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The map label for this gene is pepA

Identifier: 119944175

GI number: 119944175

Start: 502270

End: 503784

Strand: Reverse

Name: pepA

Synonym: Ping_0395

Alternate gene names: 119944175

Gene position: 503784-502270 (Counterclockwise)

Preceding gene: 119944178

Following gene: 119944174

Centisome position: 11.05

GC content: 43.63

Gene sequence:

>1515_bases
ATGGAATTTTCAGTAAAAAGCGGTAGCCCGGAAAAACAACGCAGTGCCTGTATTGTTGTGGGTGTATTTGAGCCGCGCCG
TTTATCACGCGCAGGTGAGCAGCTTGATGAGATTAGCGAAGGTTATTTAAGTACATTATTACGCCGTGGTGATATTGAAG
GAAAGATAGGGCAGGTATTATTCTTACATAATGTGCCCAATGTATTAAGTGAACGCGTATTATTAGTCGGTTGCGGTAAA
GAACGTGAACTAACCGAAACCCAGTACAAGCAAATTATAGCAAAAACCATTACGACACTTAACGATACTGGTGCTTTAGA
AGCGATCTGTTTTCTTTCTGAATTACATATCAAAGGGCGTGATACTTACTGGGCAGTGCGCCAAGCAACCGAAGCAACTC
AGGATTGTTTATATAACTTCGATAAATTTAAAACCAACAAAGAAAATACCCGCCGTCCTTTGCGTAAATTAACCTTTAAT
GTGACTAGCCGTAAAGAGTTAGCGCGCGCAGAACTTGGTCTGCAACATGCTTTAGCGGTCGCTTCCGGCGCTAAAGCATG
TAAAGATTTAGCCAATATGCCTCCCAATATCTGTACCCCATTATATTTAAGCGAACAAGCGATCGCACTGGGTCAACGAT
TTGAAAAAATAACCACAGAAATTGTTGATAGTGAGCAGATGGCAGAACTTAAAATGGACAGTTACTTGGCCGTTGCTAAA
GGCTCGGCTAATCCTGCCTATATGTCATTAATGCACTACAACGGTGGTAATGCAGATCAAAAACCTATCGTACTCGTTGG
TAAAGGGCTGACCTTTGACTCGGGCGGTATTTCTTTAAAACCAGGCGAAGCCATGGATGAGATGAAATATGATATGGGTG
GCGCGGCCAGTGTTTTTGGTGCCATGAAAGCACTTGCCAAACTTAACCTGCCAATCAATGTCATTGGCATATTAGCAGGC
GCTGAAAATATGCCGGCGGGTAACGCTTACCGTCCGGGTGATATTCTGACTACTATGTCAGGGCAAACCGTTGAAGTCTT
AAATACCGATGCTGAAGGGCGTTTAGTCTTGTGTGATGTATTAACCTACGTTGAACGTTTTGAACCGGATTGTGTTGTTG
ATATAGCAACCTTAACAGGCGCTTGTATTATGGCGTTAGGGCATCATATCAGCGGCTTAATGACGCCGCACAAAGGGCTG
GCAAATGAGTTGTTAAGCGCGTCAAATCAATCTAGTGATAAAGCATGGCAACTGCCGATGGATGATGAGTTTCAGAAACA
GCTGGAGAGTCCATTTGCCGATATGGCTAATATTGGAGGTCGTCCGGCAGGGTCTATTACTGCGGCTTGTTTCCTTTCAC
GCTTTACGAAAAGTTATACCTGGGCACATTTAGATGTTGCAGGGACAGCCTGGAGATCTGGAGCAAATAAGGGGTCAACG
GGTAGACCGGTTTCCTTATTAACGCAGTTTTTAATAAACAGAAGTGAAAATGAAACAACAGCGGTAAATAGCTAA

Upstream 100 bases:

>100_bases
GAGAAGCGTTACCAAGTCCCACTTACTTCTATAATAACTGTATTTTCTAAAAAATTGCACAGTTAATCGCATTATACATA
GCCAAGAGCCAAGGATATAT

Downstream 100 bases:

>100_bases
GTGAAACTAAGATAATGAGTCAGGTTGTTTTTTACGTTTTCACTACGGAAGAAAAATCAAGCAGTGTAGCCATAAGTGCT
CATTTTGCGTACGCTTGCAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSRAGEQLDEISEGYLSTLLRRGDIEGKIGQVLFLHNVPNVLSERVLLVGCGK
ERELTETQYKQIIAKTITTLNDTGALEAICFLSELHIKGRDTYWAVRQATEATQDCLYNFDKFKTNKENTRRPLRKLTFN
VTSRKELARAELGLQHALAVASGAKACKDLANMPPNICTPLYLSEQAIALGQRFEKITTEIVDSEQMAELKMDSYLAVAK
GSANPAYMSLMHYNGGNADQKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAASVFGAMKALAKLNLPINVIGILAG
AENMPAGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPDCVVDIATLTGACIMALGHHISGLMTPHKGL
ANELLSASNQSSDKAWQLPMDDEFQKQLESPFADMANIGGRPAGSITAACFLSRFTKSYTWAHLDVAGTAWRSGANKGST
GRPVSLLTQFLINRSENETTAVNS

Sequences:

>Translated_504_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSRAGEQLDEISEGYLSTLLRRGDIEGKIGQVLFLHNVPNVLSERVLLVGCGK
ERELTETQYKQIIAKTITTLNDTGALEAICFLSELHIKGRDTYWAVRQATEATQDCLYNFDKFKTNKENTRRPLRKLTFN
VTSRKELARAELGLQHALAVASGAKACKDLANMPPNICTPLYLSEQAIALGQRFEKITTEIVDSEQMAELKMDSYLAVAK
GSANPAYMSLMHYNGGNADQKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAASVFGAMKALAKLNLPINVIGILAG
AENMPAGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPDCVVDIATLTGACIMALGHHISGLMTPHKGL
ANELLSASNQSSDKAWQLPMDDEFQKQLESPFADMANIGGRPAGSITAACFLSRFTKSYTWAHLDVAGTAWRSGANKGST
GRPVSLLTQFLINRSENETTAVNS
>Mature_504_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSRAGEQLDEISEGYLSTLLRRGDIEGKIGQVLFLHNVPNVLSERVLLVGCGK
ERELTETQYKQIIAKTITTLNDTGALEAICFLSELHIKGRDTYWAVRQATEATQDCLYNFDKFKTNKENTRRPLRKLTFN
VTSRKELARAELGLQHALAVASGAKACKDLANMPPNICTPLYLSEQAIALGQRFEKITTEIVDSEQMAELKMDSYLAVAK
GSANPAYMSLMHYNGGNADQKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAASVFGAMKALAKLNLPINVIGILAG
AENMPAGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPDCVVDIATLTGACIMALGHHISGLMTPHKGL
ANELLSASNQSSDKAWQLPMDDEFQKQLESPFADMANIGGRPAGSITAACFLSRFTKSYTWAHLDVAGTAWRSGANKGST
GRPVSLLTQFLINRSENETTAVNS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=500, Percent_Identity=34.8, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI47155554, Length=364, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=69.6177062374245, Blast_Score=736, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=303, Percent_Identity=37.953795379538, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=293, Percent_Identity=35.8361774744027, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=217, Percent_Identity=31.3364055299539, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129969, Length=515, Percent_Identity=28.5436893203883, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24662227, Length=503, Percent_Identity=29.6222664015905, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355725, Length=326, Percent_Identity=32.2085889570552, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661038, Length=355, Percent_Identity=31.2676056338028, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161077148, Length=491, Percent_Identity=27.4949083503055, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20130057, Length=491, Percent_Identity=27.4949083503055, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21355645, Length=495, Percent_Identity=28.4848484848485, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662223, Length=495, Percent_Identity=28.4848484848485, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129963, Length=500, Percent_Identity=28.6, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19922386, Length=493, Percent_Identity=28.1947261663286, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21357381, Length=305, Percent_Identity=33.1147540983607, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221379063, Length=305, Percent_Identity=33.1147540983607, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221379062, Length=305, Percent_Identity=33.1147540983607, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646701, Length=230, Percent_Identity=29.5652173913043, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646703, Length=230, Percent_Identity=29.5652173913043, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358201, Length=230, Percent_Identity=29.5652173913043, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PSYIN (A1SRZ1)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941855.1
- ProteinModelPortal:   A1SRZ1
- SMR:   A1SRZ1
- STRING:   A1SRZ1
- MEROPS:   M17.003
- GeneID:   4624295
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0395
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- PhylomeDB:   A1SRZ1
- ProtClustDB:   PRK00913
- BioCyc:   PING357804:PING_0395-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54703; Mature: 54703

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 280-280 ACT_SITE 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSRAGEQLDEISEGYLSTLLRRGDIEGKIGQVL
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FLHNVPNVLSERVLLVGCGKERELTETQYKQIIAKTITTLNDTGALEAICFLSELHIKGR
EECCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
DTYWAVRQATEATQDCLYNFDKFKTNKENTRRPLRKLTFNVTSRKELARAELGLQHALAV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ASGAKACKDLANMPPNICTPLYLSEQAIALGQRFEKITTEIVDSEQMAELKMDSYLAVAK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEEEC
GSANPAYMSLMHYNGGNADQKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAASVFG
CCCCCCEEEEEEECCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHCCCCHHHHHH
AMKALAKLNLPINVIGILAGAENMPAGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDV
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHHH
LTYVERFEPDCVVDIATLTGACIMALGHHISGLMTPHKGLANELLSASNQSSDKAWQLPM
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEECCC
DDEFQKQLESPFADMANIGGRPAGSITAACFLSRFTKSYTWAHLDVAGTAWRSGANKGST
CHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCC
GRPVSLLTQFLINRSENETTAVNS
CCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSRAGEQLDEISEGYLSTLLRRGDIEGKIGQVL
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FLHNVPNVLSERVLLVGCGKERELTETQYKQIIAKTITTLNDTGALEAICFLSELHIKGR
EECCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
DTYWAVRQATEATQDCLYNFDKFKTNKENTRRPLRKLTFNVTSRKELARAELGLQHALAV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ASGAKACKDLANMPPNICTPLYLSEQAIALGQRFEKITTEIVDSEQMAELKMDSYLAVAK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEEEC
GSANPAYMSLMHYNGGNADQKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAASVFG
CCCCCCEEEEEEECCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHCCCCHHHHHH
AMKALAKLNLPINVIGILAGAENMPAGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDV
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHHH
LTYVERFEPDCVVDIATLTGACIMALGHHISGLMTPHKGLANELLSASNQSSDKAWQLPM
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEECCC
DDEFQKQLESPFADMANIGGRPAGSITAACFLSRFTKSYTWAHLDVAGTAWRSGANKGST
CHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCC
GRPVSLLTQFLINRSENETTAVNS
CCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA