Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 119945906

GI number: 119945906

Start: 2730716

End: 2731693

Strand: Reverse

Name: hemF [H]

Synonym: Ping_2246

Alternate gene names: 119945906

Gene position: 2731693-2730716 (Counterclockwise)

Preceding gene: 119945907

Following gene: 119945902

Centisome position: 59.91

GC content: 40.18

Gene sequence:

>978_bases
ATGAAAATTGCACCCACTTCAAATAAAGCGCAAGAAACAATGAAGATGCTGTTAACGTTACAAAGTGACTTTATGGAAAT
ATTGCAGTTGGTAAGTAAAGAGTTTGGCTGCCCGGCACAATTTAAAACCGTTGAGTGGCTTAGAGACGAAGGGCTACATG
GTGGGGGACTCAGATTTGAGGCCGTGAAAGGCAAACTCTTTAACCGTGCTTCAATCAATATTTCTCAAGTGCAATATGAC
GATCTGCCCAATAAGTCCTTTTCTTCCGCGACCGCGCTTTCGACTATCATTCACCCGAGTAATCCGTTAGCGCCTTCTCT
GCATATGCATATTAGCTGGACTGAATTTAAAAATGGTCAAGGTTCATGGCGAATAATGGCGGACTTAAATCCCTCTATAC
CCGATCAGAAAGAGAAAGAAAAATTTGATAATTGCTTAAAAGAAATAACCGGAAAATATTATCAGCAGGGGGAGCGTTTG
GGGAATGCGTATTTTTATATTCCTGCTTTGCAATGTTTTCGCGGTGTGAGCCATTTTTATCTTGAGGGCTTTAATCCTGA
TAGCATGACCACCAATCACTTTGCAAAAAACTTTGGGGAATCCGTTATACAATGTTATAGCGAGATATTAGCACAAAAAA
CACTTCATTCTGAGTCACCAACAGAGGCTCAAAAAATCGCTCAGTTAAATTATCATACTCTGTATTTTTACCAGGTTTTA
ACCTTAGACAAGGGTACCACTACCGGTTTGTTAATCCATAATCAGAATGACACCGGGACACTAGGATCCTTACCTGCGCG
AATCAATCGTGTGTTATTAGCGAGTTGGGTGGATATTACGCCTGCTCCTCAGGATAAGTTAATTAAACGATTTTTAAGGT
TGCTTCCCGAGCAAGATATTTGTCTTATTTCGACATCGCTCAAAGCACAAATAGCAGAACAAATTCGATTGCACTATAAA
GCGTTTCCCATCAATTAA

Upstream 100 bases:

>100_bases
TTAATAGTTAATAGGTGATAATTAATATTACCTCTTACTATTAAGGACCGTATTTATTACACTCGTTCTTAGTAAAAAAG
TTACCGGATTAAATAATTAT

Downstream 100 bases:

>100_bases
ATTTCTGGTGCGGCAAGCCTACTTAGCTAAACTATTTTATAATAAATGAATGCTGGTGTATTTTACTCAGAGTGTGTTAT
TTCGCTGCCTTTTGGTTTGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKIAPTSNKAQETMKMLLTLQSDFMEILQLVSKEFGCPAQFKTVEWLRDEGLHGGGLRFEAVKGKLFNRASINISQVQYD
DLPNKSFSSATALSTIIHPSNPLAPSLHMHISWTEFKNGQGSWRIMADLNPSIPDQKEKEKFDNCLKEITGKYYQQGERL
GNAYFYIPALQCFRGVSHFYLEGFNPDSMTTNHFAKNFGESVIQCYSEILAQKTLHSESPTEAQKIAQLNYHTLYFYQVL
TLDKGTTTGLLIHNQNDTGTLGSLPARINRVLLASWVDITPAPQDKLIKRFLRLLPEQDICLISTSLKAQIAEQIRLHYK
AFPIN

Sequences:

>Translated_325_residues
MKIAPTSNKAQETMKMLLTLQSDFMEILQLVSKEFGCPAQFKTVEWLRDEGLHGGGLRFEAVKGKLFNRASINISQVQYD
DLPNKSFSSATALSTIIHPSNPLAPSLHMHISWTEFKNGQGSWRIMADLNPSIPDQKEKEKFDNCLKEITGKYYQQGERL
GNAYFYIPALQCFRGVSHFYLEGFNPDSMTTNHFAKNFGESVIQCYSEILAQKTLHSESPTEAQKIAQLNYHTLYFYQVL
TLDKGTTTGLLIHNQNDTGTLGSLPARINRVLLASWVDITPAPQDKLIKRFLRLLPEQDICLISTSLKAQIAEQIRLHYK
AFPIN
>Mature_325_residues
MKIAPTSNKAQETMKMLLTLQSDFMEILQLVSKEFGCPAQFKTVEWLRDEGLHGGGLRFEAVKGKLFNRASINISQVQYD
DLPNKSFSSATALSTIIHPSNPLAPSLHMHISWTEFKNGQGSWRIMADLNPSIPDQKEKEKFDNCLKEITGKYYQQGERL
GNAYFYIPALQCFRGVSHFYLEGFNPDSMTTNHFAKNFGESVIQCYSEILAQKTLHSESPTEAQKIAQLNYHTLYFYQVL
TLDKGTTTGLLIHNQNDTGTLGSLPARINRVLLASWVDITPAPQDKLIKRFLRLLPEQDICLISTSLKAQIAEQIRLHYK
AFPIN

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=288, Percent_Identity=25, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17864388, Length=276, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36823; Mature: 36823

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAPTSNKAQETMKMLLTLQSDFMEILQLVSKEFGCPAQFKTVEWLRDEGLHGGGLRFE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEE
AVKGKLFNRASINISQVQYDDLPNKSFSSATALSTIIHPSNPLAPSLHMHISWTEFKNGQ
EHHCHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCC
GSWRIMADLNPSIPDQKEKEKFDNCLKEITGKYYQQGERLGNAYFYIPALQCFRGVSHFY
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCHHHH
LEGFNPDSMTTNHFAKNFGESVIQCYSEILAQKTLHSESPTEAQKIAQLNYHTLYFYQVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEE
TLDKGTTTGLLIHNQNDTGTLGSLPARINRVLLASWVDITPAPQDKLIKRFLRLLPEQDI
EECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCE
CLISTSLKAQIAEQIRLHYKAFPIN
EEEEHHHHHHHHHHHHHHHEECCCC
>Mature Secondary Structure
MKIAPTSNKAQETMKMLLTLQSDFMEILQLVSKEFGCPAQFKTVEWLRDEGLHGGGLRFE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEE
AVKGKLFNRASINISQVQYDDLPNKSFSSATALSTIIHPSNPLAPSLHMHISWTEFKNGQ
EHHCHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCC
GSWRIMADLNPSIPDQKEKEKFDNCLKEITGKYYQQGERLGNAYFYIPALQCFRGVSHFY
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCHHHH
LEGFNPDSMTTNHFAKNFGESVIQCYSEILAQKTLHSESPTEAQKIAQLNYHTLYFYQVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEE
TLDKGTTTGLLIHNQNDTGTLGSLPARINRVLLASWVDITPAPQDKLIKRFLRLLPEQDI
EECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCE
CLISTSLKAQIAEQIRLHYKAFPIN
EEEEHHHHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA