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The map label for this gene is thrB [H]

Identifier: 119945022

GI number: 119945022

Start: 1583352

End: 1584308

Strand: Direct

Name: thrB [H]

Synonym: Ping_1276

Alternate gene names: 119945022

Gene position: 1583352-1584308 (Clockwise)

Preceding gene: 119945021

Following gene: 119945023

Centisome position: 34.73

GC content: 43.05

Gene sequence:

>957_bases
ATGAGTGTTGTGGCATATGCTCCAGCGTCGACTGCAAATGTTAGTGTAGGTTTTGATGTATTGGGAGGGGCACTTACCCC
TATTAATGGCGATTTATTTGGTGACCGGGTAAAGATATCAAGCAGTGATATTGCTTTTTCACTCGACTGTGTTGGCCGTT
ACGCTCATAAATTACCCGTAGATTTTAAATTGAATATTGTCTATCAATGTTATTTAGGTTATCAGGCAGCATTAAAAAAA
CTGAATCAAAAAATATTGCCGGTTAAAATGACGCTTGAGAAAAATTTACCCGTTGGCAGTGGCTTAGGCTCGAGCTCTAG
TTCAATTGTTGCCGCATTAGAAGCATTAAATGCATGGCATGATTACCCTATTGATAAAACGACTCTACTTCTTTTAATGG
GCGAGATGGAAGGACAAATCAGCGGTAGTATACATTATGATAATGTTGCTCCCTGTTACCTTGGCGGGATGCAGTTGATG
ATTAATGAAGGTGGGGTTATCAGCGAAACGCTGCCTTCCTTTAAAGAATGGTATTGGGTCGTCGCCTACCCGGGGATAAC
TATTTCAACTGCGGCTGCACGAAATATTTTACCTGCGCAATATCGTCTCAGCGAAGCCTTAACCTATGGTCGACGTTTAG
GTGCCTTTGTCCATGCCTGTCACACTGCTCAGCCTGAGCTTGCAGCCAAAATGCTCAAGGATGTTATTGCTGAGCCCTAT
CGCTCACAACTTATTCCAGGTTTTAAAGAAGCGCGTCTTGTGGCAGAGCAAAGCGGGGCATTAGCGATGGGTATTTCGGG
TTCAGGTCCCACAGTATTTGCGGTAATGACTGATCTTATCCAAGCGCAATCATTACAACATTGGTTAACAGAAAATTTTC
TTCAAAATGATGACGGGTTTTGTCATATTTGCCATCTCGATGAACAAGGCGCACGCGTGTTAGGAACAGAACTATGA

Upstream 100 bases:

>100_bases
CCATTAGTTTTACGTGGTTACGGTGCTGGATCAGAAGTGACTGCTGCGGGTGTTTTTGCCGATGTATTACGTACTTTAAA
TTGGAAACAGGAGTTTTAAG

Downstream 100 bases:

>100_bases
AATTATACAACATCAAAGACAACAGTGAGCAAGTCAACTTTCAACAAGCTGTTAAGCAAGGTTTAGGACGTGGCCAGGGA
CTTTTTTTTCCAAAAGAAAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSVVAYAPASTANVSVGFDVLGGALTPINGDLFGDRVKISSSDIAFSLDCVGRYAHKLPVDFKLNIVYQCYLGYQAALKK
LNQKILPVKMTLEKNLPVGSGLGSSSSSIVAALEALNAWHDYPIDKTTLLLLMGEMEGQISGSIHYDNVAPCYLGGMQLM
INEGGVISETLPSFKEWYWVVAYPGITISTAAARNILPAQYRLSEALTYGRRLGAFVHACHTAQPELAAKMLKDVIAEPY
RSQLIPGFKEARLVAEQSGALAMGISGSGPTVFAVMTDLIQAQSLQHWLTENFLQNDDGFCHICHLDEQGARVLGTEL

Sequences:

>Translated_318_residues
MSVVAYAPASTANVSVGFDVLGGALTPINGDLFGDRVKISSSDIAFSLDCVGRYAHKLPVDFKLNIVYQCYLGYQAALKK
LNQKILPVKMTLEKNLPVGSGLGSSSSSIVAALEALNAWHDYPIDKTTLLLLMGEMEGQISGSIHYDNVAPCYLGGMQLM
INEGGVISETLPSFKEWYWVVAYPGITISTAAARNILPAQYRLSEALTYGRRLGAFVHACHTAQPELAAKMLKDVIAEPY
RSQLIPGFKEARLVAEQSGALAMGISGSGPTVFAVMTDLIQAQSLQHWLTENFLQNDDGFCHICHLDEQGARVLGTEL
>Mature_317_residues
SVVAYAPASTANVSVGFDVLGGALTPINGDLFGDRVKISSSDIAFSLDCVGRYAHKLPVDFKLNIVYQCYLGYQAALKKL
NQKILPVKMTLEKNLPVGSGLGSSSSSIVAALEALNAWHDYPIDKTTLLLLMGEMEGQISGSIHYDNVAPCYLGGMQLMI
NEGGVISETLPSFKEWYWVVAYPGITISTAAARNILPAQYRLSEALTYGRRLGAFVHACHTAQPELAAKMLKDVIAEPYR
SQLIPGFKEARLVAEQSGALAMGISGSGPTVFAVMTDLIQAQSLQHWLTENFLQNDDGFCHICHLDEQGARVLGTEL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=312, Percent_Identity=58.6538461538462, Blast_Score=381, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34361; Mature: 34230

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVAYAPASTANVSVGFDVLGGALTPINGDLFGDRVKISSSDIAFSLDCVGRYAHKLPV
CCEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCC
DFKLNIVYQCYLGYQAALKKLNQKILPVKMTLEKNLPVGSGLGSSSSSIVAALEALNAWH
CEEEEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
DYPIDKTTLLLLMGEMEGQISGSIHYDNVAPCYLGGMQLMINEGGVISETLPSFKEWYWV
CCCCCCCEEEEEEECCCCCEECEEEECCCCCHHHCCEEEEEECCCCHHHHHHHHHHCEEE
VAYPGITISTAAARNILPAQYRLSEALTYGRRLGAFVHACHTAQPELAAKMLKDVIAEPY
EEECCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
RSQLIPGFKEARLVAEQSGALAMGISGSGPTVFAVMTDLIQAQSLQHWLTENFLQNDDGF
HHHCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
CHICHLDEQGARVLGTEL
EEEEEECCCCCCHHCCCC
>Mature Secondary Structure 
SVVAYAPASTANVSVGFDVLGGALTPINGDLFGDRVKISSSDIAFSLDCVGRYAHKLPV
CEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCC
DFKLNIVYQCYLGYQAALKKLNQKILPVKMTLEKNLPVGSGLGSSSSSIVAALEALNAWH
CEEEEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
DYPIDKTTLLLLMGEMEGQISGSIHYDNVAPCYLGGMQLMINEGGVISETLPSFKEWYWV
CCCCCCCEEEEEEECCCCCEECEEEECCCCCHHHCCEEEEEECCCCHHHHHHHHHHCEEE
VAYPGITISTAAARNILPAQYRLSEALTYGRRLGAFVHACHTAQPELAAKMLKDVIAEPY
EEECCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
RSQLIPGFKEARLVAEQSGALAMGISGSGPTVFAVMTDLIQAQSLQHWLTENFLQNDDGF
HHHCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
CHICHLDEQGARVLGTEL
EEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA