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The map label for this gene is cobB [H]

Identifier: 119945142

GI number: 119945142

Start: 1726941

End: 1727696

Strand: Direct

Name: cobB [H]

Synonym: Ping_1406

Alternate gene names: 119945142

Gene position: 1726941-1727696 (Clockwise)

Preceding gene: 119945141

Following gene: 119945143

Centisome position: 37.87

GC content: 39.29

Gene sequence:

>756_bases
TTGTCATTCCATCAATATAAAAAAATAGTCGTGTTAACCGGTGCCGGCGTATCCGCCGAATCTGGTATTCAAACCTTTCG
AGATACGGATGGCCTATGGGAAAACCACAAATTAGAGGATGTAGCAACCGTAGAGGGTTATAAAAAAGATCCGGAATTGG
TACTGGAGTTTTATAATCAACGTCGTCGAGATTTCTGTTCAGGGCATAAAAAACCTAATGCTGCTCATTTAGCCTTAGCA
GAATTAGAAGAGAAGTTTGATGGTGAGTTTTTACTGGTAACACAAAATATAGATAATTTACATGAGCAGGCAGGCTCTAA
AAATATCATTCATATGCACGGAGAACTATTAAAGTCTCGTTGCCCTACAAGCAATCAACTTACTGAATGTTTCAATGATA
TTGAAACCAGTAATTTTTGCCACTGTTGCCAATATCCATCGACATTACGTCCACATATTGTTTGGTTTGGTGAAATGCCG
CTTGGTTTAGATATTATTTATCATCATTTATCACAAGCAGATCTGTTTATTTCGATTGGCACCTCCGGCACGGTTTATCC
TGCCGCTGGATTTGTTGAAGAAGCTAAAAGTGTCGGTGCATTTTCCATTGAGTTAAATTTAGAAGCGAGTGAAATTCATA
GCCACTTTGACCAGGTTATTTGTGGTAAAGCCACAAGCGTCGTCCCTGATTTGGTTAAGACTATATTAGCAAGCCAAACT
ACTGAAGATACCGAGTCGAGCGCGATCAAAGTGTAA

Upstream 100 bases:

>100_bases
TTAGCAAACTTCCAAATATAAAAACAGATCCTCAGTTTTATAGGTTAAAAATAGGTTGAGTCATTCTAAATAAGCGGATA
GCAAGCTAGAGAGGTGTTTT

Downstream 100 bases:

>100_bases
CAGGATGAGAAGGGTGATTCCCTTTTTAAGTATTCGCCTTCGAGAGAGTTTCCCAAGGGTAAAATGATCAATAATAAACG
AGACGCTTCGTTGTGTTAGA

Product: 5,6-dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSFHQYKKIVVLTGAGVSAESGIQTFRDTDGLWENHKLEDVATVEGYKKDPELVLEFYNQRRRDFCSGHKKPNAAHLALA
ELEEKFDGEFLLVTQNIDNLHEQAGSKNIIHMHGELLKSRCPTSNQLTECFNDIETSNFCHCCQYPSTLRPHIVWFGEMP
LGLDIIYHHLSQADLFISIGTSGTVYPAAGFVEEAKSVGAFSIELNLEASEIHSHFDQVICGKATSVVPDLVKTILASQT
TEDTESSAIKV

Sequences:

>Translated_251_residues
MSFHQYKKIVVLTGAGVSAESGIQTFRDTDGLWENHKLEDVATVEGYKKDPELVLEFYNQRRRDFCSGHKKPNAAHLALA
ELEEKFDGEFLLVTQNIDNLHEQAGSKNIIHMHGELLKSRCPTSNQLTECFNDIETSNFCHCCQYPSTLRPHIVWFGEMP
LGLDIIYHHLSQADLFISIGTSGTVYPAAGFVEEAKSVGAFSIELNLEASEIHSHFDQVICGKATSVVPDLVKTILASQT
TEDTESSAIKV
>Mature_250_residues
SFHQYKKIVVLTGAGVSAESGIQTFRDTDGLWENHKLEDVATVEGYKKDPELVLEFYNQRRRDFCSGHKKPNAAHLALAE
LEEKFDGEFLLVTQNIDNLHEQAGSKNIIHMHGELLKSRCPTSNQLTECFNDIETSNFCHCCQYPSTLRPHIVWFGEMPL
GLDIIYHHLSQADLFISIGTSGTVYPAAGFVEEAKSVGAFSIELNLEASEIHSHFDQVICGKATSVVPDLVKTILASQTT
EDTESSAIKV

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=237, Percent_Identity=36.7088607594937, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI6912664, Length=255, Percent_Identity=34.5098039215686, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=35.5371900826446, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI7657575, Length=249, Percent_Identity=29.718875502008, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI6912660, Length=205, Percent_Identity=30.7317073170732, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI63054862, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI308199517, Length=229, Percent_Identity=60.6986899563319, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17541892, Length=203, Percent_Identity=32.512315270936, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27929; Mature: 27797

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFHQYKKIVVLTGAGVSAESGIQTFRDTDGLWENHKLEDVATVEGYKKDPELVLEFYNQ
CCCHHCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHH
RRRDFCSGHKKPNAAHLALAELEEKFDGEFLLVTQNIDNLHEQAGSKNIIHMHGELLKSR
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEHHHHHHHHH
CPTSNQLTECFNDIETSNFCHCCQYPSTLRPHIVWFGEMPLGLDIIYHHLSQADLFISIG
CCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEC
TSGTVYPAAGFVEEAKSVGAFSIELNLEASEIHSHFDQVICGKATSVVPDLVKTILASQT
CCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TEDTESSAIKV
CCCCCCCCCCC
>Mature Secondary Structure 
SFHQYKKIVVLTGAGVSAESGIQTFRDTDGLWENHKLEDVATVEGYKKDPELVLEFYNQ
CCHHCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHH
RRRDFCSGHKKPNAAHLALAELEEKFDGEFLLVTQNIDNLHEQAGSKNIIHMHGELLKSR
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEHHHHHHHHH
CPTSNQLTECFNDIETSNFCHCCQYPSTLRPHIVWFGEMPLGLDIIYHHLSQADLFISIG
CCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEC
TSGTVYPAAGFVEEAKSVGAFSIELNLEASEIHSHFDQVICGKATSVVPDLVKTILASQT
CCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TEDTESSAIKV
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]