Click here to switch to the map view.

The map label for this gene is glyA

Identifier: 119945174

GI number: 119945174

Start: 1771646

End: 1772911

Strand: Direct

Name: glyA

Synonym: Ping_1438

Alternate gene names: 119945174

Gene position: 1771646-1772911 (Clockwise)

Preceding gene: 119945172

Following gene: 119945175

Centisome position: 38.86

GC content: 45.18

Gene sequence:

>1266_bases
ATGTTTAACCGTGATATGAATATTGCCGATTATGATCCAGAATTATGGCAGTCAATAACTGATGAAGTTCAGCGCCAAGA
AGACCATATTGAACTGATTGCATCAGAAAATTACACCAGCCCACGTGTAATGGAAGCGCAAGGCAGTCAGTTAACTAATA
AATACGCAGAAGGTTACCCGGGTAAACGTTATTACGGCGGTTGTGAATACGTTGATGTGGCTGAATCTTTAGCTATCGAA
CGTGCTAAATCTTTATTTGGTGCTGATTATGCAAACGTCCAGCCTCACTCGGGTTCGCAGGCTAATGCAGCCGTTTATCA
GGCGCTTTGTGCACCGGGTGATACTATTCTGGGCATGAGTCTTGCCCATGGTGGACATTTAACCCACGGTTCCCACGTCA
GTTTTTCTGGTAAAATGTACAATGCTGTGCAATATGGAATCACCCCTGAAACGGGTATTCTAGATTATGCGGAAATTGAA
CGTCTTGCTGTCGAACATAAACCAACCATGATTATTGCAGGGTTTTCTGCTTATTCGGGTATTGTTGACTGGGCCAAATT
TCGCGAAATAGCGGATAAAGTAGGCGCTTATCTGTTTGTTGATATGGCGCACGTTGCAGGGCTAGTGGCTGCGGGTCTTT
ACCCGAATCCAGTGCCTTTTGCCGATGTGGTGACTACGACAACGCATAAAACCTTAGGCGGTCCGCGTGGCGGCCTGATC
CTTGCTAAAGCCAATGAAGCCATTGAGAAAAAATTAAACTCAGCGGTTTTCCCAGGCCAGCAAGGTGGTCCACTAATGCA
CGTTATTGCAGCTAAAGCGGTTGCATTTAAAGAGTGTGCTGAACCTGAATTTGCTGTTTACCAGCAACAGGTTTTAGATA
ATGCTAAAGCCATGGTTAAATCATTCCTGGCGCGTGGTTACAAAATCGTTTCTGGCGGTACTGAAAACCATTTATTCCTG
GTTGATTTAATCGCTCAGGATATCACCGGTAAAGAAGCGGATGCCGCCTTAGGTAATGCGCATATTACGGTTAACAAAAA
CTCAGTGCCAAATGATCCCCGTTCTCCTTTTGTGACTTCAGGTTTACGTATTGGTACGCCGGCACTCGCACGTCGTGGTG
TTAATGCACAACAATCTGCTGAGCTTGCGTTATGGATGTGTGACGTTCTTGATGCAATCAAAGATGAAGCTAAACTTGCG
ACCACCATTACAGCGGTTAAAGTTAAAGTGGCCGCTCTTTGTAAAGCTTGCCCTGTTTACGGATAA

Upstream 100 bases:

>100_bases
ATTATTCATTTGTTTACGCTATGCAACAGGGTAAGATTAGGTAAAATTTGTTACATCAATAAATCAGCCGATTTAAAACC
AGACCCAGTAGGAGTTATGC

Downstream 100 bases:

>100_bases
TCTTTTAATAATAAGCACTCAAAAGCTACGCATTGCGTAGCTTTTTTTTACCCTTTTTTTGACTCTATAAAGCAAATTAC
TGTTAAAACAGGCGCTAAAC

Product: glycine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MFNRDMNIADYDPELWQSITDEVQRQEDHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAESLAIE
RAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMSLAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDYAEIE
RLAVEHKPTMIIAGFSAYSGIVDWAKFREIADKVGAYLFVDMAHVAGLVAAGLYPNPVPFADVVTTTTHKTLGGPRGGLI
LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVKSFLARGYKIVSGGTENHLFL
VDLIAQDITGKEADAALGNAHITVNKNSVPNDPRSPFVTSGLRIGTPALARRGVNAQQSAELALWMCDVLDAIKDEAKLA
TTITAVKVKVAALCKACPVYG

Sequences:

>Translated_421_residues
MFNRDMNIADYDPELWQSITDEVQRQEDHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAESLAIE
RAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMSLAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDYAEIE
RLAVEHKPTMIIAGFSAYSGIVDWAKFREIADKVGAYLFVDMAHVAGLVAAGLYPNPVPFADVVTTTTHKTLGGPRGGLI
LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVKSFLARGYKIVSGGTENHLFL
VDLIAQDITGKEADAALGNAHITVNKNSVPNDPRSPFVTSGLRIGTPALARRGVNAQQSAELALWMCDVLDAIKDEAKLA
TTITAVKVKVAALCKACPVYG
>Mature_421_residues
MFNRDMNIADYDPELWQSITDEVQRQEDHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAESLAIE
RAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMSLAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDYAEIE
RLAVEHKPTMIIAGFSAYSGIVDWAKFREIADKVGAYLFVDMAHVAGLVAAGLYPNPVPFADVVTTTTHKTLGGPRGGLI
LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVKSFLARGYKIVSGGTENHLFL
VDLIAQDITGKEADAALGNAHITVNKNSVPNDPRSPFVTSGLRIGTPALARRGVNAQQSAELALWMCDVLDAIKDEAKLA
TTITAVKVKVAALCKACPVYG

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=388, Percent_Identity=47.9381443298969, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI261862352, Length=388, Percent_Identity=48.4536082474227, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI261862350, Length=388, Percent_Identity=48.4536082474227, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI261862348, Length=388, Percent_Identity=48.4536082474227, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI261862346, Length=388, Percent_Identity=47.4226804123711, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI22547186, Length=429, Percent_Identity=43.5897435897436, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI22547189, Length=416, Percent_Identity=41.3461538461538, Blast_Score=278, Evalue=6e-75,
Organism=Escherichia coli, GI1788902, Length=421, Percent_Identity=75.0593824228028, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=392, Percent_Identity=47.4489795918367, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=392, Percent_Identity=47.4489795918367, Blast_Score=348, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=433, Percent_Identity=42.4942263279446, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=44.0298507462687, Blast_Score=343, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640005, Length=414, Percent_Identity=48.0676328502416, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=414, Percent_Identity=48.0676328502416, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_PSYIN (A1SUU0)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942854.1
- ProteinModelPortal:   A1SUU0
- SMR:   A1SUU0
- STRING:   A1SUU0
- GeneID:   4625500
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1438
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   INNEATI
- PhylomeDB:   A1SUU0
- BioCyc:   PING357804:PING_1438-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45184; Mature: 45184

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNRDMNIADYDPELWQSITDEVQRQEDHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCCCEECCCCHHHHHHHHCCCC
GKRYYGGCEYVDVAESLAIERAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
LAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDYAEIERLAVEHKPTMIIAGFSAYSG
ECCCCCCCCCCCEEECCCEEEHEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHH
IVDWAKFREIADKVGAYLFVDMAHVAGLVAAGLYPNPVPFADVVTTTTHKTLGGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCEE
LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVK
EEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SFLARGYKIVSGGTENHLFLVDLIAQDITGKEADAALGNAHITVNKNSVPNDPRSPFVTS
HHHHCCEEEEECCCCCCEEEHHHHHHHCCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHC
GLRIGTPALARRGVNAQQSAELALWMCDVLDAIKDEAKLATTITAVKVKVAALCKACPVY
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
G
C
>Mature Secondary Structure
MFNRDMNIADYDPELWQSITDEVQRQEDHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCCCEECCCCHHHHHHHHCCCC
GKRYYGGCEYVDVAESLAIERAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
LAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDYAEIERLAVEHKPTMIIAGFSAYSG
ECCCCCCCCCCCEEECCCEEEHEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHH
IVDWAKFREIADKVGAYLFVDMAHVAGLVAAGLYPNPVPFADVVTTTTHKTLGGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCEE
LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVK
EEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SFLARGYKIVSGGTENHLFLVDLIAQDITGKEADAALGNAHITVNKNSVPNDPRSPFVTS
HHHHCCEEEEECCCCCCEEEHHHHHHHCCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHC
GLRIGTPALARRGVNAQQSAELALWMCDVLDAIKDEAKLATTITAVKVKVAALCKACPVY
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA