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The map label for this gene is uvrD [H]

Identifier: 119943802

GI number: 119943802

Start: 13204

End: 15375

Strand: Reverse

Name: uvrD [H]

Synonym: Ping_0008

Alternate gene names: 119943802

Gene position: 15375-13204 (Counterclockwise)

Preceding gene: 119943803

Following gene: 119943801

Centisome position: 0.34

GC content: 42.36

Gene sequence:

>2172_bases
ATGGATGTTTCCTACTTAATTGATGATTTAAATGATCACCAGCGTGCTGCTGTTTCCGCACCCGAGCAGAATATGCTGGT
TTTAGCCGGTGCCGGTAGTGGTAAAACACGTGTATTAACGCATCGAATCGCATGGTTGATGCAGGTAGAAAACATTCCAA
CATATTCTATTTTGGCGGTTACCTTTACCAATAAAGCCGCCAAGGAGATGCGTGGCCGTATTACGGATATTTGCCCGCAA
CAGATAGGCGGGATGTGGATAGGTACTTTCCATGGCACCGCCCACCGCTTATTGCGCCTGCATTATCAAGAAGCTAATTT
ACCTGAACAGTTTCAAATAATTGATAGCGATGATCAAAAAAAAATGGTCAAACGTATTATCAAAAGTCTTAATTTAGATG
AAAAATATTACCCTGCTAAAGAGTTACAGTGGTATATCAACGATAAAAAAGATGAGGGTTTACGGGCAAAACATATTCAG
GTTGGTTATAGCCAGCAGGAAAAACAACGCCTGCAGGTTTATCAAGCCTACGAAGAGGCTTGCCAACTTGCCGGATTAGT
TGATTTCGCAGAATTATTATTACGTGCCCACGAATTGTTATTAAATAACCCTTCTCTGTTATTACATTATCAGCAACGTT
TCCGCCATGTGTTGGTCGATGAGTTTCAGGATACCAATAAACTTCAATATGCCTGGTTAAACCTGCTTACCGAGAACAAC
AGTTATTTGACCATAGTCGGAGATGATGACCAGTCAATTTATGGTTGGCGGGGCGCTGACGTTGAGAATATTCAACGTTT
TTTAAGGGAAAAAGATAATCCGGTGACGGTCTGCTTAGAGCAAAACTACCGATCAACGGGACATATATTAAATGCCTCTA
ACCAGCTTATTAAAAATAATAGTGACAGATTAGGCAAAGAGTTATGGACCAGCGGTGAAGATGGGCAACCCATTGCCATT
TACAGTGCATTTAATGATTATGATGAAACACGTTATGTTACCTCGCAGTTAAAACTATGGCAAAATAGTGGTAAAAAGCT
GGCTGAATGTGCCATTTTATACCGTAGCAATGCACAATCTCGTCTTTTTGAAGAACAGTTAATGGCACAACAGATTCCCT
ACCATATTTATGGTGGTCAGCGCTTCTTTGATCGTTTAGAGATAAAAGACAGTATCGCCTATCTGCGCTTAATCAATAAT
CATCAAGATGATGCGGCATTTGAACGTATTATCAATAAACCTAAACGTAAAATTGGTAATACCACACTTGATAAGATTCG
ACTTTGTGCCCGCGAGCAGGGTTATACCATGTGGCAGGCGAGTCTGTTTTTAATTGAGCAAAAACAACTGAGTGCGGGTG
CGAATATTTCATTATCCGGATTTATTGAATTAATAAAGCGTTTTGAAAATGAAACCTCTGAGCTGCCTTTGTTTCAGACG
GTTGACCATGTGATCCGTCACTCCGGTTTGCATAGCATGTTCGAAAATGAAAAAGGTGAAAAATCACGCAGCCGTATAGA
AAATTTACAAGAGCTAGTTTCTGCAACTAAATCCTTTGTGATCCCCCCCGAAGAGCAGGAAATGAGCGAGGTCACGGCCT
TTTTAGCTTATGCAGCGCTGGAATCAGGTGATAACCAGGCCGATGAATTTGATGATGCAGTACAACTAATGACCATGCAT
GCGGCAAAAGGATTAGAGTTCCCGCAAGTCTTTATGGTGGGTGTGGAAGAAGGCATGTTTCCCGGACAGCAATCTGCCGA
CGATGAAGTGCGCTTAGCCGAAGAACGTCGCCTTTGTTATGTTGGTATGACCAGAGCAATGCAAAAACTAACCCTTTGTC
ATGCCGAAAGCCGCCGTTTATACGGACAAGAGAAATTCCATTCTCCTTCTCGTTTTATTAGCGAGCTGCCAGAACAGGAT
ATTGAATATATTCGTCTTAAAACCCAGGTCCGAAGAGTCCAGCAACCTACCGTTAAGCAGCCCGCATTTACCCGGGAAAA
TCAGGATATTTCAGGCTTTAGGATTGGCCAGCAAGTAACCCATCCTAAGTTTGGAGAAGGCACTGTTATTGCGCAGGAGG
GCAGCGGAGAAAACAGTCGCTTACAAGTGAATTTTATGGGAGTAGGCAGTAAATGGTTAATGACCGCTTACGCTCGTCTC
GAGACAGTATAG

Upstream 100 bases:

>100_bases
TGGTGCGATGTTATTACCAACCGTGGAAATCAGTCGTTTAGATCAATTATATAAACTGCTATAATTTTCTTTTACTGAAT
AAATAAACAGGTCTTTTGTT

Downstream 100 bases:

>100_bases
GTAGCAGTGTCAACATTAGGTAAAATATAGGTCTATTTTAACCTTTTTTATGTTTAAATTAAAAAAGGTTAACTAAACTT
CATATAACTGTTATTACGGT

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MDVSYLIDDLNDHQRAAVSAPEQNMLVLAGAGSGKTRVLTHRIAWLMQVENIPTYSILAVTFTNKAAKEMRGRITDICPQ
QIGGMWIGTFHGTAHRLLRLHYQEANLPEQFQIIDSDDQKKMVKRIIKSLNLDEKYYPAKELQWYINDKKDEGLRAKHIQ
VGYSQQEKQRLQVYQAYEEACQLAGLVDFAELLLRAHELLLNNPSLLLHYQQRFRHVLVDEFQDTNKLQYAWLNLLTENN
SYLTIVGDDDQSIYGWRGADVENIQRFLREKDNPVTVCLEQNYRSTGHILNASNQLIKNNSDRLGKELWTSGEDGQPIAI
YSAFNDYDETRYVTSQLKLWQNSGKKLAECAILYRSNAQSRLFEEQLMAQQIPYHIYGGQRFFDRLEIKDSIAYLRLINN
HQDDAAFERIINKPKRKIGNTTLDKIRLCAREQGYTMWQASLFLIEQKQLSAGANISLSGFIELIKRFENETSELPLFQT
VDHVIRHSGLHSMFENEKGEKSRSRIENLQELVSATKSFVIPPEEQEMSEVTAFLAYAALESGDNQADEFDDAVQLMTMH
AAKGLEFPQVFMVGVEEGMFPGQQSADDEVRLAEERRLCYVGMTRAMQKLTLCHAESRRLYGQEKFHSPSRFISELPEQD
IEYIRLKTQVRRVQQPTVKQPAFTRENQDISGFRIGQQVTHPKFGEGTVIAQEGSGENSRLQVNFMGVGSKWLMTAYARL
ETV

Sequences:

>Translated_723_residues
MDVSYLIDDLNDHQRAAVSAPEQNMLVLAGAGSGKTRVLTHRIAWLMQVENIPTYSILAVTFTNKAAKEMRGRITDICPQ
QIGGMWIGTFHGTAHRLLRLHYQEANLPEQFQIIDSDDQKKMVKRIIKSLNLDEKYYPAKELQWYINDKKDEGLRAKHIQ
VGYSQQEKQRLQVYQAYEEACQLAGLVDFAELLLRAHELLLNNPSLLLHYQQRFRHVLVDEFQDTNKLQYAWLNLLTENN
SYLTIVGDDDQSIYGWRGADVENIQRFLREKDNPVTVCLEQNYRSTGHILNASNQLIKNNSDRLGKELWTSGEDGQPIAI
YSAFNDYDETRYVTSQLKLWQNSGKKLAECAILYRSNAQSRLFEEQLMAQQIPYHIYGGQRFFDRLEIKDSIAYLRLINN
HQDDAAFERIINKPKRKIGNTTLDKIRLCAREQGYTMWQASLFLIEQKQLSAGANISLSGFIELIKRFENETSELPLFQT
VDHVIRHSGLHSMFENEKGEKSRSRIENLQELVSATKSFVIPPEEQEMSEVTAFLAYAALESGDNQADEFDDAVQLMTMH
AAKGLEFPQVFMVGVEEGMFPGQQSADDEVRLAEERRLCYVGMTRAMQKLTLCHAESRRLYGQEKFHSPSRFISELPEQD
IEYIRLKTQVRRVQQPTVKQPAFTRENQDISGFRIGQQVTHPKFGEGTVIAQEGSGENSRLQVNFMGVGSKWLMTAYARL
ETV
>Mature_723_residues
MDVSYLIDDLNDHQRAAVSAPEQNMLVLAGAGSGKTRVLTHRIAWLMQVENIPTYSILAVTFTNKAAKEMRGRITDICPQ
QIGGMWIGTFHGTAHRLLRLHYQEANLPEQFQIIDSDDQKKMVKRIIKSLNLDEKYYPAKELQWYINDKKDEGLRAKHIQ
VGYSQQEKQRLQVYQAYEEACQLAGLVDFAELLLRAHELLLNNPSLLLHYQQRFRHVLVDEFQDTNKLQYAWLNLLTENN
SYLTIVGDDDQSIYGWRGADVENIQRFLREKDNPVTVCLEQNYRSTGHILNASNQLIKNNSDRLGKELWTSGEDGQPIAI
YSAFNDYDETRYVTSQLKLWQNSGKKLAECAILYRSNAQSRLFEEQLMAQQIPYHIYGGQRFFDRLEIKDSIAYLRLINN
HQDDAAFERIINKPKRKIGNTTLDKIRLCAREQGYTMWQASLFLIEQKQLSAGANISLSGFIELIKRFENETSELPLFQT
VDHVIRHSGLHSMFENEKGEKSRSRIENLQELVSATKSFVIPPEEQEMSEVTAFLAYAALESGDNQADEFDDAVQLMTMH
AAKGLEFPQVFMVGVEEGMFPGQQSADDEVRLAEERRLCYVGMTRAMQKLTLCHAESRRLYGQEKFHSPSRFISELPEQD
IEYIRLKTQVRRVQQPTVKQPAFTRENQDISGFRIGQQVTHPKFGEGTVIAQEGSGENSRLQVNFMGVGSKWLMTAYARL
ETV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=723, Percent_Identity=60.4426002766252, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=644, Percent_Identity=37.5776397515528, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322369, Length=467, Percent_Identity=30.1927194860814, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324477, Length=679, Percent_Identity=23.4167893961708, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83165; Mature: 83165

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSYLIDDLNDHQRAAVSAPEQNMLVLAGAGSGKTRVLTHRIAWLMQVENIPTYSILAV
CCHHHHHHCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
TFTNKAAKEMRGRITDICPQQIGGMWIGTFHGTAHRLLRLHYQEANLPEQFQIIDSDDQK
EECCHHHHHHHCHHHHCCHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEECCCCHH
KMVKRIIKSLNLDEKYYPAKELQWYINDKKDEGLRAKHIQVGYSQQEKQRLQVYQAYEEA
HHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
CQLAGLVDFAELLLRAHELLLNNPSLLLHYQQRFRHVLVDEFQDTNKLQYAWLNLLTENN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCC
SYLTIVGDDDQSIYGWRGADVENIQRFLREKDNPVTVCLEQNYRSTGHILNASNQLIKNN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEECCCHHHHCCC
SDRLGKELWTSGEDGQPIAIYSAFNDYDETRYVTSQLKLWQNSGKKLAECAILYRSNAQS
HHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
RLFEEQLMAQQIPYHIYGGQRFFDRLEIKDSIAYLRLINNHQDDAAFERIINKPKRKIGN
HHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
TTLDKIRLCAREQGYTMWQASLFLIEQKQLSAGANISLSGFIELIKRFENETSELPLFQT
CHHHHHHHHHHHCCCEEEEHHEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
VDHVIRHSGLHSMFENEKGEKSRSRIENLQELVSATKSFVIPPEEQEMSEVTAFLAYAAL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ESGDNQADEFDDAVQLMTMHAAKGLEFPQVFMVGVEEGMFPGQQSADDEVRLAEERRLCY
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHCCCHH
VGMTRAMQKLTLCHAESRRLYGQEKFHSPSRFISELPEQDIEYIRLKTQVRRVQQPTVKQ
HHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
PAFTRENQDISGFRIGQQVTHPKFGEGTVIAQEGSGENSRLQVNFMGVGSKWLMTAYARL
CCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCHHHHHHHHHHH
ETV
HCC
>Mature Secondary Structure
MDVSYLIDDLNDHQRAAVSAPEQNMLVLAGAGSGKTRVLTHRIAWLMQVENIPTYSILAV
CCHHHHHHCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
TFTNKAAKEMRGRITDICPQQIGGMWIGTFHGTAHRLLRLHYQEANLPEQFQIIDSDDQK
EECCHHHHHHHCHHHHCCHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEECCCCHH
KMVKRIIKSLNLDEKYYPAKELQWYINDKKDEGLRAKHIQVGYSQQEKQRLQVYQAYEEA
HHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
CQLAGLVDFAELLLRAHELLLNNPSLLLHYQQRFRHVLVDEFQDTNKLQYAWLNLLTENN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCC
SYLTIVGDDDQSIYGWRGADVENIQRFLREKDNPVTVCLEQNYRSTGHILNASNQLIKNN
CEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEECCCHHHHCCC
SDRLGKELWTSGEDGQPIAIYSAFNDYDETRYVTSQLKLWQNSGKKLAECAILYRSNAQS
HHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHH
RLFEEQLMAQQIPYHIYGGQRFFDRLEIKDSIAYLRLINNHQDDAAFERIINKPKRKIGN
HHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
TTLDKIRLCAREQGYTMWQASLFLIEQKQLSAGANISLSGFIELIKRFENETSELPLFQT
CHHHHHHHHHHHCCCEEEEHHEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
VDHVIRHSGLHSMFENEKGEKSRSRIENLQELVSATKSFVIPPEEQEMSEVTAFLAYAAL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ESGDNQADEFDDAVQLMTMHAAKGLEFPQVFMVGVEEGMFPGQQSADDEVRLAEERRLCY
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHCCCHH
VGMTRAMQKLTLCHAESRRLYGQEKFHSPSRFISELPEQDIEYIRLKTQVRRVQQPTVKQ
HHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
PAFTRENQDISGFRIGQQVTHPKFGEGTVIAQEGSGENSRLQVNFMGVGSKWLMTAYARL
CCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCHHHHHHHHHHH
ETV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]