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The map label for this gene is mtlD

Identifier: 119943882

GI number: 119943882

Start: 120193

End: 121341

Strand: Direct

Name: mtlD

Synonym: Ping_0089

Alternate gene names: 119943882

Gene position: 120193-121341 (Clockwise)

Preceding gene: 119943881

Following gene: 119943883

Centisome position: 2.64

GC content: 41.34

Gene sequence:

>1149_bases
ATGAAAGCGATACATTTTGGCGCGGGTAATATTGGCCGTGGTTTTATTGGTAAAGTTTTATCGGATGCAGGTATTAAAGT
CACCTTTGCCGATGTCAATAAAACGGTTGTAAATGCCCTGATAGCGCGAAATGAATATGATGTAAATGTTGTTGGTGCAG
ACTGTGTGGTTGAAAAAGTAACTAATGTTACTGCTGTTAATTCGGCTGGTTCTGAGATTGTTAAATTGATTGCAGAGTCT
GATTTAGTCACCACGGCGGTAGGCCCTACCGTATTGAATATTATTGCAAAAACAATTGCTGATGCTATCGAGCTGCGTTT
AAACAGCGGCAATAAGTTTCCGTTAAATATTATTGCCTGTGAAAATATGGTTCGTGGTACCAGCCAGCTAAAAGCGCAGG
TATTCAAATATCTACCCGAGTCTTTGCATGTTCAATCTGACCAGACTATTGGTTTTGTTGATTGTGCTGTTGATCGTATT
GTACCGCCAGCTGAAGCGGGAGAAACGGATCCATTAGCAGTAACCGTTGAAACCTTTAGCGAATGGATTGTTGACCAAAC
ACAATTTAAAGGTGAAATTCCAACTATTAAAGGGATGGAATGCACTGATAATTTAATGGCCTTTGTTGAGCGTAAATTAT
TTACGTTAAATACCGGGCATCTGATCACTGCATACTTAGGTGTGCTTGCCGGTTACGAGACTATTAAAGAATCAATTGAA
GATGAGGCTATTCGATCCGATGTAACCGCTGCTATGCAGGAAAGCGGTGAAGTTTTAATACGTCGCTATGGTTTTGACCC
ACAAGCCCACGCGGCTTATATTCAAAAAATATTAGGTCGTTTTGCGAATCCCTATTTACGCGATGAGGTGGATCGTGTTG
GTCGCCAGCCAATCCGTAAATTAAGTGCAAACGATCGTTTAATTAAGCCTCTTAACGGTACATTAGAGTATGGCTTACCT
AATGGGCATTTAATTAAGGGGATTGCTGCAGCATTCCTATATAAAAATGATCAAGATCCTCAAGCCGTTGAGTTGCAGGC
CATGTTCGCGGAAAAGGGGTTAGCTGCAACATTAGCACATTATTCCGGGCTGGCTGTTGACAGTGAAACTGTTAAACTGG
TCGAACAAGCTTACCAAAGCCTAAAATGA

Upstream 100 bases:

>100_bases
AACTAGAAGCTTCTTAAGGTAGCTGCTTCGATTGAGGTGGCCGATTAAATATTCGAGGCTAGATTTTCTAGCCTTTTTTA
ATTTTAGGGAAATATTTATT

Downstream 100 bases:

>100_bases
TGACTCAATTCCAGTGCCGCTTTTGCGGCACTTATTTATTTTATTAGAAAAATTATGACAAAATTTGCCCGTTTAAAATT
TGATATTGATATTGTAGAAA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKVTNVTAVNSAGSEIVKLIAES
DLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIACENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRI
VPPAEAGETDPLAVTVETFSEWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIE
DEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRKLSANDRLIKPLNGTLEYGLP
NGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAHYSGLAVDSETVKLVEQAYQSLK

Sequences:

>Translated_382_residues
MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKVTNVTAVNSAGSEIVKLIAES
DLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIACENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRI
VPPAEAGETDPLAVTVETFSEWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIE
DEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRKLSANDRLIKPLNGTLEYGLP
NGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAHYSGLAVDSETVKLVEQAYQSLK
>Mature_382_residues
MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKVTNVTAVNSAGSEIVKLIAES
DLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIACENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRI
VPPAEAGETDPLAVTVETFSEWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIE
DEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRKLSANDRLIKPLNGTLEYGLP
NGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAHYSGLAVDSETVKLVEQAYQSLK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=64.3979057591623, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1790779, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787823, Length=242, Percent_Identity=26.8595041322314, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788497, Length=203, Percent_Identity=27.0935960591133, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324401, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320765, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_PSYIN (A1SR48)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941562.1
- ProteinModelPortal:   A1SR48
- STRING:   A1SR48
- GeneID:   4625012
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0089
- eggNOG:   COG0246
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- PhylomeDB:   A1SR48
- ProtClustDB:   PRK02318
- BioCyc:   PING357804:PING_0089-MONOMER
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 41472; Mature: 41472

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKV
CCEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
TNVTAVNSAGSEIVKLIAESDLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIAC
HCHHEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEH
ENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRIVPPAEAGETDPLAVTVETFS
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHHHCCCCCCCCCCCCEEEEHHHHH
EWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIE
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHH
DEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LSANDRLIKPLNGTLEYGLPNGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAH
HCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH
YSGLAVDSETVKLVEQAYQSLK
HCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKV
CCEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
TNVTAVNSAGSEIVKLIAESDLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIAC
HCHHEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEH
ENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRIVPPAEAGETDPLAVTVETFS
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHHHCCCCCCCCCCCCEEEEHHHHH
EWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIE
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHH
DEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LSANDRLIKPLNGTLEYGLPNGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAH
HCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH
YSGLAVDSETVKLVEQAYQSLK
HCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA