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The map label for this gene is mbaA [H]

Identifier: 119944988

GI number: 119944988

Start: 1545733

End: 1548165

Strand: Direct

Name: mbaA [H]

Synonym: Ping_1239

Alternate gene names: 119944988

Gene position: 1545733-1548165 (Clockwise)

Preceding gene: 119944987

Following gene: 119944989

Centisome position: 33.9

GC content: 35.55

Gene sequence:

>2433_bases
ATGACGCTTAGAAAAAAAATAAGGTATATTATATTGCCGGTGATCATCGCTCTTTCTGCCATGATTTCTTTGCTTTATTA
TCATCTTTATAAGAATCAAATTATAGAGAATAAAATCACCCTGCTTAACGGTCGTCTTGAAAATCAATTATTGCACGCAG
AATACCAGCTTGATTATGTTAAAAGCTATTTAAGACAAAAAATTGAGAGCAAAGAAGCTTCTCTTATTTTTAATGCCAAA
CAAGGTGACAATAATCTGTCTGCCCCGGATATCACCGCGTTTCTTAATCTGTTTGTTAATCGAAAAAATAGCGCCAATAA
AAGTAATCATGTGATTAATGACTTTGTTATTTTTGATTCTTATAAAAAATTAATTGTTCATATTAATACGCGCGATCCCT
TCGCCAAGCCAATGTTAAAAACAACCACTAAAGCGGTGTTGGATCAGATCTTCGATCAAGCTGATCCGAACAAAAAAATC
TCTCAATATCACTATTTTCTTGATGACCCCTATATTAATAAAATGCCATCGTTATATATTATTCAGGCTTTTTCGCGCTA
TCAGCTATCTTCTAAATTATTCTATGAAAGTAACGAAGATACCTATTTAGCGCAAGCACAACTGGATCTCAATTTCTTTA
CAGAAGAAATTAGGGTGCTTATTGACGAAAATAATGGATATTTTAACTATCGGTTTATAAATAAAAATACCAATGCTGAT
AACTTTTCCTTCACTAGCACCCCATTTCAAGTGAATGATAACGGCGCTTATGAGGGCAGATTTGGAAGCTCATTATTTGA
TATTATATTAACACTGGATAAAAACTATTTTGCAGAGCAGTTAAATAATCTTATTGCTACATTTTTACTCCTCAATTTTA
TTGTCATTATATTAAGTTATTTGCTGCTTATTTGGCTCATTGACCAACAAATTATACTGCCTATCACCAAACTGGCTAAA
AGTATAAAGGAAGTTGAAGCTTCACTTGTTGTCGAGCTTAAGCCATTGACAACTAAGGACGAAGTTGCTGATTTAAATGA
AAGCTATATTTCACTTATTAATAAAATAAATACTCTGGCAAACAATGACTCACTGACGGGTCTTGCAAACAGGGGGAGCT
TTAACGAAAAGTTGTCCGCTATCATGGACGCCAGGCAAAAAAATAAAACCTACGTCGCACTTTTTTTTATCGATTTGGAT
AATTTTAAATATGTAAATGATACTTTTGGTCACGATACAGGAGATCGTTTACTGGTCGTTTTTAGCCAGAGGTTACAGCA
GTTACTAAGGGCTGAGGATAACTTCATTTCTGGCAATATGATTGATAGTATTGCCAGACTTGGTGGGGATGAGTTTGTTA
TTTTAATGAATGGATTACCCTCAATAGAGACGATCGAGAGTATCGGAAAACGCATTTGTGATTTATTTCATAATGGCTTT
AGGATTGGTGAAGAGCAATTTGATGTACATGCCAGTATCGGCATTGCTTATTCAAATGACCATCAAATCAATGGTGAGGG
ACTATTAACTCAAGCCGATGACGCCATGTATTTGGCCAAAAGAGCGGGTAAAAATAACTTTAAGCTTTTTTCTGATGAGA
TTAAAGAGAAAATGCTTTTTGAAAAAAATATCGAAAATGAGCTAATTGATGCGCACCGTGATAATAAATTACACTTGGTT
TTTATGCCCGCCTACTGTGCTGAAACACGCATACTAAGGGGGTATGAAATATTATTACGCTGCCCGAGTCTGCTGAATGT
AGGTATTGGGCCCGATGTTTTTATTCCGATTGCAGAAAATACAGATCTTATTTTAGCGATTGATTTATGGGTTGCACAAC
AAACTGTTATTAGGCTTAAAGAAGTCATCCATAAAAATAGATTTACAGGTTTCTTCTCGTTTAATGTCTCCTCTAAATCA
CTAAGAAATGATCGATTTTATACTACGCTAAAAGAATTTATCAATACTAGTGATATAAATCCTAAGCAGCTGGAACTTGA
AATAACAGAAACTTGCTTGATGCCGGATGATCATCAGGCGGTTGCCAGCCTTGACCAGCTTAAATCCTTAGGTGTGCGCA
TTGCGCTTGATGACTTTGGCACTGGATATACCTCATTTGGACAGATACTTAATTATCCTTTAGATACATTAAAAATTGAT
CGTTCCTTTGTGACTGATTTGCGCAATACCCCGGTTGGTCAAAAGCCCACTTTGGATATTATATTTGAGCTTGCAAAAGC
GTATCAGCTTAGTGTGATTGTTGAGGGCATTGAAACGCAAGCTGATTTTGAGCATGTTAAAACGTTGGGTTGTGATATTG
TGCAGGGTTTCTATTTTTCCAACCCGCGAACATGGACAGAGGTGCTGAAGCATTGTGGTAAATTACATCAAATAGATAAA
AGGCCCGATCAACAGAAAAATATTGCATGTTAG

Upstream 100 bases:

>100_bases
ATTCTAAAGCGTAGTTATAAATATAAACGCCTCCCTGAAAGCGATGTTATTATCCGTAACAAAATGGTCACATTATTACA
GACTCAAGAGTAGCTGAATT

Downstream 100 bases:

>100_bases
GTTAATATTATTCGCGTATAAACTCAGCCTTGGGTTTGTGATGTCTTTTTGACTTTAAACTGCCCTGGTGAATGGTATTC
GGGATTAATACAAAGGCGGG

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 810; Mature: 809

Protein sequence:

>810_residues
MTLRKKIRYIILPVIIALSAMISLLYYHLYKNQIIENKITLLNGRLENQLLHAEYQLDYVKSYLRQKIESKEASLIFNAK
QGDNNLSAPDITAFLNLFVNRKNSANKSNHVINDFVIFDSYKKLIVHINTRDPFAKPMLKTTTKAVLDQIFDQADPNKKI
SQYHYFLDDPYINKMPSLYIIQAFSRYQLSSKLFYESNEDTYLAQAQLDLNFFTEEIRVLIDENNGYFNYRFINKNTNAD
NFSFTSTPFQVNDNGAYEGRFGSSLFDIILTLDKNYFAEQLNNLIATFLLLNFIVIILSYLLLIWLIDQQIILPITKLAK
SIKEVEASLVVELKPLTTKDEVADLNESYISLINKINTLANNDSLTGLANRGSFNEKLSAIMDARQKNKTYVALFFIDLD
NFKYVNDTFGHDTGDRLLVVFSQRLQQLLRAEDNFISGNMIDSIARLGGDEFVILMNGLPSIETIESIGKRICDLFHNGF
RIGEEQFDVHASIGIAYSNDHQINGEGLLTQADDAMYLAKRAGKNNFKLFSDEIKEKMLFEKNIENELIDAHRDNKLHLV
FMPAYCAETRILRGYEILLRCPSLLNVGIGPDVFIPIAENTDLILAIDLWVAQQTVIRLKEVIHKNRFTGFFSFNVSSKS
LRNDRFYTTLKEFINTSDINPKQLELEITETCLMPDDHQAVASLDQLKSLGVRIALDDFGTGYTSFGQILNYPLDTLKID
RSFVTDLRNTPVGQKPTLDIIFELAKAYQLSVIVEGIETQADFEHVKTLGCDIVQGFYFSNPRTWTEVLKHCGKLHQIDK
RPDQQKNIAC

Sequences:

>Translated_810_residues
MTLRKKIRYIILPVIIALSAMISLLYYHLYKNQIIENKITLLNGRLENQLLHAEYQLDYVKSYLRQKIESKEASLIFNAK
QGDNNLSAPDITAFLNLFVNRKNSANKSNHVINDFVIFDSYKKLIVHINTRDPFAKPMLKTTTKAVLDQIFDQADPNKKI
SQYHYFLDDPYINKMPSLYIIQAFSRYQLSSKLFYESNEDTYLAQAQLDLNFFTEEIRVLIDENNGYFNYRFINKNTNAD
NFSFTSTPFQVNDNGAYEGRFGSSLFDIILTLDKNYFAEQLNNLIATFLLLNFIVIILSYLLLIWLIDQQIILPITKLAK
SIKEVEASLVVELKPLTTKDEVADLNESYISLINKINTLANNDSLTGLANRGSFNEKLSAIMDARQKNKTYVALFFIDLD
NFKYVNDTFGHDTGDRLLVVFSQRLQQLLRAEDNFISGNMIDSIARLGGDEFVILMNGLPSIETIESIGKRICDLFHNGF
RIGEEQFDVHASIGIAYSNDHQINGEGLLTQADDAMYLAKRAGKNNFKLFSDEIKEKMLFEKNIENELIDAHRDNKLHLV
FMPAYCAETRILRGYEILLRCPSLLNVGIGPDVFIPIAENTDLILAIDLWVAQQTVIRLKEVIHKNRFTGFFSFNVSSKS
LRNDRFYTTLKEFINTSDINPKQLELEITETCLMPDDHQAVASLDQLKSLGVRIALDDFGTGYTSFGQILNYPLDTLKID
RSFVTDLRNTPVGQKPTLDIIFELAKAYQLSVIVEGIETQADFEHVKTLGCDIVQGFYFSNPRTWTEVLKHCGKLHQIDK
RPDQQKNIAC
>Mature_809_residues
TLRKKIRYIILPVIIALSAMISLLYYHLYKNQIIENKITLLNGRLENQLLHAEYQLDYVKSYLRQKIESKEASLIFNAKQ
GDNNLSAPDITAFLNLFVNRKNSANKSNHVINDFVIFDSYKKLIVHINTRDPFAKPMLKTTTKAVLDQIFDQADPNKKIS
QYHYFLDDPYINKMPSLYIIQAFSRYQLSSKLFYESNEDTYLAQAQLDLNFFTEEIRVLIDENNGYFNYRFINKNTNADN
FSFTSTPFQVNDNGAYEGRFGSSLFDIILTLDKNYFAEQLNNLIATFLLLNFIVIILSYLLLIWLIDQQIILPITKLAKS
IKEVEASLVVELKPLTTKDEVADLNESYISLINKINTLANNDSLTGLANRGSFNEKLSAIMDARQKNKTYVALFFIDLDN
FKYVNDTFGHDTGDRLLVVFSQRLQQLLRAEDNFISGNMIDSIARLGGDEFVILMNGLPSIETIESIGKRICDLFHNGFR
IGEEQFDVHASIGIAYSNDHQINGEGLLTQADDAMYLAKRAGKNNFKLFSDEIKEKMLFEKNIENELIDAHRDNKLHLVF
MPAYCAETRILRGYEILLRCPSLLNVGIGPDVFIPIAENTDLILAIDLWVAQQTVIRLKEVIHKNRFTGFFSFNVSSKSL
RNDRFYTTLKEFINTSDINPKQLELEITETCLMPDDHQAVASLDQLKSLGVRIALDDFGTGYTSFGQILNYPLDTLKIDR
SFVTDLRNTPVGQKPTLDIIFELAKAYQLSVIVEGIETQADFEHVKTLGCDIVQGFYFSNPRTWTEVLKHCGKLHQIDKR
PDQQKNIAC

Specific function: Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass type I membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=431, Percent_Identity=31.554524361949, Blast_Score=215, Evalue=8e-57,
Organism=Escherichia coli, GI87081921, Length=456, Percent_Identity=27.8508771929825, Blast_Score=176, Evalue=6e-45,
Organism=Escherichia coli, GI226510982, Length=523, Percent_Identity=26.0038240917782, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1788849, Length=463, Percent_Identity=24.8380129589633, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786507, Length=220, Percent_Identity=33.1818181818182, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1787055, Length=528, Percent_Identity=23.2954545454545, Blast_Score=109, Evalue=7e-25,
Organism=Escherichia coli, GI87081743, Length=236, Percent_Identity=29.2372881355932, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788381, Length=480, Percent_Identity=24.5833333333333, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788502, Length=237, Percent_Identity=27.8481012658228, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87081845, Length=230, Percent_Identity=28.695652173913, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081980, Length=247, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786584, Length=175, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1788956, Length=167, Percent_Identity=37.125748502994, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1790496, Length=239, Percent_Identity=28.0334728033473, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI87082007, Length=169, Percent_Identity=33.7278106508876, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081977, Length=181, Percent_Identity=33.1491712707182, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI87082096, Length=198, Percent_Identity=29.7979797979798, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI145693134, Length=169, Percent_Identity=31.3609467455621, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI87081881, Length=191, Percent_Identity=30.3664921465969, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1787056, Length=175, Percent_Identity=32, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787262, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1787802, Length=201, Percent_Identity=24.3781094527363, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787816, Length=175, Percent_Identity=29.1428571428571, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00672 HAMP [H]

EC number: NA

Molecular weight: Translated: 92824; Mature: 92693

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRKKIRYIILPVIIALSAMISLLYYHLYKNQIIENKITLLNGRLENQLLHAEYQLDYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHH
KSYLRQKIESKEASLIFNAKQGDNNLSAPDITAFLNLFVNRKNSANKSNHVINDFVIFDS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEHEEEEEC
YKKLIVHINTRDPFAKPMLKTTTKAVLDQIFDQADPNKKISQYHYFLDDPYINKMPSLYI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCHHHCCCCHHH
IQAFSRYQLSSKLFYESNEDTYLAQAQLDLNFFTEEIRVLIDENNGYFNYRFINKNTNAD
HHHHHHHHHHHHHEEECCCCCEEEEEEECHHHHHHEEEEEEECCCCEEEEEEEECCCCCC
NFSFTSTPFQVNDNGAYEGRFGSSLFDIILTLDKNYFAEQLNNLIATFLLLNFIVIILSY
CCEECCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLIWLIDQQIILPITKLAKSIKEVEASLVVELKPLTTKDEVADLNESYISLINKINTLA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
NNDSLTGLANRGSFNEKLSAIMDARQKNKTYVALFFIDLDNFKYVNDTFGHDTGDRLLVV
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEECCCCCCCCCCHHHHH
FSQRLQQLLRAEDNFISGNMIDSIARLGGDEFVILMNGLPSIETIESIGKRICDLFHNGF
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
RIGEEQFDVHASIGIAYSNDHQINGEGLLTQADDAMYLAKRAGKNNFKLFSDEIKEKMLF
CCCCHHEEEEEEEEEEECCCCEECCCCCEEECCHHHHHHHHCCCCCCEEHHHHHHHHHHH
EKNIENELIDAHRDNKLHLVFMPAYCAETRILRGYEILLRCPSLLNVGIGPDVFIPIAEN
HHCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEECCC
TDLILAIDLWVAQQTVIRLKEVIHKNRFTGFFSFNVSSKSLRNDRFYTTLKEFINTSDIN
CCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCCC
PKQLELEITETCLMPDDHQAVASLDQLKSLGVRIALDDFGTGYTSFGQILNYPLDTLKID
CCEEEEEEHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHEEC
RSFVTDLRNTPVGQKPTLDIIFELAKAYQLSVIVEGIETQADFEHVKTLGCDIVQGFYFS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCC
NPRTWTEVLKHCGKLHQIDKRPDQQKNIAC
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TLRKKIRYIILPVIIALSAMISLLYYHLYKNQIIENKITLLNGRLENQLLHAEYQLDYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHH
KSYLRQKIESKEASLIFNAKQGDNNLSAPDITAFLNLFVNRKNSANKSNHVINDFVIFDS
HHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEHEEEEEC
YKKLIVHINTRDPFAKPMLKTTTKAVLDQIFDQADPNKKISQYHYFLDDPYINKMPSLYI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCHHHCCCCHHH
IQAFSRYQLSSKLFYESNEDTYLAQAQLDLNFFTEEIRVLIDENNGYFNYRFINKNTNAD
HHHHHHHHHHHHHEEECCCCCEEEEEEECHHHHHHEEEEEEECCCCEEEEEEEECCCCCC
NFSFTSTPFQVNDNGAYEGRFGSSLFDIILTLDKNYFAEQLNNLIATFLLLNFIVIILSY
CCEECCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLIWLIDQQIILPITKLAKSIKEVEASLVVELKPLTTKDEVADLNESYISLINKINTLA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
NNDSLTGLANRGSFNEKLSAIMDARQKNKTYVALFFIDLDNFKYVNDTFGHDTGDRLLVV
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEECCCCCCCCCCHHHHH
FSQRLQQLLRAEDNFISGNMIDSIARLGGDEFVILMNGLPSIETIESIGKRICDLFHNGF
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
RIGEEQFDVHASIGIAYSNDHQINGEGLLTQADDAMYLAKRAGKNNFKLFSDEIKEKMLF
CCCCHHEEEEEEEEEEECCCCEECCCCCEEECCHHHHHHHHCCCCCCEEHHHHHHHHHHH
EKNIENELIDAHRDNKLHLVFMPAYCAETRILRGYEILLRCPSLLNVGIGPDVFIPIAEN
HHCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEECCC
TDLILAIDLWVAQQTVIRLKEVIHKNRFTGFFSFNVSSKSLRNDRFYTTLKEFINTSDIN
CCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCCC
PKQLELEITETCLMPDDHQAVASLDQLKSLGVRIALDDFGTGYTSFGQILNYPLDTLKID
CCEEEEEEHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHEEC
RSFVTDLRNTPVGQKPTLDIIFELAKAYQLSVIVEGIETQADFEHVKTLGCDIVQGFYFS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCC
NPRTWTEVLKHCGKLHQIDKRPDQQKNIAC
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]