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The map label for this gene is clpP

Identifier: 119945201

GI number: 119945201

Start: 1810416

End: 1811039

Strand: Direct

Name: clpP

Synonym: Ping_1465

Alternate gene names: 119945201

Gene position: 1810416-1811039 (Clockwise)

Preceding gene: 119945200

Following gene: 119945202

Centisome position: 39.71

GC content: 40.22

Gene sequence:

>624_bases
ATGTCAAATCCATTTGCTGGAAATACCGATCCAATTAGTAACGCGCTTATTCCTATGGTTGTGGAACAAACAGCAAAAGG
AGAGCGTTCTTATGATATTTATTCACGTTTATTAAAAGAGCGTGTTATCTTTTTGACCGGCCCTGTTGAAGATCATGTAG
CGAATGTTATTGCTGCACAGTTATTATTTTTAGAATCAGAAAGCCCGGAAAAAGACATCTTTATTTATATTAATTCACCG
GGTGGATCGATCAGCGCCGGCATGGCAATATACGATACGATGCAGTTTATAAAACCGGATGTGAGTACTGTTTGTATGGG
GATGGCTGCGAGTATGGGCGCCTTTTTACTCGCCAGCGGTGCACCGGGTAAGCGTCATTGCCTGCCTAATGCAAAAGTGA
TGATTCATCAACCACTAGGCGGATTCCAAGGTCAAGCTTCTGATTTTGAAATTCATGCTAAAGAGATACTTGCCACCAAA
CATCGTATGAATGAATTATTAGCTTTTCATACGGGTAAAGACATTGAAATAATTGCGCAAGATACAGATCGTGATAATTT
TATGCGCGCAAGTGAAGCAGTAGAATACGGCATTGTTGATTCAGTGTTAACGCATAGAAAATAA

Upstream 100 bases:

>100_bases
CGTTTGGGTATTAGCTTTCAATGGCTCGAGTGATTTCACTCGGGCCATTTTACATTCAGTATTAGCAATTTTATTTAATT
TATTAGGGTAGAAGTTGAAC

Downstream 100 bases:

>100_bases
GTAAAGGAAAAAAAATGCCAAATAAAAATGATAGTTTACTTTATTGTTCTTTTTGTGGAAAAAGTCAGCACGAAGTAAAA
AAACTGATTGCCGGTCCTTC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSNPFAGNTDPISNALIPMVVEQTAKGERSYDIYSRLLKERVIFLTGPVEDHVANVIAAQLLFLESESPEKDIFIYINSP
GGSISAGMAIYDTMQFIKPDVSTVCMGMAASMGAFLLASGAPGKRHCLPNAKVMIHQPLGGFQGQASDFEIHAKEILATK
HRMNELLAFHTGKDIEIIAQDTDRDNFMRASEAVEYGIVDSVLTHRK

Sequences:

>Translated_207_residues
MSNPFAGNTDPISNALIPMVVEQTAKGERSYDIYSRLLKERVIFLTGPVEDHVANVIAAQLLFLESESPEKDIFIYINSP
GGSISAGMAIYDTMQFIKPDVSTVCMGMAASMGAFLLASGAPGKRHCLPNAKVMIHQPLGGFQGQASDFEIHAKEILATK
HRMNELLAFHTGKDIEIIAQDTDRDNFMRASEAVEYGIVDSVLTHRK
>Mature_206_residues
SNPFAGNTDPISNALIPMVVEQTAKGERSYDIYSRLLKERVIFLTGPVEDHVANVIAAQLLFLESESPEKDIFIYINSPG
GSISAGMAIYDTMQFIKPDVSTVCMGMAASMGAFLLASGAPGKRHCLPNAKVMIHQPLGGFQGQASDFEIHAKEILATKH
RMNELLAFHTGKDIEIIAQDTDRDNFMRASEAVEYGIVDSVLTHRK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=55.2631578947368, Blast_Score=234, Evalue=6e-62,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=75.5208333333333, Blast_Score=322, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=52.9100529100529, Blast_Score=216, Evalue=9e-57,
Organism=Drosophila melanogaster, GI20129427, Length=201, Percent_Identity=53.2338308457711, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_PSYIN (A1SUW7)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942881.1
- ProteinModelPortal:   A1SUW7
- SMR:   A1SUW7
- STRING:   A1SUW7
- MEROPS:   S14.001
- GeneID:   4626024
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1465
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   A1SUW7
- BioCyc:   PING357804:PING_1465-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22644; Mature: 22513

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 111-111 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPFAGNTDPISNALIPMVVEQTAKGERSYDIYSRLLKERVIFLTGPVEDHVANVIAAQ
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
LLFLESESPEKDIFIYINSPGGSISAGMAIYDTMQFIKPDVSTVCMGMAASMGAFLLASG
HHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECC
APGKRHCLPNAKVMIHQPLGGFQGQASDFEIHAKEILATKHRMNELLAFHTGKDIEIIAQ
CCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DTDRDNFMRASEAVEYGIVDSVLTHRK
CCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNPFAGNTDPISNALIPMVVEQTAKGERSYDIYSRLLKERVIFLTGPVEDHVANVIAAQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
LLFLESESPEKDIFIYINSPGGSISAGMAIYDTMQFIKPDVSTVCMGMAASMGAFLLASG
HHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECC
APGKRHCLPNAKVMIHQPLGGFQGQASDFEIHAKEILATKHRMNELLAFHTGKDIEIIAQ
CCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DTDRDNFMRASEAVEYGIVDSVLTHRK
CCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA