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The map label for this gene is moeA [H]

Identifier: 119945213

GI number: 119945213

Start: 1826127

End: 1827374

Strand: Direct

Name: moeA [H]

Synonym: Ping_1477

Alternate gene names: 119945213

Gene position: 1826127-1827374 (Clockwise)

Preceding gene: 119945212

Following gene: 119945214

Centisome position: 40.05

GC content: 44.63

Gene sequence:

>1248_bases
ATGGGATGTTGTGACGTACAAGGATTAATGCCTTTTGAGCTGGCATTGGATAAAATGCAGGCCGCATTAGGCAATGTTTG
TCAGGAAATTTCGCAGCCCTTATCACAGGCATTGGGTTACGCATTAGCGCAGGAGATAAAATCACCTTTAAATGTCCCCT
CTTTTAATAATTCGGCAATGGATGGATATGCCGTCAATCGTGCTGATTTAATTAACTGCTCAGCAGATCAGCCAGTCACA
TTAAAGCAGGTTGGTCAGTCTTTTGCCGGTGCCCCTTATCGCGGTCAGCTAGGGCCAGGTGATTGTATTCGTATTATGAC
TGGGGCAGTTATGCCCGATAGTGTTGACAGCGTCGTCATGCAGGAGCGCACCACAGTCAAAGATGGCTTAATTAGTTTTA
CTCAATGCCCTAAACTGGGCGACAATGTCCGCCTAGCGGGCGAAGATATCAAACTTGGCCAACGGGTGCTTTGCCAAGGT
CATAAATTAACTCCCCGAGATATCCCCTTAATTGCCTCGCTGGGATTCGCTGAGATCCCTGTTTTTAGCAAACTTAAAGT
CGCGGTTATCTCTTCCGGTGACGAACTTAAGAACGTCGGCGAAACACTGGCAGAAGGTGATATTTATGACAGTAATCGTT
ATGGCATTATCGCGCTGTTATCCCGTCTGAATGTTGATATTATTGATTTTGGTATTGTCAAAGATGATAAAAACCAGCTC
CGTGAGGCATTTATCAACGCTGACCAGCAAGCCGATGTGGTCATTAGCAGCGGAGGTGTTTCGGTGGGGGAAGCGGATTT
TATTAAAGATATTTTATTTGAATTAGGCAGCATAAATTTTTGGAAATTAGCCCTTAAACCGGGTAAACCTTTTGCTTTTG
GGAAATTACCATCGAGTGTATTTTTCGGCTTGCCAGGTAATCCCGTTTCCGCTATGGTAACTCTTTACCAGCTTGCTGTA
CCGGCGATGGCGACCTTAAGTGGTTTAAATCCTCAGCCTGCCATTCGTTTTAGCGCGATTGCGCAAGAAAAGTTTAAAAA
ATCCCCCGGACGAACTGATTTTCAACGTGCAATATACTCTGTTAATGACAATGGAACGTTAGTTGTACAATCAACTGGCC
AGCAAGGTTCGGGCGTCTTTAGTTCAATGAGCCAATCAAATTGTTTTATTGTACTGGAGCAGGATCGCGGTGATGTTAGT
GCGGGTGAAAGCGTTATTATTGAGCCGTACAATGCTTTGATGGACTAA

Upstream 100 bases:

>100_bases
AGCAGCCCTCATTTACAAAATAAACAGGTTATAAATTATTTAAAATGATCCTGAATGTCGTTATAAGTGATTATTATTAT
TAATACAATGGAGTGAAAAA

Downstream 100 bases:

>100_bases
ACCGCAGCACATTATTATACAAAAAATACACTTAACTTTTAAGCACAAAAAGTGCGCTATGGGAACTGCAATGATTAATA
CCGATGATATACATATTAAG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MGCCDVQGLMPFELALDKMQAALGNVCQEISQPLSQALGYALAQEIKSPLNVPSFNNSAMDGYAVNRADLINCSADQPVT
LKQVGQSFAGAPYRGQLGPGDCIRIMTGAVMPDSVDSVVMQERTTVKDGLISFTQCPKLGDNVRLAGEDIKLGQRVLCQG
HKLTPRDIPLIASLGFAEIPVFSKLKVAVISSGDELKNVGETLAEGDIYDSNRYGIIALLSRLNVDIIDFGIVKDDKNQL
REAFINADQQADVVISSGGVSVGEADFIKDILFELGSINFWKLALKPGKPFAFGKLPSSVFFGLPGNPVSAMVTLYQLAV
PAMATLSGLNPQPAIRFSAIAQEKFKKSPGRTDFQRAIYSVNDNGTLVVQSTGQQGSGVFSSMSQSNCFIVLEQDRGDVS
AGESVIIEPYNALMD

Sequences:

>Translated_415_residues
MGCCDVQGLMPFELALDKMQAALGNVCQEISQPLSQALGYALAQEIKSPLNVPSFNNSAMDGYAVNRADLINCSADQPVT
LKQVGQSFAGAPYRGQLGPGDCIRIMTGAVMPDSVDSVVMQERTTVKDGLISFTQCPKLGDNVRLAGEDIKLGQRVLCQG
HKLTPRDIPLIASLGFAEIPVFSKLKVAVISSGDELKNVGETLAEGDIYDSNRYGIIALLSRLNVDIIDFGIVKDDKNQL
REAFINADQQADVVISSGGVSVGEADFIKDILFELGSINFWKLALKPGKPFAFGKLPSSVFFGLPGNPVSAMVTLYQLAV
PAMATLSGLNPQPAIRFSAIAQEKFKKSPGRTDFQRAIYSVNDNGTLVVQSTGQQGSGVFSSMSQSNCFIVLEQDRGDVS
AGESVIIEPYNALMD
>Mature_414_residues
GCCDVQGLMPFELALDKMQAALGNVCQEISQPLSQALGYALAQEIKSPLNVPSFNNSAMDGYAVNRADLINCSADQPVTL
KQVGQSFAGAPYRGQLGPGDCIRIMTGAVMPDSVDSVVMQERTTVKDGLISFTQCPKLGDNVRLAGEDIKLGQRVLCQGH
KLTPRDIPLIASLGFAEIPVFSKLKVAVISSGDELKNVGETLAEGDIYDSNRYGIIALLSRLNVDIIDFGIVKDDKNQLR
EAFINADQQADVVISSGGVSVGEADFIKDILFELGSINFWKLALKPGKPFAFGKLPSSVFFGLPGNPVSAMVTLYQLAVP
AMATLSGLNPQPAIRFSAIAQEKFKKSPGRTDFQRAIYSVNDNGTLVVQSTGQQGSGVFSSMSQSNCFIVLEQDRGDVSA
GESVIIEPYNALMD

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=371, Percent_Identity=35.8490566037736, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI10880983, Length=371, Percent_Identity=35.8490566037736, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1787049, Length=409, Percent_Identity=52.5672371638142, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI25147659, Length=397, Percent_Identity=31.2342569269521, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=362, Percent_Identity=27.0718232044199, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136978, Length=384, Percent_Identity=31.5104166666667, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24638841, Length=384, Percent_Identity=31.5104166666667, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44402; Mature: 44271

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCCDVQGLMPFELALDKMQAALGNVCQEISQPLSQALGYALAQEIKSPLNVPSFNNSAM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGYAVNRADLINCSADQPVTLKQVGQSFAGAPYRGQLGPGDCIRIMTGAVMPDSVDSVVM
CCEEECCCCEEECCCCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHH
QERTTVKDGLISFTQCPKLGDNVRLAGEDIKLGQRVLCQGHKLTPRDIPLIASLGFAEIP
HHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCHHHHHCCCCCCCCCCCCEECCCCHHCC
VFSKLKVAVISSGDELKNVGETLAEGDIYDSNRYGIIALLSRLNVDIIDFGIVKDDKNQL
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEEEECCHHHH
REAFINADQQADVVISSGGVSVGEADFIKDILFELGSINFWKLALKPGKPFAFGKLPSSV
HHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCE
FFGLPGNPVSAMVTLYQLAVPAMATLSGLNPQPAIRFSAIAQEKFKKSPGRTDFQRAIYS
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEE
VNDNGTLVVQSTGQQGSGVFSSMSQSNCFIVLEQDRGDVSAGESVIIEPYNALMD
ECCCCEEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHCC
>Mature Secondary Structure 
GCCDVQGLMPFELALDKMQAALGNVCQEISQPLSQALGYALAQEIKSPLNVPSFNNSAM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGYAVNRADLINCSADQPVTLKQVGQSFAGAPYRGQLGPGDCIRIMTGAVMPDSVDSVVM
CCEEECCCCEEECCCCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHH
QERTTVKDGLISFTQCPKLGDNVRLAGEDIKLGQRVLCQGHKLTPRDIPLIASLGFAEIP
HHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHCHHHHHCCCCCCCCCCCCEECCCCHHCC
VFSKLKVAVISSGDELKNVGETLAEGDIYDSNRYGIIALLSRLNVDIIDFGIVKDDKNQL
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEEEECCHHHH
REAFINADQQADVVISSGGVSVGEADFIKDILFELGSINFWKLALKPGKPFAFGKLPSSV
HHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCE
FFGLPGNPVSAMVTLYQLAVPAMATLSGLNPQPAIRFSAIAQEKFKKSPGRTDFQRAIYS
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEE
VNDNGTLVVQSTGQQGSGVFSSMSQSNCFIVLEQDRGDVSAGESVIIEPYNALMD
ECCCCEEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]