Click here to switch to the map view.

The map label for this gene is msrAB [H]

Identifier: 119944003

GI number: 119944003

Start: 272473

End: 272919

Strand: Direct

Name: msrAB [H]

Synonym: Ping_0217

Alternate gene names: 119944003

Gene position: 272473-272919 (Clockwise)

Preceding gene: 119943998

Following gene: 119944004

Centisome position: 5.98

GC content: 41.83

Gene sequence:

>447_bases
ATGACTGACTATAAAAAACCAGATGAGCAAAAGTTACGCGAACAATTAAATAACGTTCAGTATCAAGTGACTCAGCAAGA
CGCTACGGAGCCACCTTTTGATAATGACTATTGGGACAATCATGCTGCTGGCATTTATGTTGATATTGTTTCTGGAGAGC
CTCTATTTAGCTCGCTAGATAAATTTGATGCACACTGCGGATGGCCTAGTTTTACGCAACCCCTGCAACCAAAAAAAGTG
CTAGAAAAGGTCGACACACAATTATTTGCCACACGAACGGAAGTGCGCAGTGCTATTGCGGATTCACATTTAGGGCATGT
TTTTGACGATGGCCCCGCACCCGGTGGATTGCGTTATTGTATCAATTCGGCCTCACTGCGTTTTATTAAGCTTGAGGATA
TGGCCGAACAGGGTTATCAAGAATTTCTTTATCTTTTTGATAAATAA

Upstream 100 bases:

>100_bases
TCATGTTGCGTCTTGCTCTGGTCTCCGATCTTGCGCCTGACAAAGCATCTTGAAGTAACATGGGTATTAATAATGATCAC
AATGATAATGAAGGTGAAAA

Downstream 100 bases:

>100_bases
TATAAATTTATTGATATCAGCCCCCGATAGGCAGTTTTTCTTAGGTAATAGACTGACTGCTGAGTGAGGCTCAGCTTGAT
AACCCTGTTTTTGTGGTTAT

Product: methionine-R-sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTDYKKPDEQKLREQLNNVQYQVTQQDATEPPFDNDYWDNHAAGIYVDIVSGEPLFSSLDKFDAHCGWPSFTQPLQPKKV
LEKVDTQLFATRTEVRSAIADSHLGHVFDDGPAPGGLRYCINSASLRFIKLEDMAEQGYQEFLYLFDK

Sequences:

>Translated_148_residues
MTDYKKPDEQKLREQLNNVQYQVTQQDATEPPFDNDYWDNHAAGIYVDIVSGEPLFSSLDKFDAHCGWPSFTQPLQPKKV
LEKVDTQLFATRTEVRSAIADSHLGHVFDDGPAPGGLRYCINSASLRFIKLEDMAEQGYQEFLYLFDK
>Mature_147_residues
TDYKKPDEQKLREQLNNVQYQVTQQDATEPPFDNDYWDNHAAGIYVDIVSGEPLFSSLDKFDAHCGWPSFTQPLQPKKVL
EKVDTQLFATRTEVRSAIADSHLGHVFDDGPAPGGLRYCINSASLRFIKLEDMAEQGYQEFLYLFDK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=121, Percent_Identity=43.801652892562, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI301336162, Length=121, Percent_Identity=43.801652892562, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI73089054, Length=121, Percent_Identity=43.801652892562, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI37620216, Length=121, Percent_Identity=43.801652892562, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI117606353, Length=123, Percent_Identity=41.4634146341463, Blast_Score=106, Evalue=8e-24,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=43.1818181818182, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17553450, Length=117, Percent_Identity=42.7350427350427, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=117, Percent_Identity=42.7350427350427, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319816, Length=129, Percent_Identity=34.8837209302326, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221378664, Length=124, Percent_Identity=46.7741935483871, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45553335, Length=123, Percent_Identity=47.1544715447154, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356369, Length=123, Percent_Identity=47.1544715447154, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645799, Length=123, Percent_Identity=47.1544715447154, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=45.0381679389313, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24645804, Length=134, Percent_Identity=43.2835820895522, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24645801, Length=134, Percent_Identity=43.2835820895522, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 16953; Mature: 16822

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYKKPDEQKLREQLNNVQYQVTQQDATEPPFDNDYWDNHAAGIYVDIVSGEPLFSSLD
CCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
KFDAHCGWPSFTQPLQPKKVLEKVDTQLFATRTEVRSAIADSHLGHVFDDGPAPGGLRYC
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
INSASLRFIKLEDMAEQGYQEFLYLFDK
HCCCCEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDYKKPDEQKLREQLNNVQYQVTQQDATEPPFDNDYWDNHAAGIYVDIVSGEPLFSSLD
CCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
KFDAHCGWPSFTQPLQPKKVLEKVDTQLFATRTEVRSAIADSHLGHVFDDGPAPGGLRYC
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
INSASLRFIKLEDMAEQGYQEFLYLFDK
HCCCCEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]