Click here to switch to the map view.

The map label for this gene is tipA [H]

Identifier: 119871454

GI number: 119871454

Start: 5662651

End: 5663433

Strand: Direct

Name: tipA [H]

Synonym: Mkms_5430

Alternate gene names: 119871454

Gene position: 5662651-5663433 (Clockwise)

Preceding gene: 119871453

Following gene: 119871455

Centisome position: 98.7

GC content: 67.05

Gene sequence:

>783_bases
TTGACCGCCAACACTGCTGGCGTCACCATCGGCCGAGCAGCGGCCTTCGCCGGCGTCACGATCAAGACGGTCCGCCACTA
CCACCGGATCGGCCTGCTCGACGAACCGCCCCGTGACGGTGCCGGATATCGCCGCTACGGGTCGTCCGACCTGCTGCGGC
TGATTCAGGTCCGGACGCTGGCCCAGGCCGGCGTACCGCTCTCCGACATCGGCGCATTGCTCACCGCCGATCCAGAGCAG
TTCGCCGGCCACCTGGCCGCAGTCAAACGACAGCTGACCGAGCGGGTCGATGAGCTGATCGCGCGCCGCGACCTGCTCGA
CAGGCTGACCAGCGACGATCTGACCCTGTTGCCCGACCAGGCATGCGCACTGTTGGACCGGACCATCGTCTTGGGCTTCA
CCCCCGACGCGGTGGCGCTCTTCCGCGAGAGCCTGGTGCTGGTCAGGGCACTGGTCCCCGACGGCTTCTCCGAATACCTC
ACCGAGGCCGAAAACGTCCTCACTGACCCCCAATTCGTCGACCTGGTGAAGCAGTTCTGGTCCGCCAAGGACCTGGATCC
AGATGACCCCCGCATCGAGGAACTCGCAACCGCCATGGCCGCCCGCTTCCTCGCCAACCCCGCGTTGCTCGCCGTGTCGA
ATGGCCTTCAGGCCCGAACGGACGTCACCCGGTACGGCCTGCTCAACCACCACGGCGAAGACGAGGCGCCGGCCCTGGCG
CGGTTGACCACCCTGGTCGAGGCGAAACTGCGCTCCGCGGGTATCGACATCCCGCACCAATAA

Upstream 100 bases:

>100_bases
GCGCGAAGGTCGACAGCAACCACGGCACGATCGTGCGCAAGGATTTCCGCGCCATCGCCCGGGCGGTACGCGAAGTCGCC
GCCTTCGGCCGCCAAAGTCG

Downstream 100 bases:

>100_bases
TCGCCGGCCGCCCTGGATGTGCCGAGGGGGCGGATTTCGCTCCGATTCTGCAGCGGTGCTCCCACGAAGATGTCGGTGCC
GGCGTCTACGATGCCTGCGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTANTAGVTIGRAAAFAGVTIKTVRHYHRIGLLDEPPRDGAGYRRYGSSDLLRLIQVRTLAQAGVPLSDIGALLTADPEQ
FAGHLAAVKRQLTERVDELIARRDLLDRLTSDDLTLLPDQACALLDRTIVLGFTPDAVALFRESLVLVRALVPDGFSEYL
TEAENVLTDPQFVDLVKQFWSAKDLDPDDPRIEELATAMAARFLANPALLAVSNGLQARTDVTRYGLLNHHGEDEAPALA
RLTTLVEAKLRSAGIDIPHQ

Sequences:

>Translated_260_residues
MTANTAGVTIGRAAAFAGVTIKTVRHYHRIGLLDEPPRDGAGYRRYGSSDLLRLIQVRTLAQAGVPLSDIGALLTADPEQ
FAGHLAAVKRQLTERVDELIARRDLLDRLTSDDLTLLPDQACALLDRTIVLGFTPDAVALFRESLVLVRALVPDGFSEYL
TEAENVLTDPQFVDLVKQFWSAKDLDPDDPRIEELATAMAARFLANPALLAVSNGLQARTDVTRYGLLNHHGEDEAPALA
RLTTLVEAKLRSAGIDIPHQ
>Mature_259_residues
TANTAGVTIGRAAAFAGVTIKTVRHYHRIGLLDEPPRDGAGYRRYGSSDLLRLIQVRTLAQAGVPLSDIGALLTADPEQF
AGHLAAVKRQLTERVDELIARRDLLDRLTSDDLTLLPDQACALLDRTIVLGFTPDAVALFRESLVLVRALVPDGFSEYLT
EAENVLTDPQFVDLVKQFWSAKDLDPDDPRIEELATAMAARFLANPALLAVSNGLQARTDVTRYGLLNHHGEDEAPALAR
LTTLVEAKLRSAGIDIPHQ

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 28323; Mature: 28191

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANTAGVTIGRAAAFAGVTIKTVRHYHRIGLLDEPPRDGAGYRRYGSSDLLRLIQVRTL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHH
AQAGVPLSDIGALLTADPEQFAGHLAAVKRQLTERVDELIARRDLLDRLTSDDLTLLPDQ
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
ACALLDRTIVLGFTPDAVALFRESLVLVRALVPDGFSEYLTEAENVLTDPQFVDLVKQFW
HHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
SAKDLDPDDPRIEELATAMAARFLANPALLAVSNGLQARTDVTRYGLLNHHGEDEAPALA
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
RLTTLVEAKLRSAGIDIPHQ
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TANTAGVTIGRAAAFAGVTIKTVRHYHRIGLLDEPPRDGAGYRRYGSSDLLRLIQVRTL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHH
AQAGVPLSDIGALLTADPEQFAGHLAAVKRQLTERVDELIARRDLLDRLTSDDLTLLPDQ
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
ACALLDRTIVLGFTPDAVALFRESLVLVRALVPDGFSEYLTEAENVLTDPQFVDLVKQFW
HHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
SAKDLDPDDPRIEELATAMAARFLANPALLAVSNGLQARTDVTRYGLLNHHGEDEAPALA
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
RLTTLVEAKLRSAGIDIPHQ
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]