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The map label for this gene is hemH2 [H]

Identifier: 119946175

GI number: 119946175

Start: 3097281

End: 3098303

Strand: Direct

Name: hemH2 [H]

Synonym: Ping_2535

Alternate gene names: 119946175

Gene position: 3097281-3098303 (Clockwise)

Preceding gene: 119946174

Following gene: 119946176

Centisome position: 67.93

GC content: 43.01

Gene sequence:

>1023_bases
GTGTCACGATTTTCAGGTATTACCGACAACCCTCATGAAGGGCGTTTTCATCAAAAAACCGGCATTTTACTTACCAACCT
TGGTAGCCCGGACGCCGCCACTGCCAAAGCATTACGCATCTATCTAAGAGAGTTTTTATCTGATCGACGTATAGTTGAAA
TCCCGCGTTTACTCTGGATGATGATTTTACACGGCATTATACTTAGAACACGGCCTAAACGTTCTGCGAAACTCTATGAA
AGTGTTTGGACCAAAGATGGTTCACCCTTAACCCATATGACGCGTGTTCAGAGCGATAAACTGAGTGCCTTTTTAAAAGA
GAAAGGCTATGAAAATACCGAAGTGGTGATGGCCATGCGCTACGGTAATCCCTCCATTGAAGCGGGCCTGGAAGAATTAC
GTGAGAAGGGCTTTACTCGGATTGTGGTGTTTCCTTTGTACCCGCAATATTCAAGTCCCACGATAGGTTCAACCTTTGAT
GCTGTTGCTAAGGTTTTATGTAAATGGCGCTGGGTACCTGAGCTGCACTTTATTAATGGATACCACAAAAATGAATCCTA
CATCAATTCGTTAGCCAACAGTGTCAGTGAAGACTTAGAGGCCAACGGCATGCCGCAAAAATTAGTCTTCTCCTATCATG
GTATGCCTAAACTGTTTTTAAAAAATGGCGATCCTTATCACTGCTTGTGTCTGCAAACGACACGTCTGGTGGTTGAAAAA
CTTGGCTTAGATAAGGAGCGCGTTGTCAGCACTTTCCAAAGTCGTTTTGGTAAAGCAGAATGGTTAAAGCCCTATACCGA
TGAAACCTTAAAAAGTTATCCGGGACGAGGTATTAAAGATATCGCGATTATCAGCCCTGCTTTTAGCGCCGATTGCTTAG
AAACTCTGGAAGAGATTGAAGTTGAAAATCGCGAGATATTTAAGCACGCTGGCGGTGAAAAATACCGCTATATTCCCGCA
TTAAATGATCGGGATGATCATATTGAAGCCTTGTTTGATGTGTTAAAACCGAATTTAGGTTAG

Upstream 100 bases:

>100_bases
ATGAGTGTCTTACAAATTCACTCAAAAAGTATTCTCAAATCACTGTCAATTCGTTACAGTGGCGTTTATTTCAATTCTAT
ATGCTCAAAAGGAGCTTTGC

Downstream 100 bases:

>100_bases
GAAGAGCAGCTATCAGCTATCAGCTATCAGCTATCGGCTGATGGCTGACAGCTGACGGCTGACCGCTCGCGGCTCGAGTC
TGCATTAGCCGGAATAGGTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSRFSGITDNPHEGRFHQKTGILLTNLGSPDAATAKALRIYLREFLSDRRIVEIPRLLWMMILHGIILRTRPKRSAKLYE
SVWTKDGSPLTHMTRVQSDKLSAFLKEKGYENTEVVMAMRYGNPSIEAGLEELREKGFTRIVVFPLYPQYSSPTIGSTFD
AVAKVLCKWRWVPELHFINGYHKNESYINSLANSVSEDLEANGMPQKLVFSYHGMPKLFLKNGDPYHCLCLQTTRLVVEK
LGLDKERVVSTFQSRFGKAEWLKPYTDETLKSYPGRGIKDIAIISPAFSADCLETLEEIEVENREIFKHAGGEKYRYIPA
LNDRDDHIEALFDVLKPNLG

Sequences:

>Translated_340_residues
MSRFSGITDNPHEGRFHQKTGILLTNLGSPDAATAKALRIYLREFLSDRRIVEIPRLLWMMILHGIILRTRPKRSAKLYE
SVWTKDGSPLTHMTRVQSDKLSAFLKEKGYENTEVVMAMRYGNPSIEAGLEELREKGFTRIVVFPLYPQYSSPTIGSTFD
AVAKVLCKWRWVPELHFINGYHKNESYINSLANSVSEDLEANGMPQKLVFSYHGMPKLFLKNGDPYHCLCLQTTRLVVEK
LGLDKERVVSTFQSRFGKAEWLKPYTDETLKSYPGRGIKDIAIISPAFSADCLETLEEIEVENREIFKHAGGEKYRYIPA
LNDRDDHIEALFDVLKPNLG
>Mature_339_residues
SRFSGITDNPHEGRFHQKTGILLTNLGSPDAATAKALRIYLREFLSDRRIVEIPRLLWMMILHGIILRTRPKRSAKLYES
VWTKDGSPLTHMTRVQSDKLSAFLKEKGYENTEVVMAMRYGNPSIEAGLEELREKGFTRIVVFPLYPQYSSPTIGSTFDA
VAKVLCKWRWVPELHFINGYHKNESYINSLANSVSEDLEANGMPQKLVFSYHGMPKLFLKNGDPYHCLCLQTTRLVVEKL
GLDKERVVSTFQSRFGKAEWLKPYTDETLKSYPGRGIKDIAIISPAFSADCLETLEEIEVENREIFKHAGGEKYRYIPAL
NDRDDHIEALFDVLKPNLG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=327, Percent_Identity=28.1345565749235, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI60499025, Length=327, Percent_Identity=28.1345565749235, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=48.2758620689655, Blast_Score=303, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6324750, Length=354, Percent_Identity=23.728813559322, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17864156, Length=334, Percent_Identity=26.6467065868263, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=25.2830188679245, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552018, Length=133, Percent_Identity=30.0751879699248, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38891; Mature: 38760

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFSGITDNPHEGRFHQKTGILLTNLGSPDAATAKALRIYLREFLSDRRIVEIPRLLWM
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MILHGIILRTRPKRSAKLYESVWTKDGSPLTHMTRVQSDKLSAFLKEKGYENTEVVMAMR
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
YGNPSIEAGLEELREKGFTRIVVFPLYPQYSSPTIGSTFDAVAKVLCKWRWVPELHFING
CCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YHKNESYINSLANSVSEDLEANGMPQKLVFSYHGMPKLFLKNGDPYHCLCLQTTRLVVEK
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCEEEEHHHHHHHHHH
LGLDKERVVSTFQSRFGKAEWLKPYTDETLKSYPGRGIKDIAIISPAFSADCLETLEEIE
HCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHC
VENREIFKHAGGEKYRYIPALNDRDDHIEALFDVLKPNLG
CHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRFSGITDNPHEGRFHQKTGILLTNLGSPDAATAKALRIYLREFLSDRRIVEIPRLLWM
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MILHGIILRTRPKRSAKLYESVWTKDGSPLTHMTRVQSDKLSAFLKEKGYENTEVVMAMR
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
YGNPSIEAGLEELREKGFTRIVVFPLYPQYSSPTIGSTFDAVAKVLCKWRWVPELHFING
CCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YHKNESYINSLANSVSEDLEANGMPQKLVFSYHGMPKLFLKNGDPYHCLCLQTTRLVVEK
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCEEEEHHHHHHHHHH
LGLDKERVVSTFQSRFGKAEWLKPYTDETLKSYPGRGIKDIAIISPAFSADCLETLEEIE
HCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHC
VENREIFKHAGGEKYRYIPALNDRDDHIEALFDVLKPNLG
CHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]