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The map label for this gene is kdsA

Identifier: 119945327

GI number: 119945327

Start: 1965081

End: 1965926

Strand: Direct

Name: kdsA

Synonym: Ping_1611

Alternate gene names: 119945327

Gene position: 1965081-1965926 (Clockwise)

Preceding gene: 119945326

Following gene: 119945328

Centisome position: 43.1

GC content: 41.61

Gene sequence:

>846_bases
ATGAAGCAAAAAATAATAAAAGTAGGCAATATTGACGTTGCTAATGATCGCCCCTTTGTCTTGTTTGGCGGCATGAATGT
GCTTGAATCCCGTGATATGGCGATGCGTGTCGTAGAAACCTACGTTGAAGCGACAACTGCCTTAAATATTCCTTATGTCT
TTAAAGCCTCATTTGACAAAGCGAACCGCTCATCTATTCATAGTTACCGTGGCCCTGGCCTTGAAGAGGGGCTGCGTATT
TTTGAAGAGATCAAAAATACTTTTAATGTGCCCATTATTACCGATGTGCATGAACCCTCTCAAGCAGCCCCAGTTGCTGA
GGTCGTTGATGTTATTCAATTACCCGCATTTTTAAGTAGGCAAACTGATCTGGTTAAAGCCATGGCAGAAACGAATGCGG
TTATCAATGTTAAAAAAGCACAGTTTTTAGCACCGCATGAAATGAAACACATTATTACTAAGTTTAATGAAGCGGGTAAC
GACAACATTATTCTTTGTGAGCGTGGTAGCTGTTTTGGTTATAATAATCTGGTTGTTGATATGCTGGGTTTCAGTACGAT
GAAAGAAACTGGCTATCCGGTCATTTTTGACGTCACACATTCTCTGCAAAAACCAGGCGCACGCAGTGATAGTGCTGATG
GTCGTCGCAGTCAAGTGGTACAACTTGGTTTGGCGGGGATGTCGCAGGGTATTGCTGGTCTTTTTCTAGAATCTCATCCT
GATCCGGCCAATGCAAAATGTGATGGTCCTTGCGCGTTACCATTACATCAATTAAAAGCCTTCCTTTCTCAAATGAAGCA
GATGGATGAGTTAGCCAAAAGTTTTGATATTATTGATACTGAATAA

Upstream 100 bases:

>100_bases
CTATCCCCAAGACCCTATTGTCGGTTTGTTAAAACGACAAATCAGACAAATAGATATTGATACTCCTACGCAAGTTGTCC
ATTAATCAAGTGAGCAGGTA

Downstream 100 bases:

>100_bases
TGCTTAAACAACCAATAAAATTGACTGAAACAACGCGCTTTTTTTTAATTCTGGCCTCTTTATTAGGGGCTTCGGGCGTT
GCATTAGGGGCTTATGCCAG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKQKIIKVGNIDVANDRPFVLFGGMNVLESRDMAMRVVETYVEATTALNIPYVFKASFDKANRSSIHSYRGPGLEEGLRI
FEEIKNTFNVPIITDVHEPSQAAPVAEVVDVIQLPAFLSRQTDLVKAMAETNAVINVKKAQFLAPHEMKHIITKFNEAGN
DNIILCERGSCFGYNNLVVDMLGFSTMKETGYPVIFDVTHSLQKPGARSDSADGRRSQVVQLGLAGMSQGIAGLFLESHP
DPANAKCDGPCALPLHQLKAFLSQMKQMDELAKSFDIIDTE

Sequences:

>Translated_281_residues
MKQKIIKVGNIDVANDRPFVLFGGMNVLESRDMAMRVVETYVEATTALNIPYVFKASFDKANRSSIHSYRGPGLEEGLRI
FEEIKNTFNVPIITDVHEPSQAAPVAEVVDVIQLPAFLSRQTDLVKAMAETNAVINVKKAQFLAPHEMKHIITKFNEAGN
DNIILCERGSCFGYNNLVVDMLGFSTMKETGYPVIFDVTHSLQKPGARSDSADGRRSQVVQLGLAGMSQGIAGLFLESHP
DPANAKCDGPCALPLHQLKAFLSQMKQMDELAKSFDIIDTE
>Mature_281_residues
MKQKIIKVGNIDVANDRPFVLFGGMNVLESRDMAMRVVETYVEATTALNIPYVFKASFDKANRSSIHSYRGPGLEEGLRI
FEEIKNTFNVPIITDVHEPSQAAPVAEVVDVIQLPAFLSRQTDLVKAMAETNAVINVKKAQFLAPHEMKHIITKFNEAGN
DNIILCERGSCFGYNNLVVDMLGFSTMKETGYPVIFDVTHSLQKPGARSDSADGRRSQVVQLGLAGMSQGIAGLFLESHP
DPANAKCDGPCALPLHQLKAFLSQMKQMDELAKSFDIIDTE

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=282, Percent_Identity=67.7304964539007, Blast_Score=402, Evalue=1e-113,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_PSYIN (A1SV93)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943007.1
- ProteinModelPortal:   A1SV93
- SMR:   A1SV93
- STRING:   A1SV93
- GeneID:   4624640
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1611
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   VHEPHQA
- PhylomeDB:   A1SV93
- ProtClustDB:   PRK05198
- BioCyc:   PING357804:PING_1611-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30932; Mature: 30932

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKIIKVGNIDVANDRPFVLFGGMNVLESRDMAMRVVETYVEATTALNIPYVFKASFDK
CCCCEEEECCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLEEGLRIFEEIKNTFNVPIITDVHEPSQAAPVAEVVDVIQLPAFLSR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
QTDLVKAMAETNAVINVKKAQFLAPHEMKHIITKFNEAGNDNIILCERGSCFGYNNLVVD
HHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
MLGFSTMKETGYPVIFDVTHSLQKPGARSDSADGRRSQVVQLGLAGMSQGIAGLFLESHP
HHCCHHHHHCCCCEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHEEEEECCC
DPANAKCDGPCALPLHQLKAFLSQMKQMDELAKSFDIIDTE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKQKIIKVGNIDVANDRPFVLFGGMNVLESRDMAMRVVETYVEATTALNIPYVFKASFDK
CCCCEEEECCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLEEGLRIFEEIKNTFNVPIITDVHEPSQAAPVAEVVDVIQLPAFLSR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
QTDLVKAMAETNAVINVKKAQFLAPHEMKHIITKFNEAGNDNIILCERGSCFGYNNLVVD
HHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
MLGFSTMKETGYPVIFDVTHSLQKPGARSDSADGRRSQVVQLGLAGMSQGIAGLFLESHP
HHCCHHHHHCCCCEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHEEEEECCC
DPANAKCDGPCALPLHQLKAFLSQMKQMDELAKSFDIIDTE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA