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The map label for this gene is thrC [H]

Identifier: 119945023

GI number: 119945023

Start: 1584305

End: 1585582

Strand: Direct

Name: thrC [H]

Synonym: Ping_1277

Alternate gene names: 119945023

Gene position: 1584305-1585582 (Clockwise)

Preceding gene: 119945022

Following gene: 119945024

Centisome position: 34.75

GC content: 39.67

Gene sequence:

>1278_bases
ATGAAATTATACAACATCAAAGACAACAGTGAGCAAGTCAACTTTCAACAAGCTGTTAAGCAAGGTTTAGGACGTGGCCA
GGGACTTTTTTTTCCAAAAGAAATCACGCCTCTTGATAATATTGATGCACTTTTGAAAATGAATTTAGTTGATCGCTCGA
CTGAAATTTTATCTCACTTAATTGGTGATGAGTTAAGTAAAGAAGTGCTTCACAGTATTGTATCAAAAGCTTTTACTTTC
GATGCGCCGGTAAAAAAAGTGACGGATAACATTAATGCCTTGGAACTTTTTCATGGTCCAACCTTAGCATTTAAAGATTT
TGGCGGTCGTTTTATGGCCCAGTGTTTAGCCGAATTTAAGGGAGACGATAAAATTACTATTTTAACGGCAACCTCTGGTG
ATACTGGTGCCGCTGTTGCTCATGCCTTTTTCAATATGGAAAACATTAATGTTGTTATTCTGTACCCAAAAGGAAAAATC
AGCCCGCTGCAAGAAAAACTGTTCTGTACATTAGGTGGTAATATTACCACTGTCGCTATTGAAGGCACCTTTGATGATTG
CCAAACAATGGTTAAGCAGGCTTTTGATGATCAAGAATTAAAGCAGGCCGTTGGCCTAAACTCAGCAAATTCAATCAATA
TTAGCCGCCTGCTGGCACAAATCTGTTACTACTTTGAAGCCCTGGCGCAGCTATCTGCCGCGCAGCGCAATAATTTAGTT
GTTTCTGTACCCAGTGGTAATTTTGGCGATTTAACTGCGGGTTTGCTCGCTAAATCTTTAGGGTTGCCGATTAAACGTTT
TATCGCAGCGACCAATGAAAATGATACGGTTCCCCGTTACCTGGAGGAAGGAACTTGGACGCCTAAAGCGACGGTTGCTA
CGATTTCAAATGCGATGGATGTCAGTCAGCCCAATAATTGGCCACGTATTGAAGAATTATTTAAAATACAAGGTTGGTCA
CTATCAGAACTTGGGTACGGCATGTTAAACGATGCACAAACGCGTGCCAGTCTGCTTGAATTGGATAATTTAGGTTACTT
ATGTGAACCTCATGGCGCAATTGCTTACGCTGAACTTACTAAACAATTAAAAGAAGATGAAACAGGTTTATTCTTGTGTA
CAGCGCATCCTGCTAAGTTTAAAGAAAGCGTAGAAGATATTTTAGGGCGTGATATTTTCATTCCGGAAGAGCTTGCTTCT
CGTGCGAATTTAGATTTATTATCAAAAGAATTTCCTGCTGATTTTGCAATGGTTAGAGCACTATTGATGTCTTTGTAA

Upstream 100 bases:

>100_bases
TACAACATTGGTTAACAGAAAATTTTCTTCAAAATGATGACGGGTTTTGTCATATTTGCCATCTCGATGAACAAGGCGCA
CGCGTGTTAGGAACAGAACT

Downstream 100 bases:

>100_bases
TAGTATTTGTAAATAAAAATAAGATTTGTAAATAAAAAAGGGCGGTTATTAACGCCCTTTTTTGGGGAGCTAAAATGAGT
AAAGTACTAAAAGATCTTCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKLYNIKDNSEQVNFQQAVKQGLGRGQGLFFPKEITPLDNIDALLKMNLVDRSTEILSHLIGDELSKEVLHSIVSKAFTF
DAPVKKVTDNINALELFHGPTLAFKDFGGRFMAQCLAEFKGDDKITILTATSGDTGAAVAHAFFNMENINVVILYPKGKI
SPLQEKLFCTLGGNITTVAIEGTFDDCQTMVKQAFDDQELKQAVGLNSANSINISRLLAQICYYFEALAQLSAAQRNNLV
VSVPSGNFGDLTAGLLAKSLGLPIKRFIAATNENDTVPRYLEEGTWTPKATVATISNAMDVSQPNNWPRIEELFKIQGWS
LSELGYGMLNDAQTRASLLELDNLGYLCEPHGAIAYAELTKQLKEDETGLFLCTAHPAKFKESVEDILGRDIFIPEELAS
RANLDLLSKEFPADFAMVRALLMSL

Sequences:

>Translated_425_residues
MKLYNIKDNSEQVNFQQAVKQGLGRGQGLFFPKEITPLDNIDALLKMNLVDRSTEILSHLIGDELSKEVLHSIVSKAFTF
DAPVKKVTDNINALELFHGPTLAFKDFGGRFMAQCLAEFKGDDKITILTATSGDTGAAVAHAFFNMENINVVILYPKGKI
SPLQEKLFCTLGGNITTVAIEGTFDDCQTMVKQAFDDQELKQAVGLNSANSINISRLLAQICYYFEALAQLSAAQRNNLV
VSVPSGNFGDLTAGLLAKSLGLPIKRFIAATNENDTVPRYLEEGTWTPKATVATISNAMDVSQPNNWPRIEELFKIQGWS
LSELGYGMLNDAQTRASLLELDNLGYLCEPHGAIAYAELTKQLKEDETGLFLCTAHPAKFKESVEDILGRDIFIPEELAS
RANLDLLSKEFPADFAMVRALLMSL
>Mature_425_residues
MKLYNIKDNSEQVNFQQAVKQGLGRGQGLFFPKEITPLDNIDALLKMNLVDRSTEILSHLIGDELSKEVLHSIVSKAFTF
DAPVKKVTDNINALELFHGPTLAFKDFGGRFMAQCLAEFKGDDKITILTATSGDTGAAVAHAFFNMENINVVILYPKGKI
SPLQEKLFCTLGGNITTVAIEGTFDDCQTMVKQAFDDQELKQAVGLNSANSINISRLLAQICYYFEALAQLSAAQRNNLV
VSVPSGNFGDLTAGLLAKSLGLPIKRFIAATNENDTVPRYLEEGTWTPKATVATISNAMDVSQPNNWPRIEELFKIQGWS
LSELGYGMLNDAQTRASLLELDNLGYLCEPHGAIAYAELTKQLKEDETGLFLCTAHPAKFKESVEDILGRDIFIPEELAS
RANLDLLSKEFPADFAMVRALLMSL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=435, Percent_Identity=28.9655172413793, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI153792148, Length=427, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1786185, Length=426, Percent_Identity=68.075117370892, Blast_Score=583, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319901, Length=445, Percent_Identity=32.3595505617978, Blast_Score=202, Evalue=1e-52,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46713; Mature: 46713

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNIKDNSEQVNFQQAVKQGLGRGQGLFFPKEITPLDNIDALLKMNLVDRSTEILSHL
CEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELSKEVLHSIVSKAFTFDAPVKKVTDNINALELFHGPTLAFKDFGGRFMAQCLAEFK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDDKITILTATSGDTGAAVAHAFFNMENINVVILYPKGKISPLQEKLFCTLGGNITTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEEEEECCCEEEEEE
EGTFDDCQTMVKQAFDDQELKQAVGLNSANSINISRLLAQICYYFEALAQLSAAQRNNLV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
VSVPSGNFGDLTAGLLAKSLGLPIKRFIAATNENDTVPRYLEEGTWTPKATVATISNAMD
EECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHC
VSQPNNWPRIEELFKIQGWSLSELGYGMLNDAQTRASLLELDNLGYLCEPHGAIAYAELT
CCCCCCCHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHHHHCCCCEECCCCCCHHHHHH
KQLKEDETGLFLCTAHPAKFKESVEDILGRDIFIPEELASRANLDLLSKEFPADFAMVRA
HHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHCCHHHHHHHH
LLMSL
HHHCC
>Mature Secondary Structure
MKLYNIKDNSEQVNFQQAVKQGLGRGQGLFFPKEITPLDNIDALLKMNLVDRSTEILSHL
CEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELSKEVLHSIVSKAFTFDAPVKKVTDNINALELFHGPTLAFKDFGGRFMAQCLAEFK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDDKITILTATSGDTGAAVAHAFFNMENINVVILYPKGKISPLQEKLFCTLGGNITTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEEEEECCCEEEEEE
EGTFDDCQTMVKQAFDDQELKQAVGLNSANSINISRLLAQICYYFEALAQLSAAQRNNLV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
VSVPSGNFGDLTAGLLAKSLGLPIKRFIAATNENDTVPRYLEEGTWTPKATVATISNAMD
EECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHC
VSQPNNWPRIEELFKIQGWSLSELGYGMLNDAQTRASLLELDNLGYLCEPHGAIAYAELT
CCCCCCCHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHHHHCCCCEECCCCCCHHHHHH
KQLKEDETGLFLCTAHPAKFKESVEDILGRDIFIPEELASRANLDLLSKEFPADFAMVRA
HHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHCCHHHHHHHH
LLMSL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]