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The map label for this gene is ilvD [H]

Identifier: 119945813

GI number: 119945813

Start: 2624728

End: 2626413

Strand: Direct

Name: ilvD [H]

Synonym: Ping_2151

Alternate gene names: 119945813

Gene position: 2624728-2626413 (Clockwise)

Preceding gene: 119945810

Following gene: 119945816

Centisome position: 57.56

GC content: 41.4

Gene sequence:

>1686_bases
ATGTCAGAAATAAATAAGTATTCAAAAACAGTGACGTTAGATGAATCACAACCGGCTTCACAGGCCATGCTTTATGCTAT
TGGTTTGAAAGAAGAGGATATGAAAAAAGCGCAAGTGGGTATTGTTTCAACAGGATGGGAAGGAAATCCATGCAATATGC
ACTTAAACGAATTTGCTAAAGACGTGAAAAAAAGTGTGAACGCAGCTGATTTGGTGGGATTAATCTTTCACACAATCGGA
GTGAGTGATGGTATTTCAAACGGGACTACCGGGATGAAGTACTCTTTAGTGTCTCGTGAGATCATTGCTGATTCTATTGA
AACGGTTGTAAGTGCGCAATTTTATGATGCGATTGTTGCCATTGTAGGATGTGATAAAAATATGCCCGGTGCAATGATGG
CATTGTCGCGTTTAAATCGTCCGGGAATATTGGTTTATGGCGGTTCGGTTAAAGCTGGAAAATGGAAAGGTGAAGACTTG
AATATCGTTTCTGCTTTCGAAGCTTATGGAAAAAAATTACAGGGTGTTATCTCCCATGAAGATTATAAAGGGGTAATTCA
AAATGCGATCCCGGGTCCGGGTGCTTGTGGTGGAATGTATACGGCAAATACTATGTCTTCAGCTATTGAAGCGTTAGGCA
TGAGTTTGCCTTACTCTTCATCGAACCCGGCGGTTAGCGATGACAAAAAAAGAGAATTAACAACAGTGGGTGATGCAGTT
AAAAACCTGCTGGAAAAAGATATTAAACCAAAAGATATTATGACCAAAAAAGCGTTCGAGAATGCCTTAAGAATTATTAT
GATTTTAGGGGGCTCTACCAATGCAACTTTACATATGATTGCAATGGCCCGATCATCAGGTGTTGACTTGAGTTTAGATG
ATTTCCAAAAGATGGCAGATAAAACGCCATTATTGGCAAATTTAAAACCTTCCGGGGAATTCCTAATGCAAGACTTACAT
GAAATCGGCGGGATCCCTGCAGTCATGAAATACTTATTGGCTGAAGGTTTATTACATGGGGATTGTTTGACCGTTACAGG
TAACACCATTGCTGAAAACTTAGCTGATTTACCCGGCCTTCCTGATGATCAGGACATTATCAGACCTTTGTCTAACCCCT
TGAAAGAAACTGGCCACTTACAGATTCTTTATGGAAACTTGGCACCTGAAGGTTCAGTTGCAAAGATTACAGGTAAAGAA
GGCGAAGTATTCGAAGGCCCGGCAAGAGTTTATGAAGATGAATTTTCAGCAATAAAAGGTATCGGAGACGAAGTGCAAAA
AGGTGAAGTTATCGTTATCCGTTATTCAGGACCAAAAGGTGCGCCTGGCATGCCAGAAATGCTAAAACCAACTTCAGCTG
TAATGGGGGCGGGTCTTGGAAAAGACGTGGCATTAATTACAGATGGCAGATTCTCCGGAGGTTCTCATGGTTTTGTTGTT
GGACACGTGACGCCAGAGGCATCGGAAGGTGGATTGATTGCCCTGGTCCAAAATGGAGACATGATCCGAATTGATTCTGT
TACTAACAAATTGGAATTGAAAGTCGATCAGGCTGAAATCAACAAGCGTAAAGCTGCTTGGATAAAACCAGCTTACAGAG
CGACAAATGGTGTACTAAGAAAGTATATCGCCACGGTAAAATCTGCCTCTCTAGGATGTGTTACCGATGAAATAGACGAA
CTGTAG

Upstream 100 bases:

>100_bases
AATATAACCCGGGAATAGTTTCGTTGAGTTAGTTTCAAACACCTCTTTTTCGGTCTGTCCGAAGAGAATTTATGCAATTA
ATATTTTGGAGAAAATAAAG

Downstream 100 bases:

>100_bases
TCTCTAAGTAATATTAGTTATTAATTTGTTATCTCGAAGACCTGGCAGGATCTGTTGGCTTTTTGAGTACAAATTGCGTT
CAATCTAAACGTGTTCTGAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSEINKYSKTVTLDESQPASQAMLYAIGLKEEDMKKAQVGIVSTGWEGNPCNMHLNEFAKDVKKSVNAADLVGLIFHTIG
VSDGISNGTTGMKYSLVSREIIADSIETVVSAQFYDAIVAIVGCDKNMPGAMMALSRLNRPGILVYGGSVKAGKWKGEDL
NIVSAFEAYGKKLQGVISHEDYKGVIQNAIPGPGACGGMYTANTMSSAIEALGMSLPYSSSNPAVSDDKKRELTTVGDAV
KNLLEKDIKPKDIMTKKAFENALRIIMILGGSTNATLHMIAMARSSGVDLSLDDFQKMADKTPLLANLKPSGEFLMQDLH
EIGGIPAVMKYLLAEGLLHGDCLTVTGNTIAENLADLPGLPDDQDIIRPLSNPLKETGHLQILYGNLAPEGSVAKITGKE
GEVFEGPARVYEDEFSAIKGIGDEVQKGEVIVIRYSGPKGAPGMPEMLKPTSAVMGAGLGKDVALITDGRFSGGSHGFVV
GHVTPEASEGGLIALVQNGDMIRIDSVTNKLELKVDQAEINKRKAAWIKPAYRATNGVLRKYIATVKSASLGCVTDEIDE
L

Sequences:

>Translated_561_residues
MSEINKYSKTVTLDESQPASQAMLYAIGLKEEDMKKAQVGIVSTGWEGNPCNMHLNEFAKDVKKSVNAADLVGLIFHTIG
VSDGISNGTTGMKYSLVSREIIADSIETVVSAQFYDAIVAIVGCDKNMPGAMMALSRLNRPGILVYGGSVKAGKWKGEDL
NIVSAFEAYGKKLQGVISHEDYKGVIQNAIPGPGACGGMYTANTMSSAIEALGMSLPYSSSNPAVSDDKKRELTTVGDAV
KNLLEKDIKPKDIMTKKAFENALRIIMILGGSTNATLHMIAMARSSGVDLSLDDFQKMADKTPLLANLKPSGEFLMQDLH
EIGGIPAVMKYLLAEGLLHGDCLTVTGNTIAENLADLPGLPDDQDIIRPLSNPLKETGHLQILYGNLAPEGSVAKITGKE
GEVFEGPARVYEDEFSAIKGIGDEVQKGEVIVIRYSGPKGAPGMPEMLKPTSAVMGAGLGKDVALITDGRFSGGSHGFVV
GHVTPEASEGGLIALVQNGDMIRIDSVTNKLELKVDQAEINKRKAAWIKPAYRATNGVLRKYIATVKSASLGCVTDEIDE
L
>Mature_560_residues
SEINKYSKTVTLDESQPASQAMLYAIGLKEEDMKKAQVGIVSTGWEGNPCNMHLNEFAKDVKKSVNAADLVGLIFHTIGV
SDGISNGTTGMKYSLVSREIIADSIETVVSAQFYDAIVAIVGCDKNMPGAMMALSRLNRPGILVYGGSVKAGKWKGEDLN
IVSAFEAYGKKLQGVISHEDYKGVIQNAIPGPGACGGMYTANTMSSAIEALGMSLPYSSSNPAVSDDKKRELTTVGDAVK
NLLEKDIKPKDIMTKKAFENALRIIMILGGSTNATLHMIAMARSSGVDLSLDDFQKMADKTPLLANLKPSGEFLMQDLHE
IGGIPAVMKYLLAEGLLHGDCLTVTGNTIAENLADLPGLPDDQDIIRPLSNPLKETGHLQILYGNLAPEGSVAKITGKEG
EVFEGPARVYEDEFSAIKGIGDEVQKGEVIVIRYSGPKGAPGMPEMLKPTSAVMGAGLGKDVALITDGRFSGGSHGFVVG
HVTPEASEGGLIALVQNGDMIRIDSVTNKLELKVDQAEINKRKAAWIKPAYRATNGVLRKYIATVKSASLGCVTDEIDEL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=37.3983739837398, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1788157, Length=553, Percent_Identity=30.5605786618445, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI2367371, Length=543, Percent_Identity=31.8600368324125, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786464, Length=518, Percent_Identity=33.5907335907336, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=563, Percent_Identity=55.417406749556, Blast_Score=639, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59695; Mature: 59564

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEINKYSKTVTLDESQPASQAMLYAIGLKEEDMKKAQVGIVSTGWEGNPCNMHLNEFAK
CCCCHHHCCEEEECCCCCHHHEEEEEECCCHHHHHHHHEEEEECCCCCCCCCCCHHHHHH
DVKKSVNAADLVGLIFHTIGVSDGISNGTTGMKYSLVSREIIADSIETVVSAQFYDAIVA
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEE
IVGCDKNMPGAMMALSRLNRPGILVYGGSVKAGKWKGEDLNIVSAFEAYGKKLQGVISHE
EEECCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DYKGVIQNAIPGPGACGGMYTANTMSSAIEALGMSLPYSSSNPAVSDDKKRELTTVGDAV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNLLEKDIKPKDIMTKKAFENALRIIMILGGSTNATLHMIAMARSSGVDLSLDDFQKMAD
HHHHHHCCCCHHHHHHHHHHHCEEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHC
KTPLLANLKPSGEFLMQDLHEIGGIPAVMKYLLAEGLLHGDCLTVTGNTIAENLADLPGL
CCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCC
PDDQDIIRPLSNPLKETGHLQILYGNLAPEGSVAKITGKEGEVFEGPARVYEDEFSAIKG
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHHHHHHC
IGDEVQKGEVIVIRYSGPKGAPGMPEMLKPTSAVMGAGLGKDVALITDGRFSGGSHGFVV
CCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHVTPEASEGGLIALVQNGDMIRIDSVTNKLELKVDQAEINKRKAAWIKPAYRATNGVLR
EEECCCCCCCCEEEEEECCCEEEEECCCCEEEEEEEHHHHCCHHHHHCCHHHHHHHHHHH
KYIATVKSASLGCVTDEIDEL
HHHHHHHCCCCCCCHHHHHCC
>Mature Secondary Structure 
SEINKYSKTVTLDESQPASQAMLYAIGLKEEDMKKAQVGIVSTGWEGNPCNMHLNEFAK
CCCHHHCCEEEECCCCCHHHEEEEEECCCHHHHHHHHEEEEECCCCCCCCCCCHHHHHH
DVKKSVNAADLVGLIFHTIGVSDGISNGTTGMKYSLVSREIIADSIETVVSAQFYDAIVA
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEE
IVGCDKNMPGAMMALSRLNRPGILVYGGSVKAGKWKGEDLNIVSAFEAYGKKLQGVISHE
EEECCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DYKGVIQNAIPGPGACGGMYTANTMSSAIEALGMSLPYSSSNPAVSDDKKRELTTVGDAV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNLLEKDIKPKDIMTKKAFENALRIIMILGGSTNATLHMIAMARSSGVDLSLDDFQKMAD
HHHHHHCCCCHHHHHHHHHHHCEEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHC
KTPLLANLKPSGEFLMQDLHEIGGIPAVMKYLLAEGLLHGDCLTVTGNTIAENLADLPGL
CCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCC
PDDQDIIRPLSNPLKETGHLQILYGNLAPEGSVAKITGKEGEVFEGPARVYEDEFSAIKG
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEECCHHHHHHHHHHHHHC
IGDEVQKGEVIVIRYSGPKGAPGMPEMLKPTSAVMGAGLGKDVALITDGRFSGGSHGFVV
CCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHVTPEASEGGLIALVQNGDMIRIDSVTNKLELKVDQAEINKRKAAWIKPAYRATNGVLR
EEECCCCCCCCEEEEEECCCEEEEECCCCEEEEEEEHHHHCCHHHHHCCHHHHHHHHHHH
KYIATVKSASLGCVTDEIDEL
HHHHHHHCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA