILQNSNFEAFLQTSNLPSETVLNLKALTEKKDHQKNTNNDGQLLKPVFQLSDGRWFQL
NERPTVEGGRVLLYTDISALKKAETVRYEQAMAQKSVQLHSLVDNLSQGVVLLSSEKQIEVWNSRFVQLSQLATQQLHAN
IGLRDLQALTELELPTHPRLGSDFYVQTLQGGTVLEIRVHQLHDGKTIITYTDITERHRNQQSLQENERRLRLITDNVPA
MIAYIGADLKFEFTNQVYIDWYGSTSRGLDITELDKSLNYKQIKPFVQRALKGESVIFESRELNRTGEPNYLLKSYVPNL
DGNGVVLGFFVLIRNITERRINALALQKAHDQLERRVVERTSQLSSLNQKLLNEVEERRRVQTDLQAATREAEQANFSKT
KFLAAVSHDLLQPLNAAQLFTSSIVEKTVDAQLAPLINSVSSSLDDLENLICTLVDISKLDAGVVKADKCNFKLSDLLDN
LAREYQQQSGLYGVQLRYVSCDSLVHSDSFLLARILRNFLSNAFRYTDKGKVLLGCRRVDNKLCIEVWDNGAGIAQDQQT
EIFKEFKRLKSSRSAFTNGLGLGLAIVDKISKVLEHPVKVSSTLGKGSLFSVTVPLADKTDLPQPAAQLNQALTKTELAG
RTVWLVDNDFNICAAMKQLLETWDCTIITAASLADLQAQVDIGNDHANILIVDYHLDDGINGLDVAEQINHLRSTPLPVL
MITANYNKSLQKEIKEHGLLLLHKPVRAIKLKTTMLYLLNKK

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=303, Percent_Identity=30.6930693069307, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI48994928, Length=396, Percent_Identity=26.2626262626263, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI87081816, Length=389, Percent_Identity=28.2776349614396, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789149, Length=302, Percent_Identity=27.8145695364238, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1788713, Length=402, Percent_Identity=23.3830845771144, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=26.551724137931, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=26.431718061674, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=25.5605381165919, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=27.4336283185841, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=26.1802575107296, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1787894, Length=120, Percent_Identity=37.5, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1790551, Length=197, Percent_Identity=27.9187817258883, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 95003; Mature: 95003

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEMQLSDENKRLKYDNAKLLKINEALMQRVEEGGNQSAPYAAFEHSVHLAEQVREKTQT
CCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGETLSQLERRNRQLKTFQQRFTDAIESLSEAFVLLDCDGQIILQNSNFEAFLQTSNLPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCH
ETVLNLKALTEKKDHQKNTNNDGQLLKPVFQLSDGRWFQLNERPTVEGGRVLLYTDISAL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECHHHH
KKAETVRYEQAMAQKSVQLHSLVDNLSQGVVLLSSEKQIEVWNSRFVQLSQLATQQLHAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHC
IGLRDLQALTELELPTHPRLGSDFYVQTLQGGTVLEIRVHQLHDGKTIITYTDITERHRN
CCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEEECCHHHHHCC
QQSLQENERRLRLITDNVPAMIAYIGADLKFEFTNQVYIDWYGSTSRGLDITELDKSLNY
HHHHHHHCCEEEEEECCCHHHHHHHCCCEEEEECCEEEEEEECCCCCCCCHHHHHHCCCH
KQIKPFVQRALKGESVIFESRELNRTGEPNYLLKSYVPNLDGNGVVLGFFVLIRNITERR
HHHHHHHHHHHCCCCEEEECHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
INALALQKAHDQLERRVVERTSQLSSLNQKLLNEVEERRRVQTDLQAATREAEQANFSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KFLAAVSHDLLQPLNAAQLFTSSIVEKTVDAQLAPLINSVSSSLDDLENLICTLVDISKL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAGVVKADKCNFKLSDLLDNLAREYQQQSGLYGVQLRYVSCDSLVHSDSFLLARILRNFL
CCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEHHHHHCCCHHHHHHHHHHHH
SNAFRYTDKGKVLLGCRRVDNKLCIEVWDNGAGIAQDQQTEIFKEFKRLKSSRSAFTNGL
HHHHEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
GLGLAIVDKISKVLEHPVKVSSTLGKGSLFSVTVPLADKTDLPQPAAQLNQALTKTELAG
HHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
RTVWLVDNDFNICAAMKQLLETWDCTIITAASLADLQAQVDIGNDHANILIVDYHLDDGI
CEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHCEEEEEECCCCCEEEEEEEEECCCC
NGLDVAEQINHLRSTPLPVLMITANYNKSLQKEIKEHGLLLLHKPVRAIKLKTTMLYLLN
CCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHEEEEEC
KK
CC
>Mature Secondary Structure
MNEMQLSDENKRLKYDNAKLLKINEALMQRVEEGGNQSAPYAAFEHSVHLAEQVREKTQT
CCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGETLSQLERRNRQLKTFQQRFTDAIESLSEAFVLLDCDGQIILQNSNFEAFLQTSNLPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCH
ETVLNLKALTEKKDHQKNTNNDGQLLKPVFQLSDGRWFQLNERPTVEGGRVLLYTDISAL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECHHHH
KKAETVRYEQAMAQKSVQLHSLVDNLSQGVVLLSSEKQIEVWNSRFVQLSQLATQQLHAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHC
IGLRDLQALTELELPTHPRLGSDFYVQTLQGGTVLEIRVHQLHDGKTIITYTDITERHRN
CCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEEECCHHHHHCC
QQSLQENERRLRLITDNVPAMIAYIGADLKFEFTNQVYIDWYGSTSRGLDITELDKSLNY
HHHHHHHCCEEEEEECCCHHHHHHHCCCEEEEECCEEEEEEECCCCCCCCHHHHHHCCCH
KQIKPFVQRALKGESVIFESRELNRTGEPNYLLKSYVPNLDGNGVVLGFFVLIRNITERR
HHHHHHHHHHHCCCCEEEECHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
INALALQKAHDQLERRVVERTSQLSSLNQKLLNEVEERRRVQTDLQAATREAEQANFSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KFLAAVSHDLLQPLNAAQLFTSSIVEKTVDAQLAPLINSVSSSLDDLENLICTLVDISKL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAGVVKADKCNFKLSDLLDNLAREYQQQSGLYGVQLRYVSCDSLVHSDSFLLARILRNFL
CCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEHHHHHCCCHHHHHHHHHHHH
SNAFRYTDKGKVLLGCRRVDNKLCIEVWDNGAGIAQDQQTEIFKEFKRLKSSRSAFTNGL
HHHHEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
GLGLAIVDKISKVLEHPVKVSSTLGKGSLFSVTVPLADKTDLPQPAAQLNQALTKTELAG
HHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
RTVWLVDNDFNICAAMKQLLETWDCTIITAASLADLQAQVDIGNDHANILIVDYHLDDGI
CEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHCEEEEEECCCCCEEEEEEEEECCCC
NGLDVAEQINHLRSTPLPVLMITANYNKSLQKEIKEHGLLLLHKPVRAIKLKTTMLYLLN
CCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEECCHHHHHHHHHEEEEEC
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]