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The map label for this gene is pyrC

Identifier: 119945954

GI number: 119945954

Start: 2788158

End: 2789189

Strand: Direct

Name: pyrC

Synonym: Ping_2294

Alternate gene names: 119945954

Gene position: 2788158-2789189 (Clockwise)

Preceding gene: 119945952

Following gene: 119945956

Centisome position: 61.15

GC content: 45.35

Gene sequence:

>1032_bases
ATGACCACAACAAGAACAATAACCCGCCCCGATGATTGGCACTTGCATTTGCGCGACGGTGAAGTACTAAAGGACACTGT
GCGTGATACCAGCCGTTATATGGGCCGCGCAGTTATTATGCCTAACCTTGTACCGCCCGTAACAAATACTGCATTAGCAC
TTGCATATCAGGCCAGAATTTTTGCGGCGCAGCCGAAGGCTGGCTTTAAACCATTAATGACCCTCTATTTAACCGATAAC
ACCAGCGCTGATGAGATAAAAAAAGCCAAAGCATCGGGACAAATTTATGCTGCCAAATTATACCCGGCAGGTGCCACTAC
CAACTCAGAATCAGGTGTTACCTCGGTTGAAAAAATAAAAGAGGCTCTGCAGGCGATGCAGGAGGTCGGCATGCTGCTAC
TGATTCACGGTGAAGTCACCGCCAGTGACATTGATATTTTTGACCGTGAGGAGATTTTCTTACAGAAAGTCCTTGCCCCG
ATCGTTGCATCCTATCCCAATCTGAAAATCGTTCTGGAACATATCACCACGGCGAATGCGGTAGACTTTGTTAATAATGC
AGGCGACAATGTTGCAGCAACTATTACCGCCCACCATTTAATGTTTAACCGTAACCATATGTTAGTAGGCGGAATTCGTC
CACACTTATACTGTTTACCTATTTTAAAGCGTAATATTCACCAGCAAGCATTAATAAAAGCTGCAACCAGTGGCGCTAAA
AAATTCTTTTTAGGCACCGATTCTGCTCCACACGCGGTTAACCGTAAGGAAGCGGCTTGTGGTTGCGCGGGGTGTTATAC
CGCTCATGCAGCCATTGAATTATATGCAGAAGTCTTTGAACAAGCCGGTGCATTGGATAAATTAGAAGCCTTTGCCAGTT
TTAACGGCCCTGATTTTTATAATCTACCACGTAACAGCGATACTATTACCCTTGAGAAATCAGCTTGGGATGTGCCTGCG
TCAATGAGTTTTGGTAACCAGCAAGTGGTGCCGATTAAAGCCAATGAGCAAATGCTTTGGAAAGTGCTGTAG

Upstream 100 bases:

>100_bases
TTGGCGTTAACTACAAGGTGCAGGCCAATGAAGCGTAAAATTGCCTTTAGTTCACCGCTGGATACTTGTAAAATAGTTAA
AAATTAATGGAGATAATTCA

Downstream 100 bases:

>100_bases
ATAACTTTTTTAATGTCGGCACAAAAAGCGAATAACTGTTTTTATTCGCCTTTGTGCCAAGTAGCGCCACCGTTGCTAGA
TTATTTTTCAACAAGAGTCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTTTRTITRPDDWHLHLRDGEVLKDTVRDTSRYMGRAVIMPNLVPPVTNTALALAYQARIFAAQPKAGFKPLMTLYLTDN
TSADEIKKAKASGQIYAAKLYPAGATTNSESGVTSVEKIKEALQAMQEVGMLLLIHGEVTASDIDIFDREEIFLQKVLAP
IVASYPNLKIVLEHITTANAVDFVNNAGDNVAATITAHHLMFNRNHMLVGGIRPHLYCLPILKRNIHQQALIKAATSGAK
KFFLGTDSAPHAVNRKEAACGCAGCYTAHAAIELYAEVFEQAGALDKLEAFASFNGPDFYNLPRNSDTITLEKSAWDVPA
SMSFGNQQVVPIKANEQMLWKVL

Sequences:

>Translated_343_residues
MTTTRTITRPDDWHLHLRDGEVLKDTVRDTSRYMGRAVIMPNLVPPVTNTALALAYQARIFAAQPKAGFKPLMTLYLTDN
TSADEIKKAKASGQIYAAKLYPAGATTNSESGVTSVEKIKEALQAMQEVGMLLLIHGEVTASDIDIFDREEIFLQKVLAP
IVASYPNLKIVLEHITTANAVDFVNNAGDNVAATITAHHLMFNRNHMLVGGIRPHLYCLPILKRNIHQQALIKAATSGAK
KFFLGTDSAPHAVNRKEAACGCAGCYTAHAAIELYAEVFEQAGALDKLEAFASFNGPDFYNLPRNSDTITLEKSAWDVPA
SMSFGNQQVVPIKANEQMLWKVL
>Mature_342_residues
TTTRTITRPDDWHLHLRDGEVLKDTVRDTSRYMGRAVIMPNLVPPVTNTALALAYQARIFAAQPKAGFKPLMTLYLTDNT
SADEIKKAKASGQIYAAKLYPAGATTNSESGVTSVEKIKEALQAMQEVGMLLLIHGEVTASDIDIFDREEIFLQKVLAPI
VASYPNLKIVLEHITTANAVDFVNNAGDNVAATITAHHLMFNRNHMLVGGIRPHLYCLPILKRNIHQQALIKAATSGAKK
FFLGTDSAPHAVNRKEAACGCAGCYTAHAAIELYAEVFEQAGALDKLEAFASFNGPDFYNLPRNSDTITLEKSAWDVPAS
MSFGNQQVVPIKANEQMLWKVL

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=337, Percent_Identity=55.1928783382789, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.3932584269663, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_PSYIN (A1SX20)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943634.1
- ProteinModelPortal:   A1SX20
- SMR:   A1SX20
- STRING:   A1SX20
- GeneID:   4624612
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2294
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- PhylomeDB:   A1SX20
- ProtClustDB:   PRK05451
- BioCyc:   PING357804:PING_2294-MONOMER
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 37555; Mature: 37423

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTRTITRPDDWHLHLRDGEVLKDTVRDTSRYMGRAVIMPNLVPPVTNTALALAYQARI
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHEE
FAAQPKAGFKPLMTLYLTDNTSADEIKKAKASGQIYAAKLYPAGATTNSESGVTSVEKIK
EEECCCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
EALQAMQEVGMLLLIHGEVTASDIDIFDREEIFLQKVLAPIVASYPNLKIVLEHITTANA
HHHHHHHHCCEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCHH
VDFVNNAGDNVAATITAHHLMFNRNHMLVGGIRPHLYCLPILKRNIHQQALIKAATSGAK
HHHHHCCCCCEEEEEEEEEEEEECCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
KFFLGTDSAPHAVNRKEAACGCAGCYTAHAAIELYAEVFEQAGALDKLEAFASFNGPDFY
EEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NLPRNSDTITLEKSAWDVPASMSFGNQQVVPIKANEQMLWKVL
CCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHEECC
>Mature Secondary Structure 
TTTRTITRPDDWHLHLRDGEVLKDTVRDTSRYMGRAVIMPNLVPPVTNTALALAYQARI
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHEE
FAAQPKAGFKPLMTLYLTDNTSADEIKKAKASGQIYAAKLYPAGATTNSESGVTSVEKIK
EEECCCCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
EALQAMQEVGMLLLIHGEVTASDIDIFDREEIFLQKVLAPIVASYPNLKIVLEHITTANA
HHHHHHHHCCEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCHH
VDFVNNAGDNVAATITAHHLMFNRNHMLVGGIRPHLYCLPILKRNIHQQALIKAATSGAK
HHHHHCCCCCEEEEEEEEEEEEECCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
KFFLGTDSAPHAVNRKEAACGCAGCYTAHAAIELYAEVFEQAGALDKLEAFASFNGPDFY
EEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NLPRNSDTITLEKSAWDVPASMSFGNQQVVPIKANEQMLWKVL
CCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA