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The map label for this gene is lsrR [H]

Identifier: 119943880

GI number: 119943880

Start: 116597

End: 117577

Strand: Reverse

Name: lsrR [H]

Synonym: Ping_0087

Alternate gene names: 119943880

Gene position: 117577-116597 (Counterclockwise)

Preceding gene: 119943884

Following gene: 119943879

Centisome position: 2.58

GC content: 44.65

Gene sequence:

>981_bases
ATGTCTCAAGTAAAGACTACTTCCACCACACCCGGTATTGACGATCATGAAATGTTGACCGAGATTGCTATCCTCTATTA
TCAGGAAGGTGCGACTCAAGCAGAGATATCAAAAAAGTTTTCTATCTCTAGAATTAAAATTGGACGCCTGCTGCGTAGAG
CACGAGAAGAGGGGGTTGTTGAGATTAATGTACGTTACCATCCCATCTATACGGCCCAACTTGAGAAACGCTTAATCAAG
AAATTCAATCTCAAACGTGTCCTTATTGCGCTGGATCAAGCGAATAACGAAGAGCAGCGCAAACAGGTCGCGGGGCTTGT
CTCAGCCTTTCTCGCTATCAACCTGCAGGACGATAGTACGGTCGCGGTTGGCCAAGGCCAAAATGTCGCGGCCGTTGCCG
ATCATGTAGGCCTGGTGACACAACGCAAGGCACGATTTGTTTGTGCTATTGGTGGTACTCATCGCAGTGGGGATAGCATT
AATGCAGACCATATCTGTCGTCAACTTGCTAAAAAATTTGGCGGTACCAGTGAAACCTTGTATGCACCTGCCTATGTTGA
TAATCCCGAGACTCGCAACGCTTTTATTGCTCATAACACGGTTTCTGAAACATTAAAACAAGCTAGAAATGCAGATTATG
CTCTGGTGGGTGTCGGTGATATGAATAAAAATAGTCATATGATTAAACTCGGATGGTTTACCAAGCAAGAGTTTGCAGAG
GCGCGCATCAATGAAGGTATCATTGGTGATATTGGTGGTTTTGATTTCTTTAAATCTAATGGCCAAAGAGCGAACACCCG
GTTAAGAGATCGGGTGATTGGTCTGGGCACCGAGGATTTACGCCGTATTCCAAATGTAATTGCCATTGCCAGCGAAGAAA
GAAAATCCTTAGCTCTGGCAGGTGCACTGCGTACCGGCAGTATAGATATCTTAGCCACTAGCGTAAGTTGTGCAATGACG
TTATTAAATATGGAAGATTAA

Upstream 100 bases:

>100_bases
ACCTTAGTCTATTGCCAAACAGCACTAAATTATGGGAACATCTGAAAGATTAATGACCATTTGAACACCACTTAATTTAA
TTAACTAATGAGTAATCTAG

Downstream 100 bases:

>100_bases
TCCTAAAAATAAGGACTGATTTAAGGTACTTTCCAAAAAAATTTACAAATTCAATATATTAGGAGATATAAGATAGAAGA
GTACAAAAATACCAACTCCG

Product: transcriptional regulator

Products: protein histidine; sugar phosphate

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSQVKTTSTTPGIDDHEMLTEIAILYYQEGATQAEISKKFSISRIKIGRLLRRAREEGVVEINVRYHPIYTAQLEKRLIK
KFNLKRVLIALDQANNEEQRKQVAGLVSAFLAINLQDDSTVAVGQGQNVAAVADHVGLVTQRKARFVCAIGGTHRSGDSI
NADHICRQLAKKFGGTSETLYAPAYVDNPETRNAFIAHNTVSETLKQARNADYALVGVGDMNKNSHMIKLGWFTKQEFAE
ARINEGIIGDIGGFDFFKSNGQRANTRLRDRVIGLGTEDLRRIPNVIAIASEERKSLALAGALRTGSIDILATSVSCAMT
LLNMED

Sequences:

>Translated_326_residues
MSQVKTTSTTPGIDDHEMLTEIAILYYQEGATQAEISKKFSISRIKIGRLLRRAREEGVVEINVRYHPIYTAQLEKRLIK
KFNLKRVLIALDQANNEEQRKQVAGLVSAFLAINLQDDSTVAVGQGQNVAAVADHVGLVTQRKARFVCAIGGTHRSGDSI
NADHICRQLAKKFGGTSETLYAPAYVDNPETRNAFIAHNTVSETLKQARNADYALVGVGDMNKNSHMIKLGWFTKQEFAE
ARINEGIIGDIGGFDFFKSNGQRANTRLRDRVIGLGTEDLRRIPNVIAIASEERKSLALAGALRTGSIDILATSVSCAMT
LLNMED
>Mature_325_residues
SQVKTTSTTPGIDDHEMLTEIAILYYQEGATQAEISKKFSISRIKIGRLLRRAREEGVVEINVRYHPIYTAQLEKRLIKK
FNLKRVLIALDQANNEEQRKQVAGLVSAFLAINLQDDSTVAVGQGQNVAAVADHVGLVTQRKARFVCAIGGTHRSGDSIN
ADHICRQLAKKFGGTSETLYAPAYVDNPETRNAFIAHNTVSETLKQARNADYALVGVGDMNKNSHMIKLGWFTKQEFAEA
RINEGIIGDIGGFDFFKSNGQRANTRLRDRVIGLGTEDLRRIPNVIAIASEERKSLALAGALRTGSIDILATSVSCAMTL
LNMED

Specific function: Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, lsrR is inactivated by binding phospho-AI-2, leading to the trans

COG id: COG2390

COG function: function code K; Transcriptional regulator, contains sigma factor-related N-terminal domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sorC transcriptional regulatory family [H]

Homologues:

Organism=Escherichia coli, GI1787791, Length=321, Percent_Identity=26.791277258567, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082414, Length=309, Percent_Identity=24.9190938511327, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007324
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04198 Sugar-bind [H]

EC number: 2.7.1.69

Molecular weight: Translated: 35875; Mature: 35744

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVKTTSTTPGIDDHEMLTEIAILYYQEGATQAEISKKFSISRIKIGRLLRRAREEGVV
CCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHCHHHHHHHHHHHHHHHCCEE
EINVRYHPIYTAQLEKRLIKKFNLKRVLIALDQANNEEQRKQVAGLVSAFLAINLQDDST
EEEEEEEEEEHHHHHHHHHHHHCHHEEEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCE
VAVGQGQNVAAVADHVGLVTQRKARFVCAIGGTHRSGDSINADHICRQLAKKFGGTSETL
EEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
YAPAYVDNPETRNAFIAHNTVSETLKQARNADYALVGVGDMNKNSHMIKLGWFTKQEFAE
EECEECCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHHHHH
ARINEGIIGDIGGFDFFKSNGQRANTRLRDRVIGLGTEDLRRIPNVIAIASEERKSLALA
HHHCCCCEECCCCCHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHEEHH
GALRTGSIDILATSVSCAMTLLNMED
EEECCCCEEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure 
SQVKTTSTTPGIDDHEMLTEIAILYYQEGATQAEISKKFSISRIKIGRLLRRAREEGVV
CCCCCCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHCHHHHHHHHHHHHHHHCCEE
EINVRYHPIYTAQLEKRLIKKFNLKRVLIALDQANNEEQRKQVAGLVSAFLAINLQDDST
EEEEEEEEEEHHHHHHHHHHHHCHHEEEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCE
VAVGQGQNVAAVADHVGLVTQRKARFVCAIGGTHRSGDSINADHICRQLAKKFGGTSETL
EEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
YAPAYVDNPETRNAFIAHNTVSETLKQARNADYALVGVGDMNKNSHMIKLGWFTKQEFAE
EECEECCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHHHHH
ARINEGIIGDIGGFDFFKSNGQRANTRLRDRVIGLGTEDLRRIPNVIAIASEERKSLALA
HHHCCCCEECCCCCHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHEEHH
GALRTGSIDILATSVSCAMTLLNMED
EEECCCCEEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]