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The map label for this gene is folD

Identifier: 119945209

GI number: 119945209

Start: 1821086

End: 1821943

Strand: Direct

Name: folD

Synonym: Ping_1473

Alternate gene names: 119945209

Gene position: 1821086-1821943 (Clockwise)

Preceding gene: 119945205

Following gene: 119945210

Centisome position: 39.94

GC content: 46.74

Gene sequence:

>858_bases
ATGACTGCACAAATCATAGATGGTAAGGCAATTGCAACCACGATTACAGAACGAGTTGCAAAAGGGGTTAAGCTCCGAAT
AGCCAATGGATTACGTGCTCCGGGGCTGGCCGTTATTTTGGTGGGAGGGGATCCTGCATCGCAAATATATGTTGGCAGCA
AACGTCGTACCTGTGAAGCAGTGGGCATTCACTCAAAGGCCTTTGATCTTCCTGAAACAACCACTCAAGATGAATTATTG
GCATTAATTGATAAGCTTAATGACGATCCCGATATTGATGGAATACTGGTGCAGTTTCCATTACCCGACGGCTTTGATCA
AACATCGGTGATTGAACGCATTAAGCCTGATAAAGATGTTGATGGCTTTCATCCCTATAATGTCGGGCGGCTAGCACAAC
GTATCCCATTGCTGCGCTCTTGCACACCGCGCGGTATTATCAGTATGTTGGAATATATTGGTACTGAGTTTCACGGTAAA
CATGCTGTTGTCGTCGGCGCATCTAACATTGTGGGGCGGCCGATGACATTGGAACTATTACTAGCCGGTTGTACAACAAC
CACTTGCCATCGTTTTACCACGGATCTGGCACATTATGTAAAACAGGCTGATATATTGGTCGTAGCACGCGGTAAAGCTA
ATTTTATTCCGGGCGAGTGGATTAAAAAAGGCGCCACTGTATTAGATGTGGGCATCAACCGTTTGGAAGATGGCAGTCTT
GCTGGTGATGTTGACTTTGCTGGCGCGAAAGAGCGTGCCGCATGGATTTCTCCTGTCCCTGGCGGAGTTGGACCGATGAC
GGTTGCAACCCTGATCGAAAATACGCTGTTTGCCTGTAATGAATTTCACAGCCAATAA

Upstream 100 bases:

>100_bases
GTTTGGCTATATAATGAAACTGGTCAGGATTTATGTGACATCATTCGATTGTTTTGCGACAATACGTCGATATTAAACAT
TATAAATAGAGAATTGTTCA

Downstream 100 bases:

>100_bases
AAAATGAAAATTTGCTAACGAGTGTTGTACCAAAAAAATCACCAGCATCGTTAGCAACTGCCCAGATCACCCATTATTAA
CCGTTATTATTACCTTCAGC

Product: methylenetetrahydrofolate dehydrogenase (NADP(+))

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEAVGIHSKAFDLPETTTQDELL
ALIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDVDGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGK
HAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSL
AGDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ

Sequences:

>Translated_285_residues
MTAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEAVGIHSKAFDLPETTTQDELL
ALIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDVDGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGK
HAVVVGASNIVGRPMTLELLLAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSL
AGDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ
>Mature_284_residues
TAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEAVGIHSKAFDLPETTTQDELLA
LIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDVDGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGKH
AVVVGASNIVGRPMTLELLLAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSLA
GDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=295, Percent_Identity=42.0338983050847, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI222136639, Length=295, Percent_Identity=41.6949152542373, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI94721354, Length=295, Percent_Identity=42.0338983050847, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI36796743, Length=207, Percent_Identity=28.5024154589372, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786741, Length=283, Percent_Identity=67.1378091872791, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17568735, Length=288, Percent_Identity=40.625, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=41.8118466898955, Blast_Score=215, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6321643, Length=297, Percent_Identity=41.4141414141414, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6322933, Length=316, Percent_Identity=25.9493670886076, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=45.9183673469388, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=45.9183673469388, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24645718, Length=292, Percent_Identity=41.0958904109589, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17137370, Length=292, Percent_Identity=41.0958904109589, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI62472483, Length=292, Percent_Identity=41.0958904109589, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45551871, Length=292, Percent_Identity=41.0958904109589, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PSYIN (A1SUX5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942889.1
- ProteinModelPortal:   A1SUX5
- SMR:   A1SUX5
- STRING:   A1SUX5
- GeneID:   4626032
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1473
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   HELPAST
- PhylomeDB:   A1SUX5
- BioCyc:   PING357804:PING_1473-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30578; Mature: 30446

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEA
CCCEEECCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCEEEECCCCCEEHH
VGIHSKAFDLPETTTQDELLALIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDV
HCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGKHAVVVGASNIVGRPMTLELL
CCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHCCCCCEEEHH
LAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSL
EECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCC
AGDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAQIIDGKAIATTITERVAKGVKLRIANGLRAPGLAVILVGGDPASQIYVGSKRRTCEA
CCEEECCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCEEEECCCCCEEHH
VGIHSKAFDLPETTTQDELLALIDKLNDDPDIDGILVQFPLPDGFDQTSVIERIKPDKDV
HCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNVGRLAQRIPLLRSCTPRGIISMLEYIGTEFHGKHAVVVGASNIVGRPMTLELL
CCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHCCCCCEEEHH
LAGCTTTTCHRFTTDLAHYVKQADILVVARGKANFIPGEWIKKGATVLDVGINRLEDGSL
EECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCC
AGDVDFAGAKERAAWISPVPGGVGPMTVATLIENTLFACNEFHSQ
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA