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The map label for this gene is mrdA [H]

Identifier: 119944891

GI number: 119944891

Start: 1422924

End: 1424810

Strand: Reverse

Name: mrdA [H]

Synonym: Ping_1135

Alternate gene names: 119944891

Gene position: 1424810-1422924 (Counterclockwise)

Preceding gene: 119944892

Following gene: 119944890

Centisome position: 31.25

GC content: 42.24

Gene sequence:

>1887_bases
GTGGTTAAAAAACGCATTCCCATAAGGAATCATTCCGCAGAATCCGCACTCTTTATGCGCCGTACTCTGGTAATTTTTAT
TGCGATAGTCATTGCAATAGGGGTATTAATTAGCAACCTCTATTACCTGCAAATAACCTCCTTTGAAAAATATCAAACAC
GTTCAAATGACAACCGTATAAGTGTACAAACGATCTCGCCAAACAGAGGCCTTATTTATGATCGTAATGGCATCATTATT
GCCGAGAACCGGCCAGTTTATAATCTGCAGGTGATCGTTAATAAGACAGAAAATTTAGATGAAAATATCCTTGAATTACA
AAAATTATTAGCGTTAACGGATCAAGAAATCAAAAATTTTAACGAACAAAACCGTTATGCAAGATCCTTCAAAGCTATCA
TCATTCGCCAACAATTAAGCGAAAAAGAGGTCGCTCTTTTTAGCGTTAATCAACATAGATTTAAAGGCTTTTCGATTCAA
GCGAATCTTAAACGTTTTTATCCTTTTGCTGATACCTTCACGCATGCTTTGGGTTATATCGCCAAAATTAATAGCGCTGA
CCTGCGACGAATTGAAAAGCGGGGCGAAAGCGCACGTTATCGGGCAACGGAATATATCGGTAAACTGGGCATCGAAAAAT
ATTATGAAGATTTATTACATGGGGAGCCTGGCCAACGTCAAGTTGAAGTAGACAGTTGGGGAAAAGTAATACGTACTCTG
AGCTTTACCCCGCCTATCCCGGGAAAAGACATTATATTAAACCTTGATGTCAAACTGCAATTAAAAGCACAACAATTATT
GGGTGAAAATCGCGGTAGCGTGGTTATACTGGATGCGAACACAGGTGGCGTTTTAAGTTTAGTCTCCAGTCCAAGTTATG
ATCCTAACCTTTTTGTGCAAGGCATAAGTCAGCGGGAATATCAGGCACTCCTGCAATCAAAAGACCGTCCGCTGATTAAC
CGGGCCACTCAGGGACGCTATCCGCCAGCCTCAACCATTAAACCACAAATGGCTTTGCTCGCGTTAGATGCCAGTGTTAT
AACCGAACAAACAGAAATATTCGATCCTGGTTGGTGGATTGTCCCCAATTCTAAACGCCGCTTTCGTGATTGGAAGCAAT
GGGGCCATGGTACAGTTGATGTTCACAAGGCCATAGAACAAAGCTGTGATACCTTTTTTTATCAAACCGCCTATAAAACG
GGTATTGACCGCATGAGTCCTTTTATGAAAAAGTTTGGTTTTGGCAATTATAGTGGTCTTGATATAGGGGAAGAAACAAA
AGCAATCATGCCTTCTCGTGAATGGAAAAAAGCAAGATTTAACGAGCAATGGTACGACGGTGATACAATATCGGTGGGTA
TCGGGCAAGGTTACTGGACGGTTACACCGATTCAACTAACCAAAGCCACGGCAATCTTAGCCCGGAAAGGTAAGGTAATA
GAGCCACATATGCTGCAGTCCATTATTTCAGGGGAGAGTACTTTTACCCCCACACGCGAAGCGCAAAAACCGATCCAGCT
AAAGGATGATCATTACTGGGAAGTCGCCTTAGATGCTATGTATGCCGTTACTAATAAAAAAGCCGGTACTGCTGATAAAG
CATTTGTCGGCACCTCCTATTCCGTAGCCGGTAAATCGGGTACGGCACAGGTTGTTAATATCAAAGAAAATGAATCCTAT
GATGCCGATAGCATGAAAGAGCGTCATCGGGATAATGCAATGTTTGTAGCATTTGCGCCCTTTAAAGAGCCTGAAATTGT
CGCCAGTGTTGTTCTGGAGAATGCCGGGGGTGGTAGCAGTCACGCAGCCCCGATTGTCCGTTCTTTGTTTGATGAATATT
TTAAAAATACGTCACCCTCTCCTGCTACTCAATCGTTAGGCTTATAA

Upstream 100 bases:

>100_bases
AACCTTGCCCCATCCTTTAGTACGAGTTATCGTCGCCGAAAGTTTATATCGCGCTTTTACTTTAACAATTAACCACCCAT
ACCATAGAGAATAATACGAC

Downstream 100 bases:

>100_bases
TAATGCTCAGCACGCAAGCTCAAAAGAGCATTTTTTATCGTTTGCACATAGATCCGCTGCTACTAATAGGATTATTTTCT
TTAATGGGGTTAAGCCTAAC

Product: transcriptional regulator, Fis family protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MVKKRIPIRNHSAESALFMRRTLVIFIAIVIAIGVLISNLYYLQITSFEKYQTRSNDNRISVQTISPNRGLIYDRNGIII
AENRPVYNLQVIVNKTENLDENILELQKLLALTDQEIKNFNEQNRYARSFKAIIIRQQLSEKEVALFSVNQHRFKGFSIQ
ANLKRFYPFADTFTHALGYIAKINSADLRRIEKRGESARYRATEYIGKLGIEKYYEDLLHGEPGQRQVEVDSWGKVIRTL
SFTPPIPGKDIILNLDVKLQLKAQQLLGENRGSVVILDANTGGVLSLVSSPSYDPNLFVQGISQREYQALLQSKDRPLIN
RATQGRYPPASTIKPQMALLALDASVITEQTEIFDPGWWIVPNSKRRFRDWKQWGHGTVDVHKAIEQSCDTFFYQTAYKT
GIDRMSPFMKKFGFGNYSGLDIGEETKAIMPSREWKKARFNEQWYDGDTISVGIGQGYWTVTPIQLTKATAILARKGKVI
EPHMLQSIISGESTFTPTREAQKPIQLKDDHYWEVALDAMYAVTNKKAGTADKAFVGTSYSVAGKSGTAQVVNIKENESY
DADSMKERHRDNAMFVAFAPFKEPEIVASVVLENAGGGSSHAAPIVRSLFDEYFKNTSPSPATQSLGL

Sequences:

>Translated_628_residues
MVKKRIPIRNHSAESALFMRRTLVIFIAIVIAIGVLISNLYYLQITSFEKYQTRSNDNRISVQTISPNRGLIYDRNGIII
AENRPVYNLQVIVNKTENLDENILELQKLLALTDQEIKNFNEQNRYARSFKAIIIRQQLSEKEVALFSVNQHRFKGFSIQ
ANLKRFYPFADTFTHALGYIAKINSADLRRIEKRGESARYRATEYIGKLGIEKYYEDLLHGEPGQRQVEVDSWGKVIRTL
SFTPPIPGKDIILNLDVKLQLKAQQLLGENRGSVVILDANTGGVLSLVSSPSYDPNLFVQGISQREYQALLQSKDRPLIN
RATQGRYPPASTIKPQMALLALDASVITEQTEIFDPGWWIVPNSKRRFRDWKQWGHGTVDVHKAIEQSCDTFFYQTAYKT
GIDRMSPFMKKFGFGNYSGLDIGEETKAIMPSREWKKARFNEQWYDGDTISVGIGQGYWTVTPIQLTKATAILARKGKVI
EPHMLQSIISGESTFTPTREAQKPIQLKDDHYWEVALDAMYAVTNKKAGTADKAFVGTSYSVAGKSGTAQVVNIKENESY
DADSMKERHRDNAMFVAFAPFKEPEIVASVVLENAGGGSSHAAPIVRSLFDEYFKNTSPSPATQSLGL
>Mature_628_residues
MVKKRIPIRNHSAESALFMRRTLVIFIAIVIAIGVLISNLYYLQITSFEKYQTRSNDNRISVQTISPNRGLIYDRNGIII
AENRPVYNLQVIVNKTENLDENILELQKLLALTDQEIKNFNEQNRYARSFKAIIIRQQLSEKEVALFSVNQHRFKGFSIQ
ANLKRFYPFADTFTHALGYIAKINSADLRRIEKRGESARYRATEYIGKLGIEKYYEDLLHGEPGQRQVEVDSWGKVIRTL
SFTPPIPGKDIILNLDVKLQLKAQQLLGENRGSVVILDANTGGVLSLVSSPSYDPNLFVQGISQREYQALLQSKDRPLIN
RATQGRYPPASTIKPQMALLALDASVITEQTEIFDPGWWIVPNSKRRFRDWKQWGHGTVDVHKAIEQSCDTFFYQTAYKT
GIDRMSPFMKKFGFGNYSGLDIGEETKAIMPSREWKKARFNEQWYDGDTISVGIGQGYWTVTPIQLTKATAILARKGKVI
EPHMLQSIISGESTFTPTREAQKPIQLKDDHYWEVALDAMYAVTNKKAGTADKAFVGTSYSVAGKSGTAQVVNIKENESY
DADSMKERHRDNAMFVAFAPFKEPEIVASVVLENAGGGSSHAAPIVRSLFDEYFKNTSPSPATQSLGL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=604, Percent_Identity=49.5033112582781, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=617, Percent_Identity=21.8800648298217, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70909; Mature: 70909

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKRIPIRNHSAESALFMRRTLVIFIAIVIAIGVLISNLYYLQITSFEKYQTRSNDNRI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHCCCCCEE
SVQTISPNRGLIYDRNGIIIAENRPVYNLQVIVNKTENLDENILELQKLLALTDQEIKNF
EEEEECCCCCEEEECCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
NEQNRYARSFKAIIIRQQLSEKEVALFSVNQHRFKGFSIQANLKRFYPFADTFTHALGYI
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCEEEEECHHHHCCCHHHHHHHHHHH
AKINSADLRRIEKRGESARYRATEYIGKLGIEKYYEDLLHGEPGQRQVEVDSWGKVIRTL
HCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
SFTPPIPGKDIILNLDVKLQLKAQQLLGENRGSVVILDANTGGVLSLVSSPSYDPNLFVQ
CCCCCCCCCCEEEEECEEEEEEHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCEEE
GISQREYQALLQSKDRPLINRATQGRYPPASTIKPQMALLALDASVITEQTEIFDPGWWI
CCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHCHHHEECCCEEE
VPNSKRRFRDWKQWGHGTVDVHKAIEQSCDTFFYQTAYKTGIDRMSPFMKKFGFGNYSGL
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
DIGEETKAIMPSREWKKARFNEQWYDGDTISVGIGQGYWTVTPIQLTKATAILARKGKVI
CCCCCHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEHHHHHHHHHCCCCCC
EPHMLQSIISGESTFTPTREAQKPIQLKDDHYWEVALDAMYAVTNKKAGTADKAFVGTSY
CHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCE
SVAGKSGTAQVVNIKENESYDADSMKERHRDNAMFVAFAPFKEPEIVASVVLENAGGGSS
EECCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
HAAPIVRSLFDEYFKNTSPSPATQSLGL
HHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MVKKRIPIRNHSAESALFMRRTLVIFIAIVIAIGVLISNLYYLQITSFEKYQTRSNDNRI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHCCCCCEE
SVQTISPNRGLIYDRNGIIIAENRPVYNLQVIVNKTENLDENILELQKLLALTDQEIKNF
EEEEECCCCCEEEECCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
NEQNRYARSFKAIIIRQQLSEKEVALFSVNQHRFKGFSIQANLKRFYPFADTFTHALGYI
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCEEEEECHHHHCCCHHHHHHHHHHH
AKINSADLRRIEKRGESARYRATEYIGKLGIEKYYEDLLHGEPGQRQVEVDSWGKVIRTL
HCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
SFTPPIPGKDIILNLDVKLQLKAQQLLGENRGSVVILDANTGGVLSLVSSPSYDPNLFVQ
CCCCCCCCCCEEEEECEEEEEEHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCEEE
GISQREYQALLQSKDRPLINRATQGRYPPASTIKPQMALLALDASVITEQTEIFDPGWWI
CCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHCHHHEECCCEEE
VPNSKRRFRDWKQWGHGTVDVHKAIEQSCDTFFYQTAYKTGIDRMSPFMKKFGFGNYSGL
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
DIGEETKAIMPSREWKKARFNEQWYDGDTISVGIGQGYWTVTPIQLTKATAILARKGKVI
CCCCCHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEHHHHHHHHHCCCCCC
EPHMLQSIISGESTFTPTREAQKPIQLKDDHYWEVALDAMYAVTNKKAGTADKAFVGTSY
CHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCE
SVAGKSGTAQVVNIKENESYDADSMKERHRDNAMFVAFAPFKEPEIVASVVLENAGGGSS
EECCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
HAAPIVRSLFDEYFKNTSPSPATQSLGL
HHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]