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The map label for this gene is hemA

Identifier: 119945322

GI number: 119945322

Start: 1960563

End: 1961822

Strand: Direct

Name: hemA

Synonym: Ping_1606

Alternate gene names: 119945322

Gene position: 1960563-1961822 (Clockwise)

Preceding gene: 119945320

Following gene: 119945323

Centisome position: 43.0

GC content: 40.56

Gene sequence:

>1260_bases
ATGCCTCTATTTGCTTTAGGAATTAACCATCAAACGGCTTCAGTCGCATTGCGTGAAAAAGTCGCGTTTTCAGCTGATCT
GTTATTAGATGCCTATCAAGCATTATTAGCGCAACCGACAGTATTGGAAGCGGTCATTGTTTCAACTTGTAACCGTACTG
AAATTTATTGTCATTTAAAACAGGACAACTGTGATGAGGTCATTAAGTGGCTTTGTTCTTTTCATCAGATCGAAGATCAT
AAATTAAGACCCAGTTTATATTGTTATTCTGAGTATCAAGCTATCCAGCATCTTTTTCGCGTCTCATGCGGACTGGATTC
GTTAGTGCTGGGTGAACCTCAAATTTTAGGGCAGATAAAACAAGCTTTTGCCACCGCTAAACAAGCTAAAGGTGTGGATA
AAATTGTTCAGAAATGGTTCCAGCATACTTTTACGGTGGCAAAGCGAGTACGTACTGAAACGCAAATAGGCGCTAATGCT
ATTTCTGTTGCCTTTGCAGCTGTTTGTTTAGCAAAACAAATATTCAGTGATTTATCTCAAAGCCGGGTCTTATTAATTGG
TGCGGGTGAGACAATCGAATTAGTGGGTAAATATTTAATTGAGCACCAAGTCCCTAATATTACTATTGCTAATCGTACTT
TATCACGGGCGATGGCACTGGTTGAGCAGTTTGATGCGCAGGCTATTACTCTGGGGGAAATTCCCAATCATCTTGCTCAA
GCTGATATCATTATCTCATCGACAGCAAGTCCGCTTCCTATTATTGGTAAAGGCATGGTTGAAAGGGCGTTAAAAGCGCG
TCGCAATCGACCTATGTTATTTATAGATATCGCTGTACCGCGTGATATTGAAGCGGAGGTTTCAGAGTTACGTGATATTT
ACCTTTACAGCGTTGATGATTTACAGGGCATTATCGAAGAGAATAAACAAGCCCGTCAGGTCGCAGCGCTTGAAGCCGAA
AAAATTATCGACGGCTGTATTGTTGACTTTATCTCATGGATAGAATCACTAAAGGCGGTTGAGTCTATTCGTACTTATCG
TCAAAACAGTGAACAATTACGAGATGATTTATTAAATCGAGCCTCTGCTGCGTTGCAAAACGGAGAGGAAGCTGAGAATG
TTTTAAAAGAGTTAGCCTTTAAATTAACCAATAAATTGATTCATCATCCCAGTCTGGCTCTGAACGAGACTGCTCGGTCG
GGTAATGATGATGAACTGATATTGTTGCGTAATGCTTTGGGCCTGAGCAAAAAAGATTAA

Upstream 100 bases:

>100_bases
ATGTAGTCGATATACATCGTTTTCTTTAAATCTTGCGTAAATGTCCGTAGAATTCCTCATTCTCCCCTAACCGTTTTAAC
TTGTTTTGTGAAATTATTAC

Downstream 100 bases:

>100_bases
CATTCGCTGTACACTCAGCAAATGAATAAAAGAACATAAGAGAAAAATATGAAAGCATCAATAGTGGCAAAGCTCGAAGT
CCTAGTTGAACGTTACGAAG

Product: shikimate/quinate 5-dehydrogenase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPLFALGINHQTASVALREKVAFSADLLLDAYQALLAQPTVLEAVIVSTCNRTEIYCHLKQDNCDEVIKWLCSFHQIEDH
KLRPSLYCYSEYQAIQHLFRVSCGLDSLVLGEPQILGQIKQAFATAKQAKGVDKIVQKWFQHTFTVAKRVRTETQIGANA
ISVAFAAVCLAKQIFSDLSQSRVLLIGAGETIELVGKYLIEHQVPNITIANRTLSRAMALVEQFDAQAITLGEIPNHLAQ
ADIIISSTASPLPIIGKGMVERALKARRNRPMLFIDIAVPRDIEAEVSELRDIYLYSVDDLQGIIEENKQARQVAALEAE
KIIDGCIVDFISWIESLKAVESIRTYRQNSEQLRDDLLNRASAALQNGEEAENVLKELAFKLTNKLIHHPSLALNETARS
GNDDELILLRNALGLSKKD

Sequences:

>Translated_419_residues
MPLFALGINHQTASVALREKVAFSADLLLDAYQALLAQPTVLEAVIVSTCNRTEIYCHLKQDNCDEVIKWLCSFHQIEDH
KLRPSLYCYSEYQAIQHLFRVSCGLDSLVLGEPQILGQIKQAFATAKQAKGVDKIVQKWFQHTFTVAKRVRTETQIGANA
ISVAFAAVCLAKQIFSDLSQSRVLLIGAGETIELVGKYLIEHQVPNITIANRTLSRAMALVEQFDAQAITLGEIPNHLAQ
ADIIISSTASPLPIIGKGMVERALKARRNRPMLFIDIAVPRDIEAEVSELRDIYLYSVDDLQGIIEENKQARQVAALEAE
KIIDGCIVDFISWIESLKAVESIRTYRQNSEQLRDDLLNRASAALQNGEEAENVLKELAFKLTNKLIHHPSLALNETARS
GNDDELILLRNALGLSKKD
>Mature_418_residues
PLFALGINHQTASVALREKVAFSADLLLDAYQALLAQPTVLEAVIVSTCNRTEIYCHLKQDNCDEVIKWLCSFHQIEDHK
LRPSLYCYSEYQAIQHLFRVSCGLDSLVLGEPQILGQIKQAFATAKQAKGVDKIVQKWFQHTFTVAKRVRTETQIGANAI
SVAFAAVCLAKQIFSDLSQSRVLLIGAGETIELVGKYLIEHQVPNITIANRTLSRAMALVEQFDAQAITLGEIPNHLAQA
DIIISSTASPLPIIGKGMVERALKARRNRPMLFIDIAVPRDIEAEVSELRDIYLYSVDDLQGIIEENKQARQVAALEAEK
IIDGCIVDFISWIESLKAVESIRTYRQNSEQLRDDLLNRASAALQNGEEAENVLKELAFKLTNKLIHHPSLALNETARSG
NDDELILLRNALGLSKKD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=417, Percent_Identity=55.3956834532374, Blast_Score=447, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PSYIN (A1SV88)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943002.1
- ProteinModelPortal:   A1SV88
- SMR:   A1SV88
- STRING:   A1SV88
- GeneID:   4624635
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1606
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A1SV88
- BioCyc:   PING357804:PING_1606-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46623; Mature: 46492

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFALGINHQTASVALREKVAFSADLLLDAYQALLAQPTVLEAVIVSTCNRTEIYCHLK
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEC
QDNCDEVIKWLCSFHQIEDHKLRPSLYCYSEYQAIQHLFRVSCGLDSLVLGEPQILGQIK
CCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
QAFATAKQAKGVDKIVQKWFQHTFTVAKRVRTETQIGANAISVAFAAVCLAKQIFSDLSQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
SRVLLIGAGETIELVGKYLIEHQVPNITIANRTLSRAMALVEQFDAQAITLGEIPNHLAQ
CCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
ADIIISSTASPLPIIGKGMVERALKARRNRPMLFIDIAVPRDIEAEVSELRDIYLYSVDD
HHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEHHH
LQGIIEENKQARQVAALEAEKIIDGCIVDFISWIESLKAVESIRTYRQNSEQLRDDLLNR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASAALQNGEEAENVLKELAFKLTNKLIHHPSLALNETARSGNDDELILLRNALGLSKKD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
PLFALGINHQTASVALREKVAFSADLLLDAYQALLAQPTVLEAVIVSTCNRTEIYCHLK
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEC
QDNCDEVIKWLCSFHQIEDHKLRPSLYCYSEYQAIQHLFRVSCGLDSLVLGEPQILGQIK
CCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
QAFATAKQAKGVDKIVQKWFQHTFTVAKRVRTETQIGANAISVAFAAVCLAKQIFSDLSQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
SRVLLIGAGETIELVGKYLIEHQVPNITIANRTLSRAMALVEQFDAQAITLGEIPNHLAQ
CCEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
ADIIISSTASPLPIIGKGMVERALKARRNRPMLFIDIAVPRDIEAEVSELRDIYLYSVDD
HHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEHHH
LQGIIEENKQARQVAALEAEKIIDGCIVDFISWIESLKAVESIRTYRQNSEQLRDDLLNR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASAALQNGEEAENVLKELAFKLTNKLIHHPSLALNETARSGNDDELILLRNALGLSKKD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA