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The map label for this gene is ubiE [C]

Identifier: 119945414

GI number: 119945414

Start: 2082427

End: 2082990

Strand: Direct

Name: ubiE [C]

Synonym: Ping_1708

Alternate gene names: 119945414

Gene position: 2082427-2082990 (Clockwise)

Preceding gene: 119945410

Following gene: 119945415

Centisome position: 45.67

GC content: 35.11

Gene sequence:

>564_bases
ATGAAGACGCGAGAAAAAATCGTTCCTTTAGCTTTTGGAAATGTTTTAGAGGTTGGTATGGGGTCTGCTGTCAATATGGA
TTTATATAATCCTGATCAGGTTACAAAGGTATGGGGACTTGAACCCTCTTCTGGAATGCAAAAGAAAGCGAAAAAAAACT
TAGCTAAATCAACTGTTCAGGTTGAGTGGTTAAGTCTTCCTGGTGAGAAAATCCCCCTTGATGATAATTCAGTGGACTCA
ATTGTTTTAACTTATACTCTTTGTACTATTCCTGATTGGTATGCAGCTATGAAGCAAATGCACCGAGTATTAAAGCCTGA
AGGTAAAATTCTATTCTGTGAGCATGGTCAAGCACCCGATGAATCAATTAAGAAGTGGCAAAATCGTTTAAATAAATTAT
GGGGTAAAGTTTTTGGTGGTTGTCATTTAAATAGGACAGTGATTGAAAATATACAAAGTAGCGGATTTTCTATAGATTGG
TCTAATAGTAATTATATAAAAGGTATGCCTAAATTTGCATCTTATATCAGCTTTGGTGTCGCAACTAAAATGCAGAAAAA
ATAA

Upstream 100 bases:

>100_bases
ATATTTAAATCCAAAACTAGAAAGGAGTATATCTTTGAGCTTTTATGAAAACAATATTCTTCCGCATATTCTAAATTGTG
CTTGTTCTTCAGAGGGTATA

Downstream 100 bases:

>100_bases
GGATGTGTGTTGCATAGCCGATACCTATCTGGTTGTTGAATAAGCCGGCACCAAAAACAAGAAGACACCCATTATAAAAC
CGCCTATTTTTGCGCCCTAA

Product: methyltransferase type 11

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Methyltransferase UbiE/COQ5 Family; SAM-Dependent Methyltransferase; UbiE/COQ5 Family Methlytransferase; Phosphatidylethanolamine N-Methyltransferase; Methyltransferase Domain Family; Phospholipid Methyltransferase; Sam Dependent Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase UbiE; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; UbiE Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Generic Methyltransferase; SAM-Dependent Methyltransferase UbiE/COQ5 Family; Ubiquinone/Menaquinone Biosynthesis-Related Protein; Methyltransferase Domain Family Protein; UbiE/COQ5 Methyltransferase; Response Regulator Receiver Protein

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKTREKIVPLAFGNVLEVGMGSAVNMDLYNPDQVTKVWGLEPSSGMQKKAKKNLAKSTVQVEWLSLPGEKIPLDDNSVDS
IVLTYTLCTIPDWYAAMKQMHRVLKPEGKILFCEHGQAPDESIKKWQNRLNKLWGKVFGGCHLNRTVIENIQSSGFSIDW
SNSNYIKGMPKFASYISFGVATKMQKK

Sequences:

>Translated_187_residues
MKTREKIVPLAFGNVLEVGMGSAVNMDLYNPDQVTKVWGLEPSSGMQKKAKKNLAKSTVQVEWLSLPGEKIPLDDNSVDS
IVLTYTLCTIPDWYAAMKQMHRVLKPEGKILFCEHGQAPDESIKKWQNRLNKLWGKVFGGCHLNRTVIENIQSSGFSIDW
SNSNYIKGMPKFASYISFGVATKMQKK
>Mature_187_residues
MKTREKIVPLAFGNVLEVGMGSAVNMDLYNPDQVTKVWGLEPSSGMQKKAKKNLAKSTVQVEWLSLPGEKIPLDDNSVDS
IVLTYTLCTIPDWYAAMKQMHRVLKPEGKILFCEHGQAPDESIKKWQNRLNKLWGKVFGGCHLNRTVIENIQSSGFSIDW
SNSNYIKGMPKFASYISFGVATKMQKK

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI89145417, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI164663805, Length=147, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 21042; Mature: 21042

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTREKIVPLAFGNVLEVGMGSAVNMDLYNPDQVTKVWGLEPSSGMQKKAKKNLAKSTVQ
CCCCCCCCCHHHCHHHHHCCCCEEEECCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHEE
VEWLSLPGEKIPLDDNSVDSIVLTYTLCTIPDWYAAMKQMHRVLKPEGKILFCEHGQAPD
EEEEECCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCH
ESIKKWQNRLNKLWGKVFGGCHLNRTVIENIQSSGFSIDWSNSNYIKGMPKFASYISFGV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
ATKMQKK
HHHCCCC
>Mature Secondary Structure
MKTREKIVPLAFGNVLEVGMGSAVNMDLYNPDQVTKVWGLEPSSGMQKKAKKNLAKSTVQ
CCCCCCCCCHHHCHHHHHCCCCEEEECCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHEE
VEWLSLPGEKIPLDDNSVDSIVLTYTLCTIPDWYAAMKQMHRVLKPEGKILFCEHGQAPD
EEEEECCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCH
ESIKKWQNRLNKLWGKVFGGCHLNRTVIENIQSSGFSIDWSNSNYIKGMPKFASYISFGV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
ATKMQKK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA