Click here to switch to the map view.

The map label for this gene is argHA [H]

Identifier: 119944018

GI number: 119944018

Start: 293604

End: 295484

Strand: Direct

Name: argHA [H]

Synonym: Ping_0232

Alternate gene names: 119944018

Gene position: 293604-295484 (Clockwise)

Preceding gene: 119944017

Following gene: 119944020

Centisome position: 6.44

GC content: 43.49

Gene sequence:

>1881_bases
ATGGCATTATGGGGCGGACGTTTTAGCCACGCGGCAGACGTAAAATTTAAATTGTTTAATGATTCATTAAGATTCGATTA
TCGTCTTGCGGAACAAGACATTATTGGTTCAATAGCTTGGTCAAAAGCGTTACAAACAGTTGATGTATTAACCAATGATG
AACAAAAACGCTTAGAAGCTGCGTTAAATGAATTATTAGTATCAGTTAAAGATAATCCTGAGCTGGTATTACAATCCGAT
GCCGAAGATATCCATTCTTGGACAGAAGGACAACTGATTAATAAAATCGGTGACTTAGGTAAAAAATTACATACGGGTCG
TAGTCGTAATGATCAGGTTGCAACGGATTTAAAGCTTTGGTGTAAAAAAAGAGCACAGGAATTAGTTGTCCATCTGGATG
CATTGGAAGCCAAGCTCATCGAACTGGCACGTATTCACCAGGGGGTTGTTCTACCGGGTTATACACATTTACAACGCGCA
CAACCGGTGACATTTTCGCACTGGTGTTTAGCCTATTTAGAAATGTTAGAGCGTGACCATGATCGTTTGGAAGGCTGCCT
TGAACGCCTTGATACTTGTCCTTTGGGCAGTGGCGCATTGGCAGGAACAGGCTATGCAATAGATCGCACCGCATTAGCAC
ACTCTCTTGGATTTAAACGTGCGACGCGCAACAGCTTAGATGCTGTTTCCGACCGCGACCATGTTGTTGAGTTGATGAGC
TGTGCAACGATGTCCATGATGCATATGTCGCGCATGGCAGAAGATCTGATCTTCTATAACAGTGGTGAGTCAGGATTTAT
TGAGATGTCTGATTTAGTGACGTCCGGATCATCATTAATGCCGCAAAAGAAAAATCCTGATGCAATGGAATTGATTCGTG
GCAGAACCGGCCGTGTATTTGGCTCATTAGCGGCTATGTTAATGACGCTTAAAGGTCTGCCGCTTGCTTATAACAAAGAT
ATGCAGGAAGACAAAGAAGGTTTATTCGACTCTCTGGACACTTGGGGAGACTGTTTAGAAATGGCAGCAATGGCCTTAAC
CGATCTTAAAGTGAACGAAGAACGCACCAAAGAAGCAGCCCAGGGCGGGTATTCAAACGCCACTGAACTTGCTGATTACC
TGGTTGCTAAAGGCATTCCATTCCGTGAAGCACACCATATTGTAGGTGTTGCCGTTGTCGGGGCGATTGAGAAGGGCATA
CCACTGGAAGATTTAACGGTCACCCAATTTAAAGAGTTTTCTTCTGTGATTGAAGATGACGTTTATCCGGTATTGACGCT
CGAAGCAACACTTGCCGCACGTAAAGCACTCGGTGGTGTTTCACCTGAGCAGATTGAATATGCACTAACGGAAGCAGAAC
AACGCTTAGCAGATCGTGATACATCGGGCATTGTGATAAGAGCGGCTCGTTTAACAGACATCGATCGTATTGAAGCAATG
GTTAACCACTTGGCTGATACAGGCGAAAACCTTCGAAGAGATAAGACCGACTTAGCGGAGTCAGTGGCTGAATTTGCAGT
AGCTGAAATAGATGGCAAAGTCACGGCCTGTGCTTCAGTGCATATCTATGATACCGGTTTAGCCGAAATTCGCTCATTAG
GTGTAGAGCCTGGTTTTGAACGCCGTGGTCAAGGTAGCGCATTAGTGGATTTCTTAGTTAAACGTACAGAAAAACAAGCG
ATCAAGCGTCTATTCGTATTAACACGCATGCCAGACTTCTTTATGAAGCTTGGTTTTAGTCCCGAAAGTAAGACTACGAT
GCCGGAAAAAGTCTTAAAAGATTGTTCAATGTTTGTGAGTGAACATGCAAGTGATGAAAAGGCACTAGAGTTGAATTACA
AAACAAGTATGTTGCTCCATAAAGGAATGAGCAAAATTTAA

Upstream 100 bases:

>100_bases
AGGGCGGGAATTTCTATTTTTATCTGTTTTTTTTTAAAGTATATAAAAATAGATTCTAAAAAATAGCTACAACAAACCAA
GAAAGTGATGGAGCATCAAA

Downstream 100 bases:

>100_bases
AATAACCTATCTATTTGTTCCCACGTTTCTGCGTGGGAACAAATAATGTTAACCCTGAGCAATATACTCATTTTTTAGTG
TGACATAATGCGCTGCAGAA

Product: bifunctional argininosuccinate lyase/N-acetylglutamate synthase

Products: NA

Alternate protein names: Argininosuccinate lyase; ASAL; Arginosuccinase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS; NAGS [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MALWGGRFSHAADVKFKLFNDSLRFDYRLAEQDIIGSIAWSKALQTVDVLTNDEQKRLEAALNELLVSVKDNPELVLQSD
AEDIHSWTEGQLINKIGDLGKKLHTGRSRNDQVATDLKLWCKKRAQELVVHLDALEAKLIELARIHQGVVLPGYTHLQRA
QPVTFSHWCLAYLEMLERDHDRLEGCLERLDTCPLGSGALAGTGYAIDRTALAHSLGFKRATRNSLDAVSDRDHVVELMS
CATMSMMHMSRMAEDLIFYNSGESGFIEMSDLVTSGSSLMPQKKNPDAMELIRGRTGRVFGSLAAMLMTLKGLPLAYNKD
MQEDKEGLFDSLDTWGDCLEMAAMALTDLKVNEERTKEAAQGGYSNATELADYLVAKGIPFREAHHIVGVAVVGAIEKGI
PLEDLTVTQFKEFSSVIEDDVYPVLTLEATLAARKALGGVSPEQIEYALTEAEQRLADRDTSGIVIRAARLTDIDRIEAM
VNHLADTGENLRRDKTDLAESVAEFAVAEIDGKVTACASVHIYDTGLAEIRSLGVEPGFERRGQGSALVDFLVKRTEKQA
IKRLFVLTRMPDFFMKLGFSPESKTTMPEKVLKDCSMFVSEHASDEKALELNYKTSMLLHKGMSKI

Sequences:

>Translated_626_residues
MALWGGRFSHAADVKFKLFNDSLRFDYRLAEQDIIGSIAWSKALQTVDVLTNDEQKRLEAALNELLVSVKDNPELVLQSD
AEDIHSWTEGQLINKIGDLGKKLHTGRSRNDQVATDLKLWCKKRAQELVVHLDALEAKLIELARIHQGVVLPGYTHLQRA
QPVTFSHWCLAYLEMLERDHDRLEGCLERLDTCPLGSGALAGTGYAIDRTALAHSLGFKRATRNSLDAVSDRDHVVELMS
CATMSMMHMSRMAEDLIFYNSGESGFIEMSDLVTSGSSLMPQKKNPDAMELIRGRTGRVFGSLAAMLMTLKGLPLAYNKD
MQEDKEGLFDSLDTWGDCLEMAAMALTDLKVNEERTKEAAQGGYSNATELADYLVAKGIPFREAHHIVGVAVVGAIEKGI
PLEDLTVTQFKEFSSVIEDDVYPVLTLEATLAARKALGGVSPEQIEYALTEAEQRLADRDTSGIVIRAARLTDIDRIEAM
VNHLADTGENLRRDKTDLAESVAEFAVAEIDGKVTACASVHIYDTGLAEIRSLGVEPGFERRGQGSALVDFLVKRTEKQA
IKRLFVLTRMPDFFMKLGFSPESKTTMPEKVLKDCSMFVSEHASDEKALELNYKTSMLLHKGMSKI
>Mature_625_residues
ALWGGRFSHAADVKFKLFNDSLRFDYRLAEQDIIGSIAWSKALQTVDVLTNDEQKRLEAALNELLVSVKDNPELVLQSDA
EDIHSWTEGQLINKIGDLGKKLHTGRSRNDQVATDLKLWCKKRAQELVVHLDALEAKLIELARIHQGVVLPGYTHLQRAQ
PVTFSHWCLAYLEMLERDHDRLEGCLERLDTCPLGSGALAGTGYAIDRTALAHSLGFKRATRNSLDAVSDRDHVVELMSC
ATMSMMHMSRMAEDLIFYNSGESGFIEMSDLVTSGSSLMPQKKNPDAMELIRGRTGRVFGSLAAMLMTLKGLPLAYNKDM
QEDKEGLFDSLDTWGDCLEMAAMALTDLKVNEERTKEAAQGGYSNATELADYLVAKGIPFREAHHIVGVAVVGAIEKGIP
LEDLTVTQFKEFSSVIEDDVYPVLTLEATLAARKALGGVSPEQIEYALTEAEQRLADRDTSGIVIRAARLTDIDRIEAMV
NHLADTGENLRRDKTDLAESVAEFAVAEIDGKVTACASVHIYDTGLAEIRSLGVEPGFERRGQGSALVDFLVKRTEKQAI
KRLFVLTRMPDFFMKLGFSPESKTTMPEKVLKDCSMFVSEHASDEKALELNYKTSMLLHKGMSKI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=43.0131004366812, Blast_Score=358, Evalue=9e-99,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=43.0131004366812, Blast_Score=358, Evalue=9e-99,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=41.0480349344978, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=39.9563318777293, Blast_Score=318, Evalue=1e-86,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=68.4210526315789, Blast_Score=660, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=446, Percent_Identity=45.5156950672646, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=42.2121896162528, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=42.2121896162528, Blast_Score=351, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR009049
- InterPro:   IPR011244
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF00206 Lyase_1 [H]

EC number: =4.3.2.1; =2.3.1.1 [H]

Molecular weight: Translated: 69394; Mature: 69263

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFSHAADVKFKLFNDSLRFDYRLAEQDIIGSIAWSKALQTVDVLTNDEQKRLEA
CCCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALNELLVSVKDNPELVLQSDAEDIHSWTEGQLINKIGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKKRAQELVVHLDALEAKLIELARIHQGVVLPGYTHLQRAQPVTFSHWCLAYLEMLERDH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCH
DRLEGCLERLDTCPLGSGALAGTGYAIDRTALAHSLGFKRATRNSLDAVSDRDHVVELMS
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHH
CATMSMMHMSRMAEDLIFYNSGESGFIEMSDLVTSGSSLMPQKKNPDAMELIRGRTGRVF
HHHHHHHHHHHHHHHHEEEECCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLAAMLMTLKGLPLAYNKDMQEDKEGLFDSLDTWGDCLEMAAMALTDLKVNEERTKEAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QGGYSNATELADYLVAKGIPFREAHHIVGVAVVGAIEKGIPLEDLTVTQFKEFSSVIEDD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
VYPVLTLEATLAARKALGGVSPEQIEYALTEAEQRLADRDTSGIVIRAARLTDIDRIEAM
CCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHH
VNHLADTGENLRRDKTDLAESVAEFAVAEIDGKVTACASVHIYDTGLAEIRSLGVEPGFE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCCCC
RRGQGSALVDFLVKRTEKQAIKRLFVLTRMPDFFMKLGFSPESKTTMPEKVLKDCSMFVS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EHASDEKALELNYKTSMLLHKGMSKI
HCCCCCCEEEECHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFSHAADVKFKLFNDSLRFDYRLAEQDIIGSIAWSKALQTVDVLTNDEQKRLEA
CCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALNELLVSVKDNPELVLQSDAEDIHSWTEGQLINKIGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKKRAQELVVHLDALEAKLIELARIHQGVVLPGYTHLQRAQPVTFSHWCLAYLEMLERDH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCH
DRLEGCLERLDTCPLGSGALAGTGYAIDRTALAHSLGFKRATRNSLDAVSDRDHVVELMS
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHH
CATMSMMHMSRMAEDLIFYNSGESGFIEMSDLVTSGSSLMPQKKNPDAMELIRGRTGRVF
HHHHHHHHHHHHHHHHEEEECCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLAAMLMTLKGLPLAYNKDMQEDKEGLFDSLDTWGDCLEMAAMALTDLKVNEERTKEAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QGGYSNATELADYLVAKGIPFREAHHIVGVAVVGAIEKGIPLEDLTVTQFKEFSSVIEDD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
VYPVLTLEATLAARKALGGVSPEQIEYALTEAEQRLADRDTSGIVIRAARLTDIDRIEAM
CCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHH
VNHLADTGENLRRDKTDLAESVAEFAVAEIDGKVTACASVHIYDTGLAEIRSLGVEPGFE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCCCC
RRGQGSALVDFLVKRTEKQAIKRLFVLTRMPDFFMKLGFSPESKTTMPEKVLKDCSMFVS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EHASDEKALELNYKTSMLLHKGMSKI
HCCCCCCEEEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10692366 [H]