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The map label for this gene is paaH [H]

Identifier: 119944429

GI number: 119944429

Start: 842236

End: 843771

Strand: Direct

Name: paaH [H]

Synonym: Ping_0657

Alternate gene names: 119944429

Gene position: 842236-843771 (Clockwise)

Preceding gene: 119944428

Following gene: 119944430

Centisome position: 18.47

GC content: 42.25

Gene sequence:

>1536_bases
GTGGAAAAATTACTATTTAAAACCGTCGCCGTGATAGGCGCGGGTGCAATGGGAGCGGGTATTGCTCAAGTTGCAGCGCA
ATCTGGCTATCAAGTTTATTTATTTGATCTTGCAAAAGGCAAGGCTGAAGAAGCAAAAGAGAATATCGAAAAACAACTTG
AGCGTCGCGTTAAAAAAGGACGGATGGAACAACAGACACTGGAAAGCACTCTTCTGCGAATTCACTGTTCATCGGAATTA
TCTGAAATAGCGTCAGCAAATCTGGTGATTGAAGCTATTGTTGAAAATCTTGAAATAAAGCAGGGCTTATTTAAAGAATT
AGAAACAATCTGTTCAGCGGATTGTATTTTAGCGTCGAATACATCATCAATATCGATTACCGCGATTGCCAGTGCATTAA
AATCGCCTGAACGCTTTATTGGCCTGCATTTTTTCAATCCTGCACCAGTGATGAAATTAGTCGAAGTGATTCAAGGTGTC
GCAACGGCTGATAATATCGCAGAAACAGCGCAACAATGGGCACGCTCCTGCGGGAAAAAATCTGTTCTTGCCTGCTCTAT
TCCCGGTTTTATTGTCAATCGCGTCGCTCGGCCATTTTATGCTGAAGGGTTAAGAGCACTTGAAGAGAGCGTTGCAACTA
TTGATGATATTGATCACCTGATGCGTGCGTCGGCCGGGTTTAATATGGGGCCCTTTGAGCTGATGGATTTGATTGGTCAT
GATGTTAATTATGCGGTCACCAAAAGCGTATTTGATGCCTGTTATCAAGATCGCAGATATCAACCCTCATTGGCTCAAAA
AGAATTAGTCGATGCCGGATTTTTTGGCCGTAAGAGTGGGCGGGGTTTTTATGATTACAGCGAAAAGGCATATCAAAATA
ATTATAATACTTGCCGCCCGGTGACCATGGATATTAATGCTGTCACCCTGGCGACCCATTGGGATGACTCAGAATTAACA
CTTAAAGAGCTTGTTAACCAATCCTTTGGTGATAACAAAAATACAACATTGAATAATGCTCTGTTAGCGAAAGGCGCCAT
TCTAAAAGTTGATGACGTTCTTATTATTCCAACAAGAGGGAAGACAGCAACAGAACTTTCCCATAAATTAGGCTCCGCGG
TGGTCACTATTGATTACTGCCGTGATTATTTGTCTACCTCGGTTGTTGCTGTCTCAGGTGCACTGCAAAACAGCGATGCC
CAGACGGATAAAGTCATTGCCTTTCTACAGTTATTGGATAAACAAGTCATTCTAATAAAAGATTATCCCGGCATGATTGT
TTGGCGCACATTAAGTATGTTGAGTAACGAAGCATTAGATTTAGCTAATAAAAAGGGTGCCTCCGAAGCTGATATTGATA
TCGCAATGAAAAGCGGCGTCAATTATCCCTTAGGGCCCGTTGAGTGGGGTGAGAAATTAGGCTGGAAAAACGTCAAAGAA
ACATTGGAGTCTTTAACGGCTTTTTATGGTGAAGAGCGCTACCGGCCATCCCCCTTATTAAGACAATTATCTTACGGAGT
CATTAATGGAGAATAG

Upstream 100 bases:

