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The map label for this gene is holC [H]

Identifier: 119944174

GI number: 119944174

Start: 501773

End: 502255

Strand: Reverse

Name: holC [H]

Synonym: Ping_0394

Alternate gene names: 119944174

Gene position: 502255-501773 (Counterclockwise)

Preceding gene: 119944175

Following gene: 119944173

Centisome position: 11.02

GC content: 38.92

Gene sequence:

>483_bases
ATGAGTCAGGTTGTTTTTTACGTTTTCACTACGGAAGAAAAATCAAGCAGTGTAGCCATAAGTGCTCATTTTGCGTACGC
TTGCAGAATAGCGGCGTTTTTTTATGCACAAAATAAAAAAGTGTTCATCTATACCGATTCAAAAGAAGATGCATTTGCGG
TCGATGAATATTTATGGCAGTTTGACGGTGACAGTTTTGTGCCGCACAACTTGTTAGGTGAAGGGCCAAAATTTGGTACG
CCCGTTGAAATAAGCTGGCAAGTCCCGCTGCACCCTCGCCCTATTTTAATTAATTTAAGTCAAAAAACGCCTGATTTTGC
AATCAATTTTCAAAAAATTATTGATTTTGTTCCGTTTCCGGAACCCCAAAAAATTGCAGCACGAATACGTTACAGTACCT
ATAGAAAAATGGGGCTAACGCTTTCTACTCAAACCGTTGAGAGTAATTCAACGGTTGAGTCAACCAACAAAACAGAAGAT
TAA

Upstream 100 bases:

>100_bases
AGGGGTCAACGGGTAGACCGGTTTCCTTATTAACGCAGTTTTTAATAAACAGAAGTGAAAATGAAACAACAGCGGTAAAT
AGCTAAGTGAAACTAAGATA

Downstream 100 bases:

>100_bases
CCGATGGAAAAGATATACAACCCAAGTGCAATTGAACAAAAAAATTACCAAAATTGGGAAGAAAAAGGTTATTTCAAACC
GCATGGTGATACTAGCAAAG

Product: DNA polymerase III chi subunit, HolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSQVVFYVFTTEEKSSSVAISAHFAYACRIAAFFYAQNKKVFIYTDSKEDAFAVDEYLWQFDGDSFVPHNLLGEGPKFGT
PVEISWQVPLHPRPILINLSQKTPDFAINFQKIIDFVPFPEPQKIAARIRYSTYRKMGLTLSTQTVESNSTVESTNKTED

Sequences:

>Translated_160_residues
MSQVVFYVFTTEEKSSSVAISAHFAYACRIAAFFYAQNKKVFIYTDSKEDAFAVDEYLWQFDGDSFVPHNLLGEGPKFGT
PVEISWQVPLHPRPILINLSQKTPDFAINFQKIIDFVPFPEPQKIAARIRYSTYRKMGLTLSTQTVESNSTVESTNKTED
>Mature_159_residues
SQVVFYVFTTEEKSSSVAISAHFAYACRIAAFFYAQNKKVFIYTDSKEDAFAVDEYLWQFDGDSFVPHNLLGEGPKFGTP
VEISWQVPLHPRPILINLSQKTPDFAINFQKIIDFVPFPEPQKIAARIRYSTYRKMGLTLSTQTVESNSTVESTNKTED

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=147, Percent_Identity=39.4557823129252, Blast_Score=109, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 18236; Mature: 18105

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVVFYVFTTEEKSSSVAISAHFAYACRIAAFFYAQNKKVFIYTDSKEDAFAVDEYLWQ
CCEEEEEEEEECCCCCEEEEEEHHHHHHHHEEEEEECCCEEEEEECCCCCCHHHHHHHHC
FDGDSFVPHNLLGEGPKFGTPVEISWQVPLHPRPILINLSQKTPDFAINFQKIIDFVPFP
CCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCC
EPQKIAARIRYSTYRKMGLTLSTQTVESNSTVESTNKTED
CCHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SQVVFYVFTTEEKSSSVAISAHFAYACRIAAFFYAQNKKVFIYTDSKEDAFAVDEYLWQ
CEEEEEEEEECCCCCEEEEEEHHHHHHHHEEEEEECCCEEEEEECCCCCCHHHHHHHHC
FDGDSFVPHNLLGEGPKFGTPVEISWQVPLHPRPILINLSQKTPDFAINFQKIIDFVPFP
CCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCC
EPQKIAARIRYSTYRKMGLTLSTQTVESNSTVESTNKTED
CCHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 7959067 [H]