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The map label for this gene is merR [H]

Identifier: 119945212

GI number: 119945212

Start: 1825108

End: 1826049

Strand: Direct

Name: merR [H]

Synonym: Ping_1476

Alternate gene names: 119945212

Gene position: 1825108-1826049 (Clockwise)

Preceding gene: 119945210

Following gene: 119945213

Centisome position: 40.03

GC content: 42.36

Gene sequence:

>942_bases
GTGATTGAAATCAAACACTTAAAAACCCTGACAACATTAAACGCGACAGGCAGTTTAATTGACACTGCCCGTCAATTGCA
CCTGACTCAATCGGCAATATCACATCAGCTAAAAGAGTTAGAAGGGCGGCTTAATTGCGCTTTATTTATCCGTAAATCCA
GACCGATTCGTTTTACGGTTTCCGGTTTGCGTTTATTAGATTTAGCCGAGCAGGTCTTACCGCAAATTAATAATGCCGAA
AGAGATGTTGCGCGTTTTTGTTCAGGGAATGCCGGTCGTTTACATATGGCTATTGAGTGCCACTCCTGTTTTCAGTGGTT
GATGCCGGCGATTGATAAATTTCGTGATAGTTGGCCAGAGGTGGAGTTAGATTTTTGCAGTGGTTTTAGTTTTTTACCTT
TACCCGCCTTAAAACGGGGAAATTTAGATCTTGTTGTGACCTCGGATCCGCAACCGATTGAAGGAATTAGTTACATTCCT
CTGTTTCGTTATCAGCCGATGCTGGCCTTAAGTCGCCATCATAGATTGGCGCATAAAAATTATATTGAAGCTGAGGATCT
GAGTCAGGAAACTTTAATCACTTACCCCGTCGAGAAAGAACGTTTAGATATTTTTAACCTGTTTTTAACCCCTGAGGGGG
TATCACCTGCAAAAATTCGTCATGCTGATCTGACCCTGATGATGTTGCAGTTAGTTGCCAGCGGCAGAGGCGTGGCGGGA
TTACCTAACTGGGCTTTATTTGAATATCTGCAAAAAGATTATGTGGTTGCGCGGCGTTTAGGTAAAGAAGGAATATGGAA
TACCTTGTATGCCGCAGTGCGCGAAGAGCAACAGGGTATGGCCTATTTACAGGATTTTATTAAAACGGCAATAACCTGTT
GTTTTAAAGATCTAAAAGGGATCAAAGTTGCGGATTGTGAGCAGCCCTCATTTACAAAATAA

Upstream 100 bases:

>100_bases
AAGCAAATAACAAAGACAATGCAGTATTCACGCTTTTATTATGAATTTTTTTCAAGTATTGTTGTAATAATTGTAATTTT
CTTTGAAATGGGCTTTCGCT

Downstream 100 bases:

>100_bases
ACAGGTTATAAATTATTTAAAATGATCCTGAATGTCGTTATAAGTGATTATTATTATTAATACAATGGAGTGAAAAAATG
GGATGTTGTGACGTACAAGG

Product: transcriptional regulator MetR, substrate-binding, LysR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MIEIKHLKTLTTLNATGSLIDTARQLHLTQSAISHQLKELEGRLNCALFIRKSRPIRFTVSGLRLLDLAEQVLPQINNAE
RDVARFCSGNAGRLHMAIECHSCFQWLMPAIDKFRDSWPEVELDFCSGFSFLPLPALKRGNLDLVVTSDPQPIEGISYIP
LFRYQPMLALSRHHRLAHKNYIEAEDLSQETLITYPVEKERLDIFNLFLTPEGVSPAKIRHADLTLMMLQLVASGRGVAG
LPNWALFEYLQKDYVVARRLGKEGIWNTLYAAVREEQQGMAYLQDFIKTAITCCFKDLKGIKVADCEQPSFTK

Sequences:

>Translated_313_residues
MIEIKHLKTLTTLNATGSLIDTARQLHLTQSAISHQLKELEGRLNCALFIRKSRPIRFTVSGLRLLDLAEQVLPQINNAE
RDVARFCSGNAGRLHMAIECHSCFQWLMPAIDKFRDSWPEVELDFCSGFSFLPLPALKRGNLDLVVTSDPQPIEGISYIP
LFRYQPMLALSRHHRLAHKNYIEAEDLSQETLITYPVEKERLDIFNLFLTPEGVSPAKIRHADLTLMMLQLVASGRGVAG
LPNWALFEYLQKDYVVARRLGKEGIWNTLYAAVREEQQGMAYLQDFIKTAITCCFKDLKGIKVADCEQPSFTK
>Mature_313_residues
MIEIKHLKTLTTLNATGSLIDTARQLHLTQSAISHQLKELEGRLNCALFIRKSRPIRFTVSGLRLLDLAEQVLPQINNAE
RDVARFCSGNAGRLHMAIECHSCFQWLMPAIDKFRDSWPEVELDFCSGFSFLPLPALKRGNLDLVVTSDPQPIEGISYIP
LFRYQPMLALSRHHRLAHKNYIEAEDLSQETLITYPVEKERLDIFNLFLTPEGVSPAKIRHADLTLMMLQLVASGRGVAG
LPNWALFEYLQKDYVVARRLGKEGIWNTLYAAVREEQQGMAYLQDFIKTAITCCFKDLKGIKVADCEQPSFTK

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=312, Percent_Identity=48.0769230769231, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI2367136, Length=217, Percent_Identity=25.3456221198157, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788296, Length=185, Percent_Identity=29.1891891891892, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=25.3061224489796, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=252, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790399, Length=256, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787530, Length=297, Percent_Identity=22.5589225589226, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87081904, Length=224, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788748, Length=248, Percent_Identity=22.9838709677419, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=228, Percent_Identity=23.2456140350877, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790208, Length=154, Percent_Identity=26.6233766233766, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=25.6756756756757, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=274, Percent_Identity=21.1678832116788, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35562; Mature: 35562

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIKHLKTLTTLNATGSLIDTARQLHLTQSAISHQLKELEGRLNCALFIRKSRPIRFTV
CEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE
SGLRLLDLAEQVLPQINNAERDVARFCSGNAGRLHMAIECHSCFQWLMPAIDKFRDSWPE
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
VELDFCSGFSFLPLPALKRGNLDLVVTSDPQPIEGISYIPLFRYQPMLALSRHHRLAHKN
EEEHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHC
YIEAEDLSQETLITYPVEKERLDIFNLFLTPEGVSPAKIRHADLTLMMLQLVASGRGVAG
CCCHHCCCCCCEEECCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
LPNWALFEYLQKDYVVARRLGKEGIWNTLYAAVREEQQGMAYLQDFIKTAITCCFKDLKG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
IKVADCEQPSFTK
CEEECCCCCCCCC
>Mature Secondary Structure
MIEIKHLKTLTTLNATGSLIDTARQLHLTQSAISHQLKELEGRLNCALFIRKSRPIRFTV
CEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE
SGLRLLDLAEQVLPQINNAERDVARFCSGNAGRLHMAIECHSCFQWLMPAIDKFRDSWPE
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
VELDFCSGFSFLPLPALKRGNLDLVVTSDPQPIEGISYIPLFRYQPMLALSRHHRLAHKN
EEEHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHC
YIEAEDLSQETLITYPVEKERLDIFNLFLTPEGVSPAKIRHADLTLMMLQLVASGRGVAG
CCCHHCCCCCCEEECCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
LPNWALFEYLQKDYVVARRLGKEGIWNTLYAAVREEQQGMAYLQDFIKTAITCCFKDLKG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
IKVADCEQPSFTK
CEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]