>100_bases
GCGCGACCTGCAACGTCTTGCAGGGCGTACTGATGATTACCGTGAAGGTGTTACGGCTTTCTTTGAAAAAAGACAACCGG
TCTTTAAAGGGAAATAAACT

Downstream 100 bases:

>100_bases
TCAAGAATTAGCATGGCGTTGTGCCAAAAAAATGTATAACAATGATGCTTGCTCTAATTTCTTAGGAATGAAAATCGAAG
ACATGGGTAAGGGATATGCG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MEKLLFKTVAVIGAGAMGAGIAQVAAQSGYQVYLFDLAKGKAEEAKENIEKQLERRVKKGRMEQQTLESTLLRIHCSSEL
SEIASANLVIEAIVENLEIKQGLFKELETICSADCILASNTSSISITAIASALKSPERFIGLHFFNPAPVMKLVEVIQGV
ATADNIAETAQQWARSCGKKSVLACSIPGFIVNRVARPFYAEGLRALEESVATIDDIDHLMRASAGFNMGPFELMDLIGH
DVNYAVTKSVFDACYQDRRYQPSLAQKELVDAGFFGRKSGRGFYDYSEKAYQNNYNTCRPVTMDINAVTLATHWDDSELT
LKELVNQSFGDNKNTTLNNALLAKGAILKVDDVLIIPTRGKTATELSHKLGSAVVTIDYCRDYLSTSVVAVSGALQNSDA
QTDKVIAFLQLLDKQVILIKDYPGMIVWRTLSMLSNEALDLANKKGASEADIDIAMKSGVNYPLGPVEWGEKLGWKNVKE
TLESLTAFYGEERYRPSPLLRQLSYGVINGE

Sequences:

>Translated_511_residues
MEKLLFKTVAVIGAGAMGAGIAQVAAQSGYQVYLFDLAKGKAEEAKENIEKQLERRVKKGRMEQQTLESTLLRIHCSSEL
SEIASANLVIEAIVENLEIKQGLFKELETICSADCILASNTSSISITAIASALKSPERFIGLHFFNPAPVMKLVEVIQGV
ATADNIAETAQQWARSCGKKSVLACSIPGFIVNRVARPFYAEGLRALEESVATIDDIDHLMRASAGFNMGPFELMDLIGH
DVNYAVTKSVFDACYQDRRYQPSLAQKELVDAGFFGRKSGRGFYDYSEKAYQNNYNTCRPVTMDINAVTLATHWDDSELT
LKELVNQSFGDNKNTTLNNALLAKGAILKVDDVLIIPTRGKTATELSHKLGSAVVTIDYCRDYLSTSVVAVSGALQNSDA
QTDKVIAFLQLLDKQVILIKDYPGMIVWRTLSMLSNEALDLANKKGASEADIDIAMKSGVNYPLGPVEWGEKLGWKNVKE
TLESLTAFYGEERYRPSPLLRQLSYGVINGE
>Mature_511_residues
MEKLLFKTVAVIGAGAMGAGIAQVAAQSGYQVYLFDLAKGKAEEAKENIEKQLERRVKKGRMEQQTLESTLLRIHCSSEL
SEIASANLVIEAIVENLEIKQGLFKELETICSADCILASNTSSISITAIASALKSPERFIGLHFFNPAPVMKLVEVIQGV
ATADNIAETAQQWARSCGKKSVLACSIPGFIVNRVARPFYAEGLRALEESVATIDDIDHLMRASAGFNMGPFELMDLIGH
DVNYAVTKSVFDACYQDRRYQPSLAQKELVDAGFFGRKSGRGFYDYSEKAYQNNYNTCRPVTMDINAVTLATHWDDSELT
LKELVNQSFGDNKNTTLNNALLAKGAILKVDDVLIIPTRGKTATELSHKLGSAVVTIDYCRDYLSTSVVAVSGALQNSDA
QTDKVIAFLQLLDKQVILIKDYPGMIVWRTLSMLSNEALDLANKKGASEADIDIAMKSGVNYPLGPVEWGEKLGWKNVKE
TLESLTAFYGEERYRPSPLLRQLSYGVINGE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=42.2680412371134, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=39.9350649350649, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI20127408, Length=293, Percent_Identity=33.4470989761092, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=31.5068493150685, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=31.5068493150685, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=26.6949152542373, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1787661, Length=496, Percent_Identity=47.5806451612903, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1790281, Length=246, Percent_Identity=36.5853658536585, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=32.962962962963, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.9722222222222, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=39.8625429553265, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=39.2361111111111, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=30.7692307692308, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=290, Percent_Identity=29.3103448275862, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=286, Percent_Identity=33.5664335664336, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=286, Percent_Identity=33.5664335664336, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=286, Percent_Identity=33.5664335664336, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=31.9148936170213, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=197, Percent_Identity=27.9187817258883, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=197, Percent_Identity=27.9187817258883, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583077, Length=299, Percent_Identity=33.4448160535117, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24583079, Length=299, Percent_Identity=33.4448160535117, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19921000, Length=299, Percent_Identity=33.4448160535117, Blast_Score=165, Evalue=9e-41,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=27.6595744680851, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129993, Length=231, Percent_Identity=23.3766233766234, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 56101; Mature: 56101

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLFKTVAVIGAGAMGAGIAQVAAQSGYQVYLFDLAKGKAEEAKENIEKQLERRVKKG
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
RMEQQTLESTLLRIHCSSELSEIASANLVIEAIVENLEIKQGLFKELETICSADCILASN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TSSISITAIASALKSPERFIGLHFFNPAPVMKLVEVIQGVATADNIAETAQQWARSCGKK
CCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVLACSIPGFIVNRVARPFYAEGLRALEESVATIDDIDHLMRASAGFNMGPFELMDLIGH
CEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
DVNYAVTKSVFDACYQDRRYQPSLAQKELVDAGFFGRKSGRGFYDYSEKAYQNNYNTCRP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCC
VTMDINAVTLATHWDDSELTLKELVNQSFGDNKNTTLNNALLAKGAILKVDDVLIIPTRG
EEEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCEEEEECCC
KTATELSHKLGSAVVTIDYCRDYLSTSVVAVSGALQNSDAQTDKVIAFLQLLDKQVILIK
CHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
DYPGMIVWRTLSMLSNEALDLANKKGASEADIDIAMKSGVNYPLGPVEWGEKLGWKNVKE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
TLESLTAFYGEERYRPSPLLRQLSYGVINGE
HHHHHHHHHCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKLLFKTVAVIGAGAMGAGIAQVAAQSGYQVYLFDLAKGKAEEAKENIEKQLERRVKKG
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
RMEQQTLESTLLRIHCSSELSEIASANLVIEAIVENLEIKQGLFKELETICSADCILASN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TSSISITAIASALKSPERFIGLHFFNPAPVMKLVEVIQGVATADNIAETAQQWARSCGKK
CCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVLACSIPGFIVNRVARPFYAEGLRALEESVATIDDIDHLMRASAGFNMGPFELMDLIGH
CEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
DVNYAVTKSVFDACYQDRRYQPSLAQKELVDAGFFGRKSGRGFYDYSEKAYQNNYNTCRP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCC
VTMDINAVTLATHWDDSELTLKELVNQSFGDNKNTTLNNALLAKGAILKVDDVLIIPTRG
EEEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCEEEEECCC
KTATELSHKLGSAVVTIDYCRDYLSTSVVAVSGALQNSDAQTDKVIAFLQLLDKQVILIK
CHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
DYPGMIVWRTLSMLSNEALDLANKKGASEADIDIAMKSGVNYPLGPVEWGEKLGWKNVKE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
TLESLTAFYGEERYRPSPLLRQLSYGVINGE
HHHHHHHHHCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]