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The map label for this gene is prlC [H]

Identifier: 119943998

GI number: 119943998

Start: 264982

End: 267033

Strand: Direct

Name: prlC [H]

Synonym: Ping_0212

Alternate gene names: 119943998

Gene position: 264982-267033 (Clockwise)

Preceding gene: 119943997

Following gene: 119944003

Centisome position: 5.81

GC content: 43.18

Gene sequence:

>2052_bases
ATGAATAATTCTGAAATATCAAGTATCAAGCAAACAGATGGTTTGCCTTCATTTAGCCAAATAACCCCGGATCAGATAGT
ACCGGCCGTGACTGAAGCGATCAGCAATAATAAAGCGCTAATAGAAGAGAAACTGCAAAGCTTAACGCATTTCACCTGGG
ATAATTTTGTTAATGTATTGGATGAAGCGGATGATCATCTCGGCAAGTTATGGTCACCGGTTGGACATATGAATGCCGTT
GTTAGTAATGATTCGCTCCGTCAGGCACATGATGCCTGTCTACCTTTGTTTGCTGAATACGCAACTTTTGTGGGCCAGCA
TCAAGGTCTTTATGACGCTTACCTCAGTATTTCAAAAAGTGATGAATTTACAAATTTAAAAGAGGAACAGCAGAAGGTTA
TTAACAATGCGCTGCGTGATTTTAAATTATCCGGTATTGCTTTGCCTGAAGATAAAAAGCGACGTTATGGTGAGATCACC
CAACAACTTTCGCAGTTGCAATCAGAGTTCAGTAATAATGTCATGGATGCGACGCTAGCCTGGAGTAAATTGATTTCCGA
TGTTAAGGAATTAGACGGTTTGCCTGAAAGTGCTTTGGCCGCTGCAAAACAAGCGGCTCAGGAAAAAGATCAGCAGGGCT
ATTTATTAACCTTGGATTTCCCAAGTTATTTACCGGTAATGACTTATGCAAAAAATCGCACATTACGCCACGAGGTCTAC
CAGGCTTTTGCAACGCGCGCATCGGATCAAGGTCCGCAGGCTGGTGAGTTTGATAATTCAGACATTATTGAAAAAATATT
AGCGCTGCGCCACGAACTGGCTTTATTGTTAGGTTTTGATAATTTCGCTGATTACAGTTTAGCCACTAAAATGGCTGAAA
GCCCGCTGCAGGTTATTAATTTCTTAACCGAGCTTGCTGAAAAATCTTATCCTCAAGGTCTGCGGGAGTGCGACGAGGTA
TTGGCCTTTGCTAAAGGCTTAGACGGGATTGAGCATTTAGAGTCTTGGGATTTAAGTTATTATGCCGAGCGCCTAAAGCA
GCAGAAATATGCTATCTCCGATGAGGAACTGCGTCCCTATTTTCCTGAAAATAATGTGCTGAAGGGGTTATTTGAAGTTG
TCCACCGTCTCTTTGGATTAACTATTAAGGAGATTCCAGGCGTTGATACTTGGCATGCGGATGTACACTTTTTTGAGATC
TACGATCAACAGAAAAATCATCTGGGTAGTTTTTATCTGGATCTCTATGCGCGAGCCCATAAACGGGGTGGTGCATGGAT
GAACGATTGCCGGGTTCGTCGTCGTTTAGTTAATGGACAGCTGCAATTACCCGTTGCTTATTTGACTTGTAATTTTACTA
AACCGGTTGGCGATCAACCAGCGTTATTTACTCATAACGAAGTCACTACTCTGTTTCACGAGTTTGGCCATGGTCTTCAC
CATATGCTGACCAAAATCGAATCCGCTTCGGTATCCGGCATTAATGGGGTGCCTTGGGATGCGGTTGAGTTACCCAGTCA
GTTTTTAGAAAATTGGTGCTGGGAACCACAAGCATTAGCCCTAATTTCCGGGCATGTCAAAACAGGTGAAACCTTGCCAG
CGGAGCTGCTTGAGAAAATGTTAGCCGCTAAAAACTACAACGGTGCATTAATGATGCTGCGTCAGATAGAGTTCTCTTTA
TTTGATTTTGTATTACATCATCAATACCAGCCAGAGAAAGGCTCGCAGGCGGAAAAAGTCTTGAATGACGTGCGCGATCA
GGTAGCTGTTATTAGACCTCCATCCTTTAACCGTTTCCAGCATGGTTTTAGCCATATCTTTGCGGGCGGTTACGCGGCAG
GTTATTACAGTTATAAATGGGCAGAAGTTTTATCTGCAGATGCTTTTTCCCGCTTTGAAGAGTTCGGTATTTTTGACGAG
GAGACGGGTCGTGAGTTTCTTCAGGCGATTTTAGAAAAGGGCGGCAGTTCCGATCCAATGGAACTGTTTAAAAACTTTAT
GGGCCGTGAACCGAGTATTGAGGCTTTATTACGCCATTCTGGAATAGAATAG

Upstream 100 bases:

>100_bases
CTATCTCTCTATAATAATCTATATCCAAATTATTTGAAGACTGCATCTTTAAGTTGTTTGGATATAAAGCCGTAATTTTT
TCTTTATATAGAAGACCGCT

Downstream 100 bases:

>100_bases
ATATAAGGCTATAAGGCTATAAGGTTATAAGGTTATAAGGCTATAAGGCGGGAAGGTTAACAACCCGCTTTTAGCTTTCG
GCTTTCAGCTTTCCAGCCTT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MNNSEISSIKQTDGLPSFSQITPDQIVPAVTEAISNNKALIEEKLQSLTHFTWDNFVNVLDEADDHLGKLWSPVGHMNAV
VSNDSLRQAHDACLPLFAEYATFVGQHQGLYDAYLSISKSDEFTNLKEEQQKVINNALRDFKLSGIALPEDKKRRYGEIT
QQLSQLQSEFSNNVMDATLAWSKLISDVKELDGLPESALAAAKQAAQEKDQQGYLLTLDFPSYLPVMTYAKNRTLRHEVY
QAFATRASDQGPQAGEFDNSDIIEKILALRHELALLLGFDNFADYSLATKMAESPLQVINFLTELAEKSYPQGLRECDEV
LAFAKGLDGIEHLESWDLSYYAERLKQQKYAISDEELRPYFPENNVLKGLFEVVHRLFGLTIKEIPGVDTWHADVHFFEI
YDQQKNHLGSFYLDLYARAHKRGGAWMNDCRVRRRLVNGQLQLPVAYLTCNFTKPVGDQPALFTHNEVTTLFHEFGHGLH
HMLTKIESASVSGINGVPWDAVELPSQFLENWCWEPQALALISGHVKTGETLPAELLEKMLAAKNYNGALMMLRQIEFSL
FDFVLHHQYQPEKGSQAEKVLNDVRDQVAVIRPPSFNRFQHGFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEEFGIFDE
ETGREFLQAILEKGGSSDPMELFKNFMGREPSIEALLRHSGIE

Sequences:

>Translated_683_residues
MNNSEISSIKQTDGLPSFSQITPDQIVPAVTEAISNNKALIEEKLQSLTHFTWDNFVNVLDEADDHLGKLWSPVGHMNAV
VSNDSLRQAHDACLPLFAEYATFVGQHQGLYDAYLSISKSDEFTNLKEEQQKVINNALRDFKLSGIALPEDKKRRYGEIT
QQLSQLQSEFSNNVMDATLAWSKLISDVKELDGLPESALAAAKQAAQEKDQQGYLLTLDFPSYLPVMTYAKNRTLRHEVY
QAFATRASDQGPQAGEFDNSDIIEKILALRHELALLLGFDNFADYSLATKMAESPLQVINFLTELAEKSYPQGLRECDEV
LAFAKGLDGIEHLESWDLSYYAERLKQQKYAISDEELRPYFPENNVLKGLFEVVHRLFGLTIKEIPGVDTWHADVHFFEI
YDQQKNHLGSFYLDLYARAHKRGGAWMNDCRVRRRLVNGQLQLPVAYLTCNFTKPVGDQPALFTHNEVTTLFHEFGHGLH
HMLTKIESASVSGINGVPWDAVELPSQFLENWCWEPQALALISGHVKTGETLPAELLEKMLAAKNYNGALMMLRQIEFSL
FDFVLHHQYQPEKGSQAEKVLNDVRDQVAVIRPPSFNRFQHGFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEEFGIFDE
ETGREFLQAILEKGGSSDPMELFKNFMGREPSIEALLRHSGIE
>Mature_683_residues
MNNSEISSIKQTDGLPSFSQITPDQIVPAVTEAISNNKALIEEKLQSLTHFTWDNFVNVLDEADDHLGKLWSPVGHMNAV
VSNDSLRQAHDACLPLFAEYATFVGQHQGLYDAYLSISKSDEFTNLKEEQQKVINNALRDFKLSGIALPEDKKRRYGEIT
QQLSQLQSEFSNNVMDATLAWSKLISDVKELDGLPESALAAAKQAAQEKDQQGYLLTLDFPSYLPVMTYAKNRTLRHEVY
QAFATRASDQGPQAGEFDNSDIIEKILALRHELALLLGFDNFADYSLATKMAESPLQVINFLTELAEKSYPQGLRECDEV
LAFAKGLDGIEHLESWDLSYYAERLKQQKYAISDEELRPYFPENNVLKGLFEVVHRLFGLTIKEIPGVDTWHADVHFFEI
YDQQKNHLGSFYLDLYARAHKRGGAWMNDCRVRRRLVNGQLQLPVAYLTCNFTKPVGDQPALFTHNEVTTLFHEFGHGLH
HMLTKIESASVSGINGVPWDAVELPSQFLENWCWEPQALALISGHVKTGETLPAELLEKMLAAKNYNGALMMLRQIEFSL
FDFVLHHQYQPEKGSQAEKVLNDVRDQVAVIRPPSFNRFQHGFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEEFGIFDE
ETGREFLQAILEKGGSSDPMELFKNFMGREPSIEALLRHSGIE

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=613, Percent_Identity=31.6476345840131, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI14149738, Length=673, Percent_Identity=30.1634472511144, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI156105687, Length=626, Percent_Identity=24.2811501597444, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789913, Length=669, Percent_Identity=60.2391629297459, Blast_Score=859, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=674, Percent_Identity=29.9703264094956, Blast_Score=291, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71999758, Length=571, Percent_Identity=25.569176882662, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32565901, Length=654, Percent_Identity=22.0183486238532, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319793, Length=692, Percent_Identity=29.0462427745665, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322715, Length=708, Percent_Identity=22.4576271186441, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356111, Length=693, Percent_Identity=27.8499278499279, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI20129717, Length=635, Percent_Identity=25.3543307086614, Blast_Score=188, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77331; Mature: 77331

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSEISSIKQTDGLPSFSQITPDQIVPAVTEAISNNKALIEEKLQSLTHFTWDNFVNVL
CCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DEADDHLGKLWSPVGHMNAVVSNDSLRQAHDACLPLFAEYATFVGQHQGLYDAYLSISKS
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
DEFTNLKEEQQKVINNALRDFKLSGIALPEDKKRRYGEITQQLSQLQSEFSNNVMDATLA
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
WSKLISDVKELDGLPESALAAAKQAAQEKDQQGYLLTLDFPSYLPVMTYAKNRTLRHEVY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHH
QAFATRASDQGPQAGEFDNSDIIEKILALRHELALLLGFDNFADYSLATKMAESPLQVIN
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHH
FLTELAEKSYPQGLRECDEVLAFAKGLDGIEHLESWDLSYYAERLKQQKYAISDEELRPY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC
FPENNVLKGLFEVVHRLFGLTIKEIPGVDTWHADVHFFEIYDQQKNHLGSFYLDLYARAH
CCCCHHHHHHHHHHHHHHCCCHHHCCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHH
KRGGAWMNDCRVRRRLVNGQLQLPVAYLTCNFTKPVGDQPALFTHNEVTTLFHEFGHGLH
HCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHH
HMLTKIESASVSGINGVPWDAVELPSQFLENWCWEPQALALISGHVKTGETLPAELLEKM
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHH
LAAKNYNGALMMLRQIEFSLFDFVLHHQYQPEKGSQAEKVLNDVRDQVAVIRPPSFNRFQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCHHHH
HGFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEEFGIFDEETGREFLQAILEKGGSSDPM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHH
ELFKNFMGREPSIEALLRHSGIE
HHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MNNSEISSIKQTDGLPSFSQITPDQIVPAVTEAISNNKALIEEKLQSLTHFTWDNFVNVL
CCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DEADDHLGKLWSPVGHMNAVVSNDSLRQAHDACLPLFAEYATFVGQHQGLYDAYLSISKS
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
DEFTNLKEEQQKVINNALRDFKLSGIALPEDKKRRYGEITQQLSQLQSEFSNNVMDATLA
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
WSKLISDVKELDGLPESALAAAKQAAQEKDQQGYLLTLDFPSYLPVMTYAKNRTLRHEVY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHH
QAFATRASDQGPQAGEFDNSDIIEKILALRHELALLLGFDNFADYSLATKMAESPLQVIN
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHH
FLTELAEKSYPQGLRECDEVLAFAKGLDGIEHLESWDLSYYAERLKQQKYAISDEELRPY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC
FPENNVLKGLFEVVHRLFGLTIKEIPGVDTWHADVHFFEIYDQQKNHLGSFYLDLYARAH
CCCCHHHHHHHHHHHHHHCCCHHHCCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHH
KRGGAWMNDCRVRRRLVNGQLQLPVAYLTCNFTKPVGDQPALFTHNEVTTLFHEFGHGLH
HCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHH
HMLTKIESASVSGINGVPWDAVELPSQFLENWCWEPQALALISGHVKTGETLPAELLEKM
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHH
LAAKNYNGALMMLRQIEFSLFDFVLHHQYQPEKGSQAEKVLNDVRDQVAVIRPPSFNRFQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCHHHH
HGFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEEFGIFDEETGREFLQAILEKGGSSDPM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHH
ELFKNFMGREPSIEALLRHSGIE
HHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]