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The map label for this gene is ddc [H]

Identifier: 119945948

GI number: 119945948

Start: 2780491

End: 2781975

Strand: Direct

Name: ddc [H]

Synonym: Ping_2288

Alternate gene names: 119945948

Gene position: 2780491-2781975 (Clockwise)

Preceding gene: 119945947

Following gene: 119945949

Centisome position: 60.98

GC content: 41.14

Gene sequence:

>1485_bases
ATGCAGCCTAATTCACCTTGGTCCAAGCACTTTATCCAAGTCGCCGGGGCCAATAACCAGGCCTTTACAGTCGCCAGCCA
GCAAGCACTGGATAATATAAACAGTCTCTTTGCGCAGTGCACTAAACCTTATTCGGGTTTGACGCCGGATTTGTTAAAAG
AAGCAATTTATAACAGCAATTTAGATAAGGTTGAACCACTACAGCAGGTTATTGAGCAAACCAATGATCTGATCGCTAAA
AATTCAATTATGGTACAACACCCGCATTGTATTGCGCACCTTCATACCCCGCCATTAATCTCGTCGGTGGTGGCTGAATT
TTATATTGCGGCATTGAACCAATCAATGGACTCATGGGATCAGGCATCTGCTGCGACTTATCTAGAGCAGTTTATTATCG
ATTGGCTGCTTAAAACCTATGCGCTCGGCGATAGTGCTGATGGTGTTTTCACCAGCGGCGGCACGCAGAGTAATTTAATG
GGCTTATTATTGGCACGGGACTGGTTTGCACAACACTATTCTGGCCATAATATTCAGCAGGATGGTTTACCTGATTACGG
TAATAAATTACGTATTATCTGTTCAGATAAAAGCCATTTTACCATTCAAAAATCCGCCTCATTAATGGGTCTTGGGGAAC
GTTCGGTTGTGTGCATTAAAACCAATATTCAAGGTCAGATGGATACTGTGCATTTGCAGAGCACCCTTGATGATTTGCTG
GCACAGGGATTATTGCCGATGGCAGTGGTTGCCACCGCAGGCACAACGGATCATGGCGCCATTGATGATTTACAGGAAAT
TATAAAAATCAGCCGCCATTTCGGTCTGTGGTGCCATGTCGACGGGGCCTATGGTGGCGCATTAATGCTTAGTCAAAAAC
ATAAATCCCGTCTACTAGGCATGGAATCAGCTGATTCCGTGAGTGTGGATTTTCATAAACTCTTCTATCAAACCATCAGT
TGCGGCGCTTTATTAATTAAAAATAAAACACACTTTAAAAGTCTGTTGCACCATGCAGATTACCTTAACCGGGAAGGTGA
TGATCTGCCTAACCTGGTTGATAAAAGTATTGCTACAACCAAACGTTTTGATGCATTGAAAATGTTTATGACCTTAAAAG
GGGTCGGTGCTAATACATTGGGTGAAATGTACGACAAGTTAATTGAACTCACTCAGGCGGTGGCAAAATCTGTGCAGCAA
AACAGCCATTTTGAGCTTTGTTGTGAGCCATTATTATCAACGGTTTTATTTCGCTTAAGCACAAAATATCAAGGTCTATT
AACGCTTAATGAGTTTAATCAGCTACAGCAAAAATTACGTTTGCAATTATTAACCTGTGGCGATGCTGTGATTGGCGAAA
CCAAAGTTGATGGCAAACTTTATCTTAAATTTACCCTGTTAAACCCCTGTTTAACATTAAACAATTTTGATAATTTATTT
AAAAAAATCGAAAGGCATGCACAACAATTAATACCTAATACCTAA

Upstream 100 bases:

>100_bases
TTACGCTTTTTACCACCCCTTATTATTAGCGAAACACAAATCAACTTTGTTGCTGAAACCGTTAAAGCTGCCATTATAGC
GACACAGGATAACATCACTG

Downstream 100 bases:

>100_bases
TACCCAAAATAATTAAATGATCACCTTTTTATTTTTTTATAACTTACAGAAAAATATAGATAATACCCATTCCACTCAAG
AGAAGATTCAATAAGTGGAT

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MQPNSPWSKHFIQVAGANNQAFTVASQQALDNINSLFAQCTKPYSGLTPDLLKEAIYNSNLDKVEPLQQVIEQTNDLIAK
NSIMVQHPHCIAHLHTPPLISSVVAEFYIAALNQSMDSWDQASAATYLEQFIIDWLLKTYALGDSADGVFTSGGTQSNLM
GLLLARDWFAQHYSGHNIQQDGLPDYGNKLRIICSDKSHFTIQKSASLMGLGERSVVCIKTNIQGQMDTVHLQSTLDDLL
AQGLLPMAVVATAGTTDHGAIDDLQEIIKISRHFGLWCHVDGAYGGALMLSQKHKSRLLGMESADSVSVDFHKLFYQTIS
CGALLIKNKTHFKSLLHHADYLNREGDDLPNLVDKSIATTKRFDALKMFMTLKGVGANTLGEMYDKLIELTQAVAKSVQQ
NSHFELCCEPLLSTVLFRLSTKYQGLLTLNEFNQLQQKLRLQLLTCGDAVIGETKVDGKLYLKFTLLNPCLTLNNFDNLF
KKIERHAQQLIPNT

Sequences:

>Translated_494_residues
MQPNSPWSKHFIQVAGANNQAFTVASQQALDNINSLFAQCTKPYSGLTPDLLKEAIYNSNLDKVEPLQQVIEQTNDLIAK
NSIMVQHPHCIAHLHTPPLISSVVAEFYIAALNQSMDSWDQASAATYLEQFIIDWLLKTYALGDSADGVFTSGGTQSNLM
GLLLARDWFAQHYSGHNIQQDGLPDYGNKLRIICSDKSHFTIQKSASLMGLGERSVVCIKTNIQGQMDTVHLQSTLDDLL
AQGLLPMAVVATAGTTDHGAIDDLQEIIKISRHFGLWCHVDGAYGGALMLSQKHKSRLLGMESADSVSVDFHKLFYQTIS
CGALLIKNKTHFKSLLHHADYLNREGDDLPNLVDKSIATTKRFDALKMFMTLKGVGANTLGEMYDKLIELTQAVAKSVQQ
NSHFELCCEPLLSTVLFRLSTKYQGLLTLNEFNQLQQKLRLQLLTCGDAVIGETKVDGKLYLKFTLLNPCLTLNNFDNLF
KKIERHAQQLIPNT
>Mature_494_residues
MQPNSPWSKHFIQVAGANNQAFTVASQQALDNINSLFAQCTKPYSGLTPDLLKEAIYNSNLDKVEPLQQVIEQTNDLIAK
NSIMVQHPHCIAHLHTPPLISSVVAEFYIAALNQSMDSWDQASAATYLEQFIIDWLLKTYALGDSADGVFTSGGTQSNLM
GLLLARDWFAQHYSGHNIQQDGLPDYGNKLRIICSDKSHFTIQKSASLMGLGERSVVCIKTNIQGQMDTVHLQSTLDDLL
AQGLLPMAVVATAGTTDHGAIDDLQEIIKISRHFGLWCHVDGAYGGALMLSQKHKSRLLGMESADSVSVDFHKLFYQTIS
CGALLIKNKTHFKSLLHHADYLNREGDDLPNLVDKSIATTKRFDALKMFMTLKGVGANTLGEMYDKLIELTQAVAKSVQQ
NSHFELCCEPLLSTVLFRLSTKYQGLLTLNEFNQLQQKLRLQLLTCGDAVIGETKVDGKLYLKFTLLNPCLTLNNFDNLF
KKIERHAQQLIPNT

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=447, Percent_Identity=27.7404921700224, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI58331246, Length=478, Percent_Identity=26.5690376569038, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI194294551, Length=453, Percent_Identity=28.0353200883002, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI197276620, Length=455, Percent_Identity=26.3736263736264, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4503875, Length=455, Percent_Identity=26.3736263736264, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4503281, Length=419, Percent_Identity=24.8210023866348, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI132814448, Length=419, Percent_Identity=24.8210023866348, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI92110055, Length=439, Percent_Identity=24.8291571753986, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555682, Length=448, Percent_Identity=24.7767857142857, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71993062, Length=427, Percent_Identity=24.3559718969555, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71993058, Length=368, Percent_Identity=26.6304347826087, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17534817, Length=425, Percent_Identity=23.2941176470588, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17534819, Length=425, Percent_Identity=23.2941176470588, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71981211, Length=429, Percent_Identity=21.9114219114219, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI133931025, Length=488, Percent_Identity=21.5163934426229, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71981217, Length=438, Percent_Identity=21.4611872146119, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551992, Length=481, Percent_Identity=22.6611226611227, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24657193, Length=381, Percent_Identity=30.4461942257218, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24657185, Length=381, Percent_Identity=30.4461942257218, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24657188, Length=381, Percent_Identity=30.4461942257218, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356415, Length=473, Percent_Identity=28.5412262156448, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136594, Length=422, Percent_Identity=26.303317535545, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24652373, Length=460, Percent_Identity=24.1304347826087, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28573972, Length=456, Percent_Identity=24.5614035087719, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136190, Length=457, Percent_Identity=24.507658643326, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585139, Length=384, Percent_Identity=26.3020833333333, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221476190, Length=384, Percent_Identity=26.3020833333333, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585143, Length=384, Percent_Identity=26.3020833333333, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24586044, Length=399, Percent_Identity=26.0651629072682, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585135, Length=436, Percent_Identity=24.7706422018349, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 54858; Mature: 54858

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPNSPWSKHFIQVAGANNQAFTVASQQALDNINSLFAQCTKPYSGLTPDLLKEAIYNSN
CCCCCCCHHHEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LDKVEPLQQVIEQTNDLIAKNSIMVQHPHCIAHLHTPPLISSVVAEFYIAALNQSMDSWD
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QASAATYLEQFIIDWLLKTYALGDSADGVFTSGGTQSNLMGLLLARDWFAQHYSGHNIQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DGLPDYGNKLRIICSDKSHFTIQKSASLMGLGERSVVCIKTNIQGQMDTVHLQSTLDDLL
CCCCCCCCEEEEEECCCCCEEEECCCHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AQGLLPMAVVATAGTTDHGAIDDLQEIIKISRHFGLWCHVDGAYGGALMLSQKHKSRLLG
HHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEECHHHHHHHCC
MESADSVSVDFHKLFYQTISCGALLIKNKTHFKSLLHHADYLNREGDDLPNLVDKSIATT
CCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KRFDALKMFMTLKGVGANTLGEMYDKLIELTQAVAKSVQQNSHFELCCEPLLSTVLFRLS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TKYQGLLTLNEFNQLQQKLRLQLLTCGDAVIGETKVDGKLYLKFTLLNPCLTLNNFDNLF
CCCCCEEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEEEEEEECCHHHHCCHHHHH
KKIERHAQQLIPNT
HHHHHHHHHHCCCC
>Mature Secondary Structure
MQPNSPWSKHFIQVAGANNQAFTVASQQALDNINSLFAQCTKPYSGLTPDLLKEAIYNSN
CCCCCCCHHHEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LDKVEPLQQVIEQTNDLIAKNSIMVQHPHCIAHLHTPPLISSVVAEFYIAALNQSMDSWD
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QASAATYLEQFIIDWLLKTYALGDSADGVFTSGGTQSNLMGLLLARDWFAQHYSGHNIQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DGLPDYGNKLRIICSDKSHFTIQKSASLMGLGERSVVCIKTNIQGQMDTVHLQSTLDDLL
CCCCCCCCEEEEEECCCCCEEEECCCHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AQGLLPMAVVATAGTTDHGAIDDLQEIIKISRHFGLWCHVDGAYGGALMLSQKHKSRLLG
HHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEECHHHHHHHCC
MESADSVSVDFHKLFYQTISCGALLIKNKTHFKSLLHHADYLNREGDDLPNLVDKSIATT
CCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KRFDALKMFMTLKGVGANTLGEMYDKLIELTQAVAKSVQQNSHFELCCEPLLSTVLFRLS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TKYQGLLTLNEFNQLQQKLRLQLLTCGDAVIGETKVDGKLYLKFTLLNPCLTLNNFDNLF
CCCCCEEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEEEEEEECCHHHHCCHHHHH
KKIERHAQQLIPNT
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]