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The map label for this gene is gmhA

Identifier: 119945079

GI number: 119945079

Start: 1655002

End: 1655577

Strand: Direct

Name: gmhA

Synonym: Ping_1335

Alternate gene names: 119945079

Gene position: 1655002-1655577 (Clockwise)

Preceding gene: 119945078

Following gene: 119945080

Centisome position: 36.3

GC content: 39.06

Gene sequence:

>576_bases
ATGAATCTATCAATAATTAAAGCTGAACTGTTAGAAGCTGAAAAAGTATTACAGGCATTTTTAGCCGACGAGCAAAACTT
AAAAAATATTGAAAAAGCGGCTAGTTTACTCGCTGACTCCTTTAAAAATGACGGTAAAGTGCTTTCCTGCGGTAATGGCG
GTTCACATTGTGACGCGATGCATTTCGCAGAGGAATTGACTGGGCGATACCGCGAACATAGACCCGCCTATCCCGCTATT
GCTATTTCAGATCCAAGTCATATTTCCTGTGTTGGTAATGATTACGGTTATGATGCGATTTTTGCGCGTTACCTGGAGGG
TGTGGGGCGCAAAGGTGATGTGTTATTTTGCTTATCAACCAGTGGTAATTCTAAAAATATATTAAATGCAATCGAAGTGG
CAAAAGCAAAAGGTATTTCTGTTATTGCATTAACCGGTAAAGATGGCGGCAAAATGTCGGGGCTTGCTGATGTTGAGATC
CGTGTACCTCATTTTGGTTTTGCAGATCGTATCCAAGAGGTTCATATCAAGATTATTCATATTTTGATTTATTTAATAGA
AAAGAAAATGGCTTAA

Upstream 100 bases:

>100_bases
TCAACCTGTTGATTCCTGCGTCTTCAAGCAGTTTGGGTAAAGACCTATTCTGTATTAATGCATTTTTGCCCTGAATAAAA
ATTAAATAAGAAGAGATATA

Downstream 100 bases:

>100_bases
ACTCAATTCCTTCGTTTTTAATGTTAAGTAAGTAAAGTTTTATGCCAAGGCCGCAATAAAAAAAAGCGGAATTGAGTTAA
CAGAGAGTAGGACTTATAAA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MNLSIIKAELLEAEKVLQAFLADEQNLKNIEKAASLLADSFKNDGKVLSCGNGGSHCDAMHFAEELTGRYREHRPAYPAI
AISDPSHISCVGNDYGYDAIFARYLEGVGRKGDVLFCLSTSGNSKNILNAIEVAKAKGISVIALTGKDGGKMSGLADVEI
RVPHFGFADRIQEVHIKIIHILIYLIEKKMA

Sequences:

>Translated_191_residues
MNLSIIKAELLEAEKVLQAFLADEQNLKNIEKAASLLADSFKNDGKVLSCGNGGSHCDAMHFAEELTGRYREHRPAYPAI
AISDPSHISCVGNDYGYDAIFARYLEGVGRKGDVLFCLSTSGNSKNILNAIEVAKAKGISVIALTGKDGGKMSGLADVEI
RVPHFGFADRIQEVHIKIIHILIYLIEKKMA
>Mature_191_residues
MNLSIIKAELLEAEKVLQAFLADEQNLKNIEKAASLLADSFKNDGKVLSCGNGGSHCDAMHFAEELTGRYREHRPAYPAI
AISDPSHISCVGNDYGYDAIFARYLEGVGRKGDVLFCLSTSGNSKNILNAIEVAKAKGISVIALTGKDGGKMSGLADVEI
RVPHFGFADRIQEVHIKIIHILIYLIEKKMA

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=190, Percent_Identity=70.5263157894737, Blast_Score=283, Evalue=4e-78,
Organism=Escherichia coli, GI1789539, Length=165, Percent_Identity=40.6060606060606, Blast_Score=134, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_PSYIN (A1SUJ5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942759.1
- ProteinModelPortal:   A1SUJ5
- SMR:   A1SUJ5
- STRING:   A1SUJ5
- GeneID:   4626448
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1335
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   ANDLGYD
- PhylomeDB:   A1SUJ5
- BioCyc:   PING357804:PING_1335-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20761; Mature: 20761

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS51464 SIS

Important sites: BINDING 65-65 BINDING 124-124 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSIIKAELLEAEKVLQAFLADEQNLKNIEKAASLLADSFKNDGKVLSCGNGGSHCDAM
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
HFAEELTGRYREHRPAYPAIAISDPSHISCVGNDYGYDAIFARYLEGVGRKGDVLFCLST
HHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGNSKNILNAIEVAKAKGISVIALTGKDGGKMSGLADVEIRVPHFGFADRIQEVHIKIIH
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
ILIYLIEKKMA
HHHHHHHHHCC
>Mature Secondary Structure
MNLSIIKAELLEAEKVLQAFLADEQNLKNIEKAASLLADSFKNDGKVLSCGNGGSHCDAM
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
HFAEELTGRYREHRPAYPAIAISDPSHISCVGNDYGYDAIFARYLEGVGRKGDVLFCLST
HHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGNSKNILNAIEVAKAKGISVIALTGKDGGKMSGLADVEIRVPHFGFADRIQEVHIKIIH
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
ILIYLIEKKMA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